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Elsevier

Academic Press

  • The Marmoset Brain in Stereotaxic Coordinates

    • 2nd Edition
    • George Paxinos + 3 more
    • English
    The first edition of The Marmoset Brain in Stereotaxic Coordinates (2012) was fundamental in the rapid establishment of this species as the preferred non-human primate in neuroscience research, with the atlas delineations having been adopted by all major projects using marmosets. Now, the second edition gives us the opportunity to capture 14 years of progress and introduce major enhancements:What is new in the 2nd Edition?For the first time sagittal and horizontal planes are included based on the computational average of 20 brains.For the first time cortical layers are identified.For the first time major divisions of the white matter are identified on the basis of Marmoset Brain Mapping Project (https://marmosetbra... (Liu et al., 2020).Cortical and subcortical delineations are thoroughly updated to reflect advances over the last 14 years.

  • Endotoxin in Critical Illness

    • 1st Edition
    • John Kellum + 1 more
    • English
    Endotoxin in Critical Illness intricately explores the theme of endotoxin and sepsis through the lenses of basic, clinical, and translational science. This work consolidates and synthesizes novel clinical insights and groundbreaking scientific discoveries into one comprehensive resource on endotoxic septic shock and sheds light on cutting-edge approaches in treatment. Beginning with a historical journey, the book traces the evolution of understanding from ancient concepts to modern molecular insights. It covers the physiological aspects of endotoxin sensitivity, tolerance, and human response variation. The crucial role of the gut microbiome in critical illness serves as a translational link between foundational science and clinical implications, and the complex language of bacterial communication is introduced, merging basic science with potential translational applications. In the clinical arena, chapters cover the critical role of endotoxin in septic shock, trauma, and its relevance in COVID-19, providing a translational bridge between laboratory findings and real-world clinical scenarios. The historical context of anti-endotoxin drug development is revisited, emphasizing the translational challenges faced in bridging basic science discoveries to clinical applications. The discussion on quantifying endotoxin concentration as well as the exploration of therapeutic rationale and clinical experiences with endotoxin removal therapy serve as a culmination of basic understanding translated into practical applications. The book concludes by contemplating the complexity of sepsis and acknowledging the challenges in achieving personalized medicine and underscoring the dynamic nature of the translational journey. In essence, this comprehensive exploration provides clinicians, researchers, and scientists with a holistic understanding of endotoxin and sepsis and potential advancements in patient care.

  • Harnessing Endogenous Mechanisms for Targeted Drug Delivery

    • 1st Edition
    • Anisha A. D’Souza + 2 more
    • English
    Harnessing Endogenous Mechanisms for Targeted Drug Delivery presents a comprehensive exploration of the evolving landscape of targeted drug delivery, emphasizing the strategic utilization of the body's intrinsic biological pathways. This authoritative two-volume reference addresses the critical need for precision in therapeutic delivery, overcoming physiological, anatomical, and immunological barriers through innovative endogenous mechanisms. By integrating foundational concepts with advanced methodologies, the work underscores the transition from traditional passive and active targeting to sophisticated endogenous strategies that enhance drug specificity and efficacy.The text systematically examines the multifaceted challenges inherent in drug delivery, including detailed analyses of in vivo barriers such as the blood-tumor barrier, blood-brain barrier, ocular, pulmonary, and gastrointestinal obstacles, as well as cellular and intracellular impediments. It further elucidates endogenous stimuli-responsive systems, nutrient transporter exploitation, glyco-targeting, and stealth peptide modifications. Comprehensive coverage extends to drug conjugates, protein corona phenomena, and cell-based delivery platforms encompassing stem cells, leukocytes, erythrocytes, and platelets. The series also addresses extracellular vesicles, viral vectors, and plant virus-based carriers, culminating in critical discussions on manufacturing complexities, regulatory considerations, and clinical translation challenges.This definitive resource is indispensable for graduate students, postdoctoral researchers, and professionals in academia and industry engaged in targeted drug delivery research and development. By providing an in-depth understanding of endogenous targeting mechanisms and their translational potential, the book fosters innovation and supports the advancement of precision therapeutics with the goal of improving patient outcomes.

  • Stem Cells and Tissue Regeneration

    Bridging Research and Clinical Practice
    • 1st Edition
    • Wen Zeng + 2 more
    • English
    Stem Cells and Tissue Regeneration: Bridging Research and Clinical Practice delves into the latest advancements in the dynamic field of tissue regeneration. This comprehensive book begins with an introduction that reviews stem cell classifications, characteristics, functions, and their integral relationship with tissue regeneration. This first section offers readers a solid foundation and understanding of the book’s scope and significance in contemporary research and clinical applications. Subsequent chapters explore each major organ, including skeletal muscle regeneration and vascular organoids.Additional... the book presents innovative strategies and methods for research, culminating in a forward-looking perspective on the future of tissue regeneration. Authored by experts, it serves as a vital resource for researchers, clinicians, and surgeons involved in tissue repair.

  • Drug Metabolism in Diseases

    Leveraging Drug Metabolism and Disposition in Precision Medicine and Therapeutic Development
    • 2nd Edition
    • Wen Xie
    • English
    Drug Metabolism in Diseases: Leveraging Drug Metabolism and Disposition in Precision Medicine and Therapeutic Development, Second Edition provides essential knowledge for pharmaceutical scientists and biologists to understand the interplay between diseases and physiological conditions, impacting drug metabolism and its implications in personalized treatment. Expanded with six new chapters since the first edition, this updated book covers the latest scientific findings. Other important points include the book’s comprehensive reference on mutual effects between drug metabolism and diseases, implications in precision medicine, and therapeutic development. Pharmaceutical scientists, drug metabolism researchers, and research physicians will benefit from the expert insights provided.

  • Synthesis of Best-Seller Drugs

    • 2nd Edition
    • Ruben Vardanyan + 1 more
    • English
    Synthesis of Best-Seller Drugs, Second Edition provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field.

  • Synergistic Plant Metabolomics and Plant Growth-Promoting Microorganisms in Addressing Abiotic Stress

    • 1st Edition
    • Naeem Khan + 1 more
    • English
    Synergistic Plant Metabolomics and Plant Growth-Promoting Microorganisms in Addressing Abiotic Stress unveils the latest advancements in understanding how plants respond to environmental pressures. By unraveling the complexities of metabolic pathways affected by abiotic stresses and highlighting the pivotal role of PGPMs in enhancing plant resilience, this book provides a comprehensive exploration of these intricate relationships. Recent advancements in plant sciences, metabolomics, and microbiology have deepened our understanding of the interconnected functions of metabolites and growth-promoting microorganisms in plant resilience and the role of microorganism in altering plant metabolome under environmental stresses. The book consolidates this emerging knowledge into an accessible volume, offering a holistic view of how plant metabolomics and microbial interactions contribute to plant adaptation under abiotic stresses. Aimed at researchers and practitioners, the book translates scientific findings into both research inspiration and practical applications for professionals and advanced students in plant science, agriculture, biotechnology, and related fields, addressing tangible strategies for improving plant and crop resilience and productivity.

  • Microbial Stress Survival

    • 1st Edition
    • Ashutosh Kumar
    • English
    Microbial Stress Survival explores the diversity of microbes, the microbe-host relationship, and the various strategies employed by microbes that enable them to adapt to stressful environments and persist in hostile conditions. The book aims to cover critical pathogen biology, microbial adaptation and survival strategies, and the impact of microbial resilience on therapeutic efforts. Topics include the modulation of host pathways by pathogens for their adaptation and survival; their drug tolerance and antimicrobial resistance; role of proteins in microbial stress survival; and evolutionary adaptative mechanisms of extremophiles. Microbial Stress Survival is an insightful resource for those interested in pathogen biology and the different adaptive features and resilience of microbes.

  • Fundamentals and Therapeutic Applications of Liposomes

    • 1st Edition
    • Prashant Kesharwani
    • English
    Fundamentals and Therapeutic Applications of Liposomes provides an in-depth exploration of liposomal delivery systems for therapeutic purposes. This comprehensive book covers the synthesis and scaling up of liposomes for clinical use, examining their diverse applications in cancer therapy, immunotherapy, gene delivery, wound healing, viral disease, and neurological disorders. It also summarizes the regulatory aspects associated with clinical translation and industrial production. The book addresses the toxicity, safety, and environmental considerations of using liposomes for therapeutics, making it a useful resource for researchers, academics, and R&D groups interested in the development, production, and application of liposomes in various therapeutic settings.

  • Video Health Monitoring in Hospitals

    • 1st Edition
    • Wenjin Wang + 3 more
    • English
    Video Health Monitoring in Hospitals discusses the emergence of camera-based, contactless physiological measurement as a groundbreaking solution in healthcare monitoring. The book highlights the technology's non-invasiveness, capacity for continuous and long-term monitoring, and its ability to capture not only vital signs but also contextual information and behaviors. A unique aspect of this book is its rich set of compelling healthcare applications that will attract broader audiences (including researchers, engineers, clinicians, and students) from multidisciplinary fields.Finally, the book discusses the role of artificial intelligence in enhancing healthcare applications and aims to engage the healthcare industry in adopting this innovative approach to improve patient care and outcomes.

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