Organizers in Development
- 1st Edition, Volume 157 - April 2, 2024
- Imprint: Academic Press
- Editor: Claudio Stern
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 2 3 7 5 9 - 5
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 3 7 6 0 - 1
Organizers in Development, Volume 157 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting c… Read more
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Request a sales quoteOrganizers in Development, Volume 157 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as The organizer: what it meant, and means, to developmental biology, Organizers/signaling regions that pattern the limb, Organizers/signaling regions in the branchial arches, The notochord/floor plate as a possible organizer, Transport and gradient formation of Wnt and Fgf in the early zebrafish gastrula, and more.
- Provides the authority and expertise of leading contributors from an international board of authors
- Presents the latest release in the Current Topics in Development Biology series
- Updated release includes the latest information on Organizers in Development
Researchers and students
- Cover image
- Title page
- Table of Contents
- Series Page
- Copyright
- Contributors
- Preface: Hans Spemann, Hilde Mangold and the ‘organizer’
- References
- Chapter One: The organizer: What it meant, and still means, to developmental biology
- Abstract
- 1 What did Spemann and his colleagues believe in 1921–22
- 2 What was the view in the 1930s
- 3 Evocation and individuation
- 4 Neural and mesodermal inducers
- 5 The two gradient models
- 6 Later results
- 7 Mesoderm induction
- 8 The re-emergence of experimental embryology in a “modern” guise
- 9 The second gold rush
- 10 How we should understand the organizer today
- Acknowledgments
- References
- Chapter Two: The organizer and neural induction in birds and mammals
- Abstract
- 1 Historical introduction
- 2 Hensen’s node (“the node”)
- 3 Neural induction: spatial and temporal aspects
- 4 Molecular mechanisms of neural induction
- 5 The organizer and “dorso-ventral” (axial-lateral) patterning
- 6 Neural induction and rostro-caudal (anterior-posterior) patterning: how many organizers
- 7 Is neural induction by a grafted organizer comparable to normal neural plate development
- 8 Neural induction in vivo and in vitro
- 9 Are the mechanisms of neural induction in amniotes different from those in anamniotes
- References
- Chapter Three: Tissues and signals with true organizer properties in craniofacial development
- Abstract
- 1 Introduction
- 2 Neural crest cells contain craniofacial patterning information, but do they have organizer properties
- 3 Foregut endoderm is an organizer in facial patterning
- 4 Nasal placodes as craniofacial organizers
- 5 Frontonasal mass epithelial zone a potential facial organizer
- 6 Signals with craniofacial organizer properties
- 7 Concluding remarks
- Acknowledgments
- References
- Chapter Four: Organizing activities of axial mesoderm
- Abstract
- 1 The embryonic organizer, neural induction and secondary organizers
- 2 The role of axial mesoderm in the chick
- 3 The role of axial mesoderm in Xenopus and zebrafish
- 4 The role of axial mesoderm in mouse
- 5 Summary
- References
- Chapter Five: Transport and gradient formation of Wnt and Fgf in the early zebrafish gastrula
- Abstract
- 1 Introduction
- 2 The discovery of the Spemann-Mangold Organiser
- 3 Morphogen signalling from the organiser
- 4 Comparing the Wnt and Fgf signalling pathways on a molecular level
- 5 Contrasting the role of Wnt and Fgf signalling within embryonic patterning
- 6 Anteroposterior axis formation
- 7 Neural AP axis patterning
- 8 Mesodermal and endodermal fate
- 9 Juxtaposing the transport mechanisms for Wnt and Fgf
- 10 Post-translational modification
- 11 Carrier proteins
- 12 Restricted diffusion by heparan sulphate proteoglycans (HSPGs)
- 13 Extracellular vesicles
- 14 Cytonemes facilitate paracrine morphogen signalling
- 15 Comparing Wnt and Fgf signalling gradient formation
- 16 Controlled morphogen transport shapes the gradient
- 17 Signalling modulators in the target cells
- 18 Final remarks on the importance of transport modes in morphogen gradient formation
- Acknowledgement
- References
- Edition: 1
- Volume: 157
- Published: April 2, 2024
- No. of pages (Hardback): 362
- No. of pages (eBook): 362
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780128237595
- eBook ISBN: 9780128237601
CS
Claudio Stern
Claudio Stern is at Department of Cell and Developmental Biology, UCL, London, UK
Affiliations and expertise
UCL, London, UKRead Organizers in Development on ScienceDirect