
Green Synthetic Approaches for Biologically Relevant Heterocycles
Volume 1: Advanced Synthetic Techniques
- 2nd Edition - February 26, 2021
- Imprint: Elsevier
- Editor: Goutam Brahmachari
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 0 5 8 6 - 0
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 5 1 3 0 - 5
Green Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, Volume One: Advanced Synthetic Techniques reviews this significant group of organic compounds… Read more

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Request a sales quoteGreen Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, Volume One: Advanced Synthetic Techniques reviews this significant group of organic compounds within the context of sustainable methods and processes, expanding on the first edition with fully updated coverage and a whole range of new chapters. Volume One explores advanced synthetic techniques, with each chapter presenting in-depth coverage of various green protocols for the synthesis of a wide variety of bioactive heterocycles that are classified on the basis of ring-size and/or the presence of heteroatoms. Techniques covered range from high pressure cycloaddition reactions and microwave irradiation to sustainable one-pot domino reactions.
This updated edition is an essential resource on sustainable approaches for academic researchers, R&D professionals, and students working across medicinal, organic, natural product and green chemistry.
- Provides fully updated coverage of the field of greener heterocycle synthesis
- Includes new chapters on varied multicomponent reactions, alongside both traditional and novel approaches
- Presents information in an accessible style with an emphasis on sustainability
Organic, Natural Product, Synthetic and Green Chemists across both academia and industry
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- List of contributors
- Editor
- Foreword
- Preface
- Chapter 1. Green synthetic approaches for biologically relevant heterocycles: advanced synthetic techniques—an overview
- Abstract
- 1.1 Introduction
- 1.2 An overview of the book
- 1.3 Concluding remarks
- Chapter 2. High-pressure cycloaddition reactions in the synthesis of biologically relevant heterocycles
- Abstract
- 2.1 Introduction
- 2.2 Diels-Alder cycloadditions
- 2.3 Dipolar cycloadditions
- 2.4 [2+2]-Cycloadditions
- 2.5 Concluding Remarks
- Abbreviations
- References
- Chapter 3. Microwave-assisted synthesis of medicinally privileged heterocycles
- Abstract
- 3.1 Introduction
- 3.2 Microwave irradiation: mechanism
- 3.3 Microwave-induced synthesis of heterocycles of medicinal interests
- 3.4 Concluding remarks
- Acknowledgments
- Abbreviations
- References
- Chapter 4. Application of microwave irradiation in the synthesis of P-heterocycles
- Abstract
- 4.1 Introduction
- 4.2 Functionalization of cyclic phosphinic acids
- 4.3 Diels–Alder cycloadditions, fragmentation-related phosphorylations, and inverse Wittig-type reactions
- 4.4 Phospha-Michael reactions
- 4.5 Kabachnik–Fields reactions
- 4.6 The deoxygenation of 2,5-dihydro-1H-phosphole 1-oxides
- 4.7 Synthesis and reactions of new 7-phosphanorbornene derivatives
- 4.8 Concluding remarks
- Acknowledgments
- References
- Chapter 5. Microwave-assisted multicomponent reactions as a green synthetic approach to heterocycles: special reference to Hantzsch, Biginelli, and Groebke–Blackburn–Bienayme reactions
- Abstract
- 5.1 Introduction
- 5.2 Hantzsch reaction
- 5.3 Biginelli reaction
- 5.4 Groebke–Blackburn–Bienayme reaction
- 5.5 Concluding remarks
- References
- Chapter 6. Use of ball milling for the synthesis of biologically active heterocycles
- Abstract
- 6.1 Introduction
- 6.2 Synthesis of heterocycles
- 6.3 General green aspects of mechanochemical reaction
- 6.4 Concluding remarks
- Acknowledgments
- References
- Chapter 7. Recent advances in photocatalytic Minisci reaction: an eco-friendly functionalization of biologically relevant heteroarenes
- Abstract
- 7.1 Introduction
- 7.2 Minisci reaction: a synthetic tool for bioactive molecules
- 7.3 Minisci reaction: the TiO2-mediated photocatalytic approach
- 7.4 Minisci reaction: recent advances in the photocatalytic approach
- 7.5 Concluding remarks
- References
- Chapter 8. Recent advances for construction and late-stage diversification of indole core via C–H bond activation/functionalization
- Abstract
- 8.1 Introduction
- 8.2 Methods for the synthesis of indoles
- 8.3 C–H bond activation
- 8.4 C–H bond activation approaches for synthesis of functionalized indole framework
- 8.5 Late-stage diversification of indole system (C–H activation of preformed indole framework)
- 8.6 C–H bond functionalization of indole at C6 position
- 8.7 Concluding remarks
- References
- Chapter 9. Cycloaddition reactions in ionic liquids for the synthesis of biologically relevant heterocycles
- Abstract
- 9.1 Introduction
- 9.2 The hetero-cycloaddition reactions in ionic liquids
- 9.3 Concluding remarks
- Acknowledgments
- References
- Chapter 10. Advances in greener processes for triazole synthesis via azide-alkyne cycloaddition reactions
