Asthma in the 21st Century

New Research Advances

1st Edition - September 8, 2022
Editor: Rachel Nadif
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 4 1 9 - 1
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 4 2 0 - 7

Asthma in the 21st Century: New Research Advances provides an overview on asthma, with discussions on its heterogeneity, risk factors and their interrelations, and e-health… Read more

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Asthma in the 21st Century: New Research Advances provides an overview on asthma, with discussions on its heterogeneity, risk factors and their interrelations, and e-health in an aging world based on current research knowledge. The book covers heterogeneity of the disease beyond severe asthma, new risk factors, new diagnoses with climate change, a focus on chemical exposures at home, e-health and links with aging, and notable advances in key areas such as diet and microbiota, the genetics of asthma, and the asthma versus COPD debate.

Worldwide, the total number of asthma sufferers is estimated to be ~270 million with an additional 100 million expected to develop asthma by 2025, and asthma is the most common chronic disease among children. There are a number of clinical books available on asthma, but none with much discussion on current scientific findings and new disease understanding. Yet, the concept of asthma has evolved quickly in the past 5–10 years, with many clinicians struggling to keep up with new scientific findings.

Cover Image
Title Page
Copyright
Table of Contents
Contributors
Foreword
Acknowledgments
Chapter 1 Asthma: From one disease to endotypes
1.1 Introduction
1.2 History of “asthma”
1.3 Clinical and epidemiological aspects of asthma
1.4 Asthma phenotypes
1.5 Asthma endotypes
1.6 Conclusion
References
Chapter 2 Eosinophilic and noneosinophilic asthma: Beyond severe asthma
2.1 Introduction
2.2 Eosinophilic asthma
2.2 Noneosinophilic asthma
2.3 Implications for treatment of asthma
2.4 Conclusion
References
Chapter 3 Airway microbiome and asthma
3.1 Introduction
3.2 Sampling and characterization of airway microbiome
3.3 Airway microbiota and asthma in adults
3.4 Airway microbiota, wheezing and asthma in children
3.5 Early life environment and airway microbiota
3.6 Gut microbiota, airway microbiota and the gut–lung axis in asthma
3.7 Conclusion and future directions
References
Chapter 4 Gender differences and sex-related hormonal factors in asthma
4.1 Introduction
4.2 Gender differences in asthma, findings from epidemiologic studies
4.3 Hormonal factors: Events associated with changes in sex hormones among women
4.4 Hormones and respiratory health
4.5 Gender specific determinants of asthma, beyond sex hormones
4.6 Conclusion
References
Chapter 5 Diet and asthma
5.1 Introduction
5.2 Assessment of diet in epidemiological studies
5.3 Windows of exposure and expression, and measurement error
5.4 Diet and asthma: State of the art
5.5 Complex interrelations between diet, obesity, and physical activity in asthma prevention and management
5.6 Conclusion and future directions
References
Chapter 6 Indoor air and respiratory health: Volatile organic compounds and cleaning products
6.1 Introduction
6.2 Exposure assessment of indoor chemicals: VOCs, SVOCs, and cleaning products
6.3 Respiratory health effects of residential exposure to VOCs, SVOCs, and cleaning products: Results from epidemiological studies
6.4 Conclusions on respiratory health effects of cleaning products
6.5 Conclusion and future directions
References
Chapter 7 Outdoor air pollution and asthma in a changing climate
7.1 General introduction
7.2 Air pollution and asthma
7.3 Asthma and air pollution in the context of climate change
7.4 General conclusion
References
Chapter 8 Genetic and epigenetic links to asthma
8.1 Introduction
8.2 Asthma gene discovery through genome-wide association studies
8.3 The role of rare and loss-of-function variants in asthma
8.4 Epigenomic studies of asthma
8.5 Conclusions and future directions
References
Chapter 9 Asthma and COPD: distinct diseases or components of a continuum?
9.1 Introduction
9.2 Asthma, COPD, overlap: definitions and basic epidemiology
9.3 Natural history of and risk factors for obstructive airways diseases, from childhood to advanced age
9.4 Shared and distinct underlying mechanisms
9.5 Clinical presentations and diagnostic challenges
9.6 Physiological similarities and differences between asthma and COPD
9.7 The role of imaging in the assessment of chronic airways diseases
9.8 Therapeutic implications
9.9 Conclusions
References
Chapter 10 Asthma in an aging world
10.1 Introduction
10.2 Epidemiology of asthma in the elderly
10.3 Physiological change in the airways due to aging
10.4 Phenotype of asthma in the elderly
10.5 Problems in diagnosing asthma in the elderly
10.6 Treatment of asthma in the elderly
10.7 Conclusion
References
Chapter 11 Asthma in the digital world
11.1 Introduction
11.2 Regulatory framework for data protection
11.3 Electronic health records
11.4 Registries in severe asthma
11.5 Telehealth in asthma
11.6 mHealth apps
11.7 mHealth sensors
11.8 Platforms
11.9 Serious games
11.10 Impact of digital health on asthma
11.11 Conclusion
References
Index

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Rachel Nadif