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    • Advances in Agronomy

      • 1st Edition
      • Volume 185
      • April 12, 2024
      • English
      • Hardback
        9 7 8 0 4 4 3 2 9 5 2 6 3
      • eBook
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      Advances in Agronomy, Volume 185, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field, each written by an international board of authors.

    • Ethics in Online AI-Based Systems

      • 1st Edition
      • April 10, 2024
      • Santi Caballé + 2 more
      • English
      • Paperback
        9 7 8 0 4 4 3 1 8 8 5 1 0
      • eBook
        9 7 8 0 4 4 3 1 8 8 5 0 3
      Ethics in Online AI-Based Systems: Risks and Opportunities in Current Technological Trends creates a space to explore the ethical relevance that new technologies under development may have. Stimulating reflection and considerations with respect to the design, deployment, and use of technology helps readers guide current and future technological advancements from an ethically informed position to ensure that such advancements contribute towards solving current global and social challenges that we, as a society, have today. This will not only be useful for researchers and professional engineers, but also for educators, policy makers, and ethicists.Recent technological advancements have deeply transformed society and the way people interact with each other. Instantaneous communication platforms have allowed connections with other people, forming global communities and creating unprecedented opportunities in many sectors, making access to online resources more ubiquitous by reducing limitations imposed by geographical distance and temporal constrains. These technological developments bear ethically relevant consequences with their deployment, and legislations often lag behind such advancements. Because the appearance and deployment of these technologies happen much faster than legislative procedures, the way these technologies affect social interactions have profound ethical effects before any legislative regulation can be built in order to prevent and mitigate those effects.

    • Liposomes in Drug Delivery

      • 1st Edition
      • April 10, 2024
      • Sophia G. Antimisiaris
      • English
      • Paperback
        9 7 8 0 4 4 3 1 5 4 9 1 1
      • eBook
        9 7 8 0 4 4 3 1 5 4 9 2 8
      Liposomes in Drug Delivery: What, Where, How and When to Deliver is a concise, well-structured reference covering all the important issues related to the potential of this technology. Organized to provide practical information to researchers from any discipline with a particular therapeutic or bio-active substance to deliver, this book helps readers understand if liposomes can be of benefit for their particular need, what is the best type of liposome to use according to what needs to be delivered, where/when to deliver it, and how to design/prepare/chara... liposome properties for a particular application.The book is structured in Four parts. The first covers in a concise but in-depth way, what liposomes are, which are the liposome types, advantages/disadvant... and what is their stability, characterization methods, in vitro stability, and in vivo fate after different administration methods (routes). The second part focuses on the different mechanisms for liposomal drug delivery. Methodologies/techno... for manipulation of liposome structure/properties in order to design liposomes for particular delivery applications. Specific roadmaps for liposome design are discussed, including components to incorporate in liposomes for specific types of encapsulated molecules or specific routes of administration. The third part covers liposome applications for drug delivery. It focuses on specific delivery considerations for particular diseases. Finally, the fourth part covers methods of liposome fabrication.

    • Microbial Biofilms

      • 1st Edition
      • April 10, 2024
      • Mukesh Kumar Yadav + 2 more
      • English
      • Paperback
        9 7 8 0 4 4 3 1 9 2 5 2 4
      • eBook
        9 7 8 0 4 4 3 1 9 2 5 3 1
      Microbial biofilms are serious problem in medical settings as they are associated with significant mortality and morbidity. Infection related to biofilms not only increases recovery time, but also escalates the cost of disease management. Biofilms are intrinsically resistant to antibiotics and evade human defense mechanisms. In addition, the close proximity of microbes within biofilms promotes genetic transformation, facilitating the acquisition of antibiotic-resistant genes and leading to an increased prevalence of diseases associated with resistance. Fortunately, with advances in science and technology, novel strategies are being utilized to mitigate the impact of biofilms on human health.Microbial Biofilms: Role in Human Infectious Diseases focuses on new and emerging concepts in microbial biofilm research. It explores topics such as the mechanisms of biofilm formation, biofilm-induced pathogenesis, biofilm detection and diagnosis, gene exchange within biofilms, strategies to control microbial biofilms, and the burden of biofilm-associated infections. Additionally, the book highlights the various antibiofilm strategies, such as surface coating, signal quenching, novel compounds that can be translated to curb biofilm-associated infections, and the escalation of antimicrobial resistance determinants.

    • Current Molecular Targets of Heterocyclic Compounds for Cancer Therapy

      • 1st Edition
      • April 10, 2024
      • Vivek Asati + 1 more
      • English
      • Paperback
        9 7 8 0 3 2 3 9 6 1 2 1 9
      • eBook
        9 7 8 0 3 2 3 9 9 6 3 2 7
      Current Molecular Targets of Heterocyclic Compounds for Cancer Therapy discusses recently developed treatments based on molecular targets which are genetically altered in cancer cells and are essential for tumor development and survival. Considerable research effort has been devoted to the development of targeted drugs that inhibit the action of pathogenic kinases, and clinical studies performed so far have validated the positive effects of kinase inhibitors for cancer treatment. Each chapter discusses a molecular target, such as ALK2, ATR, CK, Src-Abl, EGFR, Fyn-Blk-Lyn, IGFs, and PAK1.The book's chapters are written by experts who actively work on the targets to help readers fully understand how they can be used. This is a valuable resource for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in the potential of novel cancer therapies based on molecular targets.

