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Books in Molecular biology cellular biology and genetics

This collection offers insights into gene expression, cell signalling, and genetic regulation. Supporting researchers, clinicians, and students, it features advanced techniques, genetic engineering, and disease mechanisms, fostering innovations in personalized medicine, regenerative therapies, and molecular diagnostics.

  • Unlocking the Secrets of Extracellular Vesicles and Exosomes

    A Journey into the Cutting-Edge Frontier of Cellular Communication
    • 1st Edition
    • Chandrashekhar Singh + 4 more
    • English
    Unlocking the secrets of extracellular vesicles and exosomes: A journey into the cutting-edge frontier of cellular communication provides a comprehensive overview of the latest advances and research on extracellular vesicles (EVs) and exosomes. The book begins with a historical introduction to the field and how this has evolved since EVs were first observed, before exploring their cellular mechanisms and approaches to study their isolation, characterization, and function. It then delves into exosomes in health and disease, considering their role across cancer, regenerative medicine, neurological disorders, and metabolic disorders, highlighting their potential as biomarkers for disease diagnosis. The book moves on to discuss cutting-edge technology for the engineering of EVs and exosomes, considering how the integration of AI, machine learning, and nanotechnology can be utilized to expand the therapeutic capabilities of EV and exosome-based applications. It then closes with chapters covering novel applications in nutraceutical and cosmetic production, and a look towards the future potential of EVs and exosomes. Unlocking the secrets of extracellular vesicles and exosomes offer a thorough exploration of EV and exosome research, covering various dimensions from basic science to clinical applications and future perspectives. It is an ideal guide for researchers working across a diverse range of disciplines, including cell biology, molecular biology, biotechnology, therapeutics, and biomedicine.

  • 2D and 3D Cellular Screening Models and AI Guided Analysis

    • 1st Edition
    • Volume 204
    • English
    2D and 3D Cellular Screening Models and AI Guided Analysis provides a comprehensive overview of the latest advancements in cellular screening models, with a particular focus on both 2D and 3D systems. It explores the development, application, and comparative benefits of 2D monolayer cultures and 3D organoids, spheroids, and tissue-engineered constructs for biomedical research and drug discovery.

  • Cutting-Edge Technology for Plant Metabolite Profiling in Drug Discovery and Quality Control

    • 1st Edition
    • Ramesh Kumar Ahirwar + 4 more
    • English
    Cutting-Edge Technology for Plant Metabolite Profiling in Drug Discovery and Quality Control offers a comprehensive exploration of advanced methods in plant metabolomics, along with their integration in industrial applications across various sectors. The book delves into a range of methodologies, including metabolic engineering strategies, metabolite imaging techniques, nuclear magnetic resonance (NMR) for plant metabolite analysis, microfluidics for metabolite profiling, computational methods, and bioinformatics tools. It also explores plant metabolomics for crop improvement, pharmaceutical development, archaeological examinations, cosmetic formulations, and food quality, with case studies featured throughout the book to showcase real-world applications and scenarios. As the demand for natural products and plant-derived therapeutics continues to rise, there is a need for reliable and effective methods to identify, quantify, and optimize the bioactive compounds present in plants. This book provides a comprehensive guide to the latest advances in this field while also delivering a multidisciplinary overview of the wide-ranging impact plant metabolites have across a variety of applications. Researchers working with plant metabolites across molecular and cellular biology, pharmaceutical science, biotechnology, biochemistry and plant science will benefit from this book. Additionally, it will be of interest to specialists working across relevant industries, such as pharmaceuticals, nutraceuticals, cosmetics and agriculture.

  • Cerebellum Development and Disease

    • 1st Edition
    • Volume 167
    • English
    Cerebellum Development and Disease, Volume 167 offers a comprehensive overview of the intricate processes underlying the formation, maturation, and function of the cerebellum, as well as the wide spectrum of disorders that can affect this essential brain region. Chapters in this new release cover Olivocerebellar circuit development as a substrate for dystonia pathogenesis, Simply complex – that structure of the cerebellar neuronal lineage, Ontogenesis and diversification of cerebellar glia: a developmental perspective, Purkinje cell diversification: a blueprint for cerebellar development, patterning, and evolution, On the Emergence of Folding in the Cerebellum, Scaling and regeneration in the developing cerebellum, ASTN2 in ASD and Neurodevelopmental Disorders, and much more.Additional sections focus on Stem cell-derived in vitro models of human cerebellar development, Development of Spinocerebellar System within the Precerebellar Network, and Cerebellum evo-devo. The book brings together leading experts in neurodevelopment, neurobiology, genetics, and clinical neurosciences to explore the molecular and cellular mechanisms guiding cerebellar development, from embryogenesis to adulthood.

