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Discovery and Development of Anti-Breast Cancer Agents from Natural Products

  • 1st Edition
  • June 24, 2021
  • Goutam Brahmachari
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 2 1 2 7 7 - 6
  • eBook
    9 7 8 - 0 - 1 2 - 8 2 1 2 7 8 - 3
Discovery and Development of Anti-Breast Cancer Agents from Natural Products presents cutting-edge research advances in the field of bioactive natural products and natural drug formulations. This volume in the Natural Products Drug Discovery series focuses on molecules of natural origin and their synthetic analogs that show promising potential to act as anti-breast cancer and chemotherapeutic agents. Combining foundational background information on cancer mechanisms with details of medicinal structures from natural products, this volume compiles the latest developments from across interdisciplinary fields.Discovery and Development of Anti-Breast Cancer Agents from Natural Products will serve as a valuable resource for researchers working to discover promising leads for the development of novel pharmaceuticals for breast cancer, highlighting a number of key structures from natural products and exploring possible future developments in the area.

Recent Applications of Selected Name Reactions in the Total Synthesis of Alkaloids

  • 1st Edition
  • June 12, 2021
  • Majid M. Heravi + 1 more
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 2 4 0 2 1 - 2
  • eBook
    9 7 8 - 0 - 1 2 - 8 2 4 2 5 8 - 2
Recent Applications of Selected Name Reactions in the Total Synthesis of Alkaloids includes comprehensive coverage of name reactions in the synthesis of alkaloids. This book highlights the synthesis of various alkaloids using special name reactions including the Diels-Alder, Friedel-Crafts, Heck, Mannich, Pauson-Khand, Pictet-Spengler, Sonogashira and Suzuki reactions. In this book, some selected name reactions in the total synthesis of alkaloids are covered, as they can be used as the key step/steps in the synthesis of different alkaloids exhibiting various biological activities. All chapters include an introduction, history and mechanism of the name reaction, and present the origin of the natural product and its known biological activities. The pathway to total synthesis is visually illustrated, and the focus is on the step in which a name reaction is applied. Chemists working in the area of synthetic organic chemistry will find this reference useful, as well as those working to develop novel methodologies for the synthesis of natural products in both academia and industry. This book is also beneficial to biologists, pharmacists and botanists.

Advances in Heterocyclic Chemistry

  • 1st Edition
  • Volume 135
  • June 12, 2021
  • Eric F.V. Scriven + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 8 2 4 6 1 9 - 1
  • eBook
    9 7 8 - 0 - 3 2 3 - 8 5 1 0 3 - 9
Advances in Heterocyclic Chemistry is the definitive series in the field - one of great importance to organic chemists, polymer chemists, and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature also is being used more frequently in explanations. Written by established authorities in the field from around the world, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds.

Applications of Heterocycles in the Design of Drugs and Agricultural Products

  • 1st Edition
  • Volume 134
  • June 9, 2021
  • Nicholas A. Meanwell + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 8 2 0 1 8 1 - 7
  • eBook
    9 7 8 - 0 - 1 2 - 8 2 0 1 8 2 - 4
Applications of Heterocycles in the Design of Drugs and Agricultural Products, Volume 134 in the Advances in Heterocyclic Chemistry series represents the most definitive series in the field - one of great importance to organic chemists, polymer chemists, and many biological scientists. Chapters in this updated volume cover Hydroxy azoles as carboxylic acid bioisosteres, Cyclic sulfoxides and sulfones in drug design, Thiazoles and topological control in drug design, Applications of fused pyrrolidine [3.3.0] heterocycles in drug design, 1,4 Disubstituted and 1,4,5 trisubstituted-1,2,3-triazoles in drug discovery and development: from the flask to the clinic, and Conformationally restricted [3.2.2]- and [3.2.1]-3-azabicyclic diamines. Because biology and organic chemistry increasingly intersect, the associated nomenclature is being used more frequently in explanations. Written by established authorities in the field from around the world, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds.

Stereochemistry and Organic Reactions

  • 1st Edition
  • April 21, 2021
  • Dipak Kumar Mandal
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 2 4 0 9 2 - 2
  • eBook
    9 7 8 - 0 - 1 2 - 8 2 4 0 9 3 - 9
Stereochemistry and Organic Reactions: Conformation, Configuration, Stereoelectronic Effects and Asymmetric Synthesis provides coverage on the stereochemistry of reactions of all mechanistic types, ranging from ionic, pericyclic and transition metal-catalyzed to radical and photochemical. Chapters cover acyclic molecules, cyclic molecules, the stereochemistry of organic reactions, the perturbation molecular orbital theory for the origin of stereoelectronic effects, and an introduction to the principles of stereoselectivity and hierarchical levels of asymmetric synthesis. Each chapter includes problems that reinforce main themes, making it valuable to students, teachers and researchers working in organic, biological and medicinal chemistry, as well as biologists, pharmacologists, polymer chemists and chemists.

