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Elsevier

Books in Life sciences

  • Computational Approaches for Understanding Dynamical Systems: Protein Folding and Assembly

    • 1st Edition
    • Volume 170
    • English
    Computational Approaches for Understanding Dynamical Systems: Protein Folding and Assembly, Volume 170 in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide variety of research topics. The series includes in-depth knowledge on the molecular biological aspects of organismal physiology, with this release including chapters on Pairwise-Additive and Polarizable Atomistic Force Fields for Molecular Dynamics Simulations of Proteins, Scale-consistent approach to the derivation of coarse-grained force fields for simulating structure, dynamics, and thermodynamics of biopolymers, Enhanced sampling and free energy methods, and much more.

  • La maladie de Parkinson

    • 4th Edition
    • SOFMA + 2 more
    • French
    La maladie de Parkinson est, après la maladie d’Alzheimer, l’affection neurologique la plus répandue au sein de la population après 50 ans. Sa prévalence augmentant avec l’âge, surtout au-delà de 60 ans, on peut prévoir qu’avec le vieillissement de la population, le nombre de patients ne cessera d’augmenter dans les années à venir.La quatrième édition de cet ouvrage, entièrement en couleurs, consacrée à la maladie de Parkinson, rend compte de façon didactique des avancées de ces cinq dernières années, en abordant de façon exhaustive tous les aspects de cette pathologie : l’épidémiologie, l’étiopathogénie, les aspects génétiques, la physiopathologie, les signes moteurs et non moteurs, notamment les troubles cognitifs, psychiques et comportementaux. Un nouveau chapitre dédié aux apports des nouvelles technologies, notamment les enregistrements électrophysiologique... intracérébraux, l’évaluation neurophysiologique de la marche et du contrôle postural ou encore l’actimétrie, vient compléter cette monographie. Le chapitre consacré à la neuropathologie et la physiopathologie, est également entièrement augmenté et mis à jour avec l’approche de l’alpha-synucléine et l’évocation de la controverse autour de l’hypothèse d’un mécanisme de type prion. Les traitements de recours sont regroupés maintenant dans un chapitre spécifique et un nouveau chapitre est proposé sur les indications de la toxine botulique.Ce livre s’adresse aux praticiens et à tous les professionnels de santé, médicaux et paramédicaux, exerçant dans un service de neurologie ou concernés par la pathologie parkinsonienne : neurologues, internes préparant le diplôme d’études spécialisées de neurologie, neuropsychologues, psychiatres, rééducateurs, orthophonistes et kinésithérapeutes.

  • Agri-Food Industry Strategies for Healthy Diets and Sustainability

    New Challenges in Nutrition and Public Health
    • 1st Edition
    • Francisco J. Barba + 2 more
    • English
    Divided into five sections, Agri-Food Industry Strategies for Healthy Diets and Sustainability: New Challenges in Nutrition and Public Health provides an overview of the challenges and future perspectives related to nutrition, public health, and sustainability. The book addresses strategies to reduce fat, trans fat, saturated fat, sugar, and salt consumption, while also exploring the manufacturing, safety, and toxicology of new food manufacturing. This book examines commercial labeling and nutritional education, nutrigenomics and public health, and provides coverage of the valorization of waste and by-products from the food industry. Nutrition researchers and practitioners, food scientists, technologists, engineers, agronomists, food product developers, medical and public health professionals, and postgraduate students focused in food science and nutrition are sure to find this reference work a welcomed addition to their libraries.

  • Vasopressin

    • 1st Edition
    • Volume 113
    • Gerald Litwack
    • English
    Vasopressin, Volume 113 in the Vitamins and Hormones series, highlights new advances in the field, with this new volume presenting updates on timely topics, including Diabetes Insipidus in Pregnancy, Vasopressin Inactivation: Role of Insulin-Regulated Aminopeptidase, Vasotocin and the Origins of the Vasopressin/Oxytocin Receptor Gene Family, Vasopressin V2 Receptor Ligand Recognition, Development and Therapeutic Potential of Vasopressin Synthetic Analog [V4Q5]dDAVP as a Novel Anticancer Agent, Cellular Junctions and Vasopressin, Vasopressin Actions in the Kidney Renin Angiotensin System and its Role in Hypertension and Renal Disease, Oxytocin/Vasopressin... Neuropeptide Signaling in Insects, and much more.

  • International Review of Cell and Molecular Biology

    • 1st Edition
    • Volume 350
    • English
    International Review of Cell and Molecular Biology, Volume 350, covers all aspects of endoplasmic reticulum (ER) biology. With its multiple cellular functions, including ion storage as well protein folding, trafficking and secretion, the regulation of homeostasis within the ER is crucial to organismal health. New sections in this updated volume include DAMP emission upon ER stress, Protein misfolding disordersm Type I interferon response and ER stress, ER and autophagosome biogenesis, Mitochondria-associa... membranes, ER calcium signaling in excitable cells, and ER in viral infections.

