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Elsevier

Academic Press

  • Therapeutic Potentials of Tenofovir Alafenamide in Hepatitis B

    • 1st Edition
    • Lung-Yi Loey Mak + 1 more
    • English
    Therapeutic Potentials of Tenofovir Alafenamide in Hepatitis B offers a comprehensive examination of the therapeutic potentials of Tenofovir Alafenamide (TAF) in hepatitis B, providing a succinct and up-to-date summary of all relevant evidence for this first-line oral antiviral agent. The text delves into key topics such as the pharmacological profile of TAF, its comparative efficacy against traditional antiviral agents, safety and tolerability, and the impact of TAF on drug resistance. Additionally, it explores the use of TAF in special populations, including pediatrics, the elderly, and individuals with renal impairment, as well as future directions in hepatitis B treatment strategies.Readers will discover the diverse potential applications of TAF in chronic hepatitis B, informed by valuable lessons learned from HIV treatment while also gaining insights into future therapeutic possibilities. Authored by leading experts in the field, each chapter presents focused and insightful perspectives, making this book an indispensable resource for practitioners and researchers alike. Serving as a critical resource for physicians, researchers, pharmacologists, and biomedical scientists, this book highlights the core knowledge necessary for understanding TAF and its clinical applications.

  • Protein Misfolding

    • 1st Edition
    • Timir Tripathi
    • English
    Protein Misfolding explores the structural and biochemical foundations of protein misfolding, highlighting its wide-reaching implications for cellular function, disease progression, and biomedical innovation. This book provides a comprehensive understanding of how proteins deviate from their native conformations and the resulting biological consequences. Focusing on both physiological and pathological misfolding, the volume covers essential topics such as folding quality control, molecular chaperones, degradation pathways, and proteostasis. It presents in-depth analyses of protein aggregation mechanisms, amyloid formation, and misfolding-associate... diseases including Alzheimer's, Parkinson's, and prion-related disorders. Additional chapters explore structural approaches to understanding misfolded states, computational modeling of aggregation kinetics, and current efforts to design therapeutics that restore folding homeostasis or prevent toxic accumulation. The book also addresses the cellular response to misfolding stress and the integration of folding dynamics with cellular signaling pathways.This book is a valuable resource for researchers, educators, and professionals in biochemistry, structural biology, molecular medicine, biotechnology, and related disciplines. It supports efforts to understand the fundamental principles of protein structure and function, while offering insight into emerging therapeutic strategies and future research directions in disease-focused protein science.

  • Ethnoveterinary Practices in Animal Agriculture

    • 1st Edition
    • Munesh Kumar + 3 more
    • English
    Ethnoveterinary medicine is aimed at maintaining animal health by drawing from cultural values, traditional knowledge, surgical techniques, metaphysical principles, and local resources. Ethnoveterinary Practices in Animal Agriculture explores how traditional ethnoveterinary medicine can be integrated with contemporary animal health and production systems. By integrating age-old practices and knowledge with modern western science, the book aims to promote sustainable and organic livestock farming. It highlights the advantages of using polyherbal feed additives, providing natural living conditions for animals, and utilizing herbal derivatives to promote growth and health in animal nutrition. With emphasis on the economic and ecological benefits, Ethnoveterinary Practices in Animal Agriculture seeks to preserve and revitalize traditional veterinary knowledge, which is at risk of disappearing due to rapid technological, environmental, and socioeconomic changes. Written by a team of global, interdisciplinary experts, this work is both a useful summary of the existing literature in this area and fascinating starting point for new research.

