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Books in Molecular biology cellular biology and genetics

This collection offers insights into gene expression, cell signalling, and genetic regulation. Supporting researchers, clinicians, and students, it features advanced techniques, genetic engineering, and disease mechanisms, fostering innovations in personalized medicine, regenerative therapies, and molecular diagnostics.

BooksJournals

  • Epigenetic Regulation of Cancer - Part E

    • 1st Edition
    • Volume 400
    • English
    Epigenetic Regulation of Cancer, Part E, Volume 400 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of hot topics, including Revisiting Epigenetic Regulation in Cancer: Evolving Trends and Translational Implications, Epigenetic Alteration in Cervical Cancer Induced by Human Papillomavirus, Integrative analysis of transcriptome, chromatin accessibility, cell surface antigen in single cell level for AML, Role of miRNAs as epigenetic regulators of immune checkpoints in lung cancer immunity, and much more.Other chapters cover The translational potential of epigenetic modulatory bioactive phytochemicals as adjuvant therapy against cancer, Strategies for improving chemotherapeutic sensitivity and the epigenetic regulation of doxorubicin resistance, and more.

  • Live Biotherapeutics: Advancing Microbial Medicine

    • 1st Edition
    • Volume 220
    • English
    Microbial therapeutics are rapidly reshaping modern medicine, with live biotherapeutics emerging as a promising frontier. By harnessing the power of beneficial microbes, these innovative treatments offer new hope for conditions that resist conventional drugs, including metabolic disorders and antimicrobial-resist... infections. As the demand for safer, more effective alternatives grows, understanding this field becomes increasingly vital. The upcoming book, Live Biotherapeutics: Advancing Microbial Medicine, will provide a comprehensive and accessible overview of the science, applications, and future potential of live biotherapeutics in transforming healthcare.

  • Cell Shape and Position during Development

    • 1st Edition
    • Volume 166
    • English
    Cell Shape and Position during Development, Volume 166 provides a comprehensive overview of the fundamental roles that cell morphology and spatial organization play in the development of multicellular organisms. This volume brings together leading experts in developmental biology, cell biology, and biophysics to explore how cells acquire specific shapes. Chapters in this new release include Cell shape changes during sperm-egg interactions, Cell shape and position during organ development, Regulation of shape and position during asymmetric cell division, Cell shape dynamics during mouse peri-implantation development and embryo dormancy, Shaping the intestine: the role of cell morphology and spatial dynamics in development, and more.Additional sections Intermediate filaments in cell shape and position, Regulation of adult stem cell behavior by cytoskeletal dynamics and cell shape, Shape changes in gastrulation, and more.

  • Stem Cell-Mediated Regulation of Pyroptosis

    • 1st Edition
    • Debalina Bhattacharya + 1 more
    • English
    Stem Cell-Mediated Regulation of Pyroptosis investigates the role of pyroptosis in various types of stem cells and stem cell-derived exosomes, considering how they can accelerate tissue repair and regeneration in inflammatory diseases. The book begins with an introduction to the mechanisms of pyroptosis and methods available for its detection. It then considers pyroptosis and its relationship to stem cells before delving into the interaction across various conditions, ranging from cerebral injury, spinal injury, cardiac injury, osteoarthritis, cancer, and more. Users will find the latest research and future directions in the study of stem cells and pyroptosis, thus enabling further understanding of the cellular mechanisms underlying this form of cell death and the clinical significance of stem cells in the context of pyroptosis-induced diseases. Therapeutic implications and potential strategies targeting this pathway for the treatment of such conditions are also considered, providing a comprehensive reference that will be useful to researchers working across cell biology, regenerative medicine, immunology, therapeutics, and other related fields.

  • Lipids and Membranes: Detection by Imaging and Lipidomics

    • 1st Edition
    • Volume 726
    • English
    Lipids and Membranes: Detection by Imaging and Lipidomics, Volume 727 covers lipids, a chemically diverse set of biological molecules subject to rapid metabolism and transport. This dynamic behavior has motivated the development of methods across multiple disciplines for their detection and manipulation. Split into three parts, the chapters in this new release include Measurement of fatty acid esters of hydroxy fatty acids, Superresolution organelle imaging with lipophilic HIDE probes, Ultra-high resolution analysis of membrane lipids from 15N metabolically labeled mice, Superresolution lipid imaging with expansion microscopy, High-resolution phosphoinositide analysis in healthy versus disease cells, and much more.Additional chapters focus on Alkyne lipids as tracers of lipid metabolism, Imaging oxidative stress in biomembranes, Imaging the dynamics of phosphatidylinositol 4-phosphate metabolism, Lipidomics for studying sphingolipids in cell death, Non-invasive imaging of phosphoinositides with genetically encoded lipid biosensors, Profiling lipotypes at the single cell level in heterogenous populations, MS imaging of phosphoinositides, and much more.

