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Elsevier

Books in Molecular biology cellular biology and genetics

This collection offers insights into gene expression, cell signalling, and genetic regulation. Supporting researchers, clinicians, and students, it features advanced techniques, genetic engineering, and disease mechanisms, fostering innovations in personalized medicine, regenerative therapies, and molecular diagnostics.

  • Phosphodiesterase Inhibitors

    • 1st Edition
    • English
    Non-selective inhibitors of cyclic nucleotide phosphodiesterase (PDE), such as theophylline, have been used extensively since 1958. In the decade of the '70s, various PDE isoenzymes were defined which led to the development of the second generation of PDE inhibitors. Currently a variety of these new inhibitors are under test as potential anti-inflammatory drugs. During the past five years, molecular biology has revealed a superfamily of these phosphodiesterase isoenzymes. This book summarizes the present state of knowledge, as well as giving a comprehensive description of the compounds available. It will be invaluable for everyone who wants to choose the most suitable PDE inhibitor for their research or who is dealing with such drugs in a clinical setting.

  • Nitric Oxide Synthase: Characterization and Functional Analysis

    • 1st Edition
    • Volume 31
    • English
    Although the function of nitric oxide in a regulatory capacity in the central and peripheral nervous system is widely recognized, the full scope of its actions and its interrelationships with other classes of regulatory molecules is just beginning to be comprehended. This volume contains a number of sophisticated and advanced methods essential for exploring the activity of nitric oxide in the brain. It will be a valuable tool for the established investigator and for those just entering the field.

  • Current Topics in Developmental Biology

    • 1st Edition
    • Volume 34
    • English
    Volume 34 continues the series' tradition of timely review and incisive analyses of key research in developmental biology. Not only valuable to researchers at the forefront of animal and plant development, this volume is also a friendly introduction to students and professionals who are curious about current topics in cellular and molecular mechanisms in development.

  • Advances in Genetics

    • 1st Edition
    • Volume 34
    • English
    This volume of Advances in Genetics illustrates the series goal to publish the most current, up-to-date reviews in the field of molecular and human genetics. This volume deviates from previous volumes in that it focuses solely on the polytene chromosome. In an excellent and exhaustive review, I.F. Zhimulev illustrates the use and function of the polytene chromosome in three parts: morphology and structure, organization and functional role of the heterochromaticregio... and the transcription patterns and replication of the chromosome. To best illustrate the breadth and scope of research, Dr. Zhimulev includes more than 100 figures and more than 2900 references specifically relevant to the polytene chromosome.

  • Advances in Immunology

    • 1st Edition
    • Volume 62
    • English

  • Advances in Cancer Research

    • 1st Edition
    • Volume 69
    • English
    This volume of Advances in Cancer Research begins with a "Foundations in Cancer Research" articles by Harold Varmus. He focuses on Andrew Lwoff who influenced a generation of scientists and how Dr. Lwoff's influence on Howard Temlin, in particular, led to the identification of the cause of AIDS. Hiroto Okayama and colleagues discuss the conserved control mechanisms of the G1 and G2 phases in fission yeasts and mammals, and the newly identified control genes. Nilis Mandahl presents the cytogenetic findings in bone and soft tissue tumors and introduces the major molecular genetic findings. Hannel Tapiovaara dn co-workers review plasmin generation at restricted areas of the cell surface and hypothesize that it may be a catalyst for tumor cells to metastasize. Noël Bouck et al. review the evidence suggesting that certain types of stimulations of inducers by activated oncogenes, and decreased production of inhibitors of angiogenesis, may be instrumental in enabling developing tumour cells to attract new cells and continue the malignant growth. Peter L. Stern reviews the role of immunity and the prospects for immune intervention in cervical neoplasia. Lastly, Denis J. Moss and his associates discuss the Epstein-Barr virus (EBV) host-virus relationship and the immune control of EBV infections and examine development of vaccines and immunotherapy.

  • Rhodopsin and G-Protein Linked Receptors, Part A

    • 1st Edition
    • Volume 2
    • A.G. Lee
    • English
    The quantity of information available about membrane proteins is now too large for any one person to be familiar with anything but a very small part of the primary literature. A series of volumes concentrating on molecular aspects of biological membranes therefore seems timely. The hope is that, when complete, these volumes will provide a convenient introduction to the study of a wide range of membrane functions.Applicatio... of the techniques of molecular biology has provided the sequences of a very large number of membrane proteins, and has led to the discovery of superfamilies of membrane proteins of related structure. The classic example of the superfamily is the seven helix receptor superfamily, all related in structure to bacteriorhodpsin, and named after the seven trans-membrane a-helices identified in bacteriorhodpsin. This volume explores the structures and functions of this super family.

  • Progress in Nucleic Acid Research and Molecular Biology

    • 1st Edition
    • Volume 54
    • English
    Praise for the Series:"Full of interest not only for the molecular biologist - for whom the numerous references will be invaluable - but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell."--British Medical Journal

  • Nitric Oxide

    Principles and Actions
    • 1st Edition
    • Jack Lancaster Jr.
    • English
    This unique sourcebook serves as a comprehensive reference, bridging the well-established chemistry of nitric oxide and the new and exciting role of nitric oxide as an effector and signaling molecule in numerous biological systems. Nitric Oxide: Principles and Actions relates the chemical properties of the molecule to its possible effects on biological systems, under both normal physiological and pathophysiological conditions. Combining the chemistry and analysis of nitric oxide with newer studies of the relevance of the molecule gives this book a long life, making it extremely useful to researchers in a number of areas.

  • Nitric Oxide, Part A: Sources and Detection of NO; NO Synthase

    • 1st Edition
    • Volume 268
    • John N. Abelson + 1 more
    • English
    Nitric oxide, recently named"Molecule of the Year"by the journal Science, impinges on a wide range of fields in biological research, particularly in the areas of biomedicine and cell and organismal biology, as well as in fundamental chemistry. This volume and its companion Volume 269 highlight the most current and up-to-date methods used to research the physiology and toxicity of nitric oxide in cellular and organismal systems. It will be a valuable resourcefor the experienced researcher as well as for those newly entering the field.

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