Primary Aldosteronism: Physiopathology and Diagnosis
- 1st Edition, Volume 130 - February 1, 2026
- Editor: Marta Araujo Castro
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 4 3 1 7 0 - 8
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 4 3 1 7 1 - 5
Primary aldosteronism is one of the most common causes of secondary hypertension, and an early diagnosis and treatment can help prevent serious complications such as… Read more
Primary aldosteronism is one of the most common causes of secondary hypertension, and an early diagnosis and treatment can help prevent serious complications such as cardiovascular, kidney, and brain damage. For this reason, a correct understanding of its physiopathology and diagnosis are essential in order to improve the outcomes of these patients. In this volume we include several chapters focused on physiopathology and diagnosis of primary aldosteronism, covering some important topics such as the synthesis and regulation of aldosterone, the pathophysiology of primary aldosteronism, the prevalence and screening indications of this condition, diagnosis of primary aldosteronism: renin activity, renin concentration and aldosterone/renin ratio, confirmatory tests and novel workup strategies and biochemical tools, genetics of primary aldosteronism and aldosterone & cortisol cosecretion, among others.
- Primary aldosteronism is the most frequent etiology of endocrine hypertension and is associated with a higher cardiometabolic risk than essential hypertension
- The diagnosis of primary aldosteronism is usually performed in three steps: (1) case detection; (2) case confirmation, (which is not strictly necessary in all cases); and (3) subtype differentiation
- Subtype classification has the main aim of identifying unilateral cases, who are candidates for surgery
For the following medical specialties: Endocrinology, Internal Medicine and Nephrology (mainly), Clinical biochemical, General Digestive Surgery, Urology and Family Medicine
1. Aldosterone: synthesis and regulation
Elías Álvarez-García and Marta Bello-Rego
2. Pathophysiology of primary aldosteronism
Paola Parra-Ramírez and Patricia Martín Rojas
3. Prevalence of primary aldosteronism and screening indications
Jorge Gabriel Ruiz-Sanchez
4. Clinical manifestations of primary aldosteronism and cardiometabolic risk
Eider Pascual-Corrales
5. Diagnosis of primary aldosteronism: renin activity, renin concentration and aldosterone/renin ratio
Gregori Casals and Manuel Morales
6. Diagnosis of primary aldosteronism confirmatory test
Ana Maria García Cano, Laura Caja Guayerbas and Marta Rosillo Coronado
7. Diagnosis of Primary Aldosteronism: Novel Workup Strategies and Biochemical Tools
Arturo Vega Sr.
8. Genetics in primary aldosteronism
Verónica Barca
9. Low-renin hypertension
Paolo Mulatero and Jessica Goi
10. Adrenal venous sampling interpretation and other diagnostic lateralization tools in PA
Martin Reincke and Friederike Völter
11. Aldosterona & Cortisol cosecretion
Felicia Hanzu
Elías Álvarez-García and Marta Bello-Rego
2. Pathophysiology of primary aldosteronism
Paola Parra-Ramírez and Patricia Martín Rojas
3. Prevalence of primary aldosteronism and screening indications
Jorge Gabriel Ruiz-Sanchez
4. Clinical manifestations of primary aldosteronism and cardiometabolic risk
Eider Pascual-Corrales
5. Diagnosis of primary aldosteronism: renin activity, renin concentration and aldosterone/renin ratio
Gregori Casals and Manuel Morales
6. Diagnosis of primary aldosteronism confirmatory test
Ana Maria García Cano, Laura Caja Guayerbas and Marta Rosillo Coronado
7. Diagnosis of Primary Aldosteronism: Novel Workup Strategies and Biochemical Tools
Arturo Vega Sr.
8. Genetics in primary aldosteronism
Verónica Barca
9. Low-renin hypertension
Paolo Mulatero and Jessica Goi
10. Adrenal venous sampling interpretation and other diagnostic lateralization tools in PA
Martin Reincke and Friederike Völter
11. Aldosterona & Cortisol cosecretion
Felicia Hanzu
- Edition: 1
- Volume: 130
- Published: February 1, 2026
- Language: English
MC
Marta Araujo Castro
Marta Araujo-Castro, MD., PhD., is an endocrinologist of the Endocrinology and Nutrition Department of the Ramón y Cajal University Hospital in Madrid, Spain. She is the coordinator of the Neuroendocrinology & Adrenal Unit of the Endocrinology Department of her hospital. Her main clinical focus and research is on pituitary and adrenal gland disorders. She is the principal investigator and coordinator of the ACRO-SPAIN Registry, the SPAIN-ALDO Registry and the PHEO-PARA-RISK Study of the Spanish Society of Endocrinology & Nutrition (SEEN). Furthermore, in the last years she has received several awards related to adrenal and pituitary disorders (Cushing´s syndrome, acromegaly, adrenal incidentalomas, pheochromocytomas and so on). She is the current coordinator of the adrenal diseases group of the SEEN, a member of the scientific board of the working group of Aldosterone Producing Adenomas (APA) of ENSAT, coordinator of the Pituitary Committee of the Ramón y Cajal University Hospital and the principal investigator of the group of Endocrine-Metabolic, Digestive and Nutrition Surgery of the Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS).
She has more than 150 Medline listed manuscripts, cited >1000 times. More information
Dr. Araujo-Castro is a member of the SEEN, the European Endocrine Society (ESE), Spanish Group of Neuroendocrine Tumors (GETNE), European Network for the Study of Adrenal Tumors (ENSAT), Endocrine Society, SEEN and other many medical societies.
She actively participates in several national and international congresses with presentations related to adrenal pathology. Moreover, Dra. Araujo-Castro is a professor of the master’s degree in Endocrine Oncology Pathology at TECH University; she holds the title of master’s degree in research Methodology in Health Sciences of the Laboratory of Applied Statistics of the Autonomous University of Barcelona (UAB) (Spain) and the Diploma in Statistics in Health Sciences of the UAB.
about my professional profile below:
Researchgate: https://www.researchgate.net/profile/Marta-Araujo-Castro
Twitter: Marta_Araujo_C
ORCID: https://orcid.org/0000-0002-0519-0072
Affiliations and expertise
Ramón y Cajal University Hospital, Madrid, Spain