Skip to main content
Elsevier

Books in Immunology

Elsevier's Immunology collection equips researchers with valuable insights to address the complexities of the immune system and its role in health and disease, offering original research, insightful analysis, and current theory on diagnosing, managing, and advancing treatments for allergies, asthma, and immunologic disorders.

  • Differentiation and Immunology

    Symposia of the International Society for Cell Biology, Vol. 7
    • 1st Edition
    • Katherine Brehme Warren
    • English
    Differentiation and Immunology is a collection of papers that deals with molecular specificity—the link between immunology and differentiation. One paper reviews the status of regulation in bacteria or viruses, and extends the results to animal cells. The paper also investigates a single aspect of the control of immunoglobulin through the use of plasmacytomas. Another paper discusses the role of macrophages in the minimum theory to possibly account for the energetics of the reaction with receptors, or to the frequency of antigen-sensitive cells. Some papers investigate the immunogenic function of macrophages, the transition from monocyte to macrophage, the factors influencing the formation of macrophage lysosomes, and the origin of macrophage lysosomes. Other papers also discuss the immune response as a model system for studies on cellular differentiation, as well as the differentiation for collagen synthesis in cultured cells. One paper suggests that in differentiation, the changes that can occur in the properties of protozoan cells, perpetuated for long periods, are reversible, and can be a means for survival—as every cell line is also capable of being a germ line. This collection can prove valuable to bio-chemists, cellular biologists, micro-biologists, developmental biologists, and scientists involved in immunology research.

  • Clinical Immunobiology

    • 1st Edition
    • Volume 3
    • Fritz H. Bach + 1 more
    • English
    Clinical Immunobiology, Volume 3 covers a variety of methods used for assaying the immune status of an individual. This volume is composed of 21 chapters and begins with a presentation of the background and issues to which clinical tests would be applied. The succeeding chapters outline the methodological procedures used in the analyses. Other chapters present some examples of the kinds of data that can be generated with the procedures used and provide guidelines for interpretation of the tests. The remaining chapters discuss the value of the immunological test procedures in differential diagnosis and analysis of diseases. These chapters also explore the usefulness of these procedures in prognosis of disease and the consequences of immunological manipulation undertaken for treatment or prevention of disease. This book will be of great value to clinical immunobiologists, biochemists, and researchers.

  • Immunological Tolerance

    A Reassessment of Mechanisms of the Immune Response
    • 1st Edition
    • Maurice Landy + 1 more
    • English
    Immunological Tolerance: A Reassessment of Mechanisms of the Immune Response presents the basic biological phenomena of immunological tolerance. This book discusses immunology as a critical field for the analysis of molecular features of mammalian cell genetics, biosynthesis, differentiation, and interactions among cell types. Organized into six chapters, this book begins with an overview of the relationship between antigen structure and its ability to induce tolerance. This text then examines the essentiality of antigen for the proliferation of activated antibody-forming clones and discusses the role of antibody in homeostasis and suppression. Other chapters consider the restoration and transfer of immunological responsiveness by thoracic duct lymphocytes. This book discusses as well the distribution of antigen in tissues and cells. The final chapter deals with the origin of carrier antibody and the significance of maternal transfer of antibodies and antigens. This book is a valuable resource for immunologists, microbiologists, scientists, and clinicians.

  • Transgenesis and Targeted Mutagenesis in Immunology

    • 1st Edition
    • English
    Investigations into the field of immunology are rapidly expanding with the use of genetically altered mice at the embryonic stage. This breakthrough laboratory guide provides a complete study of transgenesis and targeted mutagenesis in laboratory mice that will be valued by researchers looking for fresh observations and interpretations when designing future experiments.

  • Methods in Virology

    Volume III
    • 1st Edition
    • Karl Maramorosch + 1 more
    • English
    Methods in Virology, Volume III focuses on the advancements of methods employed in virology, including immunological, microscopic, and serological techniques and transformation assays. The selection first offers information on the analysis of protein constituents and lipid components of viruses. Discussions focus on the applications of the existing methodology to lipid-containing viruses; physical methods for the characterization of virus proteins; renaturation of virus proteins and reconstitution of viruses; and chemical methods for the characterization of virus proteins. The text then elaborates on RNA polymerase, immunological techniques for animal viruses, and serological techniques for plant viruses. The book tackles the plaque assay of animal viruses, transformation assays, and the methods for selecting RNA bacteriophage. Topics include identification of the nucleic acid, assay methods for particular viruses, general consideration of the plaque assay method, virus-dilution media and procedures, monolayer assay methods, and incubation and staining of plates and counting of plaques. The manuscript also takes a look at the structural studies of viruses, microscopic techniques, electron microscopy of isolated virus particles and their components, and the application of thin sectioning. The selection is a vital source of data for researchers interested in the methods employed in virology.

  • Immunological Methods

    • 1st Edition
    • Ivan Lefkovits + 1 more
    • English
    Immunological Methods a compendium of basic research techniques being used in one of the largest immunology research institutes, the Basel Institute for Immunology, with particular emphasis given to new methodology. The procedures have been described by individuals judged to be highly expert in their specialties. In many instances the methods developed or adapted to unique uses by the contributors have not previously been described in detail. The book contains 34 chapters covering techniques for detection, isolation, and purification of antibodies (including dansylation, two-dimensional chromatography, isoelectric focusing, polyacrylamide gel electrophoresis, and isotachophoresis); measurement of equilibrium constants (equilibrium dialysis, filtration, and sedimentation); and isotope and fluorescent labeling and detection of cell-surface components. Techniques such as isotope laboratory maintenance; chemical modification of proteins, haptens, and solid supports, and haptenation of viable biological carriers; production of antisera against allotypes and histocompatibility antigens and production of antibody with clonai dominance; histocompatibility and MLR testing; and cell separation by haptenated gels and by velocity sedimentation of rosette-forming cells are also discussed. Other chapters cover detection of antibody-secreting and alloantigen-binding cells; immune responses in vitro and their analysis by limiting dilution; production of T-cell factors; hybridoma production by cell fusion; maintenance of cell lines and cloning in semisolid media; and the mathematical analysis of immunological data.

