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Elsevier

Academic Press

  • Structural Biology of Amyloid Fibrils

    • 1st Edition
    • Vijay Kumar + 1 more
    • English
    Structural Biology of Amyloid Fibrils provides a comprehensive reference on the structure of protein aggregates in different neurodegenerative diseases, along with their molecular bases. Chapters describe these structures in detail, highlighting their similarities and differences across different disease states along with an unprecedented overview of current developments and new hypotheses emerging in amyloid fibril structure, stability and mechanisms of formation. The book also discusses how amyloid structure may affect the ability of fibrils to spread to different sites in a prion-like manner, as well as their role in disease. Featuring chapters on NMR, X-ray crystallography, and Cryo-EM methods, and discussing the structure of amyloid fibrils obtained directly from patients, the book allows readers to understand how polymorphism is associated with disease phenotype and how fibril structure affects and influences the cellular environment. Understanding the molecular architecture of amyloid fibrils and oligomers will be an important step towards developing therapeutic interventions based on targeting the fibrils and oligomers themselves and the processes that generate them.

  • Personalized Cancer Medicine through Multiomics

    • 1st Edition
    • Mohammad Azhar Aziz + 1 more
    • English
    Personalized Cancer Medicine through Multiomics explores the integration of multiomics to transform cancer diagnosis and treatment. The book delves into how the convergence of genomics, transcriptomics, proteomics, and metabolomics offers a comprehensive understanding of cancer biology, surpassing traditional single-omics approaches. Sections detail advancements in high-throughput technologies and computational methods, including machine learning, that enable the analysis of complex cancer datasets. Additional content discusses how multiomics identifies unique molecular signatures, novel therapeutic targets, and biomarkers, facilitating precise and individualized treatment strategies, particularly for a heterogeneous cancers.For academics, this book serves as an essential resource, compiling fragmented research into a single, coherent volume. It provides foundational knowledge, the latest advancements, and practical applications of multiomics in personalized medicine. Researchers will benefit from interdisciplinary approaches, real-world examples, and cutting-edge methodologies, making it an invaluable reference for advancing their work in oncology.

  • Green Polymeric Materials in Drug Delivery

    Sustainable Solutions for Therapeutic Applications
    • 1st Edition
    • Parteek Prasher + 5 more
    • English
    Green Polymeric Materials in Drug Delivery: Sustainable Solutions for Therapeutic Applications addresses the critical intersection of polymer science, pharmaceutical technology, and environmental sustainability. This reference responds to the urgent need for eco-friendly drug delivery systems that improve therapeutic outcomes while minimizing ecological impact. It offers researchers and professionals a detailed exploration of green polymers derived from renewable sources and their transformative potential in healthcare. The comprehensive contents cover fundamental principles, synthesis, biocompatibility, formulation strategies, and innovative applications including nanomaterials, hydrogels, vesicular systems, and vaccine delivery. Chapters authored by leading experts examine targeted delivery routes such as mucosal, ocular, transdermal, and neural pathways. Regulatory frameworks and clinical trial insights further support translation from research to practice. Emerging technologies like AI-assisted formulation and 3D printing of implants are also discussed. This reference benefits polymer chemists, pharmaceutical scientists, regulatory experts, and clinicians by providing authoritative knowledge on sustainable materials for drug delivery. It equips readers with the scientific foundation and practical case studies necessary to advance green polymeric technologies in therapeutic development, fostering a sustainable future in pharmaceutical innovation and patient care.

  • Animal Models of Disease Part F

    • 1st Edition
    • Volume 212
    • English
    Animal Models of Disease, Part F, Volume 212 in the Methods in Cell Biology series, presents significant advancements in understanding disease mechanisms through animal models. The book features chapters on timely topics such as characterizing tumor-infiltrating group 1 innate lymphoid cells in PyMT breast tumors and using zebrafish to unravel the molecular mechanisms of Alzheimer’s disease. The book also covers colitis mouse models and appropriate models for studying diabetes pathophysiology, demonstrating its comprehensive approach to current research.Additional sections cover evaluating polyglutamine protein aggregation in transgenic Caenorhabditis elegans models of Huntington's disease and studying tumor responses to radioimmunotherapy in ovarian cancer models. It also highlights the antimicrobial regime for gut microbiota depletion in mice and the biodistribution of metallic nanoparticles for lymphoma studies. This book is an essential resource for researchers seeking to explore disease mechanisms and therapeutic approaches through animal models.

