Books in Biochemistry biophysics

Milk Proteins V2

1st Edition
December 2, 2012
Hugh McKenzie
English
eBook
9 7 8 0 3 2 3 1 4 5 7 7 0

Milk Proteins: Chemistry and Molecular Biology, Volume II provides an extensive and detailed discussion on individual milk proteins. This volume focuses on caseins, which constitute the major group of milk proteins, and provides an understanding of the formation and structure of casein micelles. The topics discussed include the formation and structure of casein micelles; isolation, properties, and zone electrophoresis of whole casein; casein and its attack by rennin (chymosin); biochemistry of prorennin (prochymosin) and rennin (chymosin); minor milk proteins and enzymes; milk protein research and milk technology; and milk proteins in prospect. This book is a good reference for students majoring in protein chemistry, as well as protein chemists and biochemists conducting research on milk proteins.

Practical Protein Crystallography

1st Edition
December 2, 2012
Duncan E. McRee
English
eBook
9 7 8 0 3 2 3 1 3 8 8 8 8

Designed for easy use by both new and experienced protein crystallographers, this much-needed book is for anyone interested in solving protein structures by the method of crystallography. It contains many examples ofactual experiments and data, including electron density maps. Computer methods and computer code samples are presented. Practical Protein Crystallography is loaded with new information on area detectors, synchrotron radiation techniques, and the latest computer methods, and features the XtalView software system. Graduate students and teachers in physical biochemistry and pharmaceutical researchers will find this text a timely and convenient aid.

Regulation of matrix Accumulation

1st Edition
December 2, 2012
Robert P. Mecham
English
eBook
9 7 8 0 3 2 3 1 4 9 0 0 6

Regulation of Matrix Accumulation discusses the development of research and studies on connective tissue. This book emphasizes biochemical characterization of individual connective tissue components and interactions between cells and extracellular macromolecules. Other topics include the intracellular turnover of collagen; biological regulation of collagenase activity; feedback regulation of collagen synthesis; steroid hormone regulation of extracellular matrix proteins; and control of elastin synthesis, including its molecular and cellular aspects. The catalytic and biological properties of elastases; characterization and regulation of lysyl oxidase; and matrix accumulation and the development of form, considering proteoglycans and branching morphogenesis, are explained as well. Included in this text is an autobiography and personal retrospective by Miles Partridge, one of the contributors that greatly influenced the progress in understanding extracellular matrix biology. This publication is a good reference for students and researchers conducting work on biology, specifically on connective tissue.

The Role of Membranes in Metabolic Regulation

1st Edition
December 2, 2012
Myron Mehlman
English
eBook
9 7 8 0 3 2 3 1 4 1 2 4 6

The Role of Membranes in Metabolic Regulation is the second volume in a series of in-depth reviews of specific areas of metabolic regulation. This volume is based on the 1972 symposium on The Role of Membranes in Metabolic Regulation held at the University of Nebraska Medical School. Separating 20 manuscripts into chapters, this book emphasizes membrane structure and function as well as utilization of affinity chromatography for purification of biologically important cellular components, called membrane receptors. It also discusses the role of phospholipids in hormone sensitive enzyme systems, with an emphasis on adenylate cyclase system. Other chapters describe the induction of steroidogenesis by corticotrophin and its synthetic analogues coupled by an azo linkage in free adrenal cells and the interaction between the mammary epithelial cells and insulin-sepharose systems. Topics on erythrocyte as a system for studying the properties of adenylate cyclase and the ionic effects in the sugar transport regulation in muscle are discussed in the concluding chapters of the book. Biochemists, physiologists, pharmacologists, physicians, researchers, and all others interested in the concepts about metabolic regulation will find this series of great value.

Energy Metabolism and the Regulation of Metabolic Processes in Mitochondria

1st Edition
December 2, 2012
Myron Mehlman
English
eBook
9 7 8 0 3 2 3 1 4 1 2 5 3

Energy Metabolism and the Regulation of Metabolic Processes in Mitochondria contains papers presented at the 1972 symposium on metabolic regulation, held at the University of Nebraska Medical School in Omaha, Nebraska. The contributors provide alternative views and ideas in some aspects of metabolic regulation directly concerned with mitochondrial function. Separating 16 papers into chapters, this book first discusses the general aspects of control of the biological energy regulation and the kinetic and thermodynamic control of mitochondrial electron transport and energy coupling. It then covers significant topics on citric acid cycle, including its replenishment and depletion; anion transport and regulation; dynamics and substrate compartmentation; and feedback control. Other chapters examine the mechanisms of gluconeogenesis, lipogenesis, redox reaction, and phosphorylation in the mitochondria. Discussions on hormonal regulation of selected enzyme system directly related to mitochondrial function are provided in the concluding chapters. Biochemists, physiologists, pharmacologists, physicians, researchers, and all others interested in the concepts of mitochondrial function will find this book of great value.