  • Centrifugation in Density Gradients

    • 1st Edition
    • C. A. Price
    • English
    Centrifugation in Density Gradients provides information pertinent to the fundamental aspects of density gradient centrifugation. This book discusses the benefits of density gradient centrifugation to membrane-bound particles. Organized into nine chapters, this book begins with an overview of the method of differential or fractional centrifugation. This text then explores the physical basis of density gradient centrifugation. Other chapters deal with the nuts and bolts of density gradient centrifugation, the construction and composition of gradients, the properties and operation of centrifuge systems, and certain arcane but highly useful procedures. This book discusses as well density gradient centrifugation in the analytical ultracentrifuge. The final chapter deals with a collection of protocols for separating particles ranging in size from whole cells to macromolecules. This book is intended to be suitable for readers who need to separate biological particles. Biologists, chemists, biochemists, cytologists, physiologists, scientists, and research workers will also find this book useful.

  • Laboratory Methods in Microbiology

    • 1st Edition
    • W. F. Harrigan + 1 more
    • English
    Laboratory Methods in Microbiology is a laboratory manual based on the experience of the authors over several years in devising and organizing practical classes in microbiology to meet the requirements of students following courses in microbiology at the West of Scotland Agricultural College. The primary object of the manual is to provide a laboratory handbook for use by students following food science, dairying, agriculture and allied courses to degree and diploma level, in addition to being of value to students reading microbiology or general bacteriology. It is hoped that laboratory workers in the food manufacturing and dairying industries will find the book useful in the microbiological aspects of quality control and production development. The book is organized into two parts. Part I is concerned with basic methods in microbiology and would normally form the basis of a first year course. Abbreviated recipes and formulations for a number of typical media and reagents are included where appropriate, so that the principles involved are more readily apparent. Part II consists of an extension of these basic methods into microbiology as applied in the food manufacturing, dairying and allied industries. In this part, the methods in current use are given in addition to, or in place of, the ""classical"" or conventional techniques.

  • The Antibody Molecule

    • 1st Edition
    • Alfred Nisonoff + 2 more
    • F. J. Dixon + 1 more
    • English
    The Antibody Molecule reviews the literature leading to current knowledge of the structure of immunoglobulins. The book begins by outlining some of the basic structural characteristics of immunoglobulins without citing the references on which the information is based. Separate chapters follow covering the chemical nature of the active site of an antibody molecule and mechanisms of interaction with hapten; the general structural features and properties of the various classes of human immunoglobulin; and amino acid sequences of human and mouse L chains and of human and rabbit H chains. Subsequent chapters deal with the evolution of the immunoglobulin classes; special properties of mouse, guinea pig, rabbit, and horse immunoglobulins; idiotypic specificities of immunglobulins; and the genetic control of antibodies. This book is meant for immunologists who have not personally observed the development of this exciting period in the history of immunology. It will also provide useful supplemental reading for the serious student or investigator who wishes to become familiar with the nature of the antibody molecule, its genetic control, and mode of action.

  • Immunological Tolerance

    Mechanisms and Potential Therapeutic Applications
    • 1st Edition
    • David H. Katz + 1 more
    • English
    Immunological Tolerance: Mechanisms and Potential Therapeutic Applications documents the proceedings of a conference held at Brook Lodge, Michigan, April 27-May 1, 1974. The conference brought together many of the investigators who have actively contributed to furthering knowledge and understanding of immunological tolerance. It will be immediately clear to the reader that the conference was structured in a way to consider phenomena of tolerance and immune suppression as interrelated entities with a certain degree of emphasis on the possible common cellular mechanisms involved. The volume contains 36 contributions presented during the seven sessions of the conference. The papers presented in Session I examined T-cell tolerance. The presentations in Session II focused on B cell tolerance. The papers in Sessions III and IV focused on the mechanisms of B cell and T cell tolerance, respectively. Session V dealt with the activity of suppressor cells as a mechanism of tolerance. The papers in Session VI investigated the suppressive activity of antibody and antigen-antibody complexes. In Session VII a final General Discussion was held in order to identify what has been established concerning the phenomenology and mechanisms of specific immunological tolerance, what are the major unresolved issues, and what approaches appear most promising to answer these questions.

  • Immunointervention in Autoimmune Diseases

    Papers Based on an International Meeting in Paris, France, in June 1988
    • 1st Edition
    • J. F. Bach
    • English
    Immunointervention in Autoimmune Diseases is a collection of papers presented at the 1988 International Meeting by the same title, held in Paris, France. This text contains 21 chapters and begins with surveys of the role of antigen in autoimmune responses and the moving boundaries between physiology and pathology of immunity. The succeeding chapters deal with the regulation, immunosuppressive therapy, infections, and immunointervention of autoimmune disorders. These topics are followed by discussions of specific immunosuppressive therapy for a particular disease, including type I diabetes, T-cell leukemia, and systemic lupus erythomatosus. This work also explores the principles of allograft, the use of monoclonal antibody, and OKT3. The remaining chapters consider the maintenance of autoimmunity and the risk/benefit in immunointervention for autoimmune diseases. This book will prove useful to immunologists, pathologists, physiologists, and researchers.

  • In Vitro Methods in Cell-Mediated Immunity

    • 1st Edition
    • Barry R. Bloom + 1 more
    • English
    In Vitro Methods in Cell-Mediated Immunity focuses on methods for approaching cell-mediated immune responses in vitro. This book provides, in simplified in vitro systems, a basis for understanding the mechanism of the in vivo response and discusses useful and reliable in vitro tests for cell-mediated immune responses in humans, where in vivo testing is often not possible. The topics discussed include factors and activities produced in vitro by lymphocytes; biological implications of in vitro phenomena; and requirements and prospects for improved methodology. The leucocyte migration technique for in vitro detection of cellular hypersensitivity in man; proliferation of human blood lymphocytes stimulated by antigen in vitro; and virus plaque assay for antigen-sensitive are also elaborated in this text. This publication is a good reference for microbiologist and immunologists, including medical students researching on in vitro models for cell-mediated immune reactions.

