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Elsevier

Academic Press

  • Molecular Insights into Proteinopathies

    Increased Scope from Neurodegeneration to other Pathologies of the Brain
    • 1st Edition
    • Eva Žerovnik + 1 more
    • English
    Molecular Insights into Proteinopathies: Increased Scope from Neurodegeneration to other Pathologies of the Brain investigates the molecular events that lead to various diseases. The book is divided into four parts, the first of which delves into protein aggregation across a range of diseases, including Alzheimer’s disease, Parkinson’s disease, schizophrenia, and neuropsychiatric diseases. It then moves on to discuss signaling pathways and biomarkers of disease, including oxidative stress, mitochondrial decline, and dysregulated molecular pathways. The third part explores small molecules as modulators of key processes in the pathogenesis of proteinopathies, including antioxidants, polyphenol compounds, metal chelators, and repurposed drugs that modulate proteinopathies.The final section considers biophysical methods, molecular dynamics, and machine learning approaches in the study of these aspects. The book provides a detailed overview of protein dysfunction and its implications for health and disease, aiding understanding of protein condensates and aggregates, protein misfolding, co-chaperoning and toxicity of pre-amyloid aggregates. By understanding the fundamental properties underlying these, the book paves the way for investigating how proteinopathies could be treated.

  • Dairy 4.0

    Revolutionizing the Dairy Sector Through Industry 4.0 Technologies
    • 1st Edition
    • Abderrahmane Aït Kaddour + 1 more
    • English
    Dairy 4.0: Revolutionizing the Dairy Sector Through Industry 4.0 Technologies explores how cutting-edge technologies like artificial intelligence, big data, smart sensors, 3D printing, blockchain, and digital twins can drive the future of dairy. The book provides a thorough understanding of Industry 4.0 technologies and their applications, promoting sustainability through improved resource efficiency, waste reduction, and environmental impact. The book also offers practical insights and case studies demonstrating the impact of technology on dairy quality, safety, and traceability. Challenges such as high initial costs, data security concerns, technological integration complexities, regulatory and ethical issues, and resistance to change are addressed.Users will find this to be a resource that stimulates innovation by showcasing the latest research and developments, thus fostering a culture of continuous improvement. The book explores opportunities and hurdles, providing insights to drive the industry's transformation and helping to create conducive regulatory environments for technological adoption.

  • Cell Death Part E

    • 1st Edition
    • Volume 210
    • English
    Cell Death: Part E, Volume 210 presents the latest advances and comprehensive reviews in the rapidly evolving field of cell death. This volume explores the molecular mechanisms, regulatory pathways, and biological consequences of various forms of cell death—including apoptosis, necrosis, autophagy, and other non-canonical processes. Chapters in this new release include Flow cytometry analysis of mitochondrial apoptotic priming with BH3 profiling on senescent cells, Methods to study PIDDOsome and caspase 2 signaling, Isolation, characterization, and experimental applications of apoptotic bodies in vitro, Lipid ROS Measurement by Spectral Flow Cytometry based on the ratiometric dye BODIPYTM C11 581/591, and much more.Additional chapters cover CRISPR-Cas9 Screen to Identify Genes Regulating Cell Death, Flow cytometry-assisted discrimination of early apoptotic, late apoptotic and primary necrotic morphological markers in Saccharomyces cerevisiae, Cytofluorometric analysis of cell death in primary human neutrophils, Real-time tracking of cell death in human intestinal organoids: a quantitative imaging approach, and more.

  • Computational and Experimental Approaches in Protein Engineering and Design

    • 1st Edition
    • Aditya Kumar Padhi + 1 more
    • English
    Computational and Experimental Approaches in Protein Engineering and Design offers a one-stop resource for students, researchers, and practitioners. Cutting-edge techniques in AI and machine learning applications are expertly covered in the book, empowering readers with the tools they need to tackle modern challenges in biotechnology and therapeutics. Step-by-step protocols provide readers with actionable guidance to transition smoothly from computational modelling to laboratory implementation. The inclusion of real-world case studies makes the theoretical concepts relatable and actionable and immediately applicable to solving complex problems, such as producing protein-based vaccines for immunotherapy.The book’s focus on synthetic biology positions it at the forefront of innovation, appealing to a broad audience, from those involved in tissue engineering to those exploring next-generation therapeutics. With its forward-looking approach, emphasizing machine-learning-dri... protein design and nanobody engineering, this book is an indispensable resource for researchers preparing to navigate the future of biotechnology.

  • Unveiling the Atom and Its Nucleus

    Discoveries, Insights, and Understanding
    • 1st Edition
    • Michael F. L'Annunziata
    • English
    Unveiling the Atom and Its Nucleus: Discoveries, Insights, and Understanding explores how chemists and physicists have used scientific principles and experimentation to unveil the structure of the atom, factors governing nuclear stability and decay, modes of nuclear decay, and how the components of the atom interrelate to govern nuclear stability or predict its instability. Examples are featured, showing how discoveries (some considered insignificant at the time) have led to remarkable findings and resulted in our knowledge of the concepts and properties of the atom, such as Oliphant’s discovery of nuclear fusion, Bethe’s energy production in stars, and consequent current fusion energy development.The book also provides a summary of current advances in vital applications of atomic energy, such as current applications in nuclear medicine, including positron emission tomography, hadron therapy, targeted hadron therapy and radioactive nanoparticles in cancer therapy, stable and radioactive nuclides in research to enhance agricultural production, food preservation, and applied nuclear fusion. It concludes by looking at the status of international treaties and efforts to control nuclear weapon proliferation and nuclear war.

