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Liposomes in Drug Delivery
What, Where, How and When to deliver
1st Edition - April 1, 2024
Editor: Sophia G. Antimisiaris
Paperback ISBN:9780443154911
9 7 8 - 0 - 4 4 3 - 1 5 4 9 1 - 1
Liposomes in Drug Delivery: What, Where, How and When to deliver is a concise, well-structured reference covering all the important issues related to the potential of this… Read more
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Liposomes in Drug Delivery: What, Where, How and When to deliver is a concise, well-structured reference covering all the important issues related to the potential of this technology. Organized to provide practical information to researchers from any discipline with a particular therapeutic or bio-active substance to deliver, this book helps understand if liposomes can be of benefit for the reader’s particular need, which is the best type of liposome to use according to what needs to be delivered, where/when to deliver it, and how to design/prepare/characterize/investigate/optimize liposome properties for a particular application.The book is structured in Four parts. The first covers in a concise but in-depth way, what liposomes are, which are the liposome types, advantages/disadvantages, and what is their stability, characterization methods, in vitro stability, and in vivo fate after different administration methods (routes). The second part focuses on the different mechanisms for liposomal drug delivery. Methodologies/technologies for manipulation of liposome structure/properties in order to design liposomes for particular delivery applications. Specific roadmaps for liposome design are discussed, including components to incorporate in liposomes for specific types of encapsulated molecules or specific routes of administration. The third part covers liposome applications for drug delivery. It focuses on specific delivery considerations for particular diseases. Finally, the fourth part covers methods of liposome fabrication.Liposomes in Drug Delivery: What, Where, How and When to deliver is the perfect guide for pharmaceutical science researchers and graduate students looking for the opportunities presented by liposomal drug delivery. Industry based researchers will also benefit from the practical structure of the book.
Focuses on key information - What, Where, How and When to deliver – needed for drug delivery researchers
Covers all aspects of liposomes in drug delivery in one single volume
Guides researchers through the decision process on whether and what liposomes are most applicable to their particular interest
Master and PhD students in the field of Pharmaceutics, Material Sciences, Biomedical Engineering, Academics and industrial experts coming in from other disciplines, such a Chemistry, Agricultural, Cell biology, Biochemistry, etc.
Part I – Basic concepts of Liposome-Assisted Drug Delivery
1. Introduction to Liposome Assisted Drug Delivery
2. Liposome structure, composition, and properties
3. Liposome Characterization Methodologies
4. Liposome Stability and Integrity
5. In vivo fate of Liposomes: Biodistribution and cell membrane interactions
Part II – Mechanisms of Liposome Drug Delivery
6. Liposomes in controlled drug delivery: Controlling drug release kinetics and biodistribution/pharmacokinetics
7. Liposome surface modifications-Engineering techniques
8. Special types/triggered release Liposomes for drug delivery – Body triggers
9. Special types/triggered release Liposomes for drug delivery – External triggers
Part III – Liposome Applications in drug delivery
10. Liposomes for drug delivery to the brain
11. Liposomes for drug delivery to cancer cells
12. Liposomes as vaccine delivery systems
13. Liposomes as DNA, mRNA and oligonucleotide delivery vectors
14. Liposomes for drug delivery by localized routes of administration
15. Liposome for drug delivery against infectious diseases
16. Liposomes for drug delivery via biomaterials
17. Liposomes for delivery of substances for other (non-therapeutic) applications
Part IV –Liposome fabrication
18. Introduction to liposome fabrication for clinical use
19. Conventional methods for preparing liposomes of various types (MLVs, LUVs, SUVs )
20. Size reduction, purification, sterilization and storage/packaging of Liposomes
21. Methods for preparation of Giant liposomes: Conventional methods; Modified electro-techniques
22. Microfluidic methods for liposome formation
23. Supercritical fluids and other novel methods for liposome formation
24. Design of experiment approaches for liposome property optimization
25. Development of generic liposome products for drug delivery
Part V – Conclusions and Perspectives
26. Success stories, Final remarks and directions of the field
No. of pages: 440
Language: English
Published: April 1, 2024
Imprint: Academic Press
Paperback ISBN: 9780443154911
SA
Sophia G. Antimisiaris
Dr. Antimisiaris’ lab has extensive experience (more than 25 years) in design and production of liposomal and lipid/polymer/cyclodextrin hybrid nanoparticulates for drug and/or imaging agent delivery and targeting to specific target cells. Several administration routes have been investigated or are under investigation in regards to the specific requirements of NPs for each specific route (such as: iv, ip, oral, lung, ocular (intravitreal), vaginal, oral).
Her laboratory also has long term collaborations with industries and is involved in setting up large-scale manufacturing techniques.
She has experience as WP-leaders (partners) in several large scale European Collaborative Projects, as Shiva (FP6 –for preparation of vaginal microbicides), and lately NAD (Nanoparticles for diagnosis and Therapy of AD) (WP-leader for Design and preparation of NPs with affinity for Abeta peptides).
Her team have also been working for many years on the application of arsonolipid-containing liposomes for therapy of cancer with promising results in vitro as well as in vivo results. They also investigate the development of novel platforms for sustained release of drugs following ocular (intravitreous), vaginal or subcutaneous administration.
Affiliations and expertise
Professor, Department of Pharmace Technology and Analysis, University of Patras, Patra, Greece