Plant Bioactives as Natural Panacea against Age-Induced Diseases

Nutraceuticals and Functional Lead Compounds for Drug Development

1st Edition - October 17, 2022
Imprint: Elsevier
Editors: Kanti Bhooshan Pandey, Maitree Suttajit
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 0 5 8 1 - 7
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 3 2 9 - 4

Plant Bioactives as Natural Panacea Against Age-induced Diseases: Nutraceuticals and Functional Lead Compounds for Drug Development presents comprehensive information on the compl… Read more

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Plant Bioactives as Natural Panacea Against Age-induced Diseases: Nutraceuticals and Functional Lead Compounds for Drug Development presents comprehensive information on the complications of aging and the bioactive phytochemicals that in specific herbal formulations, including beverages, can mitigate them. The book extensively describes the current information on the role of plant bioactive components in delaying or preventing the aging process and associated complications, while also covering different strategies and scientific evidence of possible synergistic effects of these studies, enabling the formulation of more effective natural drugs to intervene in aging and associated events.

Chapters cover the broad areas of plant bioactive compounds in promoting healthy aging and longevity, including balancing glucose homeostasis, in cognitive impairments, age-related diseases, food trends and the anti-aging diet in Asia and other regions, as well as the social and economic impact of dietary patterns in aging interventions. Written by a team of global experts.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Preface
Chapter 1. Aging principles and interventional perspectives
Abstract
1.1 The message of geroscience
1.2 Rejuvenation by diet
1.3 Antiaging molecules mimicking diet restrictions
1.4 Cellular senescence and senotherapy
1.5 More perspectives
Acknowledgment
References
Chapter 2. Anti-aging strategies, plant bioactives, and drug development: current insights
Abstract
2.1 Introduction
2.2 Aging theories and mechanisms
2.3 Antioxidants and antiinflammatory compounds: strategies for aging interventions
2.4 Bioactive compounds in medicinal herbs and their anti-aging properties
2.5 Plants rich in bioactives: strategic possibility to develop anti-aging drugs
2.6 Plant bioactives reported to protect against skin photoaging
2.7 Future trends
2.8 Conclusion
References
Chapter 3. Nutrigenomics, plant bioactives, and healthy aging
Abstract
3.1 Introduction
3.2 The human genome project
3.3 Functional decline in aging
3.4 Plant bioactives and healthy aging
3.5 Mechanisms of action of plant bioactives in aging
3.6 Conclusion
References
Chapter 4. Plant bioactives in balancing glucose homeostasis during aging and related diseases
Abstract
4.1 Introduction
4.2 Glucose homeostasis and the central nervous system
4.3 Natural polyphenols and glucose homeostasis
4.4 Bioactives in grape seeds and green tea
4.5 Epigenetic-mediated protective mechanisms of grape seed proanthocyanidin extract and green tea
4.6 Future prospective and conclusion
Acknowledgements
Conflict of interest
References
Chapter 5. Plant bioactives in immune modulation and their role in antiaging
Abstract
5.1 Introduction
5.2 Immune changes with age
5.3 Immunosenescence
5.4 Inflammaging
5.5 Immune cell skewing
5.6 Declining youth factors
5.7 Plant bioactive molecules
5.8 Modulation of immune function by plant bioactive molecules and antiaging effects
5.9 Conclusion and future perspectives
References
Chapter 6. Plant bioactives, genes, and longevity
Abstract
6.1 Introduction
6.2 Aging and process of aging
6.3 Longevity and process of longevity
6.4 Longevity genes influencing longevity in humans
6.5 Plant extracts and their bioactives in regulation of longevity genes
6.6 Plant bioactives and aging intervention
6.7 Conclusion
Conflict of interest statement
Funding
References
Chapter 7. Hormetic effects of plant bioactives on healthy aging and longevity
Abstract
7.1 Introduction
7.2 Hormetic effects of plant bioactives
7.3 Future prospects
7.4 Conclusion
7.5 Acknowledgements
References
Chapter 8. Anti-aging effect of polyphenols: possibilities and challenges
Abstract
8.1 Introduction
8.2 Chemistry and classification
8.3 Anti-aging properties of polyphenols and mechanisms
8.4 Future trends: possibilities and challenges
8.5 Conclusion
References
Chapter 9. Plant polyphenols in balancing the redox state during aging
Abstract
9.1 Introduction
9.2 Redox imbalance, oxidative stress, and aging
9.3 Role of polyphenols in maintaining redox status
9.4 Role of polyphenols in age-related disorders due to redox imbalance
9.5 Future trends
9.6 Conclusion
Acknowledgments
Conflict of interest
References
Chapter 10. Mechanisms involved in prevention of dementia and promotion of healthy aging by resveratrol
Abstract
10.1 Introduction
10.2 Aging and dementia
10.3 Resveratrol, French Paradox, aging, and dementia
