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Elsevier

Academic Press

  • Nutritional Epigenetics

    Food-Derived microRNAs in Health and Disease
    • 1st Edition
    • Shariful Islam + 3 more
    • English
    Nutritional Epigenetics: Food-Derived microRNAs in Health and Disease offers perspective on the role of dietary microRNAs as pivotal epigenetic regulators influencing health trajectories and disease susceptibility. The book brings together current research on the bioavailability and molecular mechanisms by which plant and food-derived microRNAs modulate gene expression, including their crosstalk with DNA methylation, histone modifications, and gut microbiota. Detailed food-specific chapters examine the epigenetic impact of key dietary sources such as Brassicaceae (crucifers), rice, milk, and fermented products, highlighting their transgenerational and life-stage effects. Practical insights into food processing, culinary traditions, and the design of microRNA-fortified products bridge the gap between bench science and real-world applications. Nutritional Epigenetics equips researchers, clinicians, and industry innovators with a resource that advances the understanding of microRNA-mediated nutritional epigenomics, while guiding the development and safety assessment of microRNA-enhanced functional foods. By integrating molecular biology with population-level evidence and translational strategies, this text fosters the development of novel dietary interventions aimed at optimizing health across the lifespan and mitigating chronic disease risk.

  • Neurochemical Substrates of Addiction Medicine

    • 1st Edition
    • Mohammad Banazadeh + 2 more
    • English
    Neurochemical Substrates of Addiction Medicine offers an in-depth exploration of the complex interplay between neurochemistry and addiction, providing critical insights for researchers, clinicians, and students alike. This book is structured into four comprehensive sections, beginning with an examination of the distribution of neurotransmitters across key brain circuitry involved in addiction, such as the mesolimbic, striatal, frontal, insular, and thalamic systems. Each chapter meticulously describes how these circuits contribute to addictive behaviors and the underlying neurobiological mechanisms. The second section delves into the major neurotransmitter systems—including dopaminergic, glutamatergic, GABAergic, adrenergic, serotonergic, cholinergic, endogenous opioid, and purinergic systems—highlighting their roles in addiction.Following this, the book addresses the neuropharmacology of various drugs of abuse, including nicotine, opioids, alcohol, psychomotor stimulants, cannabinoids, psychedelics, sedative-hypnotics, caffeine, and antihistamines, detailing how these substances alter neurochemical pathways. The final section expands the discussion to behavioral addictions, exploring the neurochemical substrates associated with disorders such as pathological gambling, internet use, sexual addiction, and binge eating.

  • Complications in Neuroanesthesia

    • 2nd Edition
    • Hemanshu Prabhakar
    • English
    Complications in Neuroanesthesia, Second Edition offers an extensive examination of the complications associated with neuroanesthesia practice, emphasizing both new and existing challenges in the field. This updated edition introduces critical topics such as locked-in syndrome, cerebellar mutism syndrome, delirium, awareness, memory loss, perioperative stroke, and coma, alongside established complications like brain herniation, hydrocephalus, and seizures. Each complication is meticulously examined in separate chapters, detailing the pathophysiology, mechanisms, diagnosis, treatment, and prevention strategies. This book also addresses cardiovascular issues, including stunned myocardium, as well as fluid and electrolyte disturbances like glucose dysregulation and conditions like post-dural puncture headache, malignant hyperthermia and reperfusion injury. Written in an accessible format for quick navigation, this resource provides invaluable insights into the perioperative management of neurosurgical and neurologic patients. This book is a practical tool for trainees, clinicians, and researchers in anesthesia, neuroanesthesia, neurosurgery, neurocritical care, and neurology. By highlighting preventable mishaps, this edition aims to enhance the safety and efficacy of neuroanesthesia and neurocritical care practice.

