Green Synthetic Approaches for Biologically Relevant Heterocycles

Volume 2: Green Catalytic Systems and Solvents

2nd Edition - February 26, 2021
Editor: Goutam Brahmachari
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 0 7 9 2 - 5
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 1 3 3 - 6

Green Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, Volume Two: Green Catalytic Systems and Solvents reviews this significant group of organic c… Read more

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Green Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, Volume Two: Green Catalytic Systems and Solvents reviews this significant group of organic compounds within the context of sustainable methods and processes, expanding on the first edition with fully updated coverage and a whole range of new chapters. Volume Two explores green catalytic systems and solvents and the techniques surrounding this approach, including metal and magnetic catalysis to organocatalysis and solid acid catalysis, cycloaddition reactions, and varied approaches using ionic liquids.

This updated edition is an essential resource on sustainable approaches for academic researchers, R&D professionals, and students working across medicinal, organic, natural product and green chemistry.

Cover image
Title page
Table of Contents
Copyright
Dedication
List of Contributors
Biography
Foreword
Preface
Chapter 1. Green synthetic approaches for biologically relevant heterocycles: green catalytic systems and solvents—an overview
Abstract
1.1 Introduction
1.2 An overview of the book
1.3 Concluding remarks
Chapter 2. Recent advances in the synthesis of bioactive five- and six-membered heterocycles catalyzed by heterogeneous metal catalysts
Abstract
2.1 Introduction
2.2 Synthesis of nitrogen-containing heterocycles
2.3 Synthesis of oxygen-containing heterocycles
2.4 Synthesis of sulfur- and selenium-containing heterocycles
2.5 Synthesis of heterocycles containing more than one type of heteroatom
2.6 Synthesis of fused heterocycles
2.7 Synthesis of other heterocycles
2.8 Concluding remarks
Acknowledgment
References
Chapter 3. Metal-catalyzed routes for the synthesis of furocoumarins and coumestans
Abstract
3.1 Introduction
3.2 Synthetic routes to furocoumarin derivatives
3.3 Synthetic routes to coumestan derivatives
3.4 Concluding remarks
Acknowledgments
References
Chapter 4. Porous catalytic systems in the synthesis of bioactive heterocycles and related compounds
Abstract
4.1 Introduction
4.2 Porous catalytic systems
4.3 Synthesis of bioactive heterocycles catalyzed by porous materials
4.4 Concluding remarks
Acknowledgment
References
Chapter 5. Solid acids for the synthesis of biologically active heterocycles
Abstract
5.1 Introduction
5.2 Solid acids
5.3 Silica based solid acids
5.4 Clays as solid acid catalysts
5.5 Zeolite based solid acids
5.6 Polymer based solid acids
5.7 Zirconia (ZrO2) based solid acids
5.8 Carbon based solid acids
5.9 Concluding remarks
References
Chapter 6. Proline and proline-derived organocatalysts in the synthesis of heterocycles
Abstract
6.1 Introduction
6.2 Synthesis of nitrogen-containing heterocycles
6.3 Synthesis of oxygen-containing heterocycles
6.4 Synthesis of sulphur-containing heterocycles
6.5 Miscellaneous reactions
6.6 Concluding remarks
References
Chapter 7. An update on a greener organocatalytic chemical approach for the synthesis of Biginelli adducts
Abstract
7.1 Introduction
7.2 Classes of organocatalysts used in the Biginelli reaction
7.3 Biological significance of 3,4-dihydropyrimidin-2(1H)-ones/-thiones
7.4 Concluding remarks
Acknowledgments
References
Chapter 8. Recent developments on ionic liquids-mediated synthetic protocols for biologically relevant five- and six-membered heterocyclic skeletons
Abstract
8.1 Introduction
8.2 Ionic liquids: impact and general consideration
8.3 Synthesis of some other spiro heterocycles
8.4 Concluding remarks
Acknowledgments
References
Chapter 9. Heterocycles-based ionic liquid–supported synthesis of small organic molecules
Abstract
9.1 Introduction
9.2 Ionic liquid–supported synthesis of small molecules
9.3 Ionic liquid–supported carbohydrate synthesis
9.4 Ionic liquid–supported reagents
9.5 Ionic liquid–supported catalysts
9.6 Concluding remarks
References
Chapter 10. Green solvents for eco-friendly synthesis of bioactive heterocycles
Abstract
10.1 Introduction
10.2 Heterocyclic synthesis in supercritical carbon dioxide
10.3 Heterocyclic synthesis in polyethylene glycol
10.4 Heterocyclic synthesis in glycerol
10.5 Heterocyclic synthesis in gluconic acid aqueous solution
10.6 Heterocyclic synthesis in ethyl lactate
10.7 Concluding remarks
References
Chapter 11. Green synthetic approaches for biologically relevant 2-amino-4H-pyrans and 2-amino-4H-pyran-annulated heterocycles in aqueous media
Abstract
11.1 Introduction
11.2 Synthetic approaches for 2-amino-4H-pyrans and 2-amino-4H-pyran-annulated heterocycles in water and ethanol–water media
11.3 Concluding remarks
Acknowledgments
References
Chapter 12. An update on synthetic methods for small and medium aza-heterocycles in aqueous media
Abstract
12.1 Introduction
12.2 Three-membered heterocycles—aziridines
12.3 Four-membered heterocycles: azetidines and 2-azetidinones
12.4 Five-membered heterocycles
12.5 Six-membered heterocycles
12.6 Seven-membered heterocycles
12.7 Concluding remarks
References
Chapter 13. Green and catalytic methods for γ-lactone synthesis
Abstract
13.1 Introduction
13.2 γ-Lactone synthesis through addition to C–C multiple bonds
13.3 γ-Lactone synthesis through addition to C–O double bond
13.4 Catalytic cycloaddition and metathesis reactions of ester-tethered substrates
13.5 Functionalization of γ-lactones
13.6 Concluding remarks
Abbreviations
References
Chapter 14. Green synthetic approaches for medium ring–sized heterocycles of biological and pharmaceutical interest
Abstract
14.1 Introduction
14.2 Use of greener solvents
14.3 Use of ionic liquids in organic synthesis
14.4 Microwave-assisted synthesis
14.5 Ultrasound as an enabling technique
14.6 Photochemical transformations
14.7 Use of ball milling
14.8 Use of fluorous techniques
14.9 Use of heterogeneous catalysis
14.10 Concluding remarks
References
Chapter 15. Green chemistry of evergreen imines in the synthesis of nitrogen-containing heterocycles
Abstract
15.1 Introduction
15.2 Synthesis of imines
15.3 Applications of imines in heterocyclic synthesis
15.4 Concluding remarks
References
Chapter 16. Green synthetic approaches towards benzimidazole and quinoxaline scaffolds
Abstract
16.1 Introduction
16.2 Methods of synthesis of benzimidazoles/quinoxalines using greener strategies
16.3 Concluding remarks
References
Index