  • Immunobiology of Transfer Factor

    • 1st Edition
    • Charles H. Kirkpatrick + 2 more
    • English
    Immunobiology of Transfer Factor compiles research papers presented at the Fourth International Transfer Factor Workshop, held at the Given Institute of Pathobiology in Aspen, Colorado, on October 3-6, 1982. This book focuses on the immunologic effects of transfer factor, which are supported by in vitro and in vivo experiments that indicate immunologically specific interactions between transfer factor and antigens. The topics include the selective removal of transfer factor activity with antigen, antigen-specific suppressor factor in human leukocyte dialysates, and specific suppressor dialysates from mice. The kinetics of immune response and production of transfer factor in bovine, dialyzable leukocyte extracts in pulmonary diseases, and mechanisms of action of human transfer factor are also elaborated. This compilation is suitable for microbiologists, immunologists, and specialists researching on transfer factor.

  • Immunodermatology

    • 1st Edition
    • D. M. Macdonald
    • English
    Immunodermatology presents a comprehensive examination of the proceedings that resulted from the International Immunodermatology Symposium which happened in London. It discusses the relationship of immuno-histochemical study to skin disease. It addresses the function and recognition of lymphocytes. Some of the topics covered in the book are the immunological observations in 12 cases of Kaposi’s herpetic eruption; anti-inflammatory effects of adrenoceptor agonists in patients with atopic eczema; a study of the sensitivity and specificity of cutaneous vascular immunofluorescence; and functional activity of granulocytes from patients with neutrophilic dermatoses. The mechanisms of cutaneous lupus erythematosus are fully covered. An in-depth account of the cytochemical and immunological findings in cutaneous multilobated cell lymphoma are provided. The immunohistological analysis of dermal leprous granulomas is completely presented. A chapter is devoted to the study of human epidermal cell differentiation using monoclonal antibodies. Another section focuses on the prognostic significance of melanoma-associated antigens in primary and metastatic melanomas. The book can provide useful information to doctors, dermatologists, students, and researchers.

  • Clinical Immunobiology

    • 1st Edition
    • Volume 1
    • Fritz H. Bach + 1 more
    • English
    Clinical Immunobiology, Volume 1 is a 12-chapter introductory text to the several aspects of immunobiology field. The opening chapters describe the structural and functional development, as well as the molecular and cellular nature of the immune apparatus. The subsequent chapters deal with the relation of structure to function in the lymphoid system and its molecules. These topics are followed by discussions of the fundamental issues of tolerance, inflammation, immunological mediators and amplifiers, and immunogenetics. The remaining chapters explore the immunobiological aspects of transplantation, allergy, tumor immunity, autoimmunity, immunodeficiency, and immunosuppression. This book will be of great value to clinical immunobiologists, practicing physicians, researchers, and medical and biology students.

  • Fish Immunology

    • 1st Edition
    • Margaret J. Manning + 1 more
    • English
    Fish Immunology contains the proceedings of a symposium organized by the Fisheries Society of the British Isles, held in Plymouth, England, 11-13 July 1983. This volume contains 29 chapters and opens with a study on the prevention of disease outbreak or treatment of disease in fish farms with drugs or chemicals. Separate chapters follow on topics such as immune phenomena in Teleostei or Anura; phagocytosis in fish; the granulocytes of three elasmobranch species, namely Scyliorhinus canicula, Raja clavata and R. microcellata; and phagocytic cells in the dogfish (Scyliorhinus canicula l.); and levels of α-precipitin in two groups of wild fish: a group believed to be suffering from Ulcerative Dermal Necrosis (UDN) and a healthy group showing no external evidence of disease. Subsequent chapters deal with sequential antigenic competition in teleosts challenged with the fish-furunculosis bacterium Aeromonas salmonicida; the occurrence of vaccine uptake at the skin surface of rainbow trout; and vaccination and development of immunological memory in carp.

  • Clinical Immunobiology

    • 1st Edition
    • Volume 4
    • Fritz H. Bach + 1 more
    • English
    Clinical Immunobiology, Volume 4 is a 13-chapter text that covers the advances in understanding of the concepts and practical applications of lymphoid subpopulations and the major histocompatibility complex (MHC). The first chapter presents an overview of the problems of various subpopulations of cells involved in the immune system. The succeeding chapters describe the techniques used for cell classification, either by their cell surface phenotype or by their responsiveness to a series of different stimuli. These chapters include surveys of the methods of detection of complement receptors and expression of these receptors on the surface of both normal and leukemic human lymphocytes. A discussion of the evidence that different T-lymphocyte populations differentially express receptor for IgG and IgM is also provided. Other chapters describe the relationship of MHC to serology of cell surface antigens and reactivity in the mixed leukocyte culture test. This work also explores the methods that employ the so-called "proliferative and cytotoxic responses". The remaining chapters look into the association between HLA antigens and a variety of different diseases. These chapters also discuss other genetic markers in the HLA linkage group. This book will be of great value to clinical immunobiologists, practicing physicians, researchers, and medical and biology students.

  • Veterinary Virology

    • 1st Edition
    • Frank J. Fenner + 2 more
    • English
    Veterinary Virology deals with basic biomedical virology and the clinical discipline of infectious diseases. The book discusses the principles of virology as effecting future developments in the search for preventive and management of infectious diseases in animals, whether singly or as a whole herd or flock. Part I explains the principles of animal virology including the structure, composition, classification, nomenclature, cultivation, and assay of viruses. This part also discusses viral genetics, replication, and evolution (including mutation and genetic engineering). The book also reviews the pathogenesis of viruses, host resistance and susceptibility, as well as the mechanisms of persistent infections and tumor induction. Part II deals with viruses found in domestic animals; this part also explains in detail the properties, replication methods, pathogenesis, immunity, diagnosis, and control of some common viruses. The book discusses some other families of viruses of which no members are yet known as to have caused serious or important diseases in animals. Veterinarians, immunologists, virologists, molecular researchers, students, and academicians in the discipline of virology and cellular biology, as well as livestock owners will find this book helpful.