  • Medicinal and Aromatic Plants in the Post-Genomics Era

    • 1st Edition
    • Rhydum Sharma + 2 more
    • English
    Medicinal and Aromatic Plants in the Post-Genomics Era brings together current research on species long valued for their therapeutic and industrial properties, now drawing renewed interest from the pharmaceutical, nutraceutical, cosmetic, and agricultural sectors amid rising demand for natural alternatives to synthetic chemistry.At the core of this shift is a deeper molecular understanding of how these plants produce their bioactive constituents. Genomics, transcriptomics, proteomics, and metabolomics have exposed the genetic architecture and biochemical pathways behind secondary metabolite synthesis, while computational biology helps make sense of the resulting complexity. Together, these tools are speeding up compound discovery and clarifying how such molecules function biologically.The chapters that follow turn this knowledge into practice: systems biology and metabolic engineering for boosting yields, CRISPR-based genome editing for reprogramming pathways, synthetic biology and AI-driven modeling for predicting and designing new biosynthetic routes, and emerging production platforms — from hairy root cultures to inducible expression systems — for expanding output sustainably.Taken together, the volume traces a progressive arc: from reading a plant's genetic blueprint to realizing its potential as a source of usable, real-world solutions in the clinic, the field, and the marketplace, offering a practical reference for both researchers and industry practitioners working at the intersection of plant biology and biotechnology.

  • The Neurobiological Underpinnings of Addiction Medicine

    Focusing on Novel Approaches
    • 1st Edition
    • Mohammad Shabani + 3 more
    • English
    The Neurobiological Underpinnings of Addiction Medicine: Focusing on Novel Approaches provides a comprehensive review of the biological mechanisms that drive addiction and innovative strategies for treatment. This book begins by examining the crucial role of the microbiome and the gut-brain axis in various substance use disorders, including opioid, alcohol, neurostimulant, and cannabis use disorders. It highlights how gut health can significantly influence addiction behaviors and treatment outcomes. Following this, the second section discusses the interplay between addiction and neuropsychiatric disorders such as depression, anxiety, schizophrenia, ADHD, bipolar disorder, PTSD, and OCD.This section emphasizes the impact of neurotransmitter systems and intracellular pathways on the development and persistence of these disorders. The final section introduces cutting-edge methodologies reshaping addiction research, including multi-OMICS approaches and the implications of CRISPR-Cas9 technology. By integrating these diverse topics, this book offers vital insights for clinicians and researchers alike.

  • Bioinformatics Essentials II

    From Multi‑omics to AI – Methods, Workflows, and Translational Applications
    • 1st Edition
    • Syed Mudasir Ahmad + 3 more
    • English
    Bioinformatics Essentials II, From Multi‑omics to AI – Methods, Workflows, and Translational Applications offers a comprehensive guide to modern bioinformatics, focusing on best-practice workflows for multi-omics data analysis and AI-assisted discovery. Designed for learners and early-career researchers, it bridges foundational knowledge with cutting-edge applications. The book covers experimental design, sequencing technologies, and core omics workflows including transcriptomics, proteomics, metabolomics, and epigenomics. Advanced chapters explore single-cell and spatial omics, multi-omics integration, AI/ML applications, and environmental bioinformatics.Each chapter includes learning objectives, worked examples, toolbox comparisons, and reproducible code. This resource empowers students, faculty, and applied researchers to confidently analyze complex datasets and translate findings into agriculture, health, and environmental solutions. Its modular structure and companion website enhance usability in both coursework and independent study.

  • Value-Based Healthcare in the Digital Age

    Economic Efficiency and Transformation
    • 1st Edition
    • Miltiadis D. Lytras + 3 more
    • English
    Value-Based Healthcare in the Digital Age: Economic Efficiency and Transformation addresses the transformation in global healthcare that has been driven by digital innovation, economic efficiency, and value-based care. The book provides comprehensive frameworks that integrate health economics, digital transformation, and patient-centered value delivery. Facing rising costs, aging populations, and chronic diseases, the healthcare sector also sees opportunities in AI, machine learning, blockchain, and IoT for smarter, more efficient delivery. Users will find an exploration of the economic implications of these technologies, offering strategies to align them with value-based care principles, optimize resources, and improve patient outcomes.For academics, policymakers, and healthcare professionals, this book bridges theory and practice with cutting-edge research and real-world case studies. It equips readers with the knowledge and frameworks to navigate the evolving healthcare landscape, emphasizing global perspectives and diverse technological applications, ultimately driving innovation and economic sustainability in healthcare delivery.

