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Elsevier

Academic Press

  • miRNA in Human Disease

    From Biomarkers to Therapeutics
    • 1st Edition
    • Parul Gupta + 6 more
    • English
    miRNA in Human Disease: From Biomarkers to Therapeutics explores the critical role of microRNAs (miRNAs) in the development and progression of various diseases, emphasizing their significance as biomarkers and therapeutic targets. Sections provide a comprehensive overview of the biogenesis, function, and regulation of miRNAs, offering insights into how these small noncoding RNA molecules influence gene expression and contribute to disease development and progression. The book covers traditional and advanced methods for miRNA extraction, the role of miRNAs in infectious diseases, cancer, neurological disorders, cardiovascular disease, hemoglobinopathies, pregnancy complications, and metabolic disorders.Sections also discuss the latest research on miRNA-based therapies, including the design and delivery of miRNA mimics and inhibitors and their potential applications in personalized medicine. With a strong focus on practical implementation, the book includes detailed case studies and real-world examples that demonstrate the clinical relevance of miRNA research. It addresses the challenges and future directions in the field, providing a roadmap for researchers, clinicians, and industry professionals to harness the potential of miRNAs for disease diagnosis, treatment, and prevention.

  • Integrating Welfare and Sustainability in Poultry Systems

    • 1st Edition
    • Dana L.M. Campbell + 1 more
    • English
    Challenges in Balancing Optimal Welfare and Sustainability in Poultry covers systems that simultaneously prioritize animal welfare and sustainability. A variety of poultry species are covered, as well as various management practices that prioritize health and wellness of birds along with reduced carbon footprints, reduced use of non-renewable resources, and improved production efficiency. The book is grounded in research that has guided what constitutes optimal animal welfare across a range of poultry species and how the housing and management practices may align with sustainability goals across production efficiency, natural capital, carbon footprint, and social acceptance.Academic and industry researchers and stakeholders won't want to miss this forward-thinking book that has gathered research from top experts in the field from around the globe.

  • Unveiling the Atom and Its Nucleus

    Discoveries, Insights, and Understanding
    • 1st Edition
    • Michael F. L'Annunziata
    • English
    Unveiling the Atom and Its Nucleus: Discoveries, Insights, and Understanding explores how chemists and physicists have used scientific principles and experimentation to unveil the structure of the atom, factors governing nuclear stability and decay, modes of nuclear decay, and how the components of the atom interrelate to govern nuclear stability or predict its instability. Examples are featured, showing how discoveries (some considered insignificant at the time) have led to remarkable findings and resulted in our knowledge of the concepts and properties of the atom, such as Oliphant’s discovery of nuclear fusion, Bethe’s energy production in stars, and consequent current fusion energy development.The book also provides a summary of current advances in vital applications of atomic energy, such as current applications in nuclear medicine, including positron emission tomography, hadron therapy, targeted hadron therapy and radioactive nanoparticles in cancer therapy, stable and radioactive nuclides in research to enhance agricultural production, food preservation, and applied nuclear fusion. It concludes by looking at the status of international treaties and efforts to control nuclear weapon proliferation and nuclear war.

  • Vertebrate Carbonic Anhydrases

    • 1st Edition
    • Volume 59
    • English
    Vertebrate Carbonic Anhydrases, Volume 59 in The Enzymes series, explores recent advances in the study of carbonic anhydrases (CAs) in vertebrate systems. This volume presents a comprehensive collection of chapters examining the diversity, structure, function, and physiological roles of vertebrate CA isoforms across multiple tissues and cellular compartments. Chapters include discussions on the phylogenetic relationships of vertebrate carbonic anhydrases and detailed examinations of several important isoforms, including carbonic anhydrases I, II, and III, as well as membrane-associated enzymes such as CA IV and XV. Additional contributions explore mitochondrial carbonic anhydrases (CA VA and VB), secreted isoforms such as CA VI, and more.The volume also examines acatalytic carbonic anhydrases and tumor-associated isoforms, providing insights into their structural characteristics and biological significance. A concluding chapter addresses current challenges and opportunities in the development of selective inhibitors and activators targeting vertebrate carbonic anhydrase isoforms, highlighting their potential therapeutic applications.

  • Sparse-Dirac Super-Resolution (S-Dirac SR) for High-Resolution Transmission Electron Microscopy Techniques

    • 1st Edition
    • Volume 240
    • English
    Sparse-Dirac Super-Resolution (S-Dirac SR) for High-Resolution Transmission Electron Microscopy Techniques, Volume 240 in the Advances in Imaging and Electron Physics series, continues the tradition of this long-standing publication in presenting authoritative reviews and advances in imaging science and electron physics. The series merges two influential serials—Advances in Electronics and Electron Physics and Advances in Optical and Electron Microscopy—and covers topics spanning electron device physics, particle optics, microlithography, image science, digital image processing, electromagnetic wave propagation, and electron microscopy.This volume focuses on the development and applications of the Sparse-Dirac super-resolution (S-Dirac SR) method for high-resolution transmission electron microscopy (HRTEM). Chapters present the historical context and motivations behind the method, followed by discussions of its physical principles, mathematical framework, and algorithmic implementation. Additional sections compare the S-Dirac approach with other state-of-the-art techniques and explore its practical applications in high-resolution electron microscopy. The volume concludes with perspectives on future developments and potential directions in super-resolution imaging methods.