Prolactin Secretion: A Multidisciplinary Approach

1st Edition
December 2, 2012
Flavio Mena
English
eBook
9 7 8 0 3 2 3 1 4 1 2 7 7

Prolactin Secretion: A Multidisciplinary Approach covers the proceedings of the 1982 symposium on the frontiers and perspective of prolactin secretion through a multidisciplinary approach, convened in Nabor Carrillo Hall of the Natural University of Mexico. The symposium represents a genuine interdisciplinary effort to provide insights into the complexities of prolactin. Separating 24 manuscripts into chapters, this book first discusses studies on the molecular evolution of prolactin (PRL) and the related growth hormones and placental lactogens and the relevance of these studies for biological research on PRL, with particular emphasis on PRL secretion. Significant topics on the physiology, biochemistry, synthesis regulation, structure, function, glycoconjugates, gene expression control, regulatory, and control mechanisms of PRL and its secretion are considered in the subsequent chapters. This book also examines the action(s) of dopamine on the PRL-producing cells, the effects of his-pro diketopiperazine on PRL secretion, and the role of cellular phospholipids and the Ca2+-calmodulin system as modulators of PRL release. The effect of the suckling stimulus on the induction of PRL release in different reproductive states and the role of PRL in parental behavior in selected species of mammals and birds are also considered. The concluding chapters describe the morphologic features of abnormal lactotrophs, the in vivo and in vitro secretory activity exhibited by different types of pituitary adenomas and hyperprolactinemia. This book serves as an important reference for a wide range of investigators and advanced medical students who are engaged in the study of basic and clinical prolactin physiology.

Systems Neuroscience

1st Edition
December 2, 2012
David Metzler
English
eBook
9 7 8 0 3 2 3 1 5 7 8 0 3

Systems Neuroscience is a compilation of interdisciplinary contributions to systems neuroscience — an approach within neuroscience that connects system theory and computer simulation. The compendium contains papers that discusses and elaborates a diverse range of studies in systems neuroscience. The topics in the book include the psychophysical data on human visual perception and memory, and indicates the value of a top-down analysis in relating quantitative measurements of human behavior to the fine-level analysis of the neurophysiology; computer analysis of a neural model of masking and flicker fusion; studies on the properties of differential equations that represent networks of neurons; the development of an interactive computer graphics language for the simulation of concurrent processes such as those occurring in neural networks; and the data structures for internal representations of spatial dimensions in the brain. The book will be a good source of valuable insight for neuroscientists.

Receptor-Mediated Binding and Internalization of Toxins and Hormones

1st Edition
December 2, 2012
John Middlebrook
English
eBook
9 7 8 0 3 2 3 1 4 1 3 3 8

Receptor-Mediated Binding and Internalization of Toxins and Hormones presents the proceedings of a conference conducted for the purpose of exploring relationships between hormones and toxins, specifically, receptor-mediated internalization of toxins and hormones and the role of this internalization in message transmission and biodegradatory processes. This book is divided into three sections, with the first focusing on model systems of internalization. It presents pictorial illustrations of the receptor-mediated endocytosis of low-density lipoprotein via coated regions of membrane and discusses the receptor for lysosomal enzymes on the surface of cultured fibroblasts. The second section focuses on toxins and hormones and discusses such topics as receptor-mediated internalization of diphtheria toxin, diphtheria toxin interactions with an inhibitory activity from plasma membranes, and uptake mechanisms for ADP-ribosylating toxins. The third and final section focuses on hybrids and discusses such topics as chimeric toxins containing fragment A from diphtheria toxin, directed entry of hybrid proteins into cells via alternate receptors, and a hybrid protein of monoclonal anti-THY 1.2 and diphtheria toxin fragment A. This book will be of interest to practitioners in the fields of endocrinology, cell biology, and molecular genetics.

Auditory Physiology

1st Edition
December 2, 2012
Aage Moller
English
eBook
9 7 8 0 3 2 3 1 5 6 1 9 6

Auditory Physiology describes the functions of the ear and the auditory nervous system, using well-documented research work. This book explains the physiology of the ear, the general function of the auditory nervous system, and its anatomy. This text also discusses in detail the neurophysiological basis for discriminating frequency and time. This discrimination refers in particular to (1) the ability to distinguish two sounds on the basis of their frequencies when the two sounds are not presented at the same time; and (2) the ability to discriminate one spectral component in a complex sound that contains several spectral components. This book notes that for low frequencies, temporal analysis is more useful in processing complex sounds than the simple determination of energy in different frequency bands. Research shows that particular spatial patterns of response to different characteristic of complex sounds can exist, which are not feature detectors such as neurons specifically tuned to special and complex properties of a certain stimulus. This book can prove beneficial for physiologists, neurobiologists, neurophysiologists, general medical practioners, and EENT specialists.

RNA and Protein Synthesis

1st Edition
December 2, 2012
Kivie Moldave
English
eBook
9 7 8 0 3 2 3 1 4 2 3 4 2

RNA and Protein Synthesis is a compendium of articles dealing with the assay, characterization, isolation, or purification of various organelles, enzymes, nucleic acids, translational factors, and other components or reactions involved in protein synthesis. One paper describes the preparatory scale methods for the reversed-phase chromatography systems for transfer ribonucleic acids. Another paper discusses the determination of adenosine- and aminoacyl adenosine-terminated sRNA chains by ion-exclusion chromatography. One paper notes that the problems involved in preparing acetylaminoacyl-tRNA are similar to those found in peptidyl-tRNA synthesis, in particular, to the lability of the ester bond between the amino acid and the tRNA. Another paper explains a new method that will attach fluorescent dyes to cytidine residues in tRNA; it also notes the possible use of N-hydroxysuccinimide esters of dansylglycine and N-methylanthranilic acid in the described method. One paper explains the use of membrane filtration in the determination of apparent association constants for ribosomal protein-RNS complex formation. This collection is valuable to bio-chemists, cellular biologists, micro-biologists, developmental biologists, and investigators working with enzymes.

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