  • The Metabolon

    • 1st Edition
    • Volume 739
    • English
    Methods in Enzymology series: The Metabolon, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Advances in Biogerontology

    • 1st Edition
    • Volume 4
    • English
    Explore the latest breakthroughs in aging research with Advances in Biogerontology Volume 4. This comprehensive volume brings together cutting-edge studies on the biological mechanisms of aging, regenerative medicine, and interventions to promote healthy longevity. Featuring contributions from leading scientists worldwide, it delves into innovative approaches to slow, halt, or reverse age-related decline, offering insights into cellular aging, genetic factors, and emerging therapies. Ideal for researchers, clinicians, and students, this volume is a vital resource for understanding the future of aging and extending healthspan. Stay at the forefront of biogerontology with this authoritative collection of scientific advancements.

  • Cell Death Part F

    • 1st Edition
    • Volume 211
    • English
    Cell Death: Part F, Volume 211 presents the latest advances and comprehensive reviews in the rapidly evolving field of cell death. This volume explores Methods to Assess BAX Conformation, Activation, Translocation, and Mitochondrial Outer Membrane Permeabilization, Proximity biotin labelling identification of Bcl-2 protein interactions in live cells, Bimolecular fluorescence complementation assays for investigating Bcl-2 family protein interactions, Assessing apoptotic sensitivity in primary mouse B cells by BH3 profiling, Liposome permeabilization assays to monitor pore formation by cell death proteins, Flow Cytometry Assessment of Mitochondrial Membrane Potential, Biomass, and ROS in OXPHOS-Dependent and Glycolytic Cancer Cells during Cell Death Induction, and much more.Additional chapters cover Assessment of Viability Versus Cell Death: What is What?, Flow cytometry-based drug response profiling of primary B-precursor ALL cells in co-culture with bone marrow-derived stromal cells, An in vitro model of efferocytosis in macrophage foam cells to probe lipid-driven dysregulation of dead cell clearance, Measuring tumor cell killing using in vivo bioluminescence imaging, and more.

  • Advances in Carbohydrate Chemistry and Biochemistry

    • 1st Edition
    • Volume 90
    • English
    Advances in Carbohydrate Chemistry and Biochemistry, Volume 89 in this series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Topics in this new release include a Roadmap for the Synthesis of Nonreducing Disaccharides as Scaffolds for Complex Biomolecules andFunctionalized D-glucosamine derivatives and their applications.

  • Emerging Trends and Imminent Applications in Immunology and Pharmaceutical Biotechnology

    • 1st Edition
    • Swagat Kumar Das + 2 more
    • English
    Emerging Trends and Imminent Applications in Immunology and Pharmaceutical Biotechnology delves into historical perspectives, current trends, and future projections for research and development of immunological and biopharmaceutical products. Sections explore immunostimulants, natural and synthetic immunostimulants in aquaculture and animal husbandry, immunomodulators, immune boosters, pre- and probiotics in health promotion, cutting-edge immunological techniques for disease diagnosis, immunotherapy in cancer treatment, and transplantation immunology. Following chapters explore the impact on pharmaceutical biotechnology, with discussions on traditional and modern approaches in drug delivery, in silico drug delivery modeling, biocomposites and their pharmaceutical applications, recent advances in monoclonal antibodies production, vaccine development, and much more. Finally, the book covers the pivotal role of AI, machine learning, and data analytics in the clinical study of immunotherapy and pharmaceutical drugs, thus paving the way for enhanced research and development efficiency. Researchers in industry and academia alike will gain valuable insights into the novel principles behind designing and developing immunological and drug products, making this title an essential resource.

  • Handbook of MRI Pulse Sequences

    • 2nd Edition
    • Xiaohong Joe Zhou + 4 more
    • English
    Handbook of MRI Pulse Sequences, Second Edition includes 92 self-contained sections, with each section focusing on a single subject. A new section on detailing the advanced pulse sequence techniques covers a variety of basic and advanced image reconstruction methods. The extensive topic coverage and cross-referencing makes this book ideal for beginners learning the building blocks of MRI pulse sequence design, as well as for experienced professionals who are seeking deeper knowledge of a particular technique.This book is among the most important medical imaging techniques available today. Each of these scanners is capable of running many different "pulse sequences." These sequences are governed by physics and engineering principles and implemented by software programs that control the MRI hardware.

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