  • Methods in Virology

    Volume V
    • 1st Edition
    • Karl Maramorosch + 1 more
    • English
    Methods in Virology, Volume V focuses on the methods used in virology, including hybridization, gel electrophoresis, freeze-etching technique, and ultracentrifugation. The selection first offers information on the fusion of cells for virus studies and production of cell hybrids; approaches to ultracentrifugation; and polyacrylamide gel electrophoresis of viral RNA. Discussions focus on applications to virological problems and analysis of results; analysis of the distribution of RNA on polyacrylamide gels after electrophoresis; and biological analysis of DNA components. The book then examines the polyacrylamide gel electrophoresis of viral proteins, DNA-RNA and DNA-DNA hybridization in virus research, and techniques of RNA-DNA hybridization in solution for the study of viral transcription. Topics include preparation of nucleic acids, hybridization and elution procedures that minimize RNA degradation, and procedures for acrylamide gel electrophoresis. The text takes a look at freeze-etching technique for the study of virus ultrastructure; procedures to increase virus yield from infected plants; and the immunoperoxidase technique. Concerns include principles of the immunoperoxidase technique, histochemical detection of peroxidase activity, sequence of events in virus infection, and factors affecting virus yield. The selection is a valuable source of data for researchers interested in the methods employed in virology.

  • Comparative Virology

    • 1st Edition
    • Karl Maramorosch + 1 more
    • English
    Comparative Virology provides an integrated comparison of viruses, based on their chemical and morphological characteristics. These descriptions will not only give the reader a background but also a detailed analysis of the various groups. In some instances the groups are still host related, as in the case of bacteriophages and polyhedral insect viruses. In others, for instance in pox viruses, the group comprises viruses of vertebrates and invertebrates. The hosts of the bacilliform Rhabdovirales range from man and other warm-blooded vertebrates through invertebrate animals to plants. A special chapter is devoted to viruses devoid of protein—a group that is of great interest and that has only recently been recognized. Since there is historical and practical interest in écologie groupings, such as arboviruses and oncogenic viruses, chapters on such groups have also been included. The book opens with a discussion on the classification of viruses. Chapters dealing with DNA viruses and RNA viruses follow, and the ecologically and disease-oriented groups complete the volume. It is hoped that ""Comparative Virology"" will help bring unity to the science of virology through the comparative approach that is not dependent on virus-host interactions. The combined efforts of eminent contributors to discuss and evaluate new information will hopefully benefit all who are interested in virology

  • Methods in Virology

    Volume VII
    • 1st Edition
    • Karl Maramorosch + 1 more
    • English
    Methods in Virology, Volume VII focuses on the methods used in virology, including radioimmunoassays, microscopy, hybridization, and mutagenesis. The selection first elaborates on monoclonal antibody techniques applied to viruses; competition radioimmunoassays for characterization of antibody reactions to viral antigens; and enzyme immunosorbent assays in plant virology. Discussions focus on the principles of enzyme immunosorbent assay, choice of enzyme and preparation of conjugate, determination of immunoglobulin class, and maintenance and specificity testing of hybridomas. The text then elaborates on electron microscopy for the identification of plant viruses in in vitro preparations and cloning and expression of viral antigens in Escherichia coli and other microorganisms, including influenza virus, expression of foreign coding sequences in Escherichia coli, hepatitis B virus, electron microscope, immunoelectron microscopy, and imaging of nucleic acids. The manuscript takes a look at the detection and characterization of subgenomic RNA in plant viruses; exploring the gene organization of baculoviruses; and spot hybridization for detection of viroids and viruses. Topics include application to viral diseases, mapping mutuations of baculoviruses, transcriptional mapping of baculovirus genomes, and genetic mapping by blot hybridization. The selection is a valuable source of information for researchers interested in the methods employed in virology.

  • Textbook of Medical Virology

    • 1st Edition
    • Erik Lycke + 1 more
    • English
    Textbook of Medical Virology presents a critical review of general principles in the field of medical virology. It discusses the description and molecular structures of virus. It addresses the morphology and classifications of viruses. It also demonstrates the principal aspects of virus particle structure. Some of the topics covered in the book are the symmetrical arrangements of viruses; introduction to different families of animal viruses; biochemistry of virus particles; the immunological properties and biological activities of viral gene products; description of enzymatic activities of viruses; and haemagglutination, cell fusion, and haemolysis of viruses. The description and characteristics of viral antigens are covered. The identification and propagation of viruses in tissue and cell cultures are discussed. An in-depth analysis of the principles of virus replication is provided. A study of the morphogenesis of virions is also presented. A chapter is devoted to virus-induced changes of cell structures and functions. The book can provide useful information to virologists, microbiologists, students, and researchers.

  • Immunobiology of the Complement System

    An Introduction for Research and Clinical Medicine
    • 1st Edition
    • Gordon D. Ross
    • English
    Immunobiology of the Complement System: An Introduction for Research and Clinical Medicine provides an introduction to the complement system. The intention was to create a primer that would provide the basic knowledge of complement required for either research or clinical medicine in diseases involving the complement system. The book begins with a historical background of complement research; it introduces certain key investigators from the past who have made important contributions. Separate chapters on the basic aspects of complement function are followed by chapters on the molecular genetics of complement and the role of complement in different diseases. Key topics discussed include the activation of complement via the classical pathway and the alternative pathway; complement mediators of inflammation; opsonization and membrane complement receptors; assembly and functions of the terminal components; and complement-dependent mechanisms of virus neutralization. This book has been written primarily for students and scientists who have not been specifically trained in complement research.

  • Anaerobic Bacteriology

    Clinical and Laboratory Practice
    • 3rd Edition
    • A. Trevor Willis
    • English
    Anaerobic Bacteriology: Clinical and Laboratory Practice, Third edition discusses the importance of the non-sporing anaerobic bacteria as a significant cause of infection in man. This edition updates the anaerobic methodology, systematics, and ecological and pathogenetic associations of the non-sporing anaerobes. The descriptive bacteriology of the non-clostridial anaerobes and clinical syndromes produced by them in man are also considered. Other topics discussed include the anaerobic jar, inoculation of media, and antibiotic susceptibility testing of anaerobes. The histotoxic clostridia of infected wounds, anaerobic cocci, and infections related to the gastrointestinal tract are also elaborated. This text likewise covers the uterine gas gangrenous infections and other clostridial infections. This book is a good source for medical practitioners, clinicians, and medical students concerned with anaerobic bacteria.

