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5-Membered Heterocycle Synthesis Using Iodine

  • 1st Edition
  • January 24, 2023
  • Navjeet Kaur
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 1 8 9 4 1 - 8
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 8 9 4 2 - 5
5-Membered Heterocycle Synthesis Using Iodine presents both old and new methods for the synthesis of various five-membered heterocycles using iodine, providing information for making specific compounds using particular reagents. Heterocyclic frameworks represent the main structural subunits of many biologically active compounds and natural products, and the ability of heterocycles to act both as reactive pharmacophores and biomimetics has greatly contributed to their unique value as traditional key elements of various drugs. Contemporary developments in process chemistry and discovery emphasize novel sustainable synthetic pathways as fast and ecologically acceptable alternatives to the traditional protocols.    This book serves as a guide for students, pharmacologists, biochemists, organic and medicinal chemists, researchers, and academic professionals to obtain easy access to synthetic protocols for different five-membered heterocycles using iodine. 

Progress in Heterocyclic Chemistry

  • 1st Edition
  • Volume 34
  • January 10, 2023
  • Gordon Gribble + 1 more
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 1 8 9 3 9 - 5
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 8 9 4 0 - 1
Progress in Heterocyclic Chemistry: Volume 34, the latest in this annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC), contains both highlights of the previous year’s literature on heterocyclic chemistry and articles on new developing topics of particular interest to heterocyclic chemists. Highlight chapters in Volume 34 are all written by leading researchers in their field, thus constituting a systematic survey of the important original material reported in the literature of heterocyclic chemistry in 2021. As with previous volumes in the series, Volume 34 will enable academic and industrial chemists and advanced students to keep abreast of developments in heterocyclic chemistry in a convenient way.

Synthesis of Azetidines from Imines by Cycloaddition Reactions

  • 1st Edition
  • January 10, 2023
  • Navjeet Kaur
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 1 9 2 0 4 - 3
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 9 2 0 5 - 0
Synthesis of Azetidines from Imines by Cycloaddition Reactions presents several methodologies for the synthesis of azetidines from imines by cycloaddition reactions.  The azetidines, known as important contribution of science to humanity, are important organic compounds that have occupied a basic position in the pharmaceutical chemistry for over a hundred years because of their biological activities. They are the fundamental skeleton of several antibiotics, probiotics and alkaloids. The synthesis of azetidines is a constant challenge for medicinal chemists, hence this book comprehensively describes azetidine ring synthesis. With this book, readers will be able to quickly assess possible synthetic approaches and evaluate whether preparation of a four-membered nitrogen containing ring is reasonable.

Special Volume in Memory of Hidetoshi Yamada Part 2

  • 1st Edition
  • Volume 82
  • December 2, 2022
  • David C. Baker
  • English
  • Hardback
    9 7 8 - 0 - 3 2 3 - 9 8 5 9 7 - 0
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 8 6 0 7 - 6
Special Volume in Memory of Hidetoshi Yamada, Part Two, Volume 82 in the Advances in Carbohydrate Chemistry and Biochemistry series, highlights new advances in the field with this new volume presenting interesting chapters written by an international board of authors. Updates in this new release include Automated and/or Electrochemical Synthesis, In Vivo Chemistry, Pseudo-Glycoconjugates with C-Glycoside linkage, Boron-Mediated Aglycon Delivery (BMAD) for the Stereoselective Synthesis of 1,2-cis Glycosides, and Conformationally Restricted Donors for Stereoselective Glycosylation.

Phytochemistry, Computational Tools, and Databases in Drug Discovery

  • 1st Edition
  • November 30, 2022
  • Chukwuebuka Egbuna + 2 more
  • English
  • Paperback
    9 7 8 - 0 - 3 2 3 - 9 0 5 9 3 - 0
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 0 7 1 6 - 3
Phytochemistry, Computational Tools and Databases in Drug Discovery presents the state-of-the-art in computational methods and techniques for drug discovery studies from medicinal plants. Various tools and databases for virtual screening and characterization of plant bioactive compounds and their subsequent predictions on biological targets for the discovery of new drugs against specific diseases are presented, along with computational tools for the prediction of the toxic effects of phytochemicals on living systems. The book also provides in-depth insight on the applications of these computational tools as well as the databases that describe the interactions of phytochemicals with diseases along with predictions for druggable bioactive compounds. Useful for drug developers, medicinal chemists, toxicologists, phytochemists, plant biochemists and analytical chemists, this book clearly presents the various computational techniques, tools and databases for phytochemical research.