  • Fish Feed Formulation with Agroindustrial Wastes and Byproducts

    • 1st Edition
    • Hrudayanath Thatoi + 3 more
    • English
    Fish Feed Formulation with Agroindustrial Wastes and Byproducts provides a comprehensive examination of various agrodindustrial wastes and byproducts, detailing their nutritional composition, processing techniques, and potential applications in fish feed formulation. Sections delve into future perspectives and research directions in the field of fish feed formulation with agroindustrial byproducts, offering readers a glimpse into emerging trends, technological advancements, and opportunities for innovation. This book will assist readers in staying abreast of the latest developments, anticipating future challenges and opportunities in aquafeed production, and positioning themselves to adapt and thrive in an ever-evolving industry landscape.Readers will gain valuable insights into the diverse range of alternative feed ingredients available, allowing them to make informed decisions regarding ingredient selection and formulation strategies. Written and edited by a diverse team of aquaculture specialists, this book includes practical case studies to provide readers with concrete illustrations of how agroindustrial wastes can be effectively utilized in commercial aquafeed production.

  • Novel Approaches to Saturated Fat Replacement in Processed Foods

    • 1st Edition
    • Pintu Choudhary + 1 more
    • English
    Novel Approaches to Saturated Fat Replacement in Processed Foods covers strategies to reduce and replace saturated fat without altering the physicochemical, textural, and full-fat sensory attributes of a final product. Beginning by introducing novel replacement fats such as oleogles, designed lipids, and other plant-based fat mimics, the book demonstrate how these tailor-made oils and fats with improved physical and organoleptic properties can enhance the role of fats and oils in food and nutrition. The book highlights the value of healthier replacement fats in bakery, diary, meat, and frying applications while addressing the nutritional profile and health benefits. It concludes with safety aspects around the use of replacement fats, future trends and developments in the category, the impact ingredients high in saturated fats can have on the environment, and insights into the acceptance of plant-based fat alternatives.

  • Pediatric Pulmonology

    A Global Handbook for Clinical Care Providers
    • 1st Edition
    • Allen J. Dozor
    • English
    Pediatric Pulmonology: A Global Handbook for Clinical Care Providers provides an in-depth exploration of pediatric respiratory diseases, offering a detailed examination of various conditions, diagnostic techniques, and treatment protocols. The book covers a wide range of topics, from the assessment of children with respiratory diseases to specific conditions such as asthma, cystic fibrosis, and bronchopulmonary dysplasia. Each chapter is contributed to by leading experts in the field, ensuring that the content is both authoritative and up-to-date. These crucial, practical skills are essential when a pediatric patient's first point-of-care is not a respiratory specialist.This is especially true of medical treatment in resource-poor areas. The book includes "how to guides" on vital procedures such as spirometry, chest imaging, and the management of respiratory emergencies. It also addresses respiratory diseases in newborns, the impact of environmental factors on children's respiratory health, and the unique challenges faced by children with neurologic and neuromuscular diseases. This comprehensive approach ensures that non-specialists gain a holistic understanding of pediatric respiratory diseases and their management.

  • Offshore Wind Turbine Foundations

    Advanced Geotechnical Engineering Approaches
    • 1st Edition
    • Susana Lopez-Querol
    • English
    Offshore Wind Turbine Foundations: Advanced Geotechnical Engineering Approaches offers an in-depth exploration of the complex challenges and potential solutions arising in the design and maintenance of offshore wind installations, covering the whole range of OWT foundation types, including gravity-based and deep foundations, suction caissons, and anchors for floating turbines, with special emphasis given to monopiles, as the most common type of foundation at present. Key aspects addressed include current design practices and standards, characterization of soils, sea depth, soil types, and loads, soil-structure interaction, long-term behavior of offshore wind turbines, decommissioning, recycling, and reuse of offshore wind turbine foundations, and future trends. Additionally, valuable case studies are used as a reference for practical guidance and for future designs, helping practitioners to learn from past experiences. By bridging the gap between theoretical concepts, research lines and real applications, this latest volume in the Elsevier Wind Energy Engineering Series will equip both practitioners and researchers with the knowledge and tools needed to address the very particular challenges of offshore wind turbine foundations.

  • Inflammation in Tumorigenesis and Cancer Treatment, Volume 9

    From Molecular Mechanisms to Personalized Therapeutic Strategies
    • 1st Edition
    • Chunxiang Zhang + 1 more
    • English
    Inflammation in Tumorigenesis and Cancer Treatment: From Molecular Mechanisms to Personalized Therapeutic Strategies explores the pivotal role of inflammation in cancer. It uncovers the molecular dialogue between inflammatory factors and tumor cells, illuminating pathways that drive oncogenesis and metastasis. Highlighting the rapid pace of discovery, the book bridges the gap by translating complex data into actionable clinical strategies, catering to students and professionals and addressing personalized medicine. Early chapters focus on the fundamental concepts of inflammation in cancer and recent advances in research, while also covering the impact of inflammatory mediators on signaling pathways and oncogenesis.Other sections explore therapeutic strategies targeting inflammatory pathways and the role of immunometabolism and discuss biomarker discovery and personalized treatment plans. The final section examines the tumor microenvironment, the microbiome's role, and the intersection of immunotherapy and inflammation. The book offers numerous benefits to its audience. For scientists and researchers, it provides cutting-edge knowledge to inspire new research directions and foster interdisciplinary collaboration while serving as a valuable educational tool for the next generation of researchers.

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