10.4 Mechanisms involved in prevention of dementia by resveratrol
10.5 Clinical trials of resveratrol on neurodegenerative diseases
10.6 Future prospective and conclusion
References
Chapter 11. An insight into plant polyphenols in prevention of brain aging
Abstract
11.1 Introduction
11.2 Phytochemicals as nutraceuticals for healthy brain aging
11.3 Conclusion and future perspectives
Acknowledgments
References
Chapter 12. Plant polyphenols in the regulation of ion channels during aging and induced diseases
Abstract
12.1 Introduction
12.2 Polyphenols
12.3 Aging process
12.4 The functions of ion channels
12.5 Potential mechanisms of polyphenols in the regulation of ion channels relevant to aging intervention
12.6 Conclusion and perspectives
References
Chapter 13. Tea catechins as potent antioxidant and anti-inflammatory agents: possibilities of drug development to promote healthy aging
Abstract
13.1 Introduction
13.2 Structure and sources of tea catechins
13.3 Tea catechins and anti-aging effects: mechanisms of action
13.4 Antioxidative and anti-inflammatory properties of tea catechins in preventing aging and age-related diseases
13.5 Future trends and conclusion
References
Chapter 14. Functional foods, bioactives, and cognitive impairments during aging
Abstract
14.1 Introduction
14.2 Cellular biomolecules, oxidative stress, aging, and cognitive dysfunction
14.3 Functional foods
14.4 Bioactives from functional foods, cognitive impairments, and aging
14.5 Dietary polyphenols, cognitive impairments, and aging
14.6 Vitamins in cognitive impairments during aging
14.7 Other bioactives in functional foods during aging
14.8 Conclusion and future remarks
References
Chapter 15. Functional foods in improving bone health during aging
Abstract
15.1 Introduction: common bone and joint changes during aging
15.2 Bones and their associated components
15.3 Nutrition for bone and joint health
15.4 Childhood and adolescence: the age to starting strong bone health
15.5 Age-related bone and joint degeneration in aging people
15.6 Future prospects
15.7 Conclusion
References
Chapter 16. Dietary restriction, vegetarian diet, and aging intervention
Abstract
16.1 Introduction
16.2 Calories, balanced energy, overweight, and obesity
16.3 Dietary restriction, calorie restriction, and intermittent fasting
16.4 The role and new insights of vegetarian and vegan diets
16.5 Future trends
16.6 Conclusion
References
Chapter 17. Plant bioactives as promising therapeutic agents in Parkinson’s disease targeting oxidative stress during aging
Abstract
17.1 Introduction
17.2 Aging: an important contributory factor for Parkinson’s disease
17.3 Treatment strategies for Parkinson’s disease
17.4 Flavonoids: promising anti-Parkinson’s disease compounds
17.5 Conclusion and future prospective
Conflict of interest
Funding
References
Chapter 18. Novel plant bioactives, their antiaging potencies: reality and promises
Abstract
18.1 Introduction
18.2 The hallmarks of aging
18.3 Plant bioactives and their classification
18.4 Novel bioactive compounds as antiaging agents
18.5 Promising antiaging bioactives that have made it to human clinical trials
18.6 Plant bioactives as antiaging/geroprotective nutraceuticals: reality and challenges and future perspectives
18.7 Conclusion
References
Chapter 19. Uses of nanotechnology in refining the anti-aging activities of plant bioactives
Abstract
19.1 Introduction
19.2 Nanotechnology in the therapeutic applications
19.3 Nano-delivery systems
19.4 Nanotechnology and plant bioactives: promise in anti-aging research
19.5 Nanotechnology in refining the effect of bioactives used in skin care
19.6 Conclusion and future outlook
References
Chapter 20. Trends in the plant-based anti-aging diet in different continents of the world
Abstract
20.1 Introduction
20.2 Importance of plant-based diets in healthy aging
20.3 Active phytochemicals versus whole plant-based diets
20.4 The reduced risk of obesity and others chronic diseases during aging by adoption of plant-based dietary pattern
20.5 Plant-based diets as prebiotics promoting probiotics
20.6 The world’s aging populations versus plant-based different dietary patterns
20.7 The strategies of plant-based diets and healthy aging establishment globally
20.8 Trending dietary patterns and effectiveness of plant-based diets as anti-aging diets
20.9 Limitations
20.10 Future perspectives
20.11 Conclusion
References
Chapter 21. Functional foods in clinical trials in aging intervention
Abstract
21.1 Introduction
21.2 Oxidative stress in aging
21.3 Impact of functional foods in the management of age-related diseases
21.4 Future prospects
21.5 Conclusion
References
Chapter 22. Plant bioactives, aging research, and drug industry: procedures and challenges
Abstract
22.1 Introduction
22.2 Aging research and interventional properties of plant bioactives
22.3 Challenges in drug discovery and development of a platform for plant bioactives
22.4 Conclusion and future perspective
References
Index

