
Plant Bioactives as Natural Panacea against Age-Induced Diseases
Nutraceuticals and Functional Lead Compounds for Drug Development
- 1st Edition - October 17, 2022
- Imprint: Elsevier
- Editors: Kanti Bhooshan Pandey, Maitree Suttajit
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 0 5 8 1 - 7
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 1 3 2 9 - 4
Plant Bioactives as Natural Panacea Against Age-induced Diseases: Nutraceuticals and Functional Lead Compounds for Drug Development presents comprehensive information on the compl… Read more

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Request a sales quotePlant Bioactives as Natural Panacea Against Age-induced Diseases: Nutraceuticals and Functional Lead Compounds for Drug Development presents comprehensive information on the complications of aging and the bioactive phytochemicals that in specific herbal formulations, including beverages, can mitigate them. The book extensively describes the current information on the role of plant bioactive components in delaying or preventing the aging process and associated complications, while also covering different strategies and scientific evidence of possible synergistic effects of these studies, enabling the formulation of more effective natural drugs to intervene in aging and associated events.
Chapters cover the broad areas of plant bioactive compounds in promoting healthy aging and longevity, including balancing glucose homeostasis, in cognitive impairments, age-related diseases, food trends and the anti-aging diet in Asia and other regions, as well as the social and economic impact of dietary patterns in aging interventions. Written by a team of global experts.
- Describes plant bioactives for specific age disorders
- Focuses on the discovery of new herbal origin drugs and potential druggable targets for the treatment of chronic diseases of world importance
- Includes cutting-edge research information on cell senescence during aging and assesses the plant bioactive compounds
Drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists and analytical chemists
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Preface
- Chapter 1. Aging principles and interventional perspectives
- Abstract
- 1.1 The message of geroscience
- 1.2 Rejuvenation by diet
- 1.3 Antiaging molecules mimicking diet restrictions
- 1.4 Cellular senescence and senotherapy
- 1.5 More perspectives
- Acknowledgment
- References
- Chapter 2. Anti-aging strategies, plant bioactives, and drug development: current insights
- Abstract
- 2.1 Introduction
- 2.2 Aging theories and mechanisms
- 2.3 Antioxidants and antiinflammatory compounds: strategies for aging interventions
- 2.4 Bioactive compounds in medicinal herbs and their anti-aging properties
- 2.5 Plants rich in bioactives: strategic possibility to develop anti-aging drugs
- 2.6 Plant bioactives reported to protect against skin photoaging
- 2.7 Future trends
- 2.8 Conclusion
- References
- Chapter 3. Nutrigenomics, plant bioactives, and healthy aging
- Abstract
- 3.1 Introduction
- 3.2 The human genome project
- 3.3 Functional decline in aging
- 3.4 Plant bioactives and healthy aging
- 3.5 Mechanisms of action of plant bioactives in aging
- 3.6 Conclusion
- References
- Chapter 4. Plant bioactives in balancing glucose homeostasis during aging and related diseases
- Abstract
- 4.1 Introduction
- 4.2 Glucose homeostasis and the central nervous system
- 4.3 Natural polyphenols and glucose homeostasis
- 4.4 Bioactives in grape seeds and green tea
- 4.5 Epigenetic-mediated protective mechanisms of grape seed proanthocyanidin extract and green tea
- 4.6 Future prospective and conclusion
- Acknowledgements
- Conflict of interest
- References
- Chapter 5. Plant bioactives in immune modulation and their role in antiaging
- Abstract
- 5.1 Introduction
- 5.2 Immune changes with age
- 5.3 Immunosenescence
- 5.4 Inflammaging
- 5.5 Immune cell skewing
- 5.6 Declining youth factors
- 5.7 Plant bioactive molecules
- 5.8 Modulation of immune function by plant bioactive molecules and antiaging effects
- 5.9 Conclusion and future perspectives
- References
- Chapter 6. Plant bioactives, genes, and longevity
- Abstract
- 6.1 Introduction
- 6.2 Aging and process of aging
- 6.3 Longevity and process of longevity
- 6.4 Longevity genes influencing longevity in humans
- 6.5 Plant extracts and their bioactives in regulation of longevity genes
- 6.6 Plant bioactives and aging intervention
- 6.7 Conclusion
- Conflict of interest statement
- Funding
- References
- Chapter 7. Hormetic effects of plant bioactives on healthy aging and longevity
- Abstract
- 7.1 Introduction
- 7.2 Hormetic effects of plant bioactives
- 7.3 Future prospects
- 7.4 Conclusion
- 7.5 Acknowledgements
- References
- Chapter 8. Anti-aging effect of polyphenols: possibilities and challenges
- Abstract
- 8.1 Introduction
- 8.2 Chemistry and classification
- 8.3 Anti-aging properties of polyphenols and mechanisms
- 8.4 Future trends: possibilities and challenges
- 8.5 Conclusion
- References
- Chapter 9. Plant polyphenols in balancing the redox state during aging
- Abstract
- 9.1 Introduction
- 9.2 Redox imbalance, oxidative stress, and aging
- 9.3 Role of polyphenols in maintaining redox status
- 9.4 Role of polyphenols in age-related disorders due to redox imbalance
- 9.5 Future trends
- 9.6 Conclusion
- Acknowledgments
- Conflict of interest
- References
- Chapter 10. Mechanisms involved in prevention of dementia and promotion of healthy aging by resveratrol
