
Computational Models in Biomedical Engineering
Finite Element Models Based on Smeared Physical Fields: Theory, Solutions, and Software
- 1st Edition - September 11, 2022
- Imprint: Academic Press
- Authors: Milos Kojic, Miljan Milosevic, Arturas Ziemys
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 8 8 4 7 2 - 3
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 0 6 6 9 - 2
Computational Models in Biomedical Engineering: Finite Element Models Based on Smeared Physical Fields: Theory, Solutions, and Software discusses novel computational methodolo… Read more
Purchase options

Institutional subscription on ScienceDirect
Request a sales quoteComputational Models in Biomedical Engineering: Finite Element Models Based on Smeared Physical Fields: Theory, Solutions, and Software discusses novel computational methodologies developed by the authors that address a variety of topics in biomedicine, with concepts that rely on the so-called smeared physical field built into the finite element method. A new and straightforward methodology is represented by their Kojic Transport Model (KTM), where a composite smeared finite element (CSFE) as a FE formulation contains different fields (e.g., drug concentration, electrical potential) in a composite medium, such as tissue, which includes the capillary and lymphatic system, different cell groups and organelles.
The continuum domains participate in the overall model according to their volumetric fractions. The governing laws and material parameters are assigned to each of the domains. Furthermore, the continuum fields are coupled at each FE node by connectivity elements which take into account biological barriers such as vessel walls and cells.
- Provides a methodology based on the smeared concept within the finite element method which is simple, straightforward and easy to use
- Enables the modeling of complex physical field problems and the mechanics of biological systems
- Includes features that are illustrated in chapters devoted to applications surrounding tissue, heart and lung
- Includes a methodology that can serve as a basis for further enhancements by including additional phenomena which can be described by relevant relationships, derived theoretically or experimentally observed in laboratories and clinics
Chapter 1 BASIC PROCESSES IN LIVING ORGANISMS
1.1 Introduction
1.2 Basic physiology of cells
1.3 Basic physiology of tissues
1.4 Basic mass transport physiology of body
Chapter 2 FUNDAMENTAL LAWS FOR PHYSICAL FIELDS AND MECHANICS
2.1 Diffusion
2.2 Heat conduction
2.3 Electrostatics
2.4 Flow through porous media
2.5 Fluid flow
2.6 Solid mechanics
Chapter 3 SMEARED FINITE ELEMENT FORMULATION
1.1 Formulation of finite element models for physical fields
1.2 FE models for mechanics
1.3 FE models for solid-fluid interaction
1.4 Kojic Transport Model (KTM). Composite smeared finite element (CSFE) for gradient driven physical fields
1.5 Composite smeared finite element for mechanics (CSFEM)
Chapter 4 CONVECTIVE AND DIFFUSIVE TRANSPORT WITHIN BLOOD VESSELS AND TISSUE
2.1 Basic physiology of tissue
2.2 Detailed modes for convective and diffusive transport within vessels and composite tissue
2.3 Smeared models
2.4 Ionic multiscale transport models
2.5 Models of tissue with tumors
2.6 Tumor growth models with including drug delivery
2.7 Migration of immune cells with chemotaxis effects
2.8 Drug delivery from implants
Chapter 5 HEART ELECTROPHYSIOLOGY AND MECHANICS
3.1 Heart physiology
3.2 Detailed and smeared models of electric potential field within heart wall
3.3 Mechanical models of heart tissue
3.4 Coupling electrical field and mechanics
3.5 Complete heart models – coupled electrophysiology wall mechanics and blood flow
3.6 Drug delivery within the heart
Chapter 6 LUNG MODELS
4.1 Lung physiology
4.2 Models of lung microstructure
4.3 Formulation of a smeared FE for air flow within the lung
4.4 Composite smeared FE for lung tissue
4.5 Mechanical model of entire lung
4.6 Drug delivery from air (inhalation) and from capillary system
Chapter 7 DESCRIPTION OF THE SOFTWARE ACCOMPANYING THE BOOK
5.1 General structure of graphical user interface (GUI) software accompanying the book
5.2 Description of software modules
5.3 Procedures for running examples and visualization of results
- Edition: 1
- Published: September 11, 2022
- No. of pages (Paperback): 400
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780323884723
- eBook ISBN: 9780323906692
MK
Milos Kojic
MM
Miljan Milosevic
AZ