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Biomarkers for Traumatic Brain Injury

  • 1st Edition - July 10, 2020
  • Latest edition
  • Editors: Alan H.B. Wu, W. Frank Peacock
  • Language: English

Biomarkers for Traumatic Brain Injury provides a comprehensive overview on the selection and implementation of serum-based and saliva-based biomarkers for traumatic brain injury. T… Read more

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Description

Biomarkers for Traumatic Brain Injury provides a comprehensive overview on the selection and implementation of serum-based and saliva-based biomarkers for traumatic brain injury. The book presents an economic analysis for implementing TBI biomarkers into clinical practice. In addition, it discusses the analytical tools needed to implement TBI biomarkers, including specifications for testing instruments and interpretative software. Neurologists, emergency department physicians, intensivists, and clinical laboratorians will find this book a great resource from which to familiarize themselves with the issues and processes regarding TBI biomarkers.

Approximately 2 million people in the U.S. sustain a traumatic brain injury (TBI) each year with over 250,000 hospitalizations and 50,000 deaths. There has been a significant rise in interest in diagnosing mild concussions, particularly in the sports world. While imaging has been the gold standard, these procedures are costly and not always available. There is great potential in using serum-based biomarkers, hence the book seeks to enlighten readers on new possibilities.

Key features

  • Offers strategies for the selection and implementation of traumatic brain injury biomarkers
  • Discusses the importance of autoantibodies and post translational modifications for TBI
  • Covers the analytical tools needed to implement TBI biomarkers, including the specifications for testing instruments and interpretative software

Readership

Researchers in neurologic diseases, neurologists, emergency department physicians, intensivists, and clinical laboratorians

Table of contents

Section I. INTRODUCTION

1. Introduction—scope of the problem

2. The need for traumatic brain injury markers

3. Regulatory considerations for diagnostics and biomarkers of traumatic brain injury
Section II. PATHOPHYSIOLOGY OF TBI

4. Peripheral markers of TBI and blood-brain barrier disruption

5. The role of autoimmunity after traumatic brain injury

6. Traumatic brain injury: glial fibrillary acidic protein posttranslational
modification
SECTION III. TBI BIOMARKERS IN MEDICAL PRACTICE

7. Economics of traumatic brain injury biomarkers

8. Electrophysiology monitoring

9. Traumatic brain injury therapeutics
SECTION IV. CLASSICAL TBI BIOMARKERS

10. S100 biomarkers in patients with traumatic brain injury

11. Pathophysiology and clinical implementation of traumatic brain injury biomarkers: neuron-specific enolase

12. Traumatic brain injury biomarkers glial fibrillary acidic protein/ubiquitin C-terminal hydrolase L1

13. Neurofilaments light chain/Neurofilaments heavy chain

14. Tau protein, biomarker for traumatic brain injury
SECTION V. NOVEL TBI BIOMARKERS

15. Neurogranin

16. Myelin basic protein in traumatic brain injury
SECTION VI. ANALYTICAL TESTING CONSIDERATION

17. Antibody selection, evaluation, and validation for analysis of traumatic brain injury biomarkers

18. Sensitive immunoassay testing platforms

19. Clinical mass spectrometry and its applications in traumatic brain injuries

20. Surface plasmon resonance

21. Point-of-care testing for concussion and traumatic brain injury
SECTION VII. NON-BLOOD TBI BIOMARKER STRATEGY

22. Clinical risk factors of traumatic brain injury

23. Saliva biomarkers of traumatic brain injury

24. Digital neurocognitive testing

25. Electroencephalographic as a biomarker of concussion

26. Neuropsychological testing

27. Outpatient risk stratification for traumatic brain injury

28. Peptidomics and traumatic brain injury: biomarker utilities for a theragnostic approach

29. Autoantibodies in central nervous system trauma: new frontiers for diagnosis and prognosis biomarkers

Review quotes

"This book does a satisfactory job of serving as an introductory reference on traumatic brain injury and associated biomarkers available or in the works. My preferred reference is Textbook of Traumatic Brain Injury, 3rd edition, Silver et al. (American Psychiatric Association Publishing, 2019,) both for its breadth and detailed information. Brain Injury Medicine: Principles and Practice, 2nd edition, Zasler et al. (Springer Publishing Company, 2013) is also a good alternative. Although these two do not strictly cover TBI, they have better organization, more comprehensive information, and better readability."—Doody

Product details

  • Edition: 1
  • Latest edition
  • Published: July 11, 2020
  • Language: English

About the editors

AW

Alan H.B. Wu

Dr. Alan Wu is a Professor of Laboratory Medicine at the University of California at San Francisco. He is the Co-Director of the Core Laboratory at the Zuckerberg San Francisco General Hospital. His research is focused on biomarkers of cardiovascular disease, clinical toxicology, and pharmacogenomics. In this capacity, his clinical and research laboratory conducts testing for routine analytes in blood, urine and cerebral spinal fluid for electrolytes, metabolites, hormones, proteins, and biomarkers. His particular area of interest is in cardiac biomarkers for acute cardiac diseases. He received a B.S. in both Chemistry and Biology at Purdue University and a Ph.D. in Analytical Chemistry at the University of Illinois. He was a professor at the University of Texas and the University of Connecticut prior to his current position at UCSF.
Affiliations and expertise
Professor of Laboratory Medicine, School of Medicine, San Francisco, CA, USA

WP

W. Frank Peacock

W. Frank Peacock IV, MD, FACEP, FACC is a Professor of Emergency Medicine and Vice Chair for Research in the department of Emergency Medicine at Baylor College of Medicine, in Houston, Texas. He has >500 publications, is a two-time winner of the Best Research Paper of the Year Award from the American College of Emergency Physicians, and the 2019 Ray Bahr Award for Excellence from the American College of Cardiology. Finally, he is the founder of Comprehensive Research Associates, LLC, and Emergencies in Medicine, LLC.
Affiliations and expertise
Professor, Vice Chair for Research, Henry JN Taub Department of Emergency Medicine, Baylor College of Medicine, Houston, TX, USA

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