  • Immunobiology of the Macrophage

    • 1st Edition
    • David S. Nelson
    • English
    Immunobiology of the Macrophage presents an account of the state of knowledge of the immunobiology of the macrophage. The book’s contributors—immunol... of diverse scientific and geographic backgrounds—have been encouraged to give personal accounts of developments in their special fields of interest as well as critical surveys of the backgrounds leading to these developments. The book begins with a study on the functions of macrophages in the initiation and regulation of antibody responses in vitro. This is followed by separate chapters on topics such as the role of macrophages in making antigen more immunogenic and less tolerogenic; functional distinctions between macrophages at different sites; and the role of the macrophage in antigen recognition by T lymphocytes. Subsequent chapters examine interactions between macrophages and lymphocytes in the production of interferon and other mediators of cellular immunity; macrophage cell lines and their uses in immunobiology; and cytotoxic macrophages in allograft rejection.

  • Immunodiffusion

    • 2nd Edition
    • Alfred J. Crowle
    • English
    Cancer and Chemotherapy, Volume III: Antineoplastic Agents is a collection of articles that deals with the treatment of cancer using drugs. The collection describes the various drugs that are used, the therapeutic approaches being taken, and agents that are being developed. Part I is a general review of anti-cancer drugs as regards their action mechanisms, pharmacokinetics, pharmacology, known toxicities, and clinical utility. These drugs include alkylating agents such as mitomycin C and nitrosoureas; plant alkaloids such as maytansine; antibiotics such as anthracyclines; platinum-containing complexes; antimetabolites; and hormones. Part II examines the molecular pharmacology of some major drug classes, namely, bleomycin and anthracycline. The text also discusses the chemistry, mechanism, and any structure-activity relationships found in these drug classes. Part III discusses in detail the clinical pharmacology of some antitumor drugs, for example, cisplatin and nitrosoureas. The text includes the clinical applications, biochemistry, metabolism, and the use of mathematical models in interpreting or describing resulting data. The book is helpful for pharmacologists, molecular biologists, and scientists involved in cancer-research.

  • Blood and Tissue Antigens

    International Symposium on Blood and Tissue Antigens Held at the University of Michigan Medical Center, September 17-19, 1969
    • 1st Edition
    • David Aminoff
    • English
    Blood and Tissue Antigens documents the proceedings of the International Symposium on Blood and Tissue Antigens held in Ann Arbor, Michigan on September 17-19, 1969. This book focuses on the immunogenetic and biochemical aspects of the blood and tissue antigens. The topics discussed include the genetics of blood groups; blood groups and serum phosphatase; immunogenetics of the mouse H-2 system; and glycolipids as membrane antigens. The carbohydrate composition of epithelial mucins; glycolipids in SV40 and polyoma virus transformed mouse cell lines; and metabolic variations of serum proteins and enzymes are also elaborated. This text likewise covers the action of glycosidases on erythrocytes; blood group specific oligosaccharides in urine; biosynthesis of submaxillary mucins; and genes, glycosyltransferases... and blood types. This publication is a good source for students and individuals researching on blood and tissue antigens.

  • Molecular Mechanisms of Immunological Self-Recognition

    • 1st Edition
    • Frederick Alt + 1 more
    • English
    Molecular Mechanisms of Immunological Self-Recognition covers the understanding of immunological self-recognition. The introductory chapter of the book summarizes the dawn of the insight into immunological tolerance, and provides an overview of research on the underlying mechanisms. The book addresses the developments in the molecular mechanisms of B and T cell tolerance and describes the failure of tolerance in autoimmunity. The text concludes by furnishing orienting perspectives and highlighting new information presented. The novel findings characterized as impressive advances pertain to the areas of B cell development and the generation of molecular diversity; V gene usage, especially from transgenes, in positive and negative thymic selection; the handling of positive and negative signals by T and B cells; anergy in postthymic T cells; the design of peptide-based therapy for autoimmune diseases; and the design of therapy with the aid of monoclonal antibodies. Immunologists will find the text useful.

  • Methods in Virology

    Volume VIII
    • 1st Edition
    • Karl Maramorosch + 1 more
    • English
    Methods in Virology, Volume VIII focuses on the methods used in virology, including microscopy, hybridization, viruses, and fingerprint analysis. The selection first offers information on the hybridization of viral nucleic acids; applications of oligonucleotide fingerprinting to the identification of viruses; and immunosorbent electron microscopy in plant virus studies. Discussions focus on the detection of double-stranded RNA, principles and mechanisms of fingerprint analysis, preparation of labeled nucleic acid probes, and basic methods of nucleic acid hybridization. The text then elaborates on quantitative transmission electron microscopy for the determination of mass-molecular weight of viruses and use of thin sectioning for visualization and identification of plant viruses. Topics include technical procedures for processing plant tissues, cytological modifications of diagnostic value, procedure and treatment of data to obtain the average mass of virus particles, and applications in virology. The book takes a look at the detection of genome-linked proteins of plant and animal viruses; methods for assay, purification, and characterization of prions; and the use of mosquitoes to detect and propagate viruses. The selection is a valuable source of information for researchers interested in the methods employed in virology.

  • Rapid Virus Diagnosis

    Application of Immunofluorescence
    • 2nd Edition
    • P. S. Gardner + 1 more
    • English
    Rapid Virus Diagnosis: Application of Immunofluorescence presents developments in immunofluorescence as a technique for the diagnosis of virus infections. It discusses the effective and rapid methods for the diagnosis of virus infections. It addresses the application of fluorescent antibody techniques to the diagnosis and the investigation of virus infections and the assessment of their value both to the clinician and to the virologist. Some of the topics covered in the book are the fluorescence microscopy; nature of fluorescence; filter systems; transmitted light microscopy; interference filters for transmitted light microscopy; lamp centration and alignment of microscope; contrast-fluorescenc... condensers; photomicrography; and choice of microscope. The culture of viruses for production of antiserum is fully covered. The selection of cell lines or tissues for virus culture is discussed in detail. The text describes in depth the fluorescent antibody staining techniques. The preparation of specimens from respiratory infections is presented completely. A chapter is devoted to the respiratory syncytial virus. Another section focuses on the analysis influenza virus, paramyxoviruses, and picornaviruses. The book can provide useful information to doctors, virologists, students, and researchers.

