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Primary Aldosteronism: Physiopathology and Diagnosis

  • 1st Edition, Volume 130 - January 29, 2026
  • Latest edition
  • Editor: Marta Araujo Castro
  • Language: English

Primary Aldosteronism: Physiopathology and Diagnosis, Volume 130 focuses on the physiopathology and diagnosis of primary aldosteronism, covering some important topics such as… Read more

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Description

Primary Aldosteronism: Physiopathology and Diagnosis, Volume 130 focuses on the physiopathology and diagnosis of primary aldosteronism, covering some important topics such as Aldosterone: synthesis and regulation, Pathophysiology of primary aldosteronism, Prevalence of primary aldosteronism and screening indications, Clinical manifestations of primary aldosteronism and cardiometabolic risk, Diagnosis of primary aldosteronism: renin activity, renin concentration and aldosterone/renin ratio, Diagnosis of primary aldosteronism confirmatory test, Diagnosis of Primary Aldosteronism: Novel Workup Strategies and Biochemical Tools, and much more.

Additional sections cover Genetics in primary aldosteronism, Low-renin hypertension, Adrenal venous sampling interpretation and other diagnostic lateralization tools in PA, and Aldosterona & Cortisol cosecretion.

Key features

  • Primary aldosteronism is the most frequent etiology of endocrine hypertension and is associated with a higher cardiometabolic risk than essential hypertension
  • The diagnosis of primary aldosteronism is usually performed in three steps: (1) case detection; (2) case confirmation, (which is not strictly necessary in all cases); and (3) subtype differentiation
  • Subtype classification has the main aim of identifying unilateral cases, who are candidates for surgery

Readership

For the following medical specialties: Endocrinology, Internal Medicine and Nephrology (mainly), Clinical biochemical, General Digestive Surgery, Urology and Family Medicine

Table of contents

1. Aldosterone: synthesis and regulation
Elías Álvarez-García and Marta Bello-Rego

2. Pathophysiology of primary aldosteronism
Paola Parra-Ramírez and Patricia Martín Rojas

3. Prevalence of primary aldosteronism and screening indications
Jorge Gabriel Ruiz-Sanchez

4. Clinical manifestations of primary aldosteronism and cardiometabolic risk
Eider Pascual-Corrales

5. Diagnosis of primary aldosteronism: renin activity, renin concentration and aldosterone/renin ratio
Gregori Casals and Manuel Morales

6. Diagnosis of primary aldosteronism confirmatory test
Ana Maria García Cano, Laura Caja Guayerbas and Marta Rosillo Coronado

7. Diagnosis of Primary Aldosteronism: Novel Workup Strategies and Biochemical Tools
Arturo Vega Sr.

8. Genetics in primary aldosteronism
Verónica Barca

9. Low-renin hypertension
Paolo Mulatero and Jessica Goi

10. Adrenal venous sampling interpretation and other diagnostic lateralization tools in PA
Martin Reincke and Friederike Völter

11. Aldosterona & Cortisol cosecretion
Felicia Hanzu

Product details

  • Edition: 1
  • Latest edition
  • Volume: 130
  • Published: January 29, 2026
  • Language: English

About the editor

MC

Marta Araujo Castro

Marta Araujo-Castro, MD, PhD, is a Consultant Endocrinologist in the Neuroendocrinology and Adrenal Unit of the Department of Endocrinology and Nutrition at Ramón y Cajal University Hospital, Madrid, Spain, and a researcher at the Ramón y Cajal Institute for Health Research (IRYCIS). She obtained her PhD from the Alcalá de Henares University, where she received the Extraordinary Doctorate Award for her research on personalized medicine in adrenal tumors using metabolomics.

Dr. Araujo-Castro completed her residency in Endocrinology and Nutrition at Hospital Universitario Puerta de Hierro Majadahonda and has developed extensive clinical and research expertise in adrenal and pituitary disorders, hereditary endocrine neoplasia, neuroendocrine tumors, and endocrine oncology. She coordinates the Adrenal and Pituitary Units at her institution and actively participates in multidisciplinary endocrine tumor and hereditary cancer boards. Her research focuses on translational endocrinology, particularly the identification of diagnostic, prognostic, and predictive biomarkers in adrenal and pituitary diseases, precision medicine, endocrine tumor genetics, and optimization of the management of patients with adrenal tumors, Cushing syndrome, pheochromocytoma/paraganglioma, and primary aldosteronism. She has led and participated in numerous national and international collaborative studies and is actively involved in several Spanish and European endocrine registries and research networks.

She is committed to advancing evidence-based endocrine practice through multidisciplinary collaboration, clinical research, education, and mentorship, with a particular focus on improving the diagnosis and personalized management of patients with hereditary endocrine tumor syndromes.

Affiliations and expertise
1Neuroendocrinology and Adrenal Unit of the Endocrinology & Nutrition Department. Hospital Universitario Ramón y Cajal. Madrid. Spain 2Ramón y Cajal Research Institute (IRYCIS), Madrid, Spain

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