Discovery and Development of Anti-Breast Cancer Agents from Natural Products
- 1st Edition - June 24, 2021
- Imprint: Elsevier
- Editor: Goutam Brahmachari
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 1 2 7 7 - 6
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 1 2 7 8 - 3
Discovery and Development of Anti-Breast Cancer Agents from Natural Products presents cutting-edge research advances in the field of bioactive natural products and natural drug f… Read more
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Request a sales quoteDiscovery and Development of Anti-Breast Cancer Agents from Natural Products presents cutting-edge research advances in the field of bioactive natural products and natural drug formulations. This volume in the Natural Products Drug Discovery series focuses on molecules of natural origin and their synthetic analogs that show promising potential to act as anti-breast cancer and chemotherapeutic agents. Combining foundational background information on cancer mechanisms with details of medicinal structures from natural products, this volume compiles the latest developments from across interdisciplinary fields.
Discovery and Development of Anti-Breast Cancer Agents from Natural Products will serve as a valuable resource for researchers working to discover promising leads for the development of novel pharmaceuticals for breast cancer, highlighting a number of key structures from natural products and exploring possible future developments in the area.
Discovery and Development of Anti-Breast Cancer Agents from Natural Products will serve as a valuable resource for researchers working to discover promising leads for the development of novel pharmaceuticals for breast cancer, highlighting a number of key structures from natural products and exploring possible future developments in the area.
- Highlights active agents from natural sources for development as novel anti-cancer agents
- Features contributions from active researchers and leading experts working in the field
- Includes foundational background information on both breast cancer mechanisms and natural product structures to support researchers from different disciplines
Medicinal chemists, Synthetic Chemists, Phytochemists, Combinatorial Chemists, Pharmacologists, Biochemists, Cancer researchers, Botanists, Students in related fields
- Cover
- Title page
- Contents
- Copyright
- Dedication
- Contributors
- Editor’s Biography
- Forewords
- Preface
- Chapter 1: Discovery and Development of Anti-Breast Cancer Agents From Natural Products: An Overview
- Abstract
- 1. Introduction
- 2. An overview of the book
- 3. Concluding remarks
- Chapter 2: Epothilones A and B: The 16-Membered Natural Macrolides as a Fascinating Template for Antibreast Cancer Drug Discovery
- Abstract
- 1. Introduction
- 2. Epothilones A and B: production and isolation, physical and spectral properties, anticancer potential, and mechanism of drug action
- 3. The epothilone template: role in anticancer drug discovery
- 4. Concluding remarks
- Chapter 3: Anti-Breast Cancer Terpenoids of Natural Origins
- Abstract
- 1. Introduction
- 2. Role of natural products in breast cancer treatment
- 3. Future prospects
- 4. Concluding remarks
- Abbreviations
- Chapter 4: Vinca Alkaloids as Chemotherapeutic Agents Against Breast Cancer
- Abstract
- 1. Introduction: an overview of breast cancer
- 2. Vinca alkaloids: general features, sources, and ethnopharmacological relevance
- 3. Isolation and characterization of vinca alkaloids
- 4. Mechanism of action of vinca alkaloids cytotoxicity
- 5. Preclinical studies: in vitro and animal research on the anti-breast activities of vinca alkaloids and its derivatives
- 6. Breast cancer clinical trials: the role of vinca alkaloids and derivatives
- 7. Commercial vinca alkaloids: pharmacokinetics, toxicity/adverse reactions and interactions
- 8. Concluding remarks
- Chapter 5: Cannabinoids and Breast Cancer
- Abstract
- 1. Introduction
- 2. Cannabinoid system
- 3. Cannabinoids and therapeutics
- 4. Cannabinoids and cancer
- 5. Cannabinoids and breast cancer
- 6. Concluding remarks
- Abbreviations
- Chapter 6: Carotenoids as Tools in Breast Cancer Therapy
- Abstract
- 1. Introduction
- 2. Carotenoids
- 3. Carotenoids and cancer
- 4. Natural carotenoids: promising role against breast cancer
- 5. Concluding remarks
- Abbreviations
- Chapter 7: Flavonoids as Inducers of Apoptosis and Autophagy in Breast Cancer
- Abstract
- 1. Introduction
- 2. Natural flavonoids with anti–breast cancer potential
- 3. Extraction and isolation of flavonoids
- 4. Biosynthesis, synthesis of flavonoids, and computational applications
