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Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B

  • 1st Edition, Volume 174 - August 19, 2020
  • Editor: Vladimir N Uversky
  • Language: English
  • Hardback ISBN:
    9 7 8 - 0 - 1 2 - 8 2 2 6 1 5 - 5
  • eBook ISBN:
    9 7 8 - 0 - 1 2 - 8 2 2 6 0 4 - 9

Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B, represents a set of selected studies on a variety of research topics related to intrinsic… Read more

Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B

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Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B, represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain.