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    • Basic Life Science Methods

      • 1st Edition
      • September 11, 2022
      • Javeed Ahmad Tantray + 3 more
      • English
      • Paperback
        9 7 8 0 4 4 3 1 9 1 7 4 9
      • eBook
        9 7 8 0 4 4 3 1 9 1 7 5 6
      Basic Life Science Methods: A Laboratory Manual for Students and Researchers presents forty of the most executed life science assays. The authors use a consistent structure to cover the preparation, execution and analysis of data from each method. Assays include estimation of cholesterol fractions, C-Reactive Protein, Genomic DNA isolation, Agarose Gel Electrophoresis, RT-PCR, DNA solution preparation, how to design primers, and enzyme-linked immunosorbent assay (ELISA). This book provides a complete reference containing step-by-step instructions on how to run life science assays. Laboratory staff can also benefit of the book as a training resource.

    • Computational Models in Biomedical Engineering

      • 1st Edition
      • September 11, 2022
      • Milos Kojic + 2 more
      • English
      • Paperback
        9 7 8 0 3 2 3 8 8 4 7 2 3
      • eBook
        9 7 8 0 3 2 3 9 0 6 6 9 2
      Computational Models in Biomedical Engineering: Finite Element Models Based on Smeared Physical Fields: Theory, Solutions, and Software discusses novel computational methodologies developed by the authors that address a variety of topics in biomedicine, with concepts that rely on the so-called smeared physical field built into the finite element method. A new and straightforward methodology is represented by their Kojic Transport Model (KTM), where a composite smeared finite element (CSFE) as a FE formulation contains different fields (e.g., drug concentration, electrical potential) in a composite medium, such as tissue, which includes the capillary and lymphatic system, different cell groups and organelles. The continuum domains participate in the overall model according to their volumetric fractions. The governing laws and material parameters are assigned to each of the domains. Furthermore, the continuum fields are coupled at each FE node by connectivity elements which take into account biological barriers such as vessel walls and cells.

    • 3D Bioprinting in Tissue and Organ Regeneration

      • 1st Edition
      • September 10, 2022
      • Yang Wu + 2 more
      • English
      • Hardback
        9 7 8 0 1 2 8 2 4 2 9 1 9
      • eBook
        9 7 8 0 3 2 3 8 5 9 0 5 9
      3D Bioprinting in Tissue and Organ Regeneration covers state-of-the-art advances and applications in bioprinting. Beginning with an introduction that considers techniques, bioinks and construct design, the authors then move onto a detailed review of applications of bioprinting in different biomedical fields (skin, cartilage, bone, vascularized tissue, etc.). This is followed by a chapter overview of intraoperative bioprinting, which is widely considered one of the important future trends in this area. Finally, the authors tackle ethical and regulation concerns regarding the utilization of bioprinting.The book is written by three global experts for an audience of students and professionals with some basic knowledge of bioprinting, but who seek a deeper understanding of the biomedical applications involved in bioprinting.

    • Phenotyping of Human iPSC-derived Neurons

      • 1st Edition
      • September 9, 2022
      • Elizabeth D. Buttermore
      • English
      • Paperback
        9 7 8 0 1 2 8 2 2 2 7 7 5
      • eBook
        9 7 8 0 1 2 8 2 2 2 7 8 2
      Phenotyping of Human iPSC-derived Neurons: Patient-Driven Research examines the steps in a preclinical pipeline that utilizes iPSC-derived neuronal technology to better understand neurological disorders and identify novel therapeutics, also providing considerations and best practices. By presenting example projects that identify phenotypes and mechanisms relevant to autism spectrum disorder and epilepsy, this book allows readers to understand what considerations are important to assess at the start of project design. Sections address reproducibility issues and advances in technology at each stage of the pipeline and provide suggestions for improvement. From patient sample collection and proper controls to neuronal differentiation, phenotyping, screening, and considerations for moving to the clinic, these detailed descriptions of each stage of the pipeline will help everyone, regardless of stage in the pipeline. In recent years, drug discovery in the neurosciences has struggled to identify novel therapeutics for patients with varying indications, including epilepsy, chronic pain, and psychosis. Current treatment options for such patients are decades old and offer little relief with many side effects. One explanation for this lull in novel therapeutics is a lack of novel target identification for neurological disorders (and target identification requires exemplar preclinical data). To improve on the preclinical work that often relies on rodent modeling, the field has begun utilizing patient-derived induced pluripotent stem cells (iPSCs) to differentiate neurons in vitro for preclinical characterization of neurological disease and target identification.

    • A Mathematical Approach to Special Relativity

      • 1st Edition
      • September 9, 2022
      • Ahmad Shariati
      • English
      • Paperback
        9 7 8 0 3 2 3 9 9 7 0 8 9
      • eBook
        9 7 8 0 3 2 3 9 9 7 0 9 6
      A Mathematical Approach to Special Relativity introduces the mathematical formalisms of special and general relativity. Developed from the author’s experience teaching physics to students across all levels, the valuable resource introduces key concepts, building in complexity and using increasingly advanced mathematical tools as it progresses. Without assuming a background in calculus, the text begins with symmetry, before delving more deeply into Galilean relativity. Throughout, the book provides examples and useful "Guides to the Literature." This unique text emphasizes the experimental consequences and verifications of the underpinning theory in order to provide students with a solid foundation in this key area.

    • Discoveries in Pharmacology - Volume 1 - Nervous System and Hormones

      • 2nd Edition
      • September 9, 2022
      • Clive Page + 2 more
      • English
      • Hardback
        9 7 8 0 3 2 3 8 5 5 1 9 8
      • eBook
        9 7 8 0 3 2 3 8 5 5 2 0 4
      Discoveries in Pharmacology: Volume 1: Nervous system and hormones (2nd Ed.) presents selected articles from the historic Discoveries in Pharmacology series enhanced with commentary from contemporary scholars about the reception and importance of the chapter along with an updated bibliography on the subject with contributions from a Nobel Prize winner and other pioneers in Pharmacology. The Discoveries in Pharmacology series brought acknowledged experts in their fields together to provide first-hand accounts of important pharmacological discoveries discussing the scientific background and stories behind these pivotal moments. They allow a true understanding of the means by which pharmacological discoveries are made. This volume brings forth discussions on key discoveries in psycho- and neuro-pharmacology, haemodynamics, and hormones including chapters on antipsychotic agents by Nobel winner Anders Carlsson, Willy Haefely on benzodiazepine, and butyrophenone-type neuroleptics by P. A. J. Janssen and J. P. Tollenaere. Academic and industry researchers in pharmacology and medicine, as well as advanced students in the area will find this series a useful teaching tool and launch to new discoveries. Chapters can also be used to supplement course material in pharmacology and medical courses. It will also be of interest to those who are interested in the history of medicine.

    • Quantum Mechanics, Cell-Cell Signaling, and Evolution

      • 1st Edition
      • September 9, 2022
      • John S. Torday
      • English
      • Paperback
        9 7 8 0 3 2 3 9 1 2 9 7 6
      • eBook
        9 7 8 0 3 2 3 9 7 2 8 1 9
      Quantum Mechanics, Cell-Cell Signaling, and Evolution offers a detailed accounting of the latest research and theorizing on the integration of quantum physics with biological action to produce a novel perspective on evolution. The book advocates for a paradigm shift towards understanding biology and medicine causally as predictive sciences, presenting quantum mechanics and physiology as vertically integrated. The author has taken a unique approach to the question of how and why evolution occurred. The account is based on extensive knowledge of lipid physical chemistry, and its role in the evolution of the lung under the influence of hormonal effects on structure and function. The title arranges lipid biochemistry and biophysics into an integrated explanation, guiding readers from the immersion of lipids in water as the origin of life, to lung surfactant in alveolar homeostasis, and leading to a new understanding of how consciousness interacts with the laws of nature. This volume argues for a novel understanding of evolutionary processes based on fundamental science and positions itself as seeking consilience among research disciplines. Starting from the origins of the cosmos, the author proceeds through nucleosynthesis and Endosymbiosis Theory, to finally describe consciousness in relation to natural law.

    • Advances in Genetics

      • 1st Edition
      • Volume 109
      • September 9, 2022
      • Gerald R. Smith
      • English
      • Hardback
        9 7 8 0 4 4 3 1 8 5 8 0 9
      • eBook
        9 7 8 0 4 4 3 1 8 5 8 1 6
      Advances in Genetics, Volume 109 in this ongoing series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this new release include Epigenetic regulation of angiogenesis in tumor progression, RecBCD and Chi hotspots as determinants of self vs. non-self: A re-evaluation, Horizontal gene transfer to plants from Agrobacterium and related bacterial species, and more.

    • Artificial Neural Networks for Renewable Energy Systems and Real-World Applications

      • 1st Edition
      • September 8, 2022
      • Ammar Hamed Elsheikh + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 8 2 0 7 9 3 2
      • eBook
        9 7 8 0 1 2 8 2 3 1 8 6 9
      Artificial Neural Networks for Renewable Energy Systems and Real-World Applications presents current trends for the solution of complex engineering problems in the application, modeling, analysis, and optimization of different energy systems and manufacturing processes. With growing research catering to the applications of neural networks in specific industrial applications, this reference provides a single resource catering to a broader perspective of ANN in renewable energy systems and manufacturing processes. ANN-based methods have attracted the attention of scientists and researchers in different engineering and industrial disciplines, making this book a useful reference for all researchers and engineers interested in artificial networks, renewable energy systems, and manufacturing process analysis.

    • Asthma in the 21st Century

      • 1st Edition
      • September 8, 2022
      • Rachel Nadif
      • English
      • Paperback
        9 7 8 0 3 2 3 8 5 4 1 9 1
      • eBook
        9 7 8 0 3 2 3 8 5 4 2 0 7
      Asthma in the 21st Century: New Research Advances provides an overview on asthma, with discussions on its heterogeneity, risk factors and their interrelations, and e-health in an aging world based on current research knowledge. The book covers heterogeneity of the disease beyond severe asthma, new risk factors, new diagnoses with climate change, a focus on chemical exposures at home, e-health and links with aging, and notable advances in key areas such as diet and microbiota, the genetics of asthma, and the asthma versus COPD debate. Worldwide, the total number of asthma sufferers is estimated to be ~270 million with an additional 100 million expected to develop asthma by 2025, and asthma is the most common chronic disease among children. There are a number of clinical books available on asthma, but none with much discussion on current scientific findings and new disease understanding. Yet, the concept of asthma has evolved quickly in the past 5–10 years, with many clinicians struggling to keep up with new scientific findings.

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