- 5. Concluding remarks
- Abbreviations
- Chapter 8: Phytoestrogens as Novel Therapeutic Molecules Against Breast Cancer
- Abstract
- 1. Introduction
- 2. Classification of phytoestrogens
- 3. Mechanism of action of phytoestrogens
- 4. Nutritional consumption, metabolism, and bioavailability of phytoestrogens
- 5. Safety concerns on phytoestrogen use
- 6. Future perspective
- 7. Concluding remarks
- Abbreviations
- Chapter 9: Chemopreventive and Therapeutic Potential of Natural Agents and Their Combinations for Breast Cancer
- Abstract
- 1. Introduction
- 2. Currently available treatments and their side effects
- 3. The potential role of natural agents in the treatment of breast cancer
- 4. Combinatorial approach
- 5. Natural products for the treatment of breast cancer
- 6. Concluding remarks
- Abbreviations
- Chapter 10: Nanoparticles for Delivering Natural Product Chemotherapeutics to Breast Cancer Cells
- Abstract
- 1. Introduction
- 2. Natural product chemotherapeutics and the need for nanoparticles
- 3. Concluding remarks
- Chapter 11: Molecular Mechanisms Underlying Breast Cancer and Role of Plant Products in Targeted Therapy
- Abstract
- 1. Introduction
- 2. Clinical classification and characteristics of breast cancer
- 3. Origin of cancer cell
- 4. Breast cancer signaling pathways
- 5. Breast cancer treatment with plant-based products
- 6. Concluding remarks
- Acknowledgments
- Abbreviations
- Index
- Edition: 1
- Published: June 24, 2021
- No. of pages (Paperback): 384
- No. of pages (eBook): 384
- Imprint: Elsevier
- Language: English
- Paperback ISBN: 9780128212776
- eBook ISBN: 9780128212783
GB
Goutam Brahmachari
Born on April 14, 1969 in Barala, a village in the district of Murshidabad (West Bengal, India), Goutam Brahmachari had his early education in his native place. He received his high school degree in scientific studies in 1986 at Barala R. D. Sen High School under the West Bengal Council of Higher Secondary Education (WBCHSE). Then, he moved to Visva-Bharati (a Central University founded by Rabindranath Tagore at Santiniketan, West Bengal, India) to study chemistry at the undergraduate level. After graduating from this university in 1990, he completed his master’s in 1992, specializing in organic chemistry. After receiving his Ph.D. 1997 in chemistry from the same university, he joined his alma mater the next year and has been a full professor of chemistry since 2011. The research interests of Prof. Brahmachari’s group include synthetic organic chemistry, green chemistry, natural products chemistry, and the medicinal chemistry of natural and natural product-inspired synthetic molecules. With more than 25 years of experience in teaching and research, he has produced over 260 scientific publications, including original research papers, review articles, books, and invited book chapters in the field of natural products and green chemistry. He has already authored/edited 27 books published by internationally reputed major publishing houses, namely, Elsevier Science (The Netherlands), Academic Press (Oxford), Wiley-VCH (Germany), Alpha Science International (Oxford), De Gruyter (Germany), World Scientific (Singapore), CRC Press (Taylor & Francis Group, USA), Royal Society of Chemistry (Cambridge), etc. Prof. Brahmachari serves several scientific bodies in India and abroad, and also many international journals as an editorial member. He has also been serving as co-editor-in-chief for Current Green Chemistry. Prof. Brahmachari is the founder series editor of the Elsevier Book Series ‘Natural Product Drug Discovery’. Prof. Brahmachari is an elected fellow of the Royal Society of Chemistry and a recipient of the CRSI (Chemical Research Society of India) Bronze Medal-2021 (for his contribution to research in chemistry), Dr Basudev Banerjee Memorial Award-2021 (for his contribution to the field of chemical sciences) from the Indian Chemical Society, INSA (Indian National Science Academy) Teachers Award-2019, Dr Kalam Best Teaching Faculty Award-2017, and Academic Brilliance Award, 2015 (Excellence in Research). Prof. Brahmachari was featured in the World Ranking of the Top 2% Scientists (Organic Chemistry Category) in 2020-23, the AD Scientific World Ranking of Scientists in 2022-2024, and as the Scholar GPS Highly Ranked Scholar-2024 (Lifetime, securing a position in the top 0.05% of all scholars worldwide).
Affiliations and expertise
Goutam Brahmachari, PhDFull Professor, Organic Chemistry, Department of Chemistry, Visva-Bharati (a Central University), Santiniketan, West Bengal, IndiaRead Discovery and Development of Anti-Breast Cancer Agents from Natural Products on ScienceDirect