  • Structural Study of Amyloid-β

    • 1st Edition
    • Volume 729
    • English
    Structural Study of Amyloid-β, Volume 729 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on important topics such as the Extraction of Amyloids from Neurodegenerative Disease Tissues for Structural Analysis, Cryo-EM Structure Determination of Amyloid Fibrils: Methodology, Insights, and Practical Tools, Methods for studying molecular architecture of Ab aggregates in tissues using cryo-ET, Cryo-EM methods to study binding between amyloid fibrils and chemical compounds or ligan, Dynamics studies of side-chains and hydration shells in amyloid-beta fibrils using deuterium and oxygen-17 solid-state NMR, and much more.Additional chapters cover the Technical aspects of pressure jump NMR applied to the study of Abeta and protein oligomerization, Characterizations of the beta-amyloid-membran... interaction intermediates, Time-resolved solid-state NMR studies of oligomer formation, Methods for characterizing the individual filament structures of amyloid peptide assemblies using atomic force microscopy, Single-molecule fluorescence spectroscopy and imaging on heterogeneous amyloid beta aggregation, Two-dimensional FT-IR methods on amyloid aggregation and folding pathways, and much more.

  • Artificial Intelligence for Multi-omics Analysis Part B

    • 1st Edition
    • Volume 222
    • English
    Artificial Intelligence for Multi-omics Analysis Part B, Volume 222 in the Progress in Molecular Biology and Translational Science series, highlights recent advances, with this new volume presenting chapters on a variety of topics, including Artificial Intelligence in multi-omics analysis of small molecule drug discovery, AI in multi-omics analysis in antimicrobial resistance, Artificial Intelligence and multi-Omics Approach in Vaccine Development, Artificial Intelligence in multi-omics Analysis of heart diseases, Artificial Intelligence in multi-omics Analysis of Kidney Diseases, Artificial Intelligence in multi-omics Analysis of Gastrointestinal Diseases, AI in multi-omics analysis in Stem cell research, and AI in multi-omics analysis in cancer, and more.Additional sections cover AI in multi-omics analysis in obstructive lung diseases, AI in multi-omics analysis in neurodiseases, AI in multi-omics analysis in autoimmune diseases, AI in multi-omics analysis of liver diseases, AI in multi-omics analysis of COVID-19 patient data, and AI in multi-omics analysis of Type 2 diabetes.

  • Autophagy – Part A

    • 1st Edition
    • Volume 403
    • English
    This comprehensive volume explores the fundamental biological process of autophagy, a critical cellular mechanism responsible for the degradation and recycling of cellular components. Beginning with the historical discovery and molecular mechanisms of autophagy, the book delves into its regulation, physiological roles, and significance in maintaining cellular homeostasis. It highlights the diverse functions of autophagy in health, development, aging, and disease, including its involvement in cancer, neurodegeneration, infection, immunity, and metabolic disorders.

  • Animal Models of Disease Part E

    • 1st Edition
    • Volume 203
    • English
    Animal Models of Disease, Part E, Volume 203 in the Methods in Cell Biology series, presents significant advancements in understanding disease mechanisms through animal models. The book features chapters on timely topics such as characterizing tumor-infiltrating group 1 innate lymphoid cells in PyMT breast tumors and using zebrafish to unravel the molecular mechanisms of Alzheimer’s disease. The book also covers colitis mouse models and appropriate models for studying diabetes pathophysiology, demonstrating its comprehensive approach to current research.Additional sections cover evaluating polyglutamine protein aggregation in transgenic Caenorhabditis elegans models of Huntington's disease and studying tumor responses to radioimmunotherapy in ovarian cancer models. It also highlights the antimicrobial regime for gut microbiota depletion in mice and the biodistribution of metallic nanoparticles for lymphoma studies. This book is an essential resource for researchers seeking to explore disease mechanisms and therapeutic approaches through animal models.

  • PACAP

    From Discovery to Function
    • 1st Edition
    • David Vaudry + 1 more
    • English
    PACAP: From Discovery to Function in Health and Disease serves as a comprehensive review covering all aspects of PACAP and its receptors, from expression to function in healthy tissues and disease models. The book introduces the biochemical, pharmacological and signaling properties of PACAP before exploring the biological actions of PACAP in normal health and pathological conditions. It considers PACAP in relation to various aspects, including pain, stress, brain injury, tumor cells and neurodegenerative disease. Effect on peripheral organs is also covered, from the gastrointestinal tract and cardiovascular system to immune cells and bones, among others. Therapeutic potential is also explored. This is a volume in the Molecular Mediators in Health and Disease book series, and provides a complete analysis of PACAP and the latest research in the field. Thus it is an ideal guide for researchers interested in PACAP and its impact across health and disease.

  • Nutritional Epigenomics

    • 2nd Edition
    • Volume 14
    • English
    Nutritional Epigenomics, Second Edition, Volume Fourteen in the Translational Epigenetics series, offers a comprehensive overview of nutritional epigenomics as a mode of study, along with nutrition’s role in the epigenomic regulation of disease, health, and developmental processes. Here, an expert team of international contributors introduces readers to nutritional epigenomic regulators of gene expression, our diet’s role in epigenomic regulation of disease and disease inheritance, caloric restriction and exercise as they relate to recent epigenomic findings, and the influence of nutritional epigenomics over circadian rhythms, aging and longevity, and fetal health and development, among other processes.Disease specific chapters address metabolic disease (obesity and diabetes), cancer, and neurodegeneration, among other disorders. Diet-gut microbiome interactions in the epigenomic regulation of disease are also discussed, as is the role of micronutrients and milk miRNAs in epigenetic regulation. Finally, chapter authors examine ongoing discussions of race and ethnicity in the social-epigenomic regulation of health and disease. This new edition has been fully updated to reflect current research in the field.

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