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Academic Press

  • Mechanics in Development and Disease

    • 1st Edition
    • Volume 160
    • English
    Mechanics in Development and Disease, Volume 160 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Gut developmental mechanics, Long bone developmental mechanics, Cranial plate fusion developmental mechanics, Mechanobiology and vasculogenesis, Morphogenesis and mechanics of the developing inner ear, Morphogenesis and mechanics of body wall closure in mammals, Salivary bud developmental mechanics, Lateral plate mesoderm developmental mechanics, Biomechanics of human embryo implantation, gastrulation, and organ formation, Mechanics of lung development across species, Mechanics early development in vertebrates.

  • Prosopis Juliflora

    Attributes, Impact, Utilization
    • 1st Edition
    • Pratiksha Patnaik + 2 more
    • English
    Prosopis (Prosopis juliflora) is a xerophyte which, in its native habitats has been a desert plant. As long as it was confined to that habitat, P. juliflora was a great resource, improving the region’s micrometeorology, binding its sandy soil, and providing shelter, fuel, feed, food, medicines, and cosmetics to the people of such regions. In particular, for the economically weaker inhabitants, P.juliflora was a lifeline.But when P. juliflora was indiscriminately introduced in other regions of the world in a hope to derive similar benefits from it, things began to go awry. Indeed, among the invasive species of plants which are spreading at an alarming rate in the tropical and sub-tropical regions of the world, P.juliflora is arguably the most hardy and resilient. It is growing so explosively that it even enters roads and homes, driving humans out of their dwellings. The resulting damage to biodiversity is enormous. This book highlights the dual role played so far by P. juliflora and itemizes the facets that make it a blessing in some contexts and a bane in other contexts.Authored by leading experts in the field, Prosopis juliflora: Attributes, Impact, Utilization is the first title of its kind to comprehensively discuss this hardy plant species. It will be an essential read for students, researchers and governmental agencies interested in plant biology, forestry, plant ecology, invasive plant species and environmental science.

  • Cancer Epigenetics and Nanomedicine

    Targeting the Right Player via Nanotechnology
    • 1st Edition
    • Prashant Kesharwani + 1 more
    • English
    Cancer Epigenetics and Nanomedicine: Targeting the Right Player via Nanotechnology is a complete package that provides a comprehensive and thorough understanding of the key players that modulate the various steps of carcinogenesis and malignant progression of the disease and the critical targets to be exploited for developing novel modalities of diagnosis and therapeutics.Since epigenetic aberrations can be potentially reversed and restored to their normal state through epigenetic therapy, the book also discusses the challenges and the future of the field with the cutting-edge revelations and limitations that this research endeavor can offer, thereby helping the readers to enhance their critical thinking and adopt strategies of therapeutic importance.

  • Macrophages Biology and Tissue Inflammation in Health and Disease

    • 1st Edition
    • Stuart Goodman + 2 more
    • English
    Macrophages Biology and Tissue Inflammation in Health and Disease outlines the important role of macrophages—keys cells in the innate immune system—as regulators and orchestrators of inflammation and repair in health and disease. It contains chapters by leading authors on the basic and translational aspects of macrophage biology, covering how to maintained tissue homeostatis and how to deal with internal and external biological threats.

  • Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies

    Applications
    • 1st Edition
    • Wendy Fantl
    • English
    Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies: ApplicationsHealthy tissues and organs rely on the precise coordination of diverse cell types, each responding to external and internal signals. Disease disrupts this coordination. Since proteins drive cellular function, analyzing their abundance and activation states in single cells helps identify key cell populations in health and disease. Bulk protein analyses mask critical differences between individual cells. Additionally, the arrangement of cells into neighborhoods through cell-cell interactions is essential for tissue function. Over the last decade, single-cell proteomic phenotyping combined with positional information has become crucial for understanding biology in health and disease. This has led to the development of multiple technology platforms, profoundly impacting fields including developmental biology, cancer biology, immunology, neuroscience, and drug discovery. This book focuses on the application of single-cell multiplex proteomic platforms to various biological systems. These platforms have proved to be essential in biomedical research, advancing our understanding of complex biological systems at the cellular level. Compelling studies where authors use these technologies to answer previously unanswerable questions are featured. Exploring this "Uncharted Biology" opens new avenues for scientific inquiry and clinical translation, covering areas including oncology, immunology, metabolomics, stem cell research, preclinical models, and translational research. The initial chapters discuss incorporating these technologies into core facilities and consortia, providing access for multiple users and integrating datasets from other omics technologies. The following chapters cover applications in diverse areas such as muscle stem cell function in skeletal muscle regeneration, metabolic regulome profiling, translational studies, developing predictive biomarkers for patients receiving immune checkpoint inhibitors, and pre-clinical studies of lung cancer. These applications demonstrate how advanced single cell proteomic technologies are reshaping our understanding of complex biological systems and enhancing clinical translation. Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies: Applications highlights the transformative benefits of single-cell proteomics, offering insights into cellular mechanisms underlying health and disease and inspiring further exploration into "Uncharted Biology." It is an essential resource for researchers, clinicians, and students aiming to advance biomedical science and improve therapeutic outcomes.