  • Mental Health and Wellbeing of Marginalised Populations in Africa

    • 1st Edition
    • Ahmed Moustafa + 3 more
    • English
    Mental Health and Wellbeing of Marginalised Populations in Africa is an authoritative reference that addresses the complex mental health challenges faced by diverse marginalised groups across the continent. It systematically examines issues stemming from civil unrest, displacement, HIV, gender-based violence, disability, and ageing, highlighting the socio-economic and political contexts that influence mental health outcomes. The volume synthesises current evidence, offering a holistic understanding of the unique mental health needs of refugees, internally displaced persons, street children, care leavers, women living with FGM, and other vulnerable groups.The content is organised into thematic chapters covering topics such as mental health impacts of genocide, conflict, climate change, and chronic illnesses, with empirical case studies from multiple African countries. It also explores resilience, community support systems, and innovative interventions, emphasising a strength-based approach aligned with health equity goals. The book provides a unified theoretical framework rooted in decolonisation and social justice, fostering a deeper understanding of structural determinants and cultural factors shaping mental health.This comprehensive resource equips professionals with the knowledge to develop culturally sensitive policies and interventions, fostering improved mental health outcomes. It also serves as a vital academic reference for courses on global health, psychiatry, social work, and public health, contributing to the development of contextually relevant strategies for marginalised populations across Africa. This book is essential for mental health professionals, social workers, policymakers, researchers, and students committed to advancing health equity and social justice.

  • Hypoxia-induced Tumor Heterogeneity and Immune Evasion

    Clinical Interventions
    • 1st Edition
    • Benjamin Bonavida + 1 more
    • English
    Hypoxia-induced Tumor Heterogeneity and Immune Evasion: Clinical Interventions explores how hypoxic stress within the tumor microenvironment drives cancer progression, immune escape, and resistance to therapy. This volume integrates foundational and cutting-edge insights into tumor biology, immunology, and therapeutic innovation. The book is structured into five parts, covering tumor heterogeneity, hypoxia-driven mechanisms, immune evasion, clinical diagnostics, and future directions. It brings together global experts to examine how hypoxia shapes tumor evolution, alters immune responses, and influences treatment outcomes. Topics include metabolic reprogramming, angiogenesis, immune suppression, and hypoxia-targeted therapies, with emphasis on translational relevance. This resource benefits researchers, clinicians, and advanced students by offering a comprehensive, up-to-date synthesis of a rapidly evolving field. It supports deeper understanding of tumor complexity and equips readers with knowledge to inform experimental design, clinical strategies, and therapeutic development in oncology.

  • The Pancreatic Tumor Microenvironment

    Systems Biology of Stroma–Microbiome Interactions for Precision Therapy
    • 1st Edition
    • Ganji Purnachandra Nagaraju + 1 more
    • English
    The Pancreatic Tumor Microenvironment: Systems Biology of Stroma–Microbiome Interactions for Precision Therapy unites leading experts to integrate stromal biology and microbiome science into a single, translational roadmap for pancreatic cancer. It frames tumor progression and treatment resistance as emergent properties of an ecosystem, not isolated cells. The book surveys the composition and heterogeneity of the tumor microenvironment; cancer associated fibroblast plasticity; extracellular matrix and signaling dynamics; immune suppression; metabolic and hypoxic reprogramming; and gut/tumor associated microbiomes. Methodological chapters highlight single cell, spatial and multi omics approaches, experimental models, biomarkers, and clinical trial design, culminating in combination strategies and future directions. Readers gain a mechanistic, systems level synthesis that clarifies conflicting literature, prioritizes targets, and bridges basic, translational, and clinical domains—accelerating precision oncology and informing study design, patient stratification, and therapeutic combinations.

  • Congenital Adrenal Hyperplasia

    A Comprehensive Guide
    • 2nd Edition
    • Peter C. Hindmarsh + 1 more
    • English
    Congenital Adrenal Hyperplasia: A Comprehensive Guide, Second Edition provides a fully-illustrated edition that outlines the basics of CAH and its interrelation with hormones and bodily function, including updated content on the latest clinical research. A new chapter dedicated to gene therapy covers principles, current status, the latest research developments, and potential treatments for congenital adrenal hyperplasia. In addition, this new release updates patient profiles due to several new clinical studies in CAH for improved condition management, with practical information on how to deal with emergencies, medic alert emergency kits, emergency injection needles, handling illness, surgery, and more.In addition, new assays are incorporated for the analysis of pituitary and adrenal hormones for the determination of the disease. This new edition continues to be a vital reference to pediatric endocrinologists as well as primary care providers to help affected patients with an updated model of care and appropriate treatment. Patients and family members will continue to benefit from the new trend-forward information presented and will be empowered to approach their health care providers with the expectation of receiving individualized care and treatment of the disorder.

  • Digital Twins and Predictive Modeling in Robotic Surgery

    • 1st Edition
    • Mudassir Khan + 3 more
    • English
    Digital Twins and Predictive Modeling in Robotic Surgery addresses the transformative convergence of digital twin technology, predictive analytics, and robotic surgery. This reference responds to the critical need for a comprehensive resource that bridges simulation science, artificial intelligence, and real-time robotic execution, facilitating enhanced surgical precision, patient-specific planning, and intraoperative decision-making. The content is organized into four parts covering foundational intelligent surgical systems, predictive modeling and simulation, clinical applications with case studies, and challenges alongside future directions. Topics include AI integration, IoT-enabled sensor networks, digital twin architectures encompassing the entire surgical ecosystem, surgical workflow modeling, risk assessment, human-robot interaction, technology acceptance, ethical and regulatory considerations. Real-world examples from smart hospitals worldwide illustrate practical implementation. This books benefits biomedical engineers, researchers, and healthcare system architects by providing interdisciplinary insights, practical implementation frameworks, and cutting-edge case studies. It supports improved surgical planning, precision, and decision-making, empowering end users to advance the adoption of intelligent, AI-powered robotic surgery systems in clinical practice and research environments.

  • Complications in Spinal Surgery

    A Comprehensive Guide
    • 1st Edition
    • Rafael De la Garza Ramos + 2 more
    • English
    Complications in Spinal Surgery: A Comprehensive Guide is a comprehensive reference for before and after surgery, covering common complications and rare complexities. The book is divided into major sections, including safety in spine surgery, general complications, complications by region (cervical, thoracic, lumbar, and sacral), complications related to pediatrics, and predictive analytics. Although some complications can happen irrespective of the spinal region, dividing into anatomical sections make the most sense for the reader. Designed to benefit both surgeons-in-training... and fellows—and seasoned professionals in orthopedic and neurosurgical spine practice, this book provides critical insights into the prevention, recognition, and management of complications.Unique to this book are the other implications of complications, such as how to approach patients and families, the medicolegal aspects of complications, and how to deal with these situations at a personal level. With its evidence-based approach, real-world case discussions, and expert perspectives, it equips readers with the knowledge and confidence to navigate the complexities of spine surgery and improve patient outcomes.

  • Management of Chronic Kidney Disease and Its Complications

    • 1st Edition
    • Thakur Gurjeet Singh + 4 more
    • English
    Management of Chronic Kidney Disease and Its Complications  presents the latest scientific advances in diagnosing and managing Chronic Kidney Disease (CKD) and its diverse complications. This authoritative text covers molecular mechanisms such as inflammation and oxidative stress, genetic and epigenetic factors, and explores cutting-edge technologies including artificial intelligence and regenerative medicine. With detailed chapters on cardiovascular, metabolic, neurological, and hematological complications, the book offers a holistic approach to understanding CKD’s complexity and evolving treatment strategies.The book’s content is organized to provide a thorough exploration of CKD, beginning with foundational topics like genetic contributions and diagnostic evaluation, progressing through specific complications such as diabetic nephropathy, hypertension, and urologic conditions. Special focus is given to management strategies, nutritional interventions, and unique considerations in pediatric, geriatric, and pregnant populations. Emerging therapies, including precision medicine, gut microbiota modulation, and AI-driven early detection, are also extensively covered to keep readers at the forefront of nephrology research and clinical practice.Management of Chronic Kidney Disease and Its Complications is an essential resource for nephrologists, general practitioners, medical students, nursing professionals, and healthcare providers involved in kidney disease care and research.

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