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Elsevier

Academic Press

  • A First Course in Model Validation and Model Risk Management

    • 1st Edition
    • Jonathan Schachter + 2 more
    • English
    A First Course in Model Validation and Model Risk Management offers robust coverage for current and future financial engineers. Useful as part of a masters program, for self-study, or as a valuable reference, the textbook explains in step-by-step, practical terms how mathematical models owned by financial institutions are essential to their public activities, including sales, trading, risk management, and internal audits. Like a diverse fleet of cars maintained by a rental car location, a bank must make sure customers can "drive" any of its models for a specific financial product. The book covers both pricing and risk models. Chapters consider modeling basics, marked-to-market and marked-to-model asset classes, market risk, credit risk, portfolio risk, operational risk, capital model risk, and financial crime, along with machine learning/AI.To support course use and practical applications, the text provides examples in Python throughout, as well as an appendix containing homework problems for all chapters, further supported by an ftp site for data and sample code. Additional appendices cover global model risk management, and a refresher in statistics.

  • Kinase Targets and Drug Discovery

    • 1st Edition
    • Xiaoyun Lu
    • English
    Kinase Targets and Drug Discovery covers the critical role of kinases as regulators of cellular functions and their implications in a range of diseases, from cancers to cardiovascular disorders and inflammatory conditions. Readers will explore foundational concepts on the functions of kinases, the role of kinase inhibitors in disease therapy, and challenges faced. The second section focuses on innovative strategies in kinase drug discovery, covering screening and computational approaches, along with the development of covalent, macrocyclic, allosteric inhibitors, and kinase degraders. Final sections examine clinical applications, detailing how kinase inhibition can be harnessed for cancer therapies, non-oncologic diseases, and even non-catalytic functions.This book will serve as an indispensable resource for pharmacologists, medicinal chemists, and researchers in both academia and industry. By bridging the gap between foundational research and clinical application, it equips professionals with the latest insights and practical approaches to advance their understanding to contribute meaningfully to the evolving landscape of drug discovery.

  • Reverse Aging

    Current Research and Future Directions
    • 1st Edition
    • Sandeep Kumar Singh + 1 more
    • English
    Reverse Aging: Current Research and Future Directions explores the integrated approach of aging and reverse aging to present a comprehensive understanding of the biological, genetic, and molecular mechanisms associated with aging. By targeting fundamental aging mechanisms, strategies are being developed to reverse and repair damage and potentially lead to greater healthspan benefits and optimal longevity. The book opens with the fundamentals of aging and how genetic, environmental, and lifestyle variables affect the biological, psychological, and social processes that lead to aging before delving into a comprehensive review of the hallmarks of aging. Next, an overview of the concept of reverse aging is presented, and subsequent chapters examine specific reverse aging models and approaches. The book explores use of cellular reprogramming techniques, provides an overview of the molecular processes that underlie NANOG-mediated reversal aging, and discusses the possible contribution of IGF-1/PKA signaling reduction to reverse aging via HSC-based therapies. The developing science of rejuvenating stems cells, histone modification, and stimulation of autophagic activity to facilitate the removal of cellular debris and reduce the impact of aging on various organ systems as well as novel concepts of mRNA enhanced cell therapy, immunological-driven signaling, mitochondrial modulations, cell-cycle regulation, and metabolic reprogramming for reserve aging are all examined. The wide range of nutritional therapies, phytochemical, prescription medications, and nutraceuticals impacting the aging process is reviewed, and the book closes with discussion of the revolutionary role AI has on anti-aging research and where the field is headed. In conclusion, the book emphasizes the importance of targeting fundamental aging mechanisms to extend health and achieve optimal longevity and provides insights into the potential implications for healthcare and aging research, highlighting the need for collaborative efforts and interdisciplinary perspectives to address the challenges of population aging and develop effective strategies for healthy aging practices.

  • Advances in Ecological Research

    • 1st Edition
    • Volume 74
    • English
    Advances in Ecological Research, Volume 74 brings together cutting-edge developments, current trends, and emerging concepts in the field of ecology. The book provides an in-depth exploration of fundamental and applied ecological research, offering insights into the complex interactions between organisms and their environments. Specific chapters cover how Conformal Prediction quantifies the uncertainty of Species Distribution Models, How do Earth Observation Foundation Models Help to Predict Multi-Trophic Soil Biodiversity, Evaluating Multi-Sensor Foundation Models as a Strategy for Leveraging Earth Observation Data in Biodiversity Modeling, Exploring Remote Sensing Contributions to High-Resolution IAS Distribution Modeling Using ML/DL Techniques, and much more. Additional sections cover Predicting Ecological Invasions, The carrying capacity of a fragmented landscape depends on the home-range size of a species, Quantitative tools that form an approach that allows social impacts of ecosystem change, Extending genomic prediction from individuals to a population and community, and Full prediction uncertainty quantification: a plea from science and decision-making.

  • Telehealth in Movement Disorders

    Principles, Strategies, Applications, and New Directions
    • 1st Edition
    • Wael Mohamed + 2 more
    • English
    The COVID-19 pandemic forced the world to pause and reevaluate how we operate specifically in medicine, shifting to telemedicine and telehealth. Integrating telemedicine and telehealth into the healthcare system enables patient safety and has been proven beneficial to medical and surgical practices including patient primary care. Telehealth in Movement Disorder: Principles, Strategies, Applications, and New Directions provides guidance on how to deliver clinical assessment and treatment to movements disorders patients through telemedicine. This book is divided into three distinct sections. The first section reviews general principles including strategies, standards, policies, and ethical aspects. The second section explores how telemedicine can be integrated into diagnosis, treatment, and care of patients with movement disorders including the use of new AI technologies. The final section discusses the integration and application of telemedicine in developing countries, including challenges and future opportunities.

  • From Conventional to Artificial Intelligence-Based Agriculture

    • 1st Edition
    • Vivek Sharma + 2 more
    • English
    From Conventional to Artificial Intelligence-Based Agriculture explores the evolving landscape of agriculture as it transitions from traditional practices to advanced, AI-driven solutions. With AI and machine learning revolutionizing industries worldwide, their impact on agriculture is becoming increasingly significant. These technologies are not only aiding in climate modeling but also opening new possibilities for precision farming, enabling more accurate crop health diagnostics, efficient resource management, and timely intervention strategies.By integrating conventional agricultural knowledge with cutting-edge AI tools, farmers and researchers can better assess soil conditions, predict optimal planting windows, monitor nutrient dynamics, and understand market trends with greater precision. This convergence of tradition and technology supports more resilient, productive, and sustainable agricultural systems, paving the way for a smarter and more food-secure future.

  • Solid State Physics

    • 1st Edition
    • Volume 77
    • English
    Solid State Physics, Volume 77, the latest release in this serial that highlights new advances in the field, presents interesting chapters written by an international board of authors, with this new release focusing on new breakthroughs in the field. Updates in this release include Electronic, optical, and transport properties of semiconducting systems with diminishing dimensions: From spin to spintronics.

  • Artificial Intelligence for Multi-omics Analysis Part A

    • 1st Edition
    • Volume 221
    • English
    Artificial Intelligence for Multi-omics Analysis, Part A, Volume 221 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as an Introduction to Artificial Intelligence in Multi-omics Analysis, Multi‐omics application in health and diseases, Artificial Intelligence in Genomics Analysis, Artificial Intelligence in Single-cell and Spatial Transcriptomics Data, Artificial Intelligence in the prediction of 3D chromatin structure and gene regulation, Artificial intelligence in Mass Spectrometry-based Proteomics, Integrating Artificial Intelligence into Metabolomics for Predicting Diseases, and more.Additional chapters cover Artificial Intelligence in Microbial Metagenomics, Artificial Intelligence in Interactomics, Artificial Intelligence Integration in Medical Imaging Data, AI in biomolecular structural data analysis, Artificial intelligence in Cryo-Electron Microscope data, Explainable artificial intelligence for multi-omics data, and Multi-Omics Cancer Stratification: from Statistical to Deep Learning Perspective.

  • Botanical Microbiomes

    Sustainable Practices in Agriculture and Ecosystem Management
    • 1st Edition
    • Shobhit Raj Vimal + 2 more
    • English
    Botanical Microbiomes: Sustainable Practices in Agriculture and Ecosystem Management explores sustainable agricultural practices in response to environmental challenges, diving into the relationships between plants and their microbiomes, and how these interactions can impact crop sustainability and soil health management. By utilizing nature-derived resources, the book explores innovative solutions and next-generation agricultural challenges. Sections examine developments in plant microbiome research and its applications in addressing environmental and agricultural challenges, while also exploring how the phyto-microbiome, endo-microbiome, and rhizo-microbiome contribute to plant health by regulating phytohormones, metabolites, antioxidants, and osmoprotectants.Fina... microbial metabolites and soil microbiome engineering for stress management in plants is explored. This book serves as an essential resource for upper-level undergraduate students, researchers, and professionals in advanced plant pathology, botany, environmental microbiology, and ecology. It also includes supplementary educational materials, such as PowerPoint slides, to enhance learning and practical application in agricultural practices.

  • Nanotechnology in the Treatment of Infertility

    Practical Applications and Future Insights
    • 1st Edition
    • Pankaj Sharma
    • English
    Nanotechnology in the Treatment of Infertility: Practical Applications and Future Insights delves into the area where nanotechnology meets reproductive health care and reveals how the latest nanoscale developments are changing how infertility is treated. It examines current developments, principles, and possibilities of nanotechnology, with an emphasis on nanoparticle delivery systems, bioengineering, and their relevance in Assisted Reproductive Technologies (ART). This edited volume, written by leading scholars, provides a comprehensive overview of nanotechnology in relation to fertility. It will be of great interest to researchers, healthcare professionals, and anyone who wants to know more about this exciting area of potential solutions for infertility.

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