  • Drug Delivery Trends

    Volume 3: Expectations and Realities of Multifunctional Drug Delivery Systems
    • 1st Edition
    • Ranjita Shegokar
    • English
    Drug Delivery Trends examines a drift in the pharmaceutical field across the wide range of dosage forms, drug delivery systems (micro and nanoparticulate), at the regulatory front and on new types of therapies in the market. This volume additionally covers the challenges on drug delivery systems in terms of preclinical and current ways of determining quality and the options to solve the challenges associated with this. Most small-medium scale industries and academics struggle with initial regulatory challenges so a detailed discussion on regulatory trend covers the necessary basic understanding of regulatory procedures and provides the required guidance. The series Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, biological aspects, regulatory and clinical success of wide range of drug delivery carriers. This series reviews multifunctionality and applications of drug delivery systems, industrial trends, regulatory challenges and in vivo success stories. Throughout the volumes discussions on diverse aspects of drug delivery carriers, such as clinical, engineering, and regulatory, facilitate insight sharing across expertise area and form a link for collaborations between industry-academic scientists and clinical researchers. Expectations and Realities of Multifunctional Drug Delivery Systems connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stake holders. The wide scope of the book ensures it as a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about drug delivery systems.

  • Chickpea: Crop Wild Relatives for Enhancing Genetic Gains

    • 1st Edition
    • Mohar Singh
    • English
    Chickpea: Crop Wild Relatives for Enhancing Genetic Gains explores aspects related to critical analysis on factors responsible for narrow genetic base of chickpea productions including domestication bottleneck, the level of diversity present in different cultivated and wild species, the uniqueness and usefulness of potential gene sources available and maintained in production systems across the globe, the level of genetic erosion both at landrace and species level over time and space etc. Despite considerable international investment in conventional breeding, production of chickpea has not yet been significantly improved beyond that achieved through its normal single domestication event and high self-pollination rate. Total annual pulse production of ~12 million tons (FAO 2016) is far below actual potential. Susceptibility to both biotic and abiotic stresses have created a production level bottleneck whose solution possibly lies in the use of crop wild relatives and other genetic traits cultivated by tailoring novel germplasm. Presenting options for widening the genetic base of chickpea cultivars by introgression of diverse genes available in distantly related wild Cicer taxa, thus expanding the genetic base and maximize genetic gains from the selection, it is necessary to accumulate other complimentary alleles from CWRs. This review will focus on present status of gene pool and species distribution, germplasm conservation, characterization and evaluation, problems associated with crop production, sources of target traits available in wild species, status of trait introgression in synthesizing new gene pool of chickpea along with progress made in chickpea genomics. An edited book with contributions from leading scientists, this information will guide and inform chickpea breeders, PGR researchers and crop biologists across the world.

  • Secondary Findings in Genomic Research

    • 1st Edition
    • English
    Secondary Findings in Genomic Research offers a single, highly accessible resource on interpreting, managing and disclosing secondary findings in genomic research. With chapters written by experts in the field, this book is the first to concisely explain the ethical and practical issues raised by secondary genomics findings for a multi and interdisciplinary audience of genomic researchers, translational scientists, clinicians, medical students, genetic counselors, ethicists, legal experts and law students, public policy specialists and regulators. Contributors from Europe, North America, and Asia effectively synthesize perspectives from a spectrum of different scientific, societal, and global contexts, and offer pragmatic approaches to a range of topics, including oversight, governance and policy surrounding secondary genomic results, criteria for identifying results for return, communication and consent, stakeholders’ attitudes and perspectives, disclosing results, and clinical, patient-centered protocols.

  • Toxoplasma Gondii

    The Model Apicomplexan - Perspectives and Methods
    • 3rd Edition
    • Louis M. Weiss + 1 more
    • English
    Toxoplasma gondii: The Model Apicomplexan - Perspectives and Methods, Third Edition, reflects significant advances in the field in the last five years, including new information on the genomics, epigenomics and proteomics of T. gondii, along with a new understanding of the population biology and genetic diversity of this organism. This edition expands information on the effects of T. gondii on human psychiatric disease and new molecular techniques, such as CAS9/CSPR. T gondii remains the best model system for studying the entire Apicomplexa group of protozoans, which includes Malaria, making this new edition essential for a broad group of researchers and scientists.

  • Biscuit, Cookie and Cracker Process and Recipes

    • 1st Edition
    • Glyn Barry Sykes + 1 more
    • English
    Biscuit, Cookie and Cracker Process and Recipes: A practical reference for a wide range of recipes and production information for crackers, snack crackers, semi-sweet biscuits, short doughs, cookies and sandwich biscuits. These recipes have been developed in Europe, Asia, Australia, North America and South America. Beginning with an explanation of the production process and formulations, this book provides easy-access information for developing new biscuits, cookies and crackers for international markets. All the process details, formulations, technical information are based on the notes and files of the late Glyn Sykes. Glyn gained wide experience over a working lifetime in the biscuit baking industry, working with over fifty biscuit manufacturers world-wide. Glyn Sykes family have made the information available for the new book, which is a valuable reference for professionals in the biscuit baking industry and students in the food technology field.

  • Tumor Immunology and Immunotherapy - Integrated Methods Part A

    • 1st Edition
    • Volume 635
    • English
    Tumor Immunology and Immunotherapy Integrated Methods - Part A, Volume 635 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Specific chapters to this release include Deconvolution of the immunological contexture of mouse tumors with multiplexed immunohistochemistry... High-dimensional multiplexed immunohistochemical characterization of immune contexture in human cancers, Multiplex assay by IHC for melanoma tumor microenvironment evaluation, Characterization of the tumor immune microenvironment by multispectral image analysis of multiplex immunofluorescence images, Phenotyping of immune cells in situ using multispectral imaging quantification, and much more.

