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Elsevier

Books in Life sciences

  • Cellular Communication in Mammalian Germ-line Development

    • 1st Edition
    • Volume 169
    • English
    Cellular Communication in Development, Volume 169 provides a comprehensive overview of the intricate signaling pathways and molecular mechanisms that govern how cells communicate during the development of multicellular organisms. This volume explores the essential roles of cell-to-cell communication in processes such as embryogenesis, tissue patterning, organ formation, and differentiation. Specific chapters include Specification of pgcs, Establishing and maintaining gonadal cell fate, Role of retinoic acid in meiosis, Assembly of primordial follicles, Activation of primordial follicles, Mechanisms of germ-soma communication during follicular growth, Somatic regulation of oocyte meiotic arrest and resumption, Ovarian stroma/function/role in aging, and much more.Additional sections explore New approaches to supporting follicle growth/ovarian function in vitro, Cancer therapy - effects on survival/development of oocyte/follicle, Female germ cells from somatic cells, Spermatogenic stem cell niche, Role of macrophages in testis function, Male germ cells from somatic cells, and more.

  • Retina Assessments, Disease, and Treatments

    • 1st Edition
    • Volume 218
    • Machelle T. Pardue
    • English
    Retina Assessments, Disease, and Treatments, Volume Two explores retinal disease, assessment, and treatment for rehabilitation of visual function. Focusