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Elsevier

Phytochemicals and Hallmarks of Cancer

From Molecules to Medicine

  • 1st Edition - June 23, 2026
  • Latest edition
  • Editors: Gautam Sethi, Lekshmi R. Nath
  • Language: English

Phytochemicals and Hallmarks of Cancer: From Molecules to Medicine delves into the potential of phytomedicine to effectively address both established and emerging hallmarks of can… Read more

Description

Phytochemicals and Hallmarks of Cancer: From Molecules to Medicine delves into the potential of phytomedicine to effectively address both established and emerging hallmarks of cancer, offering valuable insights into their translational applications from bench to bedside. The book provides comprehensive information about how the plant-derived product tackles cancer by targeting different hall markers that drive cancer progression. In 12 chapters the book not only describes the implications of plant products on cancer immunotherapy, gives insight in the hurdles in clinical translating plant derived products for cancer therapy, but also focuses on the therapeutic aspects of phytochemicals, providing insights into how understanding of mechanism of actions of phytochemicals can aid to develop innovative therapies.

By addressing these knowledge and information needs Phytochemicals and Hallmarks of Cancer: From Molecules to Medicine is designed to be accessible to clinicians and researchers alike in the field of phytochemical applications in medicine.

Key features

  • Provides a detailed overview of the molecular mechanisms through which phytochemicals can modulate various hallmarks of cancer
  • Discusses the potential of phytochemicals to reverse the metastatic process via inhibition of migration, invasion, and angiogenesis
  • Covers the implication of natural products as apoptosis inducers

Readership

(Post)graduate students as well as early- to mid-stage researchers in the field of oncology and disease therapy, especially cancer, as well as those working on drug discovery and scientists in the field of drug delivery.

Table of contents

1. Phytochemical-mediated targeting of apoptotic pathways in cancer cells

2. Targeting autophagy with phytochemicals

3. Impact of phytochemicals on cancer cell migration, invasion and angiogenesis

4. Phytochemicals as cell cycle modulators

5. Phytochemicals to suppress tumor-promoting inflammation

6. Impact of phytochemicals on cancer-associated Extracellular matrix(ECM)

7. Implication of phytochemicals for cancer immunotherapy

8. Phytochemical mediated re-programming of energy metabolism in cancer

9. Phytoradiotherapy: An Integrative Approach to Cancer Treatment

10. Cancer epigenetic modulation mediated by phytochemicals

11. Natural products as anti-cancer drugs: where do we stand now?

12. Hurdles in clinical translation plant-derived natural products for cancer therapy

Product details

  • Edition: 1
  • Latest edition
  • Published: June 23, 2026
  • Language: English

About the editors

GS

Gautam Sethi

Dr. Gautam Sethi is a tenured Associate Professor in the Department of Pharmacology at the Yong Loo Lin School of Medicine, National University of Singapore. His research focuses on elucidating the molecular mechanisms underlying cancer initiation and progression, particularly the activation of oncogenic transcription factors by carcinogens and inflammatory agents, and the identification of novel therapeutic inhibitors. Dr. Sethi has made substantial and direct scholarly contributions to the fields of gut microbiota, cancer pathophysiology, and host–microbiome interactions, with particular emphasis on immunotherapy, tumor microenvironment modulation, metabolic signaling, and therapy response prediction. He has authored numerous peer reviewed research and review articles in high impact journals, received multiple international awards, and serves on the editorial boards of several international journals.

Affiliations and expertise
Associate Professor, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

LN

Lekshmi R. Nath

Dr Lekshmi R. Nath is working as an Associate Professor in the Department of Pharmacognosy at Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, India. She pursued her PhD. in Cancer Research Program. She has more than 50 publications and has been invited as a resource person to many national and international conferences. She is the editorial board member and reviewer of high-impact scientific journals. Her current research interest includes the study of signalling events associated with the fatty liver to Hepatocellular carcinoma, elucidating the role of plant-derived pure compounds in cancer chemoprevention, chemo sensitization, and chemotherapy. She is also exploring the potential of traditional knowledge for cancer and various infectious diseases, their mechanism of action and validation through pre-clinical models
Affiliations and expertise
Associate Professor, Department of Pharmacognosy, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, India

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