Fundamental Principles of Oxidative Stress in Metabolism and Reproduction

Prevention and Management

1st Edition - April 1, 2024
Editors: Faiza Alam, Rehana Rehman
Language: English
Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 1 8 8 0 7 - 7
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 8 8 0 6 - 0

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Fundamental Principles of Oxidative Stress in Metabolism and Reproduction: Prevention and Management is a comprehensive resource for anyone needing awareness and recognition of oxidative stress as a basic component of disease to determine the precise treatment plan considering the cause of the disease. It describes the effects of oxidative stress in the human body, the detection of metabolic changes, psychological impact and effect on reproductive outcomes. In addition, it discusses alterations at the cellular level occurring due to oxidative stress along with the genetic aspects involved in its pathogenesis.

Cover image
Title page
Table of Contents
Copyright
Dedication
Preface
Acknowledgments
Section I. Overview: Cause and mechanisms
Chapter 1. Introduction to oxidative stress
Oxidative stress
Influence of ROS on body functions
OS and the defense of the human body
Influence of oxidative stress: From health to disease
Diagnosis: Biomarkers of OS
Antioxidant defense and therapeutic implications
Chapter 2. Role of free radicals in normal human physiology
Overview of oxidative stress
Enzymatic and nonenzymatic reactions of free radicals
Free radicals, antioxidant, and tissue injuries
Categories of defense mechanisms
Oxidative stress and diabetes mellitus
Techniques used for the identification of free radicals
Oxidative stress and mitochondria
Oxidative stress and inflammation
Oxidative stress and chronic inflammatory disorders
Oxidative stress and infertility
Chapter 3. Role of diet in the development of oxidative stress
Introduction to oxidative stress
Conclusion
Chapter 4. Occupational hazards and oxidative stress
Introduction
History
Example at workplaces
Mechanism of oxidative stress
Effects to the workers
Prevention/management of occupational hazards and oxidative stress
Conclusion
Chapter 5. Role of radio-frequency electromagnetic waves in causing oxidative stress
Introduction
Material and methods
Results
Conclusion
Chapter 6. Genetic variations and lifestyle in oxidative stress
Introduction
Genetic variations and oxidative stress
Lifestyle factors and oxidative stress
Interplay between genetic variations and lifestyle in oxidative stress
Conclusion
Chapter 7. Aging: Generation of oxidative stress
What is aging?
Why it is important to know about the processes involved in aging?
Overview of aging theories
Cell and role of organelles in ROS production
Oxidative stress and age-related diseases
How can we minimize OS?
Summary
Section II. Systemic effects of oxidative stress
Chapter 8. Oxidative stress and insulin resistance
Introduction
Insulin resistance
Insulin and insulin signaling
Pathophysiology of insulin resistance
Etiology of insulin resistance
Mechanisms causing insulin resistance by oxidative stress
Symptoms of insulin resistance
Complications of insulin resistance
Role of antioxidants in insulin resistance
Conclusion
Chapter 9. Oxidative stress and cardiovascular diseases
Background
Free radicals involved in cardiovascular diseases
Oxidative stress and myocardial damage
Oxidative stress and atherosclerosis
Antioxidant therapy and drugs used to treat cardiovascular diseases due to oxidative stress
Conclusion and future perspective
Chapter 10. Oxidative stress and chronic kidney disease
Background
Introduction
Oxidative stress and chronic kidney disease
Biomarkers of oxidative stress in CKD patients
Clinical implications of oxidative stress in CKD patients
Treatment
Conclusion
Chapter 11. Oxidative stress in neurodegenerative diseases
Alzheimer disease
Treatment of Alzheimer's disease
Parkinson's disease
Treatment of Parkinson's disease
Amyotrophic lateral sclerosis
Treatment of amyotrophic lateral sclerosis
Chapter 12. Oxidative stress, mechanisms of subfertility, and reproductive disorders in females
Introduction
Sources of ROS in the female reproductive system
The role of reactive oxygen species in the normal functions of female reproductive organs
Impact of oxidative stress on ovarian function
The impact of OS on female reproductive health organs
Oxidative stress manifestations as a disease leading to infertility
Lifestyle: Oxidative stress and female infertility
Conclusion and future directions
Chapter 13. Oxidative stress, mechanisms, and subfertility in male
Male subfertility
Oxidative stress definition
Sources of reactive oxygen stress
Physiological role of reactive oxygen stress on spermatozoa
Pathological effects of reactive oxygen stress on spermatozoa
Current approach for assessment of reactive oxygen stress markers in sperm and semen
Life-style factors associated with high reactive oxygen species and male subfertility
Reactive oxygen species and assisted reproductive technique
Conclusion
Chapter 14. Oxidative stress, varicocele, and disorders of male reproduction
Oxidative stress
Varicocele
Analysis of oxidative stress
Sperm DNA fragmentation
Management of oxidative stress in varicocele
Conclusion
Chapter 15. Oxidative stress, vitamin D deficiency, and subfertility
Oxidative stress, vitamin D deficiency, and subfertility
Oxidative stress, vitamin D deficiency, and subfertility in males
Oxidative stress, vitamin D deficiency, and subfertility in females
ROS and its role in female physiology
VD and its role in female physiology
Diseases associated with subfertility and VDD
Section III. Overview of prevention and management of oxidative stress
Chapter 16. Overview of prevention and management of oxidative stress
Oxidative stress
Conclusion
Chapter 17. Treatment challenges in oxidative stress, metabolic, and reproductive disorders
Introduction: ROS are by-products of cellular energy production and can damage various molecules in the body, resulting in OS
Oxidative stress and food
Lifestyle choices
Physical activity
Consanguinity
Challenges in the public sector to include the component of OS in existing healthcare
The situation in the private sector
Chapter 18. Current antioxidant medicinal regime and treatments used to alleviate oxidative stress in infertility issues
Oxidative stress in protein metabolism mediating cellular repose element impairment
Oxidative stress
Oxidative stress in carbohydrate metabolism
Oxidative stress in protein metabolism
Oxidative stress in lipid metabolism
Cross-talk of oxidative stress with reproduction
Vital involvement of oxidative stress in health and disease
Preventive measures to cope with oxidative stress
Conclusion
Chapter 19. Role of complementary and alternative medicine in management of oxidative stress
Summary
Complementary and alternative medicine
Oxidative stress-related diseases
Role of complementary and alternative medicine in oxidative stress-related diseases
Role of complementary and alternative medicine in oxidative stress-induced reproductive problems
Index