  • Giardia and Giardiasis - Part B

    • 1st Edition
    • Volume 107
    • English
    Giardia and Giardiasis Volume 107-Part B, in the Advances in Parasitology series, is dedicated to aspects of cytoskeletal structure of this parasite with an emphasis on insights of new components and their function in trophozoites. Further, microtubule function and its critical involvement in motility, attachment, mitosis and cell division as well as in transitions between developmental stages are reviewed. Also a comprehensive revision in the progress of tools to explore and understand the functional biology of Giardia, its coding and non-coding genes, features and cellular and molecular biology is contained in this volume. Additionally, an exciting perspective on the interactions between Giardia and intestinal epithelial cell by reviewing transcriptomic and proteomic investigations is included along with a state-of-the art of the understanding pathophysiology of giardiasis and of how Giardia can cause post-infectious and extra-intestinal complications. A complete review of current knowledge including commonly prescribed drugs, causes of therapeutic fails, drug resistance mechanisms, strategies for the discovery of new agents for alternative drug therapies is covered.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 95
    • English
    Advances in Clinical Chemistry, Volume 95, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, with this new release including sections on Advances in diagnostic microfluidics, Vascular and valvular calcification biomarkers, Long noncoding RNAs in cancer: From discovery to therapeutic targets, Exosomes of male reproduction, Tryptophan in health and disease, Biochemistry of blood platelet activation, and the beneficial role of plant oils in cardiovascular diseases.

  • Systems Simulation and Modeling for Cloud Computing and Big Data Applications

    • 1st Edition
    • Dinesh Peter + 1 more
    • English
    Systems Simulation and Modelling for Cloud Computing and Big Data Applications provides readers with the most current approaches to solving problems through the use of models and simulations, presenting SSM based approaches to performance testing and benchmarking that offer significant advantages. For example, multiple big data and cloud application developers and researchers can perform tests in a controllable and repeatable manner. Inspired by the need to analyze the performance of different big data processing and cloud frameworks, researchers have introduced several benchmarks, including BigDataBench, BigBench, HiBench, PigMix, CloudSuite and GridMix, which are all covered in this book. Despite the substantial progress, the research community still needs a holistic, comprehensive big data SSM to use in almost every scientific and engineering discipline involving multidisciplinary research. SSM develops frameworks that are applicable across disciplines to develop benchmarking tools that are useful in solutions development.

  • The Electronic Health Record

    Ethical Considerations
    • 1st Edition
    • Eike-Henner W. Kluge
    • English
    The Electronic Health Record: Ethical Considerations analyses the ethical issues that surround the construction, maintenance, storage, use, linkage, manipulation and communication of electronic health records. Its purpose is to provide ethical guidance to formulate and implement policies at the local, national and global level, and to provide the basis for global certification in health information ethics. Electronic health records (EHRs) are increasingly replacing the use of paper-based records in the delivery of health care. They are integral to providing eHealth, telehealth, mHealth and pHealth - all of which are increasingly replacing direct and personal physician-patient interaction - as well as in the developing field of artificial intelligence and expert systems in health care. The book supplements considerations that are raised by national and international regulations dealing with electronic records in general, for instance the General Data Protection Regulation of the European Union. This book is a valuable resource for physicians, health care administrators and workers, IT service providers and several members of biomedical field who are interested in learning more about how to ethically manage health data.

  • Cognitive Biases in Health and Psychiatric Disorders

    Neurophysiological Foundations
    • 1st Edition
    • Tatjana Aue + 1 more
    • English
    Cognitive Biases in Health and Psychiatric Disorders: Neurophysiological Foundations focuses on the neurophysiological basis of biases in attention, interpretation, expectancy and memory. Each chapter includes a review of each specific bias, including both positive and negative information in both healthy individuals and psychiatric populations. This book provides readers with major theories, methods used in investigating biases, brain regions associated with the related bias, and autonomic responses to specific biases. Its end goal is to provide a comprehensive overview of the neural, autonomic and cognitive mechanisms related to processing biases.

  • Food and Society

    • 1st Edition
    • Mark Gibson
    • English
    Food and Society provides a broad spectrum of information to help readers understand how the food industry has evolved from the 20th century to present. It includes information anyone would need to prepare for the future of the food industry, including discussions on the drivers that have, and may, affect food supplies. From a historical perspective, readers will learn about past and present challenges in food trends, nutrition, genetically modified organisms, food security, organic foods, and more. The book offers different perspectives on solutions that have worked in the past, while also helping to anticipate future outcomes in the food supply. Professionals in the food industry, including food scientists, food engineers, nutritionists and agriculturalists will find the information comprehensive and interesting. In addition, the book could even be used as the basis for the development of course materials for educators who need to prepare students entering the food industry.

  • Neutron Crystallography in Structural Biology

    • 1st Edition
    • Volume 634
    • English
    Neutron Crystallography in Structural Biology, Volume 634, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this updated release include Fundamentals of neutron crystallography in structural biology, Large crystal growth for neutron protein crystallography, Prospects for membrane protein crystals in NMX, IMAGINE: The neutron protein crystallography beamline at the high flux isotope reactor, The macromolecular neutron diffractometer at the spallation neutron source, Current status and near future plan of neutron protein crystallography at J-PARC, Neutron macromolecular crystallography at the European spallation source, and much more.