  • Molecules, Cells, and Parasites in Immunology

    • 1st Edition
    • Carlos Larralde + 2 more
    • English
    Molecules, Cells, and Parasites in Immunology contains the proceedings of a symposium on immunology held in Mexico City in the fall of 1979 under the auspices of the National University of Mexico (UNAM). This volume brings together prominent foreign scientists and Mexican investigators to discuss the areas of immunology that being developed at UNAM. Either in the form of reviews or of original presentations, the various authors proffer observations and ideas that generally relate to the regulation of the immune response at the molecular and cellular levels. The topic of Molecules encompasses the effect of molecular aggregation upon the triggering of physiological events, cooperative binding, and the expression of immunoglobulins during the lymphocyte differentiation process. Under the heading of Cells, there are contributions dealing with the physiological and pathological roles of interiorized antibodies; the mechanisms of antigen recognition by T cells; and the synthesis of membrane proteins by myeloma cells which somehow protect them from killer T cells. The section on Parasites includes some unique contributions on the immunology of human and animal cysticercosis and amebiasis, complemented by a general discussion of host-parasite relationships.

  • Lymphocyte Differentiation, Recognition, and Regulation

    • 1st Edition
    • David H. Katz
    • F. J. Dixon + 1 more
    • English
    Lymphocyte Differentiation, Recognition, and Regulation provides an overview of the state of knowledge on cellular immunology. The focus is on animal work than on studies in man, although in certain areas human lymphocyte biology has been discussed in some detail. The book attempts to integrate information from diverse areas of cellular immunology, immunogenetics, and immunochemistry to form some cohesive concepts that can be perhaps utilized as a working foundation for students and investigators in various areas of immunology. The book begins with a general description of some of techniques and principles underlying the systems frequently employed in cellular immunology. This is followed by detailed analyses of lymphocyte differentiation, receptor function, and regulatory processes. The main points that emerge from such analyses are that the immune system is an infinitely complex and finely tuned network of cells, receptors, and molecules which interact with one another in a genetically controlled manner that is manifested ultimately in the process known as differentiation.

  • Antigens, Lymphoid Cells and the Immune Response

    • 1st Edition
    • G. J. V. Nossal + 1 more
    • F. J. Dixon + 1 more
    • English
    Antigens, Lymphoid Cells, and the Immune Response deals with the nature and properties of antigens and with the functional anatomy and cell physiology of the mammalian lymphoid system which responds to antigens. The book discusses the central questions in cellular immunology; the antigens and the afferent limb of the immune response; and antibodies and the afferent limb of the immune response. The text also describes the organ distribution of antigens; the functional anatomy of the lymphoid system; and the behavior patterns of lymphoid cells. The microscopic and electron microscopic distribution of antigen in lymphoid organs; the interaction of antigens with cells of the reticuloendothelial system; and the interaction of antigen with lymphoid cells are also considered. The book further tackles the role of antigen in immunological tolerance; antibody production and tolerance dissociated; and antigen and lymphoid cells.

  • Clinical Immunobiology

    • 1st Edition
    • Volume 2
    • Fritz H. Bach + 1 more
    • English
    Clinical Immunobiology, Volume 2 covers the advances in the field being made to apply bone marrow transplantation to the treatment of several diseases. This volume is divided into 11 chapters and begins with surveys of the clinical considerations of bone marrow transplantation. Considerable chapters are devoted to the application of this transplantation to the treatment of various diseases, including aplastic anemia, aregenerative pancytopenia, leukemia, uniformly fatal severe combined immunodeficiency diseases, and Wiskott-Aldrich syndrome. Other chapters examine the cellular engineering in the form of bone marrow and thymus transplantation. The remaining chapters consider the effects of exposure to excessive amounts of radiation or cytotoxic chemicals, as well as the hematopoietic failure based on malfunction of the complex process of normal hematological development and maintenance. This book will be of great value to clinical immunobiologists, practicing physicians, researchers, and medical and biology students.

  • Psychoneuroimmunology

    • 1st Edition
    • Robert Ader
    • English
    Psychoneuroimmunolog... Second Edition presents reports on the relationship between the nervous and immune systems. The book is divided into four sections. The first section details the role of neural structures and neurotransmitter signals in communication with the immune system. It documents the extensive neural connections with organs of the immune system; the dynamics of noradrenergic sympathetic innervation of spleen and thymus; and the evidence for immune signaling of the CNS. Part II elaborates the role of hormones in the modulation of immune functions; the basis for bidirectional communication between the neuroendocrine and immune systems; and the potential physiological implications of these neuroendocrine-immun... system interactions. The third part addresses behavioral influences on immune response; the effects of conditioning, stress and social interactions in modulating immune responses; and the behavioral consequences of experimentally altered or genetically determined immunologic states. The final section presents the effects of psychosocial factors on immune responses and the potential impact of behavioral interventions in modulating immunity in healthy human subjects and in patients with AIDS. Neuroscientists, endocrinologists, and immunologists will find the book interesting.

  • Membranes and Viruses in Immunopathology

    • 1st Edition
    • Stacey B. Day + 1 more
    • English
    Membranes and Viruses in Immunopathology covers the proceedings of the 1972 symposium by the same title, held at the University of Minnesota Medical School, sponsored by the Bell Museum of Pathology. This book is composed of 40 chapters that highlight the significant advances in fundamental experiments of membrane structure chemistry. Considerable chapters explore the diagnosis and analysis of slow and oncogenic virus infections, as well as the role of immunobiologic processes in the pathogenesis, prevention, and treatment of disease. The remaining chapters contain research works on the detailed mechanisms that may contribute to cancer induction and dissemination. This book will prove useful to immunopathologists and practicing physicians.