  • Lipids and Membranes: Dynamics and Interorganelle Lipid Transport

    • 1st Edition
    • Volume 727
    • English
    Lipids and Membranes: Dynamics and Interorganelle Lipid Transport, Volume 728 covers lipids, a chemically diverse set of biological molecules subject to rapid metabolism and transport. This dynamic behavior has motivated the development of methods across multiple disciplines for their detection and manipulation. Split into three parts, the book's chapters include topics such as Assay of phospholipid scrambling, Tracking lipid transport with bifunctional lipids, Tracking interorganelle lipid transport using genetically encoded mass tags, Molecular Dynamics Simulation of Lipid and Ligand Binding in ORD Domains, Imaging lipid droplet-organelle membrane contact sites using fluorogenic complementation, Studying interactions of amphipathic helices with lipid droplets, and more.Additional chapters cover Metabolic labeling of to trace changes in sphingolipid metabolism, Imaging intracellular lipid heterogeneity with fluorogen-activated coincidence sensing, Tagging lipoproteins in mycobacteria, Probes for studying sphingolipid dynamics, Measuring Flipper-TR Lifetime with Multiple Analysis Strategies, Reconstitution approaches to understanding cellular lipid dynamics, Prediction and characterization of the bacterial lipid handling machinery, From Molecular Dynamics to Cryo-EM: Imaging Liposomes in Silico, and much more.

  • Design and Applications of Cell-Free Systems Part B

    • 1st Edition
    • Volume 219
    • English
    Design and Applications of Cell-Free Systems, Part B, Volume 219 offers the latest information on cell free systems for the expression of transmembrane proteins, enzymes, proteins, therapeutics, vaccines, and uses in the biotransformation, translational modification, self-assembly of nano-biomaterials, and in synthetic biology design, challenges, and opportunities. It will help students, researchers, scientists, clinicians, stakeholders, policymakers, and practitioners understand cell-free systems and their applications in many areas. The book represents an important component in the field of biochemistry, duly acknowledging the pioneering effort made by Nobel laureate Eduard Buchner for discovery of fermentation in yeast cell extracts (YCE).CFS requires core molecular machinery, including RNA polymerase, translational apparatus (ribosomes, tRNA synthases, and translation factors), energy-generating molecules, and their cofactors, substrates, and DNA or plasmid templates for obtaining desired products. CFS is a simple, rapid, and sensitive platform, which is devoid of membrane-bound barriers, yet contains all the mandatory substrates, biomolecules, and machineries required for the synthesis of the desired proteins.

  • Immuno-oncology and Immunotherapy Part G

    • 1st Edition
    • Volume 202
    • English
    Immuno-oncology and Immunotherapy, Part G, Volume 202 in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including In situ imaging of pulmonary invariant Natural Killer T cells in precision cut lung slices, Immunofluorescent microscopy to quantify and characterize chromosomal instability, Spatial techniques for understanding the tumor microenvironment, Very high-flex immunophenotyping using co-linear cytofluorometric evaluation, Large-scale CRISPR-Cas9 screens to define regulators of immune checkpoint biology, Assessment of cytoplasmic dsDNA for cellular immunogenicty, and much more.Additional sections cover Harmonization of a multiparametric flow cytometry panel for immunological monitoring on PBMC and whole blood samples: a real-life example, Quantitative assessment of arterial remodeling from confocal microscopy image analysis of the mid-gestation mouse decidua, Phenotypic characterization and function of tumor infiltrating and peripheral B cells in cancer patients, Methodological Advances to analyze Cancer-Associated Fibroblast-derived ECM effects on Macrophage Polarization, and many other topics that will be of interest to readers.

  • Simulating Protein Folding in Variable Environmental Conditions

    Transformation from Globular Proteins to Amyloids
    • 1st Edition
    • Irena Roterman-Konieczna
    • English
    Simulating Protein Folding in Variable Environmental Conditions: Transformation from Globular Proteins to Amyloids delves into the effects of external conditions upon the protein folding process. The book considers how this can lead to amyloid formation and why proteins fold the way they do. It presents the fuzzy oil drop model (FOD-M), which enables the measurements of external factors influencing the folding process and considers changed external conditions as the source for the misfolding process. Sections provide an introduction to amyloid transformation and outline the hypothesis of the model simulation before considering the role of environmental factors, including the water environment and membrane environment. This book is a useful resource for researchers interested in investigating protein folding across molecular biology, structural biology, biochemistry, computational biology and related fields.

  • Proteomics: A Promising Approach for Cancer Research

    Proteome Signaling Dysregulation in Cancer, Therapeutic Interventions, and Future Perspectives, Volume 2
    • 1st Edition
    • Muneeb U Rehman + 3 more
    • English
    Proteomics: A Promising Approach for Cancer Research Volume 2 Proteome signaling dysregulation in cancer, therapeutic interventions, and future perspectives provides an updated overview of scientific knowledge, achievements, and findings in the field of cancer proteomics. The field of cancer proteomics is very dynamic, with emerging trends specifically related to clinical solutions. The book content was developed to help readers get up to speed on the topic and easily apply learnings into research or clinical practice.Volume 2 covers proteome signaling, their dysregulation to therapeutics options and future prospects in 17 different signaling pathways. It capitalizes the enormous interest in proteomics among academics and gives new viewpoints on this topic in cancer treatment. It is a valuable resource for cancer researchers, oncologists, graduate students, and members of biomedical field who are interested in the potential of proteomics in cancer research and treatment.

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