  • Risk Factors for Psychosis

    Paradigms, Mechanisms, and Prevention
    • 1st Edition
    • Andrew Thompson + 1 more
    • English
    Risk Factors for Psychosis: Paradigms, Mechanisms, and Prevention combines the related, but disparate research endeavors into a single text that considers all risk factors for psychosis, including biological, psychological and environmental factors. The book also introduces the ethics and current treatment evidence that attempts to ameliorate risk or reduce the number of individuals with risk factors developing a psychotic disorder. Finally, the book highlights new research paradigms that will further enhance the field in the future. Psychotic disorders affect more than 50 million people worldwide, creating a devastating effect on lives and causing major financial and emotional impact on families and on society as a whole. The search for risk factors for psychosis has developed rapidly over the past decades, invigorated by changes in the thinking about the malleability and treatability of psychotic disorders. The paradigms for investigating psychosis risk have developed, often in parallel, but there has been no book to date that has summarized and synthesized the current approaches.

  • Drying Atlas

    Drying Kinetics and Quality of Agricultural Products
    • 1st Edition
    • Werner Muhlbauer + 1 more
    • English
    Drying Atlas: Drying Kinetics and Quality of Agricultural Products provides, in a condensed and systematic way, specific insights on the drying-relevant properties and coefficients of over 40 agricultural products. It also presents information about the production methods that influence the drying process, the quality of the dried product, the official quality standards of the products, and the design principles and operating characteristics of drying systems that are widely used in the postharvest processing and food industry. Available books on drying technology mainly focus on drying theory and simulation of drying processes. This book offers systematic information on the impact of other important parameters, such as relative humidity, air flow rate, mechanical, thermal and chemical pre-treatment, and drying mode for specific products. It is a unique and valuable reference for scientists and engineers who want to focus on industrial drying applications and dryers, as well as graduate and post-graduate students in postharvest technology and drying.

  • The Neuroscience of Meditation

    Understanding Individual Differences
    • 1st Edition
    • Yi-Yuan Tang + 1 more
    • English
    The Neuroscience of Meditation: Understanding Individual Differences explores the individual differences in learning and practicing meditation, while also providing insights on how to learn and practice effectively. The book comprehensively covers the research in brain areas and networks that mediate the positive effects of meditation upon physical and mental health. Though it examines how people differ in how they learn and practice meditation, it underscores how underlying mechanisms differ in learning and practicing meditation and how they remain unclear to researchers. This book addresses the research gap and explores the brain science behind meditation.

  • Microbiomics

    Dimensions, Applications, and Translational Implications of Human and Environmental Microbiome Research
    • 1st Edition
    • English
    Microbiomics: Dimensions, Applications, and Translational Implications of Human and Environmental Microbiome Research describes a new, holistic approach to microbiomics. International experts provide in-depth discussion of current research methods for studying human, environmental, viral and fungal microbiomes, as well as the implications of new discoveries for human health, nutrition, disease, cancer research, probiotics and in the food and agricultural industries. Distinct chapters covering culturomics and sub-microbiomes, such as the viriome and mycetobiome, provide an integrative framework for the expansion of microbiomics into new areas of application, as well as crosspollination between research areas. Detailed case studies include the use of microbiomics to develop natural products with antimicrobial properties, microbiomic enhancements in food and beverage technology, microbes for bioprotection and biopreservation, microbial tools to reduce antibiotic resistance, and maintenance and cultivation of human microbial communities.

  • GPCR Signaling in Cancer

    • 1st Edition
    • Volume 145
    • English
    GPCR Signaling in Cancer, Volume 145, the latest release in the Advances in Cancer Research series, highlights recent developments in the area of GPCRs and cancer biology. Chapters included in this volume cover several GPCRs and their downstream effectors as case examples to highlight their fundamental understanding and therapeutic potential. Specific chapters address the Role of GRKs and beta-arrestins in cancer, Atypical GPCRs in cancer, the Role of a chemokine receptor (CCR) 5 in cancer, Targeting G protein-coupled receptors for therapeutics in cancer, Emerging GPCR signaling pathways in cancer, and more. G protein-coupled receptors (GPCRs) constitute a large family of cell surface receptors which are involved in nearly every cellular and physiological event. These receptors can recognize a broad array of ligands and they are targeted by nearly one third of the currently prescribed drugs including anti-cancer therapeutics.

  • Pharmacological Advances in Natural Product Drug Discovery

    • 1st Edition
    • Volume 87
    • English
    Pharmacological Advances in Natural Product Drug Discovery, Volume 87 in the Advances in Pharmacology series, presents the latest pharmacological research progresses of 8 medicinal compounds from natural products, including salvianolic acid, tanshinone, paeonol, chlorogenic acid, astragaloside, icariin, ganoderan, and febrifugine. Specific chapters to this new release include Potential Role of Paeonol on Atherosclerosis Related Cells, A Review on Salvianolic Acid, Pharmacological Advances of Tanshinones, the Natural Product of Salvia Miltiorrhiza, Pharmacological Action and Potential Targets Analysis of Major Pharmacological Effects of Chlorogenic Acid, Modern TCM: Identifying and Defining the "Medicinal Mix", Pharmacological Advances in Astragaloside IV Derived from Astragalus Membranaceus, and much more.