  • Handbook of Immunological Investigations in Children

    Handbooks of Investigation in Children
    • 1st Edition
    • J. Graham Watson + 1 more
    • English
    Handbook of Immunological Investigations in Children presents an extensive examination of the immune system of children. It discusses the fundamental concepts in immunology. It addresses studies in the primary immunodeficiency diseases. Some of the topics covered in the book are the respiratory disorders; renal disorders; gastrointestinal disorders; endocrine disorders; neurological and psychiatric disease; identifications of diseases of the skin; muscle malfunction and connective tissue disorder; and the methods of infections and immunizations. The definition and description of factors influencing blood and blood-forming elements are fully covered. An in-depth account of the factors causing allergies and cardiovascular diseases are provided. The general characteristics of severe combined immunodeficiency are completely presented. A chapter is devoted to usage of immunoglobulin therapy. Another section focuses on the disorders of neutrophils, monocytes, and macrophages. The book can provide useful information to immunologists, pediatricians, doctors, students, and researchers.

  • Viral Immunology and Immunopathology

    • 1st Edition
    • Abner Louis Notkins
    • English
    Viral Immunology and Immunopathalogy covers topics concerning the role of cellular and humoral immunity in viral infections, factors responsible for the persistence and recurrence of viral infections in the presence of immunity, mechanisms of viral immunopathology, and concepts in the development of vaccines. The book describes the history of viral immunology; the synthesis and properties of viral antigens; and the humoral immune response to viruses. The text also discusses the mechanisms of viral neutralization; cellular immunity; the role of inflammatory cells and effector molecules in combating viral infections; and the genetic control of resistance. The book concludes with chapters on herd immunity; viral immunopathology; and viral immunology and immunopathology. Immunologists, pathologists, virologists, and microbiologists will find the book useful.

  • Interleukins in Cancer Biology

    Their Heterogeneous Role
    • 1st Edition
    • Arseniy Yuzhalin + 1 more
    • English
    Interleukins in Cancer Biology responds to the growing need for credible and up-to-date information about the impact of interleukins on occurrence, development and progression of cancer. It provides reliable information about all known interleukins (38), describes recent discoveries in the field, and moreover, suggests further directions of research on the most promising aspects of this topic. The structure and presentation of the work is very understandable and clear with attention to detail maintained throughout. There are multiple illustrations throughout to help in comprehending and remembering the most important facts. .

  • Introductory Immunology

    Basic Concepts for Interdisciplinary Applications
    • 1st Edition
    • Jeffrey K. Actor
    • English
    Introductory Immunology quickly acquaints readers with natural immune responses manifesting in diseases and disorders. The book presents a complete picture of natural defenses to infectious agents, as well as the mechanisms that lead to autoimmune dysfunction. In addition, it examines immunologically based diseases, giving the reader sufficient knowledge to make sound clinical decisions leading to better treatment outcomes. Introductory Immunology is aimed at researchers, postgraduates, or any scientifically inclined reader interested in immunology. No prior expertise in medical, biochemical, or cellular science is needed to benefit from the clear presentation of immunology concepts in this book.

  • Cellular and Molecular Immunology

    • 8th Edition
    • Abul K. Abbas + 2 more
    • English
    Popular for its highly visual, straightforward approach, Cellular and Molecular Immunology delivers an accessible yet thorough understanding of this active and fast-changing field. Drs. Abul K. Abbas, Andrew H. Lichtman, and Shiv Pillai present key updates in this new edition to cover the latest developments in antigen receptors and signal transduction in immune cells, mucosal and skin immunity, cytokines, leukocyte-endothelia... interaction, and more. With additional online features, this is an ideal resource for medical, graduate and undergraduate students of immunology who need a clear, introductory text for immunology courses.

  • A Text-Book of Bacteriology

    • 9th Edition
    • R. W. Fairbrother + 1 more
    • English
    Fairbrother's Textbook of Bacteriology, Tenth Edition provides an outline of the medical aspects of bacteriology. This book emphasizes the biological relationship of allied organisms. This edition begins with an overview of the various elements of the bacterial cell in detail, starting with external features such as flagella and capsules, and working inwards to the cytoplasm. This text then describes the principal toxic effects of the different groups of anti-bacterial substances. Other chapters consider the relationship of the different types of hypersensitivity to classical immune responses. This book discusses as well the earliest application of a specific chemical substance to the treatment of microbial disease. This book is a valuable resource for medical students. Bacteriologists, chemists, pathologists, and microbiologists will also find this book useful.

  • Current Advances in Immunology

    • 1st Edition
    • H. Smith
    • English
    Current Advances in Immunology presents the advances in immunology in an easy-to-use format. The book is split into 51 main areas that are further classified into sections. Where appropriate, cross-referencing to other sections is given. The text also provides a guide on how to use the book. Papers included in the book focus on a variety of topics ranging from immunoglobulins and antigens to interferons, lymphocytes, leukocytes, and macrophages as well as natural killer cells, Langerhans cells, dendritic cells, lymphoid tissue, and humoral mediators of immune responses and immunomodulators. Other papers discuss blood groups, transplantation, anti-bacterial immunity, chronic inflammation, delayed hypersensitivity, and contact sensitivity. Immunodeficiency, immune complexes, tumor immunity, immunopharmacology and immunotoxicology, and the link between nutrition and immunity are also explored. A section devoted to psychoneuroimmunolog... focuses on the effect of stress on graft-versus-host reaction; immunological response to stress in agoraphobia and panic attacks; and anti-beta-endorphin immunoglobulin G in humans. This book will be of interest to working scientists in the field of immunology.

  • Fairbrother's Textbook of Bacteriology

    • 10th Edition
    • R. L. Vollum + 2 more
    • English
    Fairbrother's Textbook of Bacteriology, Tenth Edition provides an outline of the medical aspects of bacteriology. This book emphasizes the biological relationship of allied organisms. Organized into three parts encompassing 38 chapters, this edition begins with an overview of the various elements of the bacterial cell in detail, starting with external features such as flagella and capsules, and working inwards to the cytoplasm. This text then describes the principal toxic effects of the different groups of anti-bacterial substances. Other chapters consider the relationship of the different types of hypersensitivity to classical immune responses. This book discusses as well the earliest application of a specific chemical substance to the treatment of microbial disease. The final chapter deals with the various methods used to determine the sensitivity of bacteria to the different sulphonamides. This book is a valuable resource for medical students. Bacteriologists, chemists, pathologists, and microbiologists will also find this book useful.