- Abstract
- 10.1 Introduction
- 10.2 Aging and dementia
- 10.3 Resveratrol, French Paradox, aging, and dementia
- 10.4 Mechanisms involved in prevention of dementia by resveratrol
- 10.5 Clinical trials of resveratrol on neurodegenerative diseases
- 10.6 Future prospective and conclusion
- References
- Chapter 11. An insight into plant polyphenols in prevention of brain aging
- Abstract
- 11.1 Introduction
- 11.2 Phytochemicals as nutraceuticals for healthy brain aging
- 11.3 Conclusion and future perspectives
- Acknowledgments
- References
- Chapter 12. Plant polyphenols in the regulation of ion channels during aging and induced diseases
- Abstract
- 12.1 Introduction
- 12.2 Polyphenols
- 12.3 Aging process
- 12.4 The functions of ion channels
- 12.5 Potential mechanisms of polyphenols in the regulation of ion channels relevant to aging intervention
- 12.6 Conclusion and perspectives
- References
- Chapter 13. Tea catechins as potent antioxidant and anti-inflammatory agents: possibilities of drug development to promote healthy aging
- Abstract
- 13.1 Introduction
- 13.2 Structure and sources of tea catechins
- 13.3 Tea catechins and anti-aging effects: mechanisms of action
- 13.4 Antioxidative and anti-inflammatory properties of tea catechins in preventing aging and age-related diseases
- 13.5 Future trends and conclusion
- References
- Chapter 14. Functional foods, bioactives, and cognitive impairments during aging
- Abstract
- 14.1 Introduction
- 14.2 Cellular biomolecules, oxidative stress, aging, and cognitive dysfunction
- 14.3 Functional foods
- 14.4 Bioactives from functional foods, cognitive impairments, and aging
- 14.5 Dietary polyphenols, cognitive impairments, and aging
- 14.6 Vitamins in cognitive impairments during aging
- 14.7 Other bioactives in functional foods during aging
- 14.8 Conclusion and future remarks
- References
- Chapter 15. Functional foods in improving bone health during aging
- Abstract
- 15.1 Introduction: common bone and joint changes during aging
- 15.2 Bones and their associated components
- 15.3 Nutrition for bone and joint health
- 15.4 Childhood and adolescence: the age to starting strong bone health
- 15.5 Age-related bone and joint degeneration in aging people
- 15.6 Future prospects
- 15.7 Conclusion
- References
- Chapter 16. Dietary restriction, vegetarian diet, and aging intervention
- Abstract
- 16.1 Introduction
- 16.2 Calories, balanced energy, overweight, and obesity
- 16.3 Dietary restriction, calorie restriction, and intermittent fasting
- 16.4 The role and new insights of vegetarian and vegan diets
- 16.5 Future trends
- 16.6 Conclusion
- References
- Chapter 17. Plant bioactives as promising therapeutic agents in Parkinson’s disease targeting oxidative stress during aging
- Abstract
- 17.1 Introduction
- 17.2 Aging: an important contributory factor for Parkinson’s disease
- 17.3 Treatment strategies for Parkinson’s disease
- 17.4 Flavonoids: promising anti-Parkinson’s disease compounds
- 17.5 Conclusion and future prospective
- Conflict of interest
- Funding
- References
- Chapter 18. Novel plant bioactives, their antiaging potencies: reality and promises
- Abstract
- 18.1 Introduction
- 18.2 The hallmarks of aging
- 18.3 Plant bioactives and their classification
- 18.4 Novel bioactive compounds as antiaging agents
- 18.5 Promising antiaging bioactives that have made it to human clinical trials
- 18.6 Plant bioactives as antiaging/geroprotective nutraceuticals: reality and challenges and future perspectives
- 18.7 Conclusion
- References
- Chapter 19. Uses of nanotechnology in refining the anti-aging activities of plant bioactives
- Abstract
- 19.1 Introduction
- 19.2 Nanotechnology in the therapeutic applications
- 19.3 Nano-delivery systems
- 19.4 Nanotechnology and plant bioactives: promise in anti-aging research
- 19.5 Nanotechnology in refining the effect of bioactives used in skin care
- 19.6 Conclusion and future outlook
- References
- Chapter 20. Trends in the plant-based anti-aging diet in different continents of the world
- Abstract
- 20.1 Introduction
- 20.2 Importance of plant-based diets in healthy aging
- 20.3 Active phytochemicals versus whole plant-based diets
- 20.4 The reduced risk of obesity and others chronic diseases during aging by adoption of plant-based dietary pattern
- 20.5 Plant-based diets as prebiotics promoting probiotics
- 20.6 The world’s aging populations versus plant-based different dietary patterns
- 20.7 The strategies of plant-based diets and healthy aging establishment globally
- 20.8 Trending dietary patterns and effectiveness of plant-based diets as anti-aging diets
- 20.9 Limitations
- 20.10 Future perspectives
- 20.11 Conclusion
- References
- Chapter 21. Functional foods in clinical trials in aging intervention
- Abstract
- 21.1 Introduction
- 21.2 Oxidative stress in aging
- 21.3 Impact of functional foods in the management of age-related diseases
- 21.4 Future prospects
- 21.5 Conclusion
- References
- Chapter 22. Plant bioactives, aging research, and drug industry: procedures and challenges
- Abstract
- 22.1 Introduction
- 22.2 Aging research and interventional properties of plant bioactives
- 22.3 Challenges in drug discovery and development of a platform for plant bioactives
- 22.4 Conclusion and future perspective
- References
- Index
- Edition: 1
- Published: October 17, 2022
- Imprint: Elsevier
- No. of pages: 498
- Language: English
- Paperback ISBN: 9780323905817
- eBook ISBN: 9780323913294
KP
Kanti Bhooshan Pandey
MS