Studies in Natural Products Chemistry

  • 1st Edition
  • Volume 69
  • April 16, 2021
  • Atta-ur Rahman
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 8 1 9 4 8 7 - 4
  • eBook
    9 7 8 - 0 - 3 2 3 - 8 9 8 1 5 - 7
Studies in Natural Products Chemistry, Volume 69 covers the synthesis, testing and recording of the medicinal properties of natural products, providing cutting-edge accounts of fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes. With rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to rapidly isolate and determine the structures and biological activity of natural products, thus opening up opportunities in drug development.

Basic Principles of Drug Discovery and Development

  • 2nd Edition
  • March 30, 2021
  • Benjamin E. Blass
  • English
  • Paperback
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  • eBook
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Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics. Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator’s fields. This book bridges the knowledge gaps that invariably lead to communication issues in a new scientist’s early career, providing a fundamental understanding of the various techniques and disciplines required for the multifaceted endeavor of drug research and development. It provides students, new industrial scientists, and academics with a basic understanding of the drug discovery and development process. The fully updated text provides an excellent overview of the process and includes chapters on important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles of in vivo pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process.

Phytochemistry, the Military and Health

  • 1st Edition
  • March 2, 2021
  • Andrew G. Mtewa + 1 more
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 2 1 5 5 6 - 2
  • eBook
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Phytochemistry, the Military and Health: Phytotoxins and Natural Defenses comes as a response to the gap that there has for so long existed between phytochemistry and survival of both service personnel and civilian communities during and after conflicts. Armed conflicts cause a lot of devastation to communities and should be avoided as much as it can be possible. The devastation is usually evident in service provisions such as Health, Education, Water, and Food among many others. Both service personnel and civilians are affected to various degrees. Facilities usually end up being physically destroyed, with no essential supplies and/or having dysfunctional systems. Going with untreated wounds, communicable and non-communicable diseases for weeks with no medical interventions due to the conflicts, disease burdens heavily weigh down on communities as well as security personnel. To make the situation even more complicated, masses of people are forced to migrate for safety and security reasons, likely going with diseases along wherever they go. In such instances, phytochemicals become handy in providing solutions from first aid, basic analgesia, antimicrobials, and the general improvement of health. Phytochemicals are known to play a major role in the day to day management of diseases and health. There has been much research into their effectiveness as community medicines and as alternatives to conventional drugs. However, the role that phytochemicals play in the military, counterterrorism, and security has been overlooked. Phytochemistry, the Military and Health: Phytotoxins and Natural Defenses discusses the roles that phytochemicals play as friends and foes in the military, including insights aimed to help develop antidotes against phytochemicals and other chemical agents used maliciously as weapons. Filling a gap between drug discovery, security, and emergency medicine, this book describes which plants can be categorized for protection and controls, which can be helpful in times of conflicts and soon after conflicts, in military operations, and those that can be used as deterrents and as emergency medicines. Carefully designed to show the contribution that phytochemicals play in safety and security, this book is useful for researchers, regulators and anyone interested in plant chemistry.

Green Synthetic Approaches for Biologically Relevant Heterocycles

  • 2nd Edition
  • February 26, 2021
  • Goutam Brahmachari
  • English
  • Paperback
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  • eBook
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Green Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, Volume One: Advanced Synthetic Techniques reviews this significant group of organic compounds within the context of sustainable methods and processes, expanding on the first edition with fully updated coverage and a whole range of new chapters. Volume One explores advanced synthetic techniques, with each chapter presenting in-depth coverage of various green protocols for the synthesis of a wide variety of bioactive heterocycles that are classified on the basis of ring-size and/or the presence of heteroatoms. Techniques covered range from high pressure cycloaddition reactions and microwave irradiation to sustainable one-pot domino reactions. This updated edition is an essential resource on sustainable approaches for academic researchers, R&D professionals, and students working across medicinal, organic, natural product and green chemistry.

Green Synthetic Approaches for Biologically Relevant Heterocycles

  • 2nd Edition
  • February 26, 2021
  • Goutam Brahmachari
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 2 0 7 9 2 - 5
  • eBook
    9 7 8 - 0 - 3 2 3 - 8 5 1 3 3 - 6
Green Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, Volume Two: Green Catalytic Systems and Solvents reviews this significant group of organic compounds within the context of sustainable methods and processes, expanding on the first edition with fully updated coverage and a whole range of new chapters. Volume Two explores green catalytic systems and solvents and the techniques surrounding this approach, including metal and magnetic catalysis to organocatalysis and solid acid catalysis, cycloaddition reactions, and varied approaches using ionic liquids. This updated edition is an essential resource on sustainable approaches for academic researchers, R&D professionals, and students working across medicinal, organic, natural product and green chemistry.

Related subjects

Bioorganic chemistry

Carbohydrate chemistry

Combinatorial chemistry

Heterocyclic chemistry

Medicinal chemistry

Natural products chemistry

Organic synthesis

Pharmaceutical chemistry

Physical organic chemistry

Phytochemistry

Stereochemistry