Advances in Physical Organic Chemistry

  • 1st Edition
  • Volume 56
  • November 17, 2022
  • Nick Williams + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 3 2 3 - 9 8 5 9 1 - 8
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 8 6 0 1 - 4
Advances in Physical Organic Chemistry, Volume 56 presents the latest reviews of recent work in physical organic chemistry. The book provides a valuable source of information that is ideal not only for physical organic chemists applying their expertise to both novel and traditional problems, but also for non-specialists across diverse areas who identify a physical organic component in their approach to research. Chapters due to be included in this release cover flavin-dependent enzyme catalysed reactions, coacervates and their properties, heavy atom tunnelling, machine learning, acidity and substituent effects.

Virtual Screening and Drug Docking

  • 1st Edition
  • Volume 59
  • November 17, 2022
  • Julio Caballero
  • English
  • Hardback
    9 7 8 - 0 - 3 2 3 - 9 8 5 9 5 - 6
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 8 6 0 5 - 2
Virtual Screening and Drug Docking, Volume 59 in the Annual Reports on Medicinal Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Can docking scoring functions guarantee success in virtual screening?, No dance, no partner! A tale of flexibility in docking and virtual screening, Handling Imbalance Data in Virtual Screening, Rational computational approaches to predict novel drug candidates against leishmaniasis, Virtual screening against Mtb DNA gyrase: Applications and success stories, Using Filters in Virtual Screening: A Brief Guide to Minimize Errors and Maximize Efficiency, and more. Additional chapters in the new release include Machine Learning and Deep Learning Strategies for Virtual Screening, Applications of the Virtual Screening to find the novel HIV-1 therapeutic agents, and Large-scale screening of small molecules with docking strategies and its impact on drug discovery.

Special Volume in Memory of Hidetoshi Yamada Part 1

  • 1st Edition
  • Volume 81
  • November 16, 2022
  • David C. Baker
  • English
  • Hardback
    9 7 8 - 0 - 3 2 3 - 9 8 5 8 8 - 8
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 8 5 9 8 - 7
Special Volume in Memory of Hidetoshi Yamada, Volume 81, Part One, the latest release in the Advances in Carbohydrate Chemistry and Biochemistry series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Automated and/or Electrochemical Synthesis, Chemical synthesis of sialoglyco-architectures, In Vivo Chemistry, Pseudo-Glycoconjugates with C-Glycoside linkage, Glycoproteins, Boron-Mediated Aglycon Delivery (BMAD) for the Stereoselective Synthesis of 1,2-cis Glycosides, Conformationally Restricted Donors for Stereselective Glycosylation, Yamada’s carbohydrate chemistry, Bacterial Glycolipid Essential for Membrane Protein Integration, and Hidetoshi Yamada: his journey in the carbohydrate world.

Medicinal Chemistry of Tick-Borne Encephalitis

  • 1st Edition
  • Volume 58
  • October 25, 2022
  • Dmitry I Osolodkin
  • English
  • Hardback
    9 7 8 - 0 - 3 2 3 - 9 8 8 9 3 - 3
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 8 8 9 4 - 0
Medicinal Chemistry of Tick-Borne Encephalitis, Volume 58 in the Annual Reports in Medicinal Chemistry serial, highlights new advances in the field, with this new volume presenting interesting chapters on the Discovery of small molecule TBEV antivirals, Perylene as a controversial antiviral scaffold, Animal models of TBEV infection for preclinical studies of drugs and vaccines, Insights from experience in the treatment of tick-borne bacterial co-infections with tick-borne encephalitis, Small molecule-based inhibitors of flaviviral RNA-dependent RNA-polymerase: prospective candidates for treatment of tick-borne encephalitis virus infection, and Structural Biology and Proteomics of Tick-Borne Encephalitis Virus.

Plant Bioactives as Natural Panacea against Age-Induced Diseases

  • 1st Edition
  • October 17, 2022
  • Kanti Bhooshan Pandey + 1 more
  • English
  • Paperback
    9 7 8 - 0 - 3 2 3 - 9 0 5 8 1 - 7
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 1 3 2 9 - 4
Plant Bioactives as Natural Panacea Against Age-induced Diseases: Nutraceuticals and Functional Lead Compounds for Drug Development presents comprehensive information on the complications of aging and the bioactive phytochemicals that in specific herbal formulations, including beverages, can mitigate them. The book extensively describes the current information on the role of plant bioactive components in delaying or preventing the aging process and associated complications, while also covering different strategies and scientific evidence of possible synergistic effects of these studies, enabling the formulation of more effective natural drugs to intervene in aging and associated events. Chapters cover the broad areas of plant bioactive compounds in promoting healthy aging and longevity, including balancing glucose homeostasis, in cognitive impairments, age-related diseases, food trends and the anti-aging diet in Asia and other regions, as well as the social and economic impact of dietary patterns in aging interventions. Written by a team of global experts.

Related subjects

Bioorganic chemistry

Carbohydrate chemistry

Combinatorial chemistry

Heterocyclic chemistry

Medicinal chemistry

Natural products chemistry

Organic synthesis

Pharmaceutical chemistry

Physical organic chemistry

Phytochemistry

Stereochemistry