Kanti Bhooshan Pandey

Dr. Kanti Bhooshan Pandey is a Senior Scientist and Assistant Professor in the Faculty of Biological Sciences, AcSIR; CSIR-Central Salt and Marine Chemicals Research Institute, Gujarat, India. He is doctorate in Biochemistry. His research expertise includes clinical biochemistry, food biochemistry, molecular cell biology, and Gerontology. He has done significant work on investigation of molecular mechanisms of action of plant-derived polyphenols, a major constituent in food and vital in nutrition point of view. He is working to investigate human aging impairments at molecular level including cellular signaling. He has designed a new protocol in cell biology and investigated a novel mechanism of action of bioactive compounds involved in cellular homeostasis and ascorbate recycling. His findings have found commercial applications. Dr. Pandey is the recipient of many national and international fellowships and has been authored more than 57 research papers and book chapters. He is in the editorial/advisory board of many reputed international journals.

Affiliations and expertise

AcSIR; CSIR-Central Salt and Marine Chemicals Research Institute, Bhavnagar, India

Maitree Suttajit

Dr. Maitree Suttajit is Professor Emeritus previously at School of Medicine, Chiangmai University and later at School of Medical Sciences, University of Phayao, Thailand. He was Dean of this School between 2010-2015 and currently acts as a Research Advisor. He got his Ph.D from SUNY/Buffalo, USA in 1971. His active research has been on functional foods, and phytochemicals such as pigmented rice, perilla (Nga-mon), omega fatty acids, flavonoids, anthocyanidins, rosmarinic acid as well as antioxidants and anti-inflammation and antiaging activities. He has published more than 100 research papers and many book chapters with reputed international publishers. He was the Chairman organizing the first international conference on Innovation of Functional Foods in Asia (IFFA2018), Phayao, Thailand which was reported as "The innovation of functional foods in Asia: IFFA 2018", Asia Pacific J. Clin. Nutri. Sept.2019, 28(2):419-426. Dr. Maitree is in the editorial/review /coordinating/committee of many international journals.

Affiliations and expertise

Maitree Suttajit, Phayao Province Thailand

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health