- Abstract
- 10.1 Introduction
- 10.2 Methods of synthesis of triazoles using greener processes
- 10.3 Concluding remarks
- References
- Chapter 11. Employing arynes in transition-metal-free synthesis of benzo-fused five and six-membered heterocycles: an update
- Abstract
- 11.1 Introduction
- 11.2 Synthesis of five-membered heterocycles
- 11.3 Synthesis of six-membered heterocycles
- 11.4 Selected examples for the synthesis of medium-sized heterocycles
- 11.5 Concluding remarks
- References
- Chapter 12. Multicomponent approach for the sustainable synthesis of lawsone-based heterocycles
- Abstract
- 12.1 Introduction
- 12.2 Synthesis of lawsone-based heterocycles via multicomponent approach
- 12.3 Concluding remarks
- References
- Chapter 13. Synthesis of biologically relevant heterocyclic skeletons under solvent-free condition
- Abstract
- 13.1 Introduction
- 13.2 Synthesis of nitrogen-containing heterocycles
- 13.3 Synthesis of biologically relevant oxygen heterocycles
- 13.4 Syntheses of heterocycles with two different heteroatoms
- 13.5 Synthesis of larger ring size heterocycles
- 13.6 Concluding remarks
- Acknowledgment
- References
- Chapter 14. Ultrasound-promoted metal-catalyzed synthesis of heterocyclic compounds of medicinal interest
- Abstract
- 14.1 Introduction
- 14.2 Ultrasound-promoted metal-catalyzed synthesis of heterocycles of medicinal interest
- 14.3 Concluding remarks
- References
- Chapter 15. Ultrasonication under catalyst-free condition: an advanced synthetic technique toward the green synthesis of bioactive heterocycles
- Abstract
- 15.1 Introduction
- 15.2 Ultrasound wave-assisted catalyst-free multicomponent synthesis of N-/O-heterocycles
- 15.3 Concluding remarks
- References
- Chapter 16. Self-catalytic techniques for the synthesis of biologically relevant heterocyclic scaffolds at room temperature: a recent update
- Abstract
- 16.1 Introduction
- 16.2 Self-catalytic synthetic endeavors for biologically relevant heterocyclic scaffolds without the aid of any catalysts
- 16.3 Concluding remarks
- Acknowledgment
- References
- Index
- Edition: 2
- Published: February 26, 2021
- Imprint: Elsevier
- No. of pages: 646
- Language: English
- Paperback ISBN: 9780128205860
- eBook ISBN: 9780323851305
GB
Goutam Brahmachari
Born on April 14, 1969 in Barala, a village in the district of Murshidabad (West Bengal, India), Goutam Brahmachari had his early education in his native place. He received his high school degree in scientific studies in 1986 at Barala R. D. Sen High School under the West Bengal Council of Higher Secondary Education (WBCHSE). Then, he moved to Visva-Bharati (a Central University founded by Rabindranath Tagore at Santiniketan, West Bengal, India) to study chemistry at the undergraduate level. After graduating from this university in 1990, he completed his master’s in 1992, specializing in organic chemistry. After receiving his Ph.D. 1997 in chemistry from the same university, he joined his alma mater the next year and has been a full professor of chemistry since 2011. The research interests of Prof. Brahmachari’s group include synthetic organic chemistry, green chemistry, natural products chemistry, and the medicinal chemistry of natural and natural product-inspired synthetic molecules. With more than 25 years of experience in teaching and research, he has produced over 260 scientific publications, including original research papers, review articles, books, and invited book chapters in the field of natural products and green chemistry. He has already authored/edited 27 books published by internationally reputed major publishing houses, namely, Elsevier Science (The Netherlands), Academic Press (Oxford), Wiley-VCH (Germany), Alpha Science International (Oxford), De Gruyter (Germany), World Scientific (Singapore), CRC Press (Taylor & Francis Group, USA), Royal Society of Chemistry (Cambridge), etc. Prof. Brahmachari serves several scientific bodies in India and abroad, and also many international journals as an editorial member. He has also been serving as co-editor-in-chief for Current Green Chemistry. Prof. Brahmachari is the founder series editor of the Elsevier Book Series ‘Natural Product Drug Discovery’. Prof. Brahmachari is an elected fellow of the Royal Society of Chemistry and a recipient of the CRSI (Chemical Research Society of India) Bronze Medal-2021 (for his contribution to research in chemistry), Dr Basudev Banerjee Memorial Award-2021 (for his contribution to the field of chemical sciences) from the Indian Chemical Society, INSA (Indian National Science Academy) Teachers Award-2019, Dr Kalam Best Teaching Faculty Award-2017, and Academic Brilliance Award, 2015 (Excellence in Research). Prof. Brahmachari was featured in the World Ranking of the Top 2% Scientists (Organic Chemistry Category) in 2020-23, the AD Scientific World Ranking of Scientists in 2022-2024, and as the Scholar GPS Highly Ranked Scholar-2024 (Lifetime, securing a position in the top 0.05% of all scholars worldwide).