Faiza Alam

Dr Faiza Alam is currently working as an Assistant Professor at Pengiran-Anak-Puteri-Rashidah-Sa’adatul-Bolkiah Institute of Health Sciences, Brunei, and previously worked at Aga Khan University. She has been teaching Physiology for the last 14 years. After completing her Masters (Physiology), her research as a (PHD)scholar was dedicated to identifying the polymorphisms of the SIRT1 gene affecting oxidative environment and fertility. Broadly, her research is aimed towards the causative factors of non-communicable diseases.

She cultivated a solid foundation in teaching and research within the field of Physiology. Her commitment to academic excellence and track record of delivering engaging lectures align seamlessly with the goals and ethos of your department. Moreover, her collaborative nature and interpersonal finesse have enabled her to foster strong professional relationships, enhancing both her teaching methodologies and research endeavors.

Affiliations and expertise

Assistant Professor, Pengiran-Anak-Puteri-Rashidah-Sa’adatul-Bolkiah Institute of Health Sciences, Brunei, Institute of Health Sciences, Brunei Darussalam, Jalan Tungku Link, Gadon, Pakistan

Rehana Rehman

Dr Rehana Rehman MBBS, MPhil, PhD, FHEA, MHPE Professor of Physiology and Director of Graduate Studies in the Department of Biological and Biomedical Sciences Aga Khan University, Karachi Pakistan. She has been involved in teaching of Physiology for the last 30 years in public and private sector medical colleges. She is a well-recognized authority in the field of Reproductive Physiology. Her research is focused on infertility, maternal and fetal wellbeing, wellness of students and ergonomics. She has more than 200 publications in high impact national & international journals. She has compiled; Clinical Case Orientation in Cardiovascular and Respiratory Physiology, Renal and Gastrointestinal Physiology, Endocrine and Reproductive Physiology published by Paramount. She is author of books; “Five minutes to Wellness”, “Research till publication in Health Care”, “Subfertility Recent Advances in Management and prevention”, Polycystic Ovary Syndrome from Basic Sciences to Clinical Advances Across Clinical Science Life Span published by Elsevier”.

Affiliations and expertise

Professor, Department of Biological & Biomedical Sciences, Aga Khan University, Karachi, Pakistan

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health