  • Inflammatory Disorders - Part B

    • 1st Edition
    • Volume 120
    • English
    Inflammatory Disorders - Part B, Volume 120 explores inflammation in the immune system and how the body’s own cells or tissues may cause abnormal inflammation, thus resulting in chronic pain, redness, swelling, stiffness, and damage to normal tissues. Chapters in this updated volume include Proteins in monogenic autoinflammatory disorders, Virulence factors and their roles in periodontal disease pathogenesis, Role of Heat shock proteins in Inflammatory disorder Rheumatoid Arthritis, Novel targeted therapies for Crohn's disease: Recent progress and future perspectives, Dietary plant flavonoids in prevention of obesity and diabetes, Small RNAs in allergic diseases, Inflammation and inflammasome during ageing and age-related diseases, and more.

  • A Beginner's Guide to Data Agglomeration and Intelligent Sensing

    • 1st Edition
    • Amartya Mukherjee + 2 more
    • English
    A Beginners Guide to Data Agglomeration and Intelligent Sensing provides an overview of the Sensor Cloud Platform, Converge-casting, and Data Aggregation in support of intelligent sensing and relaying of information. The book begins with a brief introduction on sensors and transducers, giving readers insight into the various types of sensors and how one can work with them. In addition, it gives several real-life examples to help readers properly understand concepts. An overview of concepts such as wireless sensor networks, cloud platforms, and device-to-cloud and sensor cloud architecture are explained briefly, as is data gathering in wireless sensor networks and aggregation procedures. Final sections explore how to process gathered data and relay the data in an intelligent way, including concepts such as supervised and unsupervised learning, software defined networks, sensor data mining and smart systems.

  • Plant Small RNA

    Biogenesis, Regulation and Application
    • 1st Edition
    • Praveen Guleria + 1 more
    • English
    Plant Small RNA: Biogenesis, Regulation and Application describes the biosynthesis of small RNA in plant systems. With an emphasis on the various molecular mechanisms affected by small RNA and their applications in supporting plant growth and survival, this books presents the basics and most recent advancements in small RNA mediated plant genomics, metabolomics, proteomics and physiology. In addition, it emphasizes the various molecular mechanisms affected by small RNA and their applications in supporting plant growth and survival. Final sections cover the most recent advancements in small RNA mediated plant genomics, metabolomics, proteomics and physiology.

  • BEST

    Implementing Career Development Activities for Biomedical Research Trainees
    • 1st Edition
    • Lorena Infante Lara + 2 more
    • English
    BEST: Implementing Career Development Activities for Biomedical Research Trainees provides an instructional guide for institutions wanting to create, supplement or improve their career and professional development offerings. Each chapter provides an exclusive perspective from an administrator from the 17 Broadening Experiences in Scientific Training (BEST) institutions. The book can aid institutions who train graduate students in a variety of careers by teaching faculty and staff how to create and implement career development programming, how to highlight the effectiveness of offerings, how to demonstrate that creating a program from scratch is doable, and how to inform faculty and staff on getting institutional buy-in. This is a must-have for graduate school deans and faculty and staff who want to implement and institutionalize career development programing at their institutions. It is also ideal for graduate students and postdocs.

  • An Introduction to Interdisciplinary Toxicology

    From Molecules to Man
    • 1st Edition
    • Carey N. Pope + 1 more
    • English
    An Introduction to Interdisciplinary Toxicology: From Molecules to Man integrates the various aspects of toxicology, from “simple” molecular systems, to complex human communities, with expertise from a spectrum of interacting disciplines. Chapters are written by specialists within a given subject, such as a chemical engineer, nutritional scientist, or a microbiologist, so subjects are clearly explained and discussed within the toxicology context. Many chapters are comparative across species so that students in ecotoxicology learn mammalian toxicology and vice versa. Specific citations, further reading, study questions, and other learning features are also included. The book allows students to concurrently learn concepts in both biomedical and environmental toxicology fields, thus better equipping them for the many career opportunities toxicology provides. This book will also be useful to those wishing to reference how disciplines interact within the broad field of toxicology.

  • Genome Engineering via CRISPR-Cas9 System

    • 1st Edition
    • Vijai Singh + 1 more
    • English
    Genome Engineering via CRISPR-Cas9 Systems presents a compilation of chapters from eminent scientists from across the globe who have established expertise in working with CRISPR-Cas9 systems. Currently, targeted genome engineering is a key technology for basic science, biomedical and industrial applications due to the relative simplicity to which they can be designed, used and applied. However, it is not easy to find relevant information gathered in a single source. The book contains a wide range of applications of CRISPR in research of bacteria, virus, algae, plant and mammalian and also discusses the modeling of drosophila, zebra fish and protozoan, among others. Other topics covered include diagnosis, sensor and therapeutic applications, as well as ethical and regulatory issues. This book is a valuable source not only for beginners in genome engineering, but also researchers, clinicians, stakeholders, policy makers, and practitioners interested in the potential of CRISPR-Cas9 in several fields.

  • Advances in Immunology in China - Part B

    • 1st Edition
    • Volume 145
    • English
    Advances in Immunology in China - Part B, Volume 145, the latest release in the Advances in Immunology series, presents the latest release in a long-established and highly respected publication. The book includes current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, with this release focusing on advances in immunology in China.

  • Functional and Preservative Properties of Phytochemicals

    • 1st Edition
    • Bhanu Prakash
    • English
    Functional and Preservative Properties of Phytochemicals examines the potential of plant-based bioactive compounds as functional food ingredients and preservative agents against food-spoiling microbes and oxidative deterioration. The book provides a unified and systematic accounting of plant-based bioactive compounds by illustrating the connections among the different disciplines, such as food science, nutrition, pharmacology, toxicology, combinatorial chemistry, nanotechnology and biotechnological approaches. Chapters present the varied sources of raw materials, biochemical properties, metabolism, health benefits, preservative efficacy, toxicological aspect, safety and Intellectual Property Right issue of plant-based bioactive compounds. Written by authorities within the field, the individual chapters of the book are organized according to the following practical and easy to consult format: introduction, chapter topics and text, conclusions (take-home lessons), and references cited for further reading.

  • Advances in Cyanobacterial Biology

    • 1st Edition
    • Prashant Kumar Singh + 3 more
    • English
    Advances in Cyanobacterial Biology presents the novel, practical, and theoretical aspects of cyanobacteria, providing a better understanding of basic and advanced biotechnological application in the field of sustainable agriculture. Chapters have been designed to deal with the different aspects of cyanobacteria including their role in the evolution of life, cyanobacterial diversity and classification, isolation, and characterization of cyanobacteria through biochemical and molecular approaches, phylogeny and biogeography of cyanobacteria, symbiosis, Cyanobacterial photosynthesis, morphological and physiological adaptation to abiotic stresses, stress-tolerant cyanobacterium, biological nitrogen fixation. Other topics include circadian rhythms, genetics and molecular biology of abiotic stress responses, application of cyanobacteria and cyanobacterial mats in wastewater treatments, use as a source of novel stress-responsive genes for development of stress tolerance and as a source of biofuels, industrial application, as biofertilizer, cyanobacterial blooms, use in Nano-technology and nanomedicines as well as potential applications. This book will be important for academics and researchers working in cyanobacteria, cyanobacterial environmental biology, cyanobacterial agriculture and cyanobacterial molecular biologists.

  • Aquaporin Regulation

    • 1st Edition
    • Volume 112
    • Gerald Litwack
    • English
    Aquaporin Regulation, Volume 112, the latest release in the Vitamins and Hormones series, highlights new advances in the field, with this new volume presenting interesting chapters highlighting Perspectives on the evolution of aquaporin superfamily, Structure and dynamics of aquaporin-1, Selectivity and Transport in Aquaporins from Molecular Simulation Studies, Aquaporin regulation in metabolic organs, Phosphorylation of human AQP2 and its role in trafficking, Regulation of Aquaporin-2 by RNA Interference, Aquaporin Regulation: Lessons from Secretory Vesicles, CFTR Regulation of Aquaporin-mediated Water Transport, Glucocorticoid Gene Regulation of Aquaporin-7, and much more.

  • Protein Homeostasis Diseases

    Mechanisms and Novel Therapies
    • 1st Edition
    • Angel L. Pey
    • English
    Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. Contributions from international experts discuss the biochemical and genetic components of protein homeostasis disorders, the mechanisms by which genetic variants may cause loss-of-function and gain-of-toxic-functi... and how natural ligands can restore protein function and homeostasis in genetic diseases. Applied chapters provide guidance on employing high throughput sequencing and screening methodologies to develop pharmacological chaperones and repurpose approved drugs to treat protein homeostasis disorders.

  • Controlled and Modified Atmospheres for Fresh and Fresh-Cut Produce

    • 1st Edition
    • Maria Isabel Gil + 1 more
    • English
    Controlled and Modified Atmospheres for Fresh and Fresh-Cut Produce is the ultimate reference book of CA/MA recommendations for selected commodities. It includes the basic knowledge of physiology and technologies to the current application of recommended CA/MAP conditions for fresh and fresh-cut fruits and vegetables. For each commodity, a summary with requirements and recommendations is presented. The book is divided into three parts, with each focusing on different aspects of CA/MA, including fundamental topics on the physiological and quality effects of CA and MAP for fresh and fresh-cut fruits and vegetables, optimal CA/MAP conditions and recommendations, and optimal conditions for fresh-cut fruits and vegetables.

  • Preclinical Research in Down Syndrome: Insights for Pathophysiology and Treatments

    • 1st Edition
    • Volume 251
    • English
    Preclinical Research in Down Syndrome: From Bench to Bedside, Volume 251, the latest release in the Progress in Brain Research series, highlights new advances in the field. Chapters in this updated release include Exploring genetic and epigenetic mechanisms underlying cognitive deficits in Dow syndrome, The trisomy paradox: gene expression dysregulation domains, the Influence of allelic differences in mouse models of Down syndrome, Modelling Down syndrome in cells: From stem cells to organoids, Modelling Down syndrome in animals from the early stage to the new generation of models, Mapping behavioral landscapes in Down syndrome animal models, and more.