  • On Epigenetics and Evolution

    • 1st Edition
    • Carlos M. Guerrero-Bosagna
    • English
    On Epigenetics and Evolution, a new volume in the Translational Epigenetics series, introduces key themes from current epigenetic evolution research, with contributions from leading scientists around the world that investigate the role of epigenetic mechanisms in evolution from a variety of different angles, with each contribution combining theory, current research overviews, and applications. This book gives researchers, students, and clinicians a better understanding of the origin of genotypic and phenotypic variability, the role of epigenetics in development and inheritance, how epigenetics may affect speciation, and the evolution of epigenetic mechanisms in different taxa, and helps them apply their learnings across new research. Other modalities and subtopics explored include epigenetics in neutral and also adaptive evolution; epigenetic evolution in plants, invertebrates, and vertebrates; and the role of epigenetics in human evolution and its societal impact.

  • Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies

    Platforms
    • 1st Edition
    • Wendy Fantl
    • English
    Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies: Platforms. Understanding the intricate coordination of highly diverse cell types within healthy tissues and organs is essential for grasping their functionality. This coordination, often disrupted in disease, hinges on proteins—the primary drivers of cellular function. By examining protein abundance and activation states in single cells, researchers can identify key cell populations involved in both healthy and diseased states, including those influencing disease initiation, progression, and therapeutic responses. Single-cell multiplex proteomic platforms have recently emerged as powerful tools for biomedical research. Their strengths lie in revealing cell types that are rare or subtly different and would otherwise go undetected in bulk cellular analyses. This unique capability enables deeper insights into cellular behavior and disease mechanisms.This book offers comprehensive overviews of technologies developed for multiplex single-cell proteomic analyses. It begins with the pioneering work from Professors Scott Tanner, Mitchell Winnick and Garry Nolan resulting in the development and early application of the mass cytometer, (CyTOF). The instrument merges flow cytometry with time-of-flight mass spectrometry and analyzes cells labelled with metal tagged antibodies. These components work together to enable CyTOF to perform highly multiplexed protein analysis at the single-cell level, offering a powerful tool for understanding complex cellular behaviors and interactions.Recogni... that cellular organization is critical for tissue function, subsequent chapters explore advanced multiplex imaging platforms including Imaging Mass Cytometry (IMC), Multiplexed Ion Beam Imaging (MIBI), CODetection by InDExing, and Chip Cytometry. Later chapters present recent advances in these imaging platforms and data analysis approaches - Combined Nucleic Acid and Protein Quantification in situ, Tissue Schematics, and High-definition CODEX for 3D Multiplex Spatial Cell Phenotyping. These techniques integrate deep phenotyping with spatial mapping to provide unprecedented insights into cellular interactions within tissues. The book also highlights computational approaches essential for managing and interpreting the vast datasets generated by these technologies. Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies: Platforms help researchers in many fields, including developmental biology, cancer biology, immunology, neuroscience, and drug discovery gain an understanding about the theories and detailed methodologies behind these technologies. Integrating proteomics with genetic, epigenetic, and transcriptomic platforms, this book aims to inspire new research opportunities, ultimately advancing the development of reliable biomarkers and improving patient outcomes.

  • Resilient Health

    Leveraging Technology and Social Innovations to Transform Healthcare for COVID-19 Recovery and Beyond
    • 1st Edition
    • Judy Kuriansky + 1 more
    • English
    Resilient Health: Leveraging Technology and Social Innovations to Transform Healthcare for COVID-19 Recovery and Beyond presents game-changing and disruptive technological innovations and social applications in physical and mental healthcare around the world for the post-COVID age and beyond, addressing the urgent need for care. In this first-of-its kind comprehensive volume, experts and stakeholders from all sectors - government and the public and private sectors - offer models and frameworks for policy, programming, and financing to transform healthcare, address inequities, close the treatment gap, and “build back better,” especially for under-resourced vulnerable communities globally, to “leave no one behind” and advance development globally. Contributions from world experts cover 8 essential parts: The context and challenges for resilient health systems to shape the future; developments and directions (AI, VR, MR, IVAs and more); an innovations toolbox, also targeted for special populations and settings (women, youth, ageing, migrants, disabled persons, indigenous peoples, in the workplace); the role of stakeholders (governments, the United Nations bodies, and the public and private sector); forums and networks; innovative financing; resources, lessons learned and the way forward.

  • Encyclopedia of Adolescence

    • 2nd Edition
    • Wendy Troop-Gordon + 1 more
    • English
    Encyclopedia of Adolescence, Second Edition presents a comprehensive overview of the theories, methods, and empirical evidence needed to understand this critical developmental period. Split across 3 volumes, and spanning over 130 chapters, the title begins with an overview of the history of the study of adolescence and the emerging theories and tools used to study adolescent development, as well as normative changes of adolescence, encompassing a broad range of adolescent experiences. It then examines the interpersonal and socioecological contexts which are both shaped by the adolescent and play a formative role in the adolescent’s development.In conclusion, the book examines those experiences that can compromise healthy development in adolescence and the specific mental health challenges that are common or emergent during the adolescent years. This updated edition addresses identified gaps in the earlier edition, and in similar works, expanding coverage to topics that have often been overlooked but are key experiences, tasks, or contexts affecting adolescent development.

  • Enzymatic Processes for Food Valorization

    • 1st Edition
    • Monica L. Chavez Gonzalez + 3 more
    • English
    Enzymatic Processes for Food Valorization describes the most recent research in the field of catalysis for food valorization, revealing the impact of the implementation of enzymatic catalysis in the different stages that make up the production processes. Sections review advances in food processing using enzymes, explore the use of enzymes on by-products for the release of compounds of interest, and show recent trends in biocatalysis and its application in the food industry. Written by a team of international experts, this is an invaluable guide for professionals in the area of enzyme technology applied in the food industry, as well as technicians and scientists involved in the use of enzymes on food waste for the valorization and/or recovery of compounds.

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