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Elsevier

Encyclopedia of Bone Biology

  • 1st Edition - June 18, 2020
  • Latest edition
  • Editor: Mone Zaidi
  • Language: English

Encyclopedia of Bone Biology, Three Volume Set covers hot topics from within the rapidly expanding field of bone biology and skeletal research, enabling a complete understan… Read more

Description

Encyclopedia of Bone Biology, Three Volume Set covers hot topics from within the rapidly expanding field of bone biology and skeletal research, enabling a complete understanding of both bone physiology and its relation to other organs and pathophysiology. This encyclopedia will serve as a vital resource for those involved in bone research, research in other fields that cross link with bone, such as metabolism and immunology, and physicians who treat bone diseases. Each article provides a comprehensive overview of the selected topic to inform a broad spectrum of readers from advanced undergraduate students to research professionals.

Chapters also explore the latest advances and hot topics that have emerged in recent years, including the Hematopoietic Niche and Nuclear Receptors. In the electronic edition, each chapter will include hyperlinked references and further readings as well as cross-references to related articles.

Key features

  • Incorporates perspectives from experts working within the domains of biomedicine, including physiology, pathobiology, pharmacology, immunology, endocrinology, orthopedics and metabolism
  • Provides an authoritative introduction for non-specialists and readers from undergraduate level upwards, as well as up-to-date foundational content for those familiar with the field
  • Includes multimedia features, cross-references and color images/videos

Readership

Students and researchers in the fields of bone biology, tissue engineering, pathology and oncology in order to seek specific information on topics outside their immediate area of expertise, as well as diagnosing and treating bone diseases

Table of contents

1. General Introduction

2. The Notch Pathway

3. Wnt Signaling

4. The RANK-L/LGR4 Loop

5. The Sphingosine Pathway

6. Nuclear Receptors

7. Epigenetic Regulation of Bone and Bone Cells

8. The Brain-Bone Connection

9. Pituitary-Bone Axis

10. Muscle-Bone Interactions

11. Bone and Fat

12. Bone and Energy Homeostasis

13. Hematopoietic niches, Blood Cells and Skeletal Homeostasis

14. Bone and the Vasculature

15. Osseous-Immune Interactions

Review quotes

"There is very little to compare to this impressive and comprehensive reference. It is wonderful and should be on the institutional library shelves and within the actual laboratory where any bone research is being performed. It will be a foundational reference in our orthopedic library where residents and fellows in training will turn to it for better understanding of the foundational science of bone biology."—© Doody’s Review Service, 2021, Mark R Hutchinson, MD, reviewer, expert opinion

Product details

  • Edition: 1
  • Latest edition
  • Published: June 18, 2020
  • Language: English

About the editor

MZ

Mone Zaidi

Professor Mone Zaidi, MBBS, PhD, MD, FRCP, FRCPI, FRCPath, MACP, MD (h.c.), DSc (h.c.) Mone Zaidi graduated in medicine from King George’s Medical College, India, and trained clinically at the Hammersmith Hospital, London, under the tutelage of Professor Iain MacIntyre, FRS, who discovered calcitonin. After obtaining a PhD and MD from the University of London, Dr. Zaidi held appointments as Lecturer at the Royal Postgraduate Medical School and Senior Lecturer and Consultant at St. George’s Hospital Medical School for over 8 years. In 1999, he was recruited to Mount Sinai School of Medicine in New York as Professor of Medicine and Founding Director of The Mount Sinai Bone Program. Zaidi has made groundbreaking discoveries on the mechanisms of skeletal homeostasis in health and its dysregulation in common and rare diseases. These studies, spanning over 30 years, included the first description of calcium sensing in the osteoclast and the discovery that locally released nitric oxide acts to suppress bone cells. In 2003, Zaidi’s group published the first evidence for a pituitary–bone axis of medical significance, a breakthrough in physiology in which pituitary hormones could affect the skeleton directly. In a recent groundbreaking paper in Nature, he found that inhibiting FSH not only increased bone mass, but also reduced body fat–in essence, laying a firm foundation for a single anti-FSH agent to treat both osteoporosis and obesity. This corpus of work was selected by Nature Medicine as one of eight “Notable Advances” in biomedicine for 2017, and was editorialized widely in the scientific and lay press, including New York Times. Constituting a total of over 409 publications in quality journals, including Cell, Nature and PNAS, Zaidi’s research has been funded continuously by the U.S. National Institutes of Health. He has been bestowed upon by many honors, such as his election to the Association of American Physicians, the Interurban Clinical Club (established by Sir William Osler in 1905) of which he is President, the Practitioners’ Society (the oldest medical society in the U.S.) and the Association of Professors of Medicine. Zaidi was made Master of the American College of Physicians, received the Harrington Scholar–Innovator Award, was elected as Fellow of the American Association of Advancement of Science, and is recipient of three honorary doctorates.
Affiliations and expertise
Professor, Icahn School of Medicine at Mount Sinai, NY, USA

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