Goutam Brahmachari

Born on April 14, 1969 in Barala, a village in the district of Murshidabad (West Bengal, India), Goutam Brahmachari had his early education in his native place. He received his high school degree in scientific studies in 1986 at Barala R. D. Sen High School under the West Bengal Council of Higher Secondary Education (WBCHSE). Then, he moved to Visva-Bharati (a Central University founded by Rabindranath Tagore at Santiniketan, West Bengal, India) to study chemistry at the undergraduate level. After graduating from this university in 1990, he completed his master’s in 1992, specializing in organic chemistry. After receiving his Ph.D. 1997 in chemistry from the same university, he joined his alma mater the next year and has been a full professor of chemistry since 2011. The research interests of Prof. Brahmachari’s group include synthetic organic chemistry, green chemistry, natural products chemistry, and the medicinal chemistry of natural and natural product-inspired synthetic molecules. With more than 25 years of experience in teaching and research, he has produced over 260 scientific publications, including original research papers, review articles, books, and invited book chapters in the field of natural products and green chemistry. He has already authored/edited 27 books published by internationally reputed major publishing houses, namely, Elsevier Science (The Netherlands), Academic Press (Oxford), Wiley-VCH (Germany), Alpha Science International (Oxford), De Gruyter (Germany), World Scientific (Singapore), CRC Press (Taylor & Francis Group, USA), Royal Society of Chemistry (Cambridge), etc. Prof. Brahmachari serves several scientific bodies in India and abroad, and also many international journals as an editorial member. He has also been serving as co-editor-in-chief for Current Green Chemistry. Prof. Brahmachari is the founder series editor of the Elsevier Book Series ‘Natural Product Drug Discovery’. Prof. Brahmachari is an elected fellow of the Royal Society of Chemistry and a recipient of the CRSI (Chemical Research Society of India) Bronze Medal-2021 (for his contribution to research in chemistry), Dr Basudev Banerjee Memorial Award-2021 (for his contribution to the field of chemical sciences) from the Indian Chemical Society, INSA (Indian National Science Academy) Teachers Award-2019, Dr Kalam Best Teaching Faculty Award-2017, and Academic Brilliance Award, 2015 (Excellence in Research). Prof. Brahmachari was featured in the World Ranking of the Top 2% Scientists (Organic Chemistry Category) in 2020-23, the AD Scientific World Ranking of Scientists in 2022-2024, and as the Scholar GPS Highly Ranked Scholar-2024 (Lifetime, securing a position in the top 0.05% of all scholars worldwide).

Affiliations and expertise

Goutam Brahmachari, PhDFull Professor, Organic Chemistry, Department of Chemistry, Visva-Bharati (a Central University), Santiniketan, West Bengal, India

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