  • Chemical and Synthetic Biology Approaches to Understand Cellular Functions - Part C

    • 1st Edition
    • Volume 633
    • English
    Chemical and Synthetic Biology Approaches to Understand Cellular Functions - Part C, Volume 633, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial. This release includes sections on Next generation probes for molecular imaging in cells, Competitive binding assay for biotin and biotin derivatives, based on avidin and biotin-4-fluorescein... Converting avidin to bind ligands other than biotin, especially steroids, Chemoenzymatic Labeling Strategy, Engineered Siderophores, Small molecules to inhibit bacterial population behavior, NMR tube bioreactor, Small molecule controlled RAS activation system, Small molecule regulated Cas9, the Design and application of synthetic receptors, and much more.

  • Second Generation Cell and Gene-Based Therapies

    Biological Advances, Clinical Outcomes and Strategies for Capitalisation
    • 1st Edition
    • Alain Vertes + 3 more
    • English
    Second Generation Cell and Gene-Based Therapies: Biological Advances, Clinical Outcomes, and Strategies for Capitalisation serves as the only volume to the market to bridge basic science, clinical therapy, technology development, and business in the field of cellular therapy/cytotherapy. After more than two decades of painstaking fundamental research, the concept of therapeutic cells (stem cells, genes, etc.), beyond the concept of vaccines, is reaching clinical trial, with mounting confidence in the safety and efficacy of these products. Nonetheless, numerous incremental technical advances remain to be achieved. Thus, this volume highlights the possible R&D paths, which will ultimately facilitate clinical delivery of cutting edge curative products.The next waves of innovation are reviewed in depth for hematopoietic stem cells, mesenchymal stem cells, tissue engineering, CAR-T cells, and cells of the immune system, as well as for enabling technologies such as gene and genome editing. Additionally, deep dives in product fundamentals, history of science, pathobiology of diseases, scientific and technological bases, and financing and technology adoption constraints are taken to unravel what will shape the cytotherapy industry to the horizon 2025 and beyond. The outcome is not simply a scientific book, but a global perspective on the nascent field combining science, business, and strategic fundamentals.

  • 100 Years of Human Chorionic Gonadotropin

    Reviews and New Perspectives
    • 1st Edition
    • Laurence A. Cole + 1 more
    • English
    100 years of Human Chorionic Gonadotropin: Reviews and New Perspectives is a collection of articles written by some of the world’s leading experts on the pregnancy hormone and cancer marker hCG. In 2019 it is difficult to ignore the effect that our understanding of hCG has had on the lives of millions of people worldwide. The hCG immunoassay, in one form or another, is now one of the most common medical tests conducted and is often the first indication that a mother-to-be is pregnant. Not only a marker of pregnancy, hCG is utilized in the diagnosis and monitoring in oncology and presents a potential target for novel cancer therapeutics. 100 years ago, in 1919, Hirose was demonstrating gonadotropic functions which resulted from a chorionic factor. Over the last century this factor has become defined as hCG and more recently explored as not one molecule but a group of molecules with variable structure and variable functions in both pregnancy and cancer. hCG is a multi-faceted molecule that has clinical and therapeutic implications but can be a challenging topic for researchers and physicians alike. This text covers the different structures and functions of hCG exploring the genes and evolution of the molecule, the different protein and glycosylation structures which can exist and their effect on structure, detection and quantification. 100 Years of hCG is not an attempt to recount the history of every publication on hCG, but rather a collection of reviews and new perspectives by "hCG-ologists", the term used by Hussa to describe biochemists working on HCG in the first book written on the topic over 30 years ago. Some of the authors have been around a while, some not so long, but others are just beginning their journey with a most beguiling molecule.

  • Advances in Food and Nutrition Research

    • 1st Edition
    • Volume 91
    • Fidel Toldra
    • English
    Approx.322 pages

  • Handbook of Research on Blockchain Technology

    • 1st Edition
    • Saravanan Krishnan + 5 more
    • English
    Handbook of Research on Blockchain Technology presents the latest information on the adaptation and implementation of Blockchain technologies in real world business, scientific, healthcare and biomedical applications. The book's editors present the rapid advancements in existing business models by applying Blockchain techniques. Novel architectural solutions in the deployment of Blockchain comprise the core aspects of this book. Several use cases with IoT, biomedical engineering, and smart cities are also incorporated. As Blockchain is a relatively new technology that exploits decentralized networks and is used in many sectors for reliable, cost-effective and rapid business transactions, this book is a welcomed addition on existing knowledge. Financial services, retail, insurance, logistics, supply chain, public sectors and biomedical industries are now investing in Blockchain research and technologies for their business growth. Blockchain prevents double spending in financial transactions without the need of a trusted authority or central server. It is a decentralized ledger platform that facilitates verifiable transactions between parties in a secure and smart way.

  • Prognostic and Therapeutic Applications of RKIP in Cancer

    • 1st Edition
    • Benjamin Bonavida + 1 more
    • English
    Prognostic and Therapeutic Applications of RKIP in Cancer provides updated reviews on the chemistry, signaling, pre-clinical and clinical activities, and role of RKIP expression levels for diagnostics, prognosis and potential interventions. The development of novel compounds and conjugates that selectively induce RKIP expression in cancer open a novel era of new therapeutics and their potential in the treatment of highly resistant cancers and metastases. Edited and written by internationally renowned experts in the field of novel therapeutics for cancer, this book is a valuable source for cancer researchers, medical scientists, clinicians, clinical pharmacologists, and graduate students.