  • Immunology of the Liver

    Proceedings of an International Meeting Held at King's College Hospital Medical School London, on 6th and 7th July, 1970
    • 1st Edition
    • Martin Smith + 1 more
    • English
    Immunology of the Liver contains the proceedings of an International Meeting held at King's College Hospital Medical School in London on July 6-7, 1970. The meeting provided a forum for discussing progress made in understanding the immunology of the liver and tackled topics ranging from the pathology of chronic hepatitis to the occurrence and distribution of tissue antibodies in liver diseases. Cell-mediated responses and manifestations of immunological damage are also explored. Comprised of 33 chapters, this book begins with an introduction to the clinical, morphological, and virological aspects of liver disease. In particular, the clinical spectrum of autoimmune liver disease is considered, along with the pathology of chronic hepatitis. Morphological and immunological studies on chronic aggressive hepatitis and primary biliary cirrhosis are presented. Subsequent chapters focus on antibodies related to mitochondria; leukocyte migration in active chronic hepatitis and primary biliary cirrhosis; immunologic observations and electron microscopy of halothane-induced hepatic injury; and humoral and delayed hypersensitivity in chronic hepatitis. The final sections deal with results of immunosuppressive therapy and the immunology of liver transplantation. This monograph will be of interest to immunologists, pathologists, physiologists, clinicians, and research workers in the field of medicine.

  • Immunological Aspects of Reproduction in Mammals

    • 1st Edition
    • D. B. Crighton
    • English
    Immunological Aspects of Reproduction in Mammals contains papers presented during a symposium at the University of Nottingham Easter School. The scholarly presentations provide a wealth of information on the field of reproductive immunology and indicate just how complex this field is and how many questions still remain to be answered. The book begins with reviews of the current status of the complexities and uncertainties of the cellular basis of the immune response and the structure and function of antibodies. This is followed by separate chapters on the assessment and interpretation of the phenomena surrounding autoimmune and isoimmune reactions to spermatozoa; advances in defining the distribution and degree of exposure of major histocompatibility antigens; the reproductive immunology of the mouse, horse, and sheep; and fetal and neonatal immunity. Subsequent chapters present studies of immunization of several species with either the hypothalamic hormone LH-RH, pituitary gonadotrophins, or ovarian steroids; and studies directed towards efforts to enhance animal production by either active or passive immunization of female farm animals against steroid hormones. This book will be a valuable reference text for those already involved in the field and a stimulus for others to enter this complex and fascinating area of research.

  • General Immunology

    • 1st Edition
    • Edwin L. Cooper
    • English
    General Immunology provides a general overview of the immune system. It presents topics in immunology from all living groups, treating cells, tissues, organs, and organismal levels of biological organization. The book contains 23 chapters organized into eight sections. Section I serves as an introduction to immunology—a science, a sketch of its history, some of its more recent contributors, something about gathering facts, immunology journals, and the entire biomedical enterprise of which immunology is just a part. Section II is devoted to antigens while Section III examines the immune system in chordates and the ontogeny of the immune system. Section IV on cells of the immune system covers monocytes, macrophages, the three granulocytic types, and mast cells. Section V deals with phagocytosis and the interaction of lymphocytes. Section VI is devoted to antigens in relation to antibody synthesis, antigen-antibody interactions, immunologlobulin structure, and immunologlobulin assembly. Section VII on organs of the immune system examines bone marrow, thymus, spleen, lymph nodes, and lymphoid aggregations. Section VIII discusses the evolution of the immune system. This text was written for advanced undergraduates. However, its comprehensiveness makes it useful to immunologists and biologists at all levels as well as medical students and clinicians.

  • Immunopathology of Insulin

    Clinical and Experimental Studies
    • 1st Edition
    • K. Federlin
    • F. Gross + 2 more
    • English
    Monographs on Endocrinology, Volume 6: Immunopathology of Insulin provides information pertinent to the fundamental aspects of immunopathology of insulin. This book covers a variety of topics, including cell mediated immunity, biological effects of insulin, insulin allergy, insulin immunology, and humoral insulin antibodies. Organized into six chapters, this volume begins with an overview of the causal relationship between delayed hypersensitivity and antibody production. This text then explains the molecular localization of the most important immunologic components of the insulin molecule. Other chapters consider the clinical observation of allergic reactions of insulin antibodies in the tissue and the in vitro method of standard serology. This book discusses as well methods used for demonstration of insulin antibodies in humans and experimental animals. The final chapter deals with the investigations concerned with the various kinds of immune reactions, which follow the injection of insulin. This book is a valuable resource for endocrinologists, immunologists, and diabetologists.

  • A History of Medical Bacteriology and Immunology

    • 1st Edition
    • W. D. Foster
    • English
    A History of Medical Bacteriology and Immunology provides the account of the history of bacteriology from the year 1900 to 1938. This book presents details about the discovery of the important pathogenic bacteria of man, of how they were shown to be causally related to disease, and of the use of these discoveries in the diagnosis, treatment, and prevention of disease. Other topics discussed include the development of the germ theory of infectious diseases; contribution of Louis Pasteur and Robert Koch to medical bacteriology; and discovery of the more important human pathogenic bacteria. This text also discusses the scientific basis and practical application of immunology to medicine; main developments in bacteriology during the early 20th century; and chemotherapy of bacterial disease. This medically oriented text is beneficial for students and individuals conducting study on medical bacteriology and immunology.

  • Immunology

    • 1st Edition
    • Lars Å. Hanson + 1 more
    • English
    Immunology focuses on the study of immunology. The first half of this book provides a treatise of basic immunology, while the rest is more clinically orientated and illustrates the importance of immune mechanisms for health and disease. This text emphasizes the three good reasons why immunology should be studied. First is that man cannot survive without immunological defense against foreign material. Second is that these same immunological defense mechanisms can cause various forms of tissue damage that result in different diseases. Finally, some immunological reactions can be used as sensitive and highly specific methods for analytical and diagnostically useful determinations of low molecular substances. This publication is primarily intended for students of medicine and natural sciences, as well as clinicians concerned with the field of immunology.

Related subjects