  • Advances in Cancer Research

    • 1st Edition
    • Volume 172
    • English
    Advances in Cancer Research, Volume 172 in this ongoing series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Memantine and its Analogs: Potential Applications in Cancer Therapy, The role of epigenetic modifications in mediating cancer health disparities, Tumor Associated Macrophages: Ontogeny, Plasticity, Spatial Ecosystems, and Therapeutic Targeting, Recognizing the significance of cancer-nerve crosstalk in advanced prostate cancer, and much more.

  • Erythropoiesis/Hematopoiesis

    • 1st Edition
    • Volume 170
    • English
    Erythropoiesis/Hemat... Volume 170 provides a comprehensive overview of erythropoiesis and hematopoiesis—the processes by which blood cells are formed, developed, and maintained in the body. The book covers the molecular, cellular, and physiological mechanisms that regulate the formation of red blood cells (erythropoiesis) and all other blood cell lineages (hematopoiesis), including stem cell biology, signaling pathways, and genetic regulation. Timely chapters in this new release include Ribosomal RNA transcription in normal and leukemic hematopoiesis, Regulation of erythroid development by iron metabolism, Mediator at the Helm: Coordinating Transcription and Biomolecular Condensates in Hematopoiesis, and much more.Additional chapters explore Cell fate decision and lineage specification mechanisms in hematopoiesis, Hijacking the Host: Red Blood Cell Remodeling and Extracellular Vesicle Release During Babesia Infection, How advances in chromosome conformation capture methods are reshaping our understanding of gene regulation in haematopoiesis, Post-transcriptional regulation in erythropoiesis, Erythropoiesis resolved through spatial omics, and Transcription elongation mechanisms that control gene expression in erythropoiesis.

  • Dairy 4.0

    Revolutionizing the Dairy Sector Through Industry 4.0 Technologies
    • 1st Edition
    • Abderrahmane Aït Kaddour + 1 more
    • English
    Dairy 4.0: Revolutionizing the Dairy Sector Through Industry 4.0 Technologies explores how cutting-edge technologies like artificial intelligence, big data, smart sensors, 3D printing, blockchain, and digital twins can drive the future of dairy. The book provides a thorough understanding of Industry 4.0 technologies and their applications, promoting sustainability through improved resource efficiency, waste reduction, and environmental impact. The book also offers practical insights and case studies demonstrating the impact of technology on dairy quality, safety, and traceability. Challenges such as high initial costs, data security concerns, technological integration complexities, regulatory and ethical issues, and resistance to change are addressed.Users will find this to be a resource that stimulates innovation by showcasing the latest research and developments, thus fostering a culture of continuous improvement. The book explores opportunities and hurdles, providing insights to drive the industry's transformation and helping to create conducive regulatory environments for technological adoption.

  • Complications in Spinal Surgery

    A Comprehensive Guide
    • 1st Edition
    • Rafael De la Garza Ramos + 2 more
    • English
    Complications in Spinal Surgery: A Comprehensive Guide is a comprehensive reference for before and after surgery, covering common complications and rare complexities. The book is divided into major sections, including safety in spine surgery, general complications, complications by region (cervical, thoracic, lumbar, and sacral), complications related to pediatrics, and predictive analytics. Although some complications can happen irrespective of the spinal region, dividing into anatomical sections make the most sense for the reader. Designed to benefit both surgeons-in-training... and fellows—and seasoned professionals in orthopedic and neurosurgical spine practice, this book provides critical insights into the prevention, recognition, and management of complications.Unique to this book are the other implications of complications, such as how to approach patients and families, the medicolegal aspects of complications, and how to deal with these situations at a personal level. With its evidence-based approach, real-world case discussions, and expert perspectives, it equips readers with the knowledge and confidence to navigate the complexities of spine surgery and improve patient outcomes.

  • Digital Transformation and Equitable Global Health

    A Future-Ready Perspective
    • 1st Edition
    • Arletty Pinel + 2 more
    • English
    Digital Transformation and Equitable Global Health: A Future-Ready Perspective presents a collective body of knowledge and global experiences that demonstrate current status and future trends in the use of exponential technologies and their potential for poverty reduction, improving health outcomes, strengthening health systems, and transforming traditional development aid structures. The book uses a translational innovation perspective to guide the reader—regardless of their area of expertise—on the rationale behind the co-creation of human-centered, affordable, and sustainable digital solutions.It addresses the interest of professionals from multiple areas (e.g., technology, health, social development, global financing), and it is a valuable resource for professionals, social scientists, practitioners, researchers, instructors, and undergraduate and graduate students interested in understanding the challenges and complexities of global public health and the applied uses of health technologies for equitable access to primary health care and universal health coverage.

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