  • Evidence-informed Approaches for Managing Dementia Transitions

    Riding the Waves
    • 1st Edition
    • Linda Garcia + 2 more
    • English
    Evidence-Informed Approaches for Managing Dementia Transitions provides evidence-informed approaches and future directions for supporting a higher quality of life for people living with dementia. Through a person-centered lens, this book equips care providers to better help people living with dementia align their expectations and hopes with the trajectories they can expect in their journey. It highlights the various transitions that those with dementia will experience and describes best practices for optimal adjustment to each. Topics covered include problem identification, driving cessation, loss of financial autonomy, acute hospital admission, moving to assisted living residences and long term care homes, and palliative and end of life care. This is a must have reference for researchers, clinicians, and mental health professionals (psychologists, counsellors, social workers, mental health nurses) as well as policy makers and other health and social care providers working with individuals with dementia.

  • Delivery of Drugs

    Volume 2: Expectations and Realities of Multifunctional Drug Delivery Systems
    • 1st Edition
    • Ranjita Shegokar
    • English
    Delivery of Drugs: Expectations and Realities of Multifunctional Drug Delivery Systems, Volume Two examines the formulation of micro-nanosized drug delivery systems and recaps opportunities for using physical methods to improve efficacy via mechano-, electroporation. The book highlights innovative delivery methods like PIPAC, including discussions on the regulatory aspects of complex injectables. Written by a diverse range of international researchers from industry and academia, the chapters examine specific aspects of characterization and manufacturing for pharmaceutical applications as well as regulatory and policy aspects.This book connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stakeholders. This level of discussion makes it a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about the status of drug delivery systems.

  • Regulation of Nitrogen-Fixing Symbioses in Legumes

    • 1st Edition
    • Volume 94
    • English
    The Nitrogen-Fixing Legume-Rhizobium Symbiosis, Volume 94, the latest release in the Advances in Botanical Research series, highlights new advances in the field, with this new volume presenting interesting chapters on The diversity of legume-rhizobium symbioses, Parasponia; an evolutionary outlier of rhizobium symbiosis, Rhizobium diversity in the light of evolution, Genomes of rhizobia, Gene regulation by extracytoplasmic function (ECF) sigma factors in alpha-rhizobia, Early symbiotic signaling between Plant and Bacteria, Rhizobia infection, a journey to the inside of plant cells, Differentiation of symbiotic nodule cells and their rhizobium endosymbionts, Nodule Organogenesis, Nitrogen Fixation by the Legume-Rhizobium Symbiosis, and much more.

  • Sustainability of the Food System

    Sovereignty, Waste, and Nutrients Bioavailability
    • 1st Edition
    • Noelia Betoret + 1 more
    • English
    Sustainability of the Food System: Sovereignty, Waste, and Nutrients Bioavailability addresses the concept of global sustainability, focusing on three key areas of action within the food production system: food sovereignty, environmentally friendly food processes, and food technologies that increase the bioavailability of bioactive compounds. The book defines key concepts in the food production system and provides examples of specific and tailored actions that contribute to global sustainability. Sustainability of the Food System: Sovereignty, Waste, and Nutrients Bioavailability will serve as a welcomed resource for food scientists and technologists, agriculturists, agronomic engineers, food engineers, environmental technologists, nutritionists, and post-graduate students studying bioresource technology and sustainability.

  • On Call Neurology

    On Call Series
    • 4th Edition
    • Stephan A. Mayer + 1 more
    • English
    Ideal for any on-call professional, resident, or medical student, this popular reference covers the common problems you’ll encounter while on call in the hospital. On Call Neurology, 4th Edition, by Drs. Randolph S. Marshall and Stephan A. Mayer, fits perfectly in your pocket, ready to provide key information in time-sensitive, challenging situations. You’ll gain speed, skill, and knowledge with every call - from diagnosing a difficult or life-threatening situation to prescribing the right medication.

  • Parkinson’s Disease Therapeutics

    Emphasis on Nanotechnological Advances
    • 1st Edition
    • Magisetty Obulesu
    • English
    Parkinson’s Disease Therapeutics: Emphasis on Nanotechnological Advances presents the latest information on the second most common neurodegenerative disorder in the elderly. Despite remarkable progress in various PD therapeutics, such as microRNAs and brain drug delivery systems, a few limitations impede their success. This book sheds light on the pros and cons of recently developed novel therapeutics. Very few books have highlighted the protective efficacy of natural products, antioxidants, and biomaterial design for other diseases.

  • Introduction to the Chemistry of Food

    • 1st Edition
    • Michael Zeece
    • English
    Introduction to the Chemistry of Food describes the molecular composition of food and the chemistry of its components. It provides students with an understanding of chemical and biochemical reactions that impact food quality and contribute to wellness. This innovative approach enables students in food science, nutrition and culinology to better understand the role of chemistry in food. Specifically, the text provides background in food composition, demonstrates how chemistry impacts quality, and highlights its role in creating novel foods. Each chapter contains a review section with suggested learning activities. Text and supplemental materials can be used in traditional face-to-face, distance, or blended learning formats.

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