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Elsevier

Academic Press

  • Quadruplex Nucleic Acids As Targets For Medicinal Chemistry

    • 1st Edition
    • Volume 54
    • English
    The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-us... regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human clinical trials.

  • Actin Cytoskeleton in Cancer Progression and Metastasis - Part A

    • 1st Edition
    • Volume 355
    • English
    Actin Cytoskeleton in Cancer Progression and Metastasis - Part A, Volume 355 in the International Review of Cell and Molecular Biology series, provides an overview of the roles of the actin cytoskeleton and some of its key structural regulators, including WASp, Paxillin, Myosin, Testin, L-Plastin and profilin, in central processes underlying cancer progression and metastasis, such as changes in cell morphology and gene expression, acquisition of migratory and invasive capabilities, and evasion from the immune response.

  • Fundamentals of Optimization Techniques with Algorithms

    • 1st Edition
    • Sukanta Nayak
    • English
    Optimization is a key concept in mathematics, computer science, and operations research, and is essential to the modeling of any system, playing an integral role in computer-aided design. Fundamentals of Optimization Techniques with Algorithms presents a complete package of various traditional and advanced optimization techniques along with a variety of example problems, algorithms and MATLAB© code optimization techniques, for linear and nonlinear single variable and multivariable models, as well as multi-objective and advanced optimization techniques. It presents both theoretical and numerical perspectives in a clear and approachable way. In order to help the reader apply optimization techniques in practice, the book details program codes and computer-aided designs in relation to real-world problems. Ten chapters cover, an introduction to optimization; linear programming; single variable nonlinear optimization; multivariable unconstrained nonlinear optimization; multivariable constrained nonlinear optimization; geometric programming; dynamic programming; integer programming; multi-objective optimization; and nature-inspired optimization. This book provides accessible coverage of optimization techniques, and helps the reader to apply them in practice.

  • The Stem Cell Niche during Ageing

    • 1st Edition
    • Volume 4
    • Susie Nilsson
    • English
    Advances in Stem Cells and Their Niches addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice.

  • Histone Modifications in Therapy

    • 1st Edition
    • Volume 20
    • Pedro Castelo-Branco + 1 more
    • English
    Histone Modifications in Therapy provides an in-depth analysis of the role of histone mechanisms in major diseases and the promise of targeting histone modifications for disease prevention and treatment. Here, researchers, clinicians and students will discover a thorough, evidence-based discussion of the biology of histones, the diseases engaged by aberrant histone modifications, and pathways with therapeutic potential. Expert chapter addresses the role of histone modifications across a variety of disorders, including cancer, neuropsychiatric, neurodegenerative, cardiac, metabolic, infectious, bacterial, autoimmune and inflammatory disorders, among others. In relation to these disease types, histone modifications are discussed, both as mechanisms of prevention and possible treatment. A concluding chapter brings together future perspectives for targeting histone modifications in therapy and next steps in research.

  • Odorant Binding and Chemosensory Proteins

    • 1st Edition
    • Volume 642
    • English
    This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field.

  • Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B

    • 1st Edition
    • Volume 174
    • English
    Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B, represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain.

  • The Future of Pharmaceutical Product Development and Research

    • 1st Edition
    • English
    The Future of Pharmaceutical Product Development and Research examines the latest developments in the pharmaceutical sciences, also highlighting key developments, research and future opportunities. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of the product development phase of drug discovery and drug development. Each chapter covers fundamental principles, advanced methodologies and technologies employed by pharmaceutical scientists, researchers and the pharmaceutical industry. The book focuses on excipients, radiopharmaceuticals... and how manufacturing should be conducted in an environment that follows Good Manufacturing Practice (GMP) guidelines. Researchers and students will find this book to be a comprehensive resource for those working in, and studying, pharmaceuticals, cosmetics, biotechnology, foods and related industries.

  • Emerging Technologies for Heart Diseases

    Volume 2: Treatments for Myocardial Ischemia and Arrhythmias
    • 1st Edition
    • Udi Nussinovitch
    • English
    The increasing pace of advances in cardiology throughout the last few decades has fundamentally altered the natural course of heart patients. In the last few years, available therapies have been revolutionized completely by new transcatheter therapeutic approaches, novel ventricular assist devices, and new drugs. Also, molecular biology and genetics have a rapidly growing impact on cardiovascular diseases, enabling the field of regenerative medicine to become increasingly closer to routine clinical implementation. Emerging Technologies for Heart Diseases was conceived to cover the recent extensive literature on current and novel therapeutic options for cardiac patients. The first volume is dedicated to heart failure and valvular disorders, and the second covers myocardial ischemia and arrhythmias. The clinical topic is addressed in several chapters divided according to the therapeutic approach (mechanical or electrical device-based, or cell and gene-based). Each of the 46 chapters focuses on clinically available solutions, new therapies currently under evaluation in clinical trials, promising preclinical technologies, and emerging concepts and innovations that have not yet been tested in a preclinical model. Also, the book discusses future challenges and opportunities for clinical implementation. Lessons learned from abandoned experimental practices are also covered, giving the readers the widest possible perspective of current therapeutic dilemmas. Overall, this textbook was designed for physicians who want to stay up-to-date with current therapies and those of the future, for biomedical companies, and for those who wish to broaden their knowledge of new cardiovascular therapeutic options.

  • Soft Numerical Computing in Uncertain Dynamic Systems

    • 1st Edition
    • Tofigh Allahviranloo + 1 more
    • English
    Soft Numerical Computing in Uncertain Dynamic Systems is intended for system specialists interested in dynamic systems that operate at different time scales. The book discusses several types of errors and their propagation, covering numerical methods—including convergence and consistence properties and characteristics—and proving of related theorems within the setting of soft computing. Several types of uncertainty representation like interval, fuzzy, type 2 fuzzy, granular, and combined uncertain sets are discussed in detail. The book can be used by engineering students in control and finite element fields, as well as all engineering, applied mathematics, economics, and computer science students. One of the important topics in applied science is dynamic systems and their applications. The authors develop these models and deliver solutions with the aid of numerical methods. Since they are inherently uncertain, soft computations are of high relevance here. This is the reason behind investigating soft numerical computing in dynamic systems. If these systems are involved with complex-uncertain data, they will be more practical and important. Real-life problems work with this type of data and most of them cannot be solved exactly and easily—sometimes they are impossible to solve. Clearly, all the numerical methods need to consider error of approximation. Other important applied topics involving uncertain dynamic systems include image processing and pattern recognition, which can benefit from uncertain dynamic systems as well. In fact, the main objective is to determine the coefficients of a matrix that acts as the frame in the image. One of the effective methods exhibiting high accuracy is to use finite differences to fill the cells of the matrix.

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