    • Sinusoidal Cells in Liver Diseases

      • 1st Edition
      • April 9, 2024
      • Jordi Gracia-Sancho
      • English
      • Paperback
        9 7 8 0 3 2 3 9 5 2 6 2 0
      • eBook
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      Sinusoidal Cells in Liver Diseases: Role in their Pathophysiology, Diagnosis, and Treatment provides a state-of-the-art review on recent advances surrounding the role of liver sinusoidal cells (LSECs, HSCs, macrophages, and other non-parenchymal cells) in acute and chronic liver diseases. Coverage emphasizes disease pathophysiology, novel mechanisms, unmet clinical questions, development of biomarkers, and treatment opportunities. By focusing on the role of sinusoidal cells in human liver diseases, this reference provides a comprehensive overview of the role of sinusoidal cells in acute and chronic liver diseases, in its pathophysiology and mechanisms, and in the development of novel biomarkers and new therapeutics.Cells of the liver vasculature play an essential role in the pathophysiology of acute and chronic liver diseases and are considered key therapeutic targets to treat most of human hepatopathies. Coverage in this reference includes the phenotypic changes occurring in liver vascular cells and how cells contribute to the development of microcirculatory dysfunction, fibrosis, inflammation, and liver failure.

    • Mass-Action Law Dynamics Theory and Algorithm for Translational and Precision Medicine Informatics

      • 1st Edition
      • April 9, 2024
      • Ting-Chao Chou
      • English
      • Paperback
        9 7 8 0 4 4 3 2 8 8 7 4 6
      • eBook
        9 7 8 0 4 4 3 2 8 8 7 5 3
      “Mass-Action Law Dynamics Theory and Algorithm for Translational and Precision Medicine Informatics” provides a comprehensive overview and update of the mass-action law-based unified dose-effect biodynamics, pharmacodynamics, bioinformatics, and the combination index theorem for synergy definition (MAL-BD/PD/BI/CI). Contents advocate the fundamental MAL-PD/BI/CI/BI principle for biomedical R&D, clinical trials protocol design computerized data analysis, illustrates the MAL-dynamics theory with sample analysis, and includes data entry and automated computer report print-outs. In 11 sections “Mass-Action Law Dynamics Theory and Algorithm for Translational and Precision Medicine Informatics” leads the reader from an introduction and overview, to trial protocols and MAL-PD/CI approach for biomedical R&D in vitro and in animals. It describes the current Landscape of International FDA Drug Evaluation, Clinical Pharmacology, and Clinical Trials Guidance. This is a valuable resource for biomedical researchers, healthcare professionals, and students seeking to harness the power of data informatics in precision medicine.

    • Cranial Surgery - Part 1

      • 1st Edition
      • Volume 284
      • April 9, 2024
      • Jeremy Christopher Ganz
      • English
      • Hardback
        9 7 8 0 4 4 3 2 3 8 7 1 0
      • eBook
        9 7 8 0 4 4 3 2 3 8 7 2 7
      This is a study of the evolution of the principles and techniques of cranial surgery from Hippocrates to the nineteenth century. The methods of conveying information by text and image are considered.

    • Pathophysiology, Risk Factors, and Management of Chronic Heart Failure

      • 1st Edition
      • April 4, 2024
      • Ram B. Singh + 3 more
      • English
      • Paperback
        9 7 8 0 1 2 8 2 2 9 7 2 9
      • eBook
        9 7 8 0 1 2 8 2 3 1 1 1 1
      Chronic Heart Failure: Pathophysiology, Risk Factors, and Mechanisms aims to provide an inclusive overview on Chronic Heart Failure (CHF).This book is focused on the epidemiology, classification, molecular mechanisms, pathophysiology, causes, identification and interactions of heart failure. It will explain the uncertainties and issues in Heart Failure by helping readers understand the physiopathology of CHF in the light of behavioural risk factors. 2D and 3D speckle tracking echocardiography have been used to quantify regional alterations of longitudinal strain and area strain, through their polar projection, which allows a further evaluation of both the site and extent of myocardial damage. The analysis of strain can identify subclinical cardiac failure (myocyte remodelling) which is a major issue in CHF. Myocardial Strain, measure by speckle tracking echocardiography, is frequently attenuated in these conditions and can be utilized for the evaluation of disease progression and the effect of therapeutic interventions as well as prevention because it could be a manifestation of behavioural risk factors.This title will function as an essential reference to both researchers and practicing clinicians, proposing novel methods of research by using behavioural and environmental risk factors as intervention agents, as well as discussing deficiency in the present approaches in management of HF and proposing new methods of early diagnosis and therapies for the clinical management of CHF.

    • Microbiome-Based Decontamination of Environmental Pollutants

      • 1st Edition
      • April 4, 2024
      • Ajay Kumar + 2 more
      • English
      • Paperback
        9 7 8 0 4 4 3 2 1 7 8 1 4
      • eBook
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      Microbiome-Based Decontamination of Environmental Pollutants explores the complex interactions of plant-associated microbiomes, providing insights into the pressing challenges of managing environmental resources such as soil, water, and waste. Analysis has shown a formidable potential based in the network interactions between plant microbiota and environmental contaminants. This book presents insights into the potential exploitation of these plant-associated microbial functions. This volume in the Plant and Soil Microbiome series summarizes microbiological aspects of environmental management from the basics to advanced theoretical as well as practical aspects of microbial-based approaches.The physical and chemical changes caused by pollution of an ecosystem can occur rapidly, significantly impacting the functionality of ecosystem services in that environment. Environmental contamination poses and increasingly global challenge through direct and indirect adverse impacts on the climate, soil productivity and the health concerns of human beings. Traditional remediation techniques are not consistently feasible in mitigating environmental contaminants challenges in terms of cost-effectiveness, limited land resources and toxic residual products. The use of plant-associated microbes as part of a network of tools opens a new door to explore an alternative, eco-friendly and economical technology to mitigate the challenges of environmental contamination.

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