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Quadruplex Nucleic Acids As Targets For Medicinal Chemistry

  • 1st Edition, Volume 54 - August 25, 2020
  • Editor: Stephen Neidle
  • Language: English
  • Hardback ISBN:
    9 7 8 - 0 - 1 2 - 8 2 1 0 1 7 - 8
  • eBook ISBN:
    9 7 8 - 0 - 1 2 - 8 2 1 0 1 8 - 5

The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other ph… Read more

Quadruplex Nucleic Acids As Targets For Medicinal Chemistry

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The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human clinical trials.