  • Insights from Educational Neuroscience and Serious Games in Math Learning

    • 1st Edition
    • Flávia H. Santos + 2 more
    • English
    Insights from Educational Neuroscience and Serious Games in Math Learning presents how educational games can transform math education, also including support on the latest research in neuroscience. The book addresses challenges faced by educators in selecting the right games and highlights the key characteristics that promote student growth. With contributions from educators, psychologists, and game developers, each chapter is clearly written with a goal of engaging the reader in making complex ideas easy to understand. Topics include early math skills, spatial cognition, the impact of anxiety on learning, and the development of dyscalculia, along with insights on technology’s role in the classroom.Sections also examine the impact of AI in education and present strategies for effectively implementing serious games. By connecting neuroscience and gaming, this book helps teachers enhance their teaching methods and provides developers with guidance for creating impactful educational experiences. This resource is essential for anyone looking to harness the potential of serious games to improve math learning in diverse educational settings.

  • Responsible AI in Healthcare

    Navigating the EU AI Act and Global Regulatory Frameworks
    • 1st Edition
    • Miltiadis D. Lytras + 4 more
    • English
    Responsible AI in Healthcare: Navigating the EU AI Act and Global Regulatory Frameworks examines how health systems design, deploy, and oversee AI under evolving legal and ethical mandates. It provides an integrated, practice‑oriented roadmap for compliance and responsible innovation. This book offers the first integrated, comparative treatment of the EU AI Act and global regulatory frameworks for healthcare, translating ethics and law into operational evaluation, governance, and value assessment. Through structured cases, decision tools, and stakeholder methods, it equips researchers and clinicians to design, validate, and deploy AI responsibly—and to keep learning as regulations evolve. Readers gain actionable tools, checklists, and frameworks to operationalize ethical AI, prepare for audits and certifications, and anticipate global convergence (“Brussels Effect”) shaping digital health. The volume serves clinicians, administrators, developers, policy and legal experts seeking rigorous yet accessible guidance.

  • Nanomedicine for Neurological Disorders

    Design, Delivery, and Clinical Perspectives
    • 1st Edition
    • Saman Fatima + 4 more
    • English
    Nanomedicine for Neurological Disorders: Design, Delivery, and Clinical Perspectives addresses the urgent need for innovative solutions in treating complex neurological and neurodegenerative diseases. As the global burden of conditions such as Alzheimer's, Parkinson's, multiple sclerosis, and brain tumors continues to rise, the scientific community faces the critical challenge of safely and effectively delivering therapeutics across the blood-brain barrier. This reference meets the needs of neuroscientists, clinicians, pharmaceutical scientists, and biomedical engineers seeking advanced strategies and translational insights in neuro-nanomedicine. The contents are structured to provide a comprehensive, interdisciplinary exploration of the field. Chapters cover the anatomy and connectivity of the human brain, the global burden and mechanisms of neurological disorders, conventional and nanomedicine-based drug delivery systems, and the intricacies of the blood-brain barrier. Readers will benefit from detailed analyses of nanocarrier engineering, stability, analytical techniques, toxicological safety, regulatory challenges, and artificial intelligence-driven drug design. Real-world case studies, clinical trial data, and future outlooks are presented alongside ethical and patient-centric considerations, ensuring a holistic perspective on the evolving landscape of neuro-nanomedicine. Nanomedicine for Neurological Disorders delivers essential benefits by bridging the gap between laboratory innovation and clinical practice. It equips readers with practical knowledge, foundational advances, and visionary insights to inspire new research directions, inform better decision-making, and accelerate the development of safer, more precise treatments for brain-related disorders. This reference is an indispensable resource for researchers, clinicians, and innovators at the forefront of neurological therapeutics.

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