Organizers in Development

1st Edition, Volume 157 - April 1, 2024
Editor: Claudio Stern
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 2 3 7 5 9 - 5
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 3 7 6 0 - 1

Organizers in Development, Volume 157 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting c… Read more

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Organizers in Development, Volume 157 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as The organizer: what it meant, and means, to developmental biology, Organizers/signaling regions that pattern the limb, Organizers/signaling regions in the branchial arches, The notochord/floor plate as a possible organizer, Transport and gradient formation of Wnt and Fgf in the early zebrafish gastrula, and more.

Cover image
Title page
Table of Contents
Series Page
Copyright
Contributors
Preface: Hans Spemann, Hilde Mangold and the ‘organizer’
References
Chapter One: The organizer: What it meant, and still means, to developmental biology
Abstract
1 What did Spemann and his colleagues believe in 1921–22
2 What was the view in the 1930s
3 Evocation and individuation
4 Neural and mesodermal inducers
5 The two gradient models
6 Later results
7 Mesoderm induction
8 The re-emergence of experimental embryology in a “modern” guise
9 The second gold rush
10 How we should understand the organizer today
Acknowledgments
References
Chapter Two: The organizer and neural induction in birds and mammals
Abstract
1 Historical introduction
2 Hensen’s node (“the node”)
3 Neural induction: spatial and temporal aspects
4 Molecular mechanisms of neural induction
5 The organizer and “dorso-ventral” (axial-lateral) patterning
6 Neural induction and rostro-caudal (anterior-posterior) patterning: how many organizers
7 Is neural induction by a grafted organizer comparable to normal neural plate development
8 Neural induction in vivo and in vitro
9 Are the mechanisms of neural induction in amniotes different from those in anamniotes
References
Chapter Three: Tissues and signals with true organizer properties in craniofacial development
Abstract
1 Introduction
2 Neural crest cells contain craniofacial patterning information, but do they have organizer properties
3 Foregut endoderm is an organizer in facial patterning
4 Nasal placodes as craniofacial organizers
5 Frontonasal mass epithelial zone a potential facial organizer
6 Signals with craniofacial organizer properties
7 Concluding remarks
Acknowledgments
References
Chapter Four: Organizing activities of axial mesoderm
Abstract
1 The embryonic organizer, neural induction and secondary organizers
2 The role of axial mesoderm in the chick
3 The role of axial mesoderm in Xenopus and zebrafish
4 The role of axial mesoderm in mouse
5 Summary
References
Chapter Five: Transport and gradient formation of Wnt and Fgf in the early zebrafish gastrula
Abstract
1 Introduction
2 The discovery of the Spemann-Mangold Organiser
3 Morphogen signalling from the organiser
4 Comparing the Wnt and Fgf signalling pathways on a molecular level
5 Contrasting the role of Wnt and Fgf signalling within embryonic patterning
6 Anteroposterior axis formation
7 Neural AP axis patterning
8 Mesodermal and endodermal fate
9 Juxtaposing the transport mechanisms for Wnt and Fgf
10 Post-translational modification
11 Carrier proteins
12 Restricted diffusion by heparan sulphate proteoglycans (HSPGs)
13 Extracellular vesicles
14 Cytonemes facilitate paracrine morphogen signalling
15 Comparing Wnt and Fgf signalling gradient formation
16 Controlled morphogen transport shapes the gradient
17 Signalling modulators in the target cells
18 Final remarks on the importance of transport modes in morphogen gradient formation
Acknowledgement
References

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Claudio Stern