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Quadruplex Nucleic Acids As Targets For Medicinal Chemistry
- 1st Edition, Volume 54 - August 25, 2020
- Editor: Stephen Neidle
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 2 1 0 1 7 - 8
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 1 0 1 8 - 5
The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other ph… Read more
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Request a sales quoteThe realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human clinical trials.
- Provides the authority and expertise of leading contributors from an international board of authors
- Presents the latest release in the Annual Reports in Medicinal Chemistry series
Undergraduates, graduates, academics and researchers in the field of medicinal chemistry
Part 1. Fundamentals of quadruplexes and their biology
- Fundamentals of G-quadruplex biology
F. Brad Johnson
Fernaldo Richtia Winnerdy and Anh Tuân Phan
Part 2. Quadruplex targets in human and other organisms
Sefan Asamitsu, Norifumi Shioda and Hiroshi Sugiyama
Emanuela Ruggiero and Sara N. Richter
David Monchaud
Part 3. Discovery and design of quadruplex-binding compounds
Valentina Pirota, Michele Stasi, Alessandra Benassi and Filippo Doria
Jiri Sponer, Barira Islam, Petr Stadlbauer and Shozeb Haider
Anton Granzhan, Rodrigo Prado Martins, Robin Fåhraeus, Marc Blondel and Marie-Paule Teulade-Fichou
Jyotirmayee Dash, Puja Saha and Khushnood Fatma
Luigi E. Xodo
Sumirtha Balaratnam and John S. Schneekloth
Silvia Ceschi and Claudia Sissi
Janez Plavec
Tim Kench and Ramon Vilar
Stephen Neidle
- No. of pages: 564
- Language: English
- Edition: 1
- Volume: 54
- Published: August 25, 2020
- Imprint: Academic Press
- Hardback ISBN: 9780128210178
- eBook ISBN: 9780128210185
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Stephen Neidle
Stephen Neidle is an Emeritus Professor of Chemical Biology at University College London, where he has also been the Director of Research in the School of Pharmacy. He has published over 500 primary papers and reviews and is a principal inventor on 14 patent filings. He has also written and edited several books on nucleic acids and anti-cancer drugs.
Affiliations and expertise
Emeritus Professor of Chemical Biology, The School of Pharmacy, University College London, UKRead Quadruplex Nucleic Acids As Targets For Medicinal Chemistry on ScienceDirect