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Academic Press

  • Approaches for Brain Targeting Using Nanoparticulate Systems

    • 1st Edition
    • Bhagyashree V. Salvi + 2 more
    • English
    Approaches for Brain Targeting Using Nanoparticulate Systems aims to explore variety of nanoparticulate systems in the enhancement of therapeutic delivery, promotion for effective brain targeting, and reduction in the off-targets. Presenting the latest research, this book offers comprehensive insight into various nanosystems designed to overcome the blood brain barrier. This book presents the latest research on targeting approaches, physicochemical characteristics of nanoparticles, and the role of nanoparticles in enhancing the permeation of therapeutic systems across the blood brain barrier. Readers will also be able to develop a deeper understanding of how nanotherapeutics can revolutionize brain targeting through clinical applications.

  • Innovations in the Blue Economy

    Sustainable Practices in Marine Macro- and Microalgae Cultivation
    • 1st Edition
    • José Carlos Magalhães Pires
    • English
    Innovations in the Blue Economy: Sustainable Practices in Marine Macro- and Microalgae Cultivation explores the latest technologies, advancements, and ongoing research surrounding the sustainable cultivation of microalgae and seaweed. Cultivation strategies, challenges, applications, products, and regulatory considerations are covered through an interdisciplinary lens to provide readers with a holistic understanding. Written by a globally diverse network of experts, the book is systematically structured to be accessible to readers across multiple sectors. Chapters describe the biology, diversity, and vital ecological roles of various microalgal and seaweed species and explore differing cultivation systems, emphasizing the critical aspects of site selection and ecosystem compatibility. Cultivation strategies are also described and illustrated through applied case studies that showcase successful large-scale cultivation initiatives. Final chapters consider regulatory landscapes and multifaceted hurdles to sustainable industry scale-up and provide innovative solutions and research gaps for industry consideration. This is an essential read for algal aquaculturists, bioengineers, and students of marine biology and biotechnology.

  • Cutting-Edge Technology for Plant Metabolite Profiling in Drug Discovery and Quality Control

    • 1st Edition
    • Ramesh Kumar Ahirwar + 4 more
    • English
    Cutting-Edge Technology for Plant Metabolite Profiling in Drug Discovery and Quality Control offers a comprehensive exploration of advanced methods in plant metabolomics, along with their integration in industrial applications across various sectors. The book delves into a range of methodologies, including metabolic engineering strategies, metabolite imaging techniques, nuclear magnetic resonance (NMR) for plant metabolite analysis, microfluidics for metabolite profiling, computational methods, and bioinformatics tools. It also explores plant metabolomics for crop improvement, pharmaceutical development, archaeological examinations, cosmetic formulations, and food quality, with case studies featured throughout the book to showcase real-world applications and scenarios. As the demand for natural products and plant-derived therapeutics continues to rise, there is a need for reliable and effective methods to identify, quantify, and optimize the bioactive compounds present in plants. This book provides a comprehensive guide to the latest advances in this field while also delivering a multidisciplinary overview of the wide-ranging impact plant metabolites have across a variety of applications. Researchers working with plant metabolites across molecular and cellular biology, pharmaceutical science, biotechnology, biochemistry and plant science will benefit from this book. Additionally, it will be of interest to specialists working across relevant industries, such as pharmaceuticals, nutraceuticals, cosmetics and agriculture.

  • Explainable AI in Clinical Practice

    Methods, Applications, and Implementation
    • 1st Edition
    • Arvind Panwar + 4 more
    • English
    Explainable AI in Clinical Practice: Methods, Applications, and Implementation bridges the gap between artificial intelligence capabilities and their practical implementation in healthcare. The book explores applications of explainable AI in diagnostic support and treatment planning, offering insights into making AI systems interpretable and accountable. Through real-world case studies and ethical frameworks, readers learn to transform opaque AI systems into tools that enhance clinical practice while maintaining high patient care standards. This volume unites leading experts to provide a comprehensive framework for implementing explainable AI, ensuring that AI-driven decisions are transparent, trustworthy, and clinically sound. Targeted solutions in the book cater to diverse stakeholders in the healthcare AI ecosystem. Healthcare professionals will gain confidence in integrating AI tools, while technical teams will receive implementation guidelines. This book is essential for anyone seeking to responsibly and effectively navigate the complexities of AI in healthcare.

  • Chalcones

    From Drug Discovery to Pharmaceutical Applications
    • 1st Edition
    • Simone Carradori + 2 more
    • English
    Chalcones: From Drug Discovery to Pharmaceutical Applications serves as a comprehensive reference on chalcones, detailing their natural occurrence, synthetic methods, and therapeutic applications. The book provides both novice and experienced researchers with the foundational knowledge necessary to advance their work in this area. Sections cover the natural sources of chalcones, various extraction methods, structural characterization techniques, synthesis, and their role in organic chemistry and metal complexes, while also addressing pharmacokinetic properties, toxicity, and the medicinal uses of chalcones, including their effectiveness against viruses, bacteria, cancer, and neurodegenerative diseases. Final sections explore chalcone-containing products, drug formulation strategies, and clinical trials involving chalcone-based drug candidates. This reference is an essential resource for pharmaceutical researchers, providing critical insights into the applications and potential of chalcones in drug development and therapeutic interventions.

  • Measure and Integration

    Concepts, Examples, and Applications
    • 1st Edition
    • Ahmed Ghatasheh + 2 more
    • English
    Measure and Integration: Examples, Concepts, and Applications instructs on core proofs, theorems, and approaches of real analysis as illustrated via compelling exercises and carefully crafted, practical examples. Following early chapters on core concepts and approaches of real analysis, the authors apply real analysis across integration on product spaces, radon functionals, bounded variation and lebesgue-stieltjes measures, convolutions, probability, and differential equations, among other topics. Advanced exercises are also included at the end of each chapter, with exercise difficulty level noted for instructors, and solutions included in an appendix.From chapter one onward, students are asked to apply concepts to reinforce understanding and gain applied experience in real analysis. In particular, exercises challenge students to use key proofs of major real analysis theorems to encourage independent thinking, problem-solving, and new areas of research powered by real analysis.

  • The Gut Microbiome in Precision Medicine

    From Research to Clinical Practice
    • 1st Edition
    • S Rehan Ahmad
    • English
    The Gut Microbiome in Precision Medicine: From Research to Clinical Practice explores the significant role of the gut microbiome in health and disease, particularly within gastrointestinal conditions such as inflammatory bowel disease, irritable bowel syndrome, and colorectal cancer. It covers how understanding and analyzing the gut microbiome can lead to personalized treatments, dietary plans, and precision medicine approaches in gastroenterology. Chapters explore multi-omics integration, examining complex techniques for gut microbiome profiling, including genomics, transcriptomics, proteomics, and metabolomics. Users will find updates on microbiome-based interventions, such as probiotics, prebiotics, and personalized nutrition that highlight practical applications in gastrointestinal disease management. Real-world examples and case studies discuss strategies for overcoming barriers to implementing microbiome analysis. Additionally, it addresses the challenges and opportunities of implementing microbiome analysis in clinical practice, with a special emphasis on its implications for developing countries. Finally, the book covers emerging technologies in microbiome research and their applications in gastroenterology, emphasizing future directions and research priorities.

  • Cerebellum Development and Disease

    • 1st Edition
    • Volume 167
    • English
    Cerebellum Development and Disease, Volume 167 offers a comprehensive overview of the intricate processes underlying the formation, maturation, and function of the cerebellum, as well as the wide spectrum of disorders that can affect this essential brain region. Chapters in this new release cover Olivocerebellar circuit development as a substrate for dystonia pathogenesis, Simply complex – that structure of the cerebellar neuronal lineage, Ontogenesis and diversification of cerebellar glia: a developmental perspective, Purkinje cell diversification: a blueprint for cerebellar development, patterning, and evolution, On the Emergence of Folding in the Cerebellum, Scaling and regeneration in the developing cerebellum, ASTN2 in ASD and Neurodevelopmental Disorders, and much more.Additional sections focus on Stem cell-derived in vitro models of human cerebellar development, Development of Spinocerebellar System within the Precerebellar Network, and Cerebellum evo-devo. The book brings together leading experts in neurodevelopment, neurobiology, genetics, and clinical neurosciences to explore the molecular and cellular mechanisms guiding cerebellar development, from embryogenesis to adulthood.

  • Sports Medicine and the Pelvic Floor

    Science to Practice
    • 1st Edition
    • Gráinne M. Donnelly
    • English
    Sports Medicine and the Pelvic Floor: Science to Practice shines a spotlight on a critical but often overlooked aspect of female athlete health: the pelvic floor. Bringing together the expertise of international clinicians and researchers, this book highlights persistent gaps in knowledge and practice, offering valuable direction for future research. It educates professionals on how to effectively screen, treat, and rehabilitate athletes, emphasizing that pelvic floor dysfunction can profoundly impact engagement, athletic performance, and overall well-being. By addressing this traditionally taboo subject, the authors provide evidence-based insights that call for the pelvic floor to be considered as essential in sports medicine.Sections discuss practical strategies for screening and supporting athletes, managing or alleviating symptoms, and ensuring a safe return to sport, all while prioritizing long-term pelvic health. This is an indispensable resource for anyone working with female athletes, blending science and clinical experience to advance care in this vital area.

  • The Itch Spectrum

    • 1st Edition
    • Xinzhong Dong + 2 more
    • English
    The Itch Spectrum: The Neurological and Immunological Basis of Itch and Dermatological Disorders covers the latest research on the itch signalling pathway from the skin to the brain. With a multidisciplinary approach, this book will cover the mechanisms underlying the sensation of itch from the fields of neuroscience, immunology, genetics, and dermatology as they have intersected in the study of one somatosensory system. The purpose of this comprehensive reference is to summarize the revelatory discoveries in the field of itch and provide a comprehensive overview of what is known about this remarkable sensation and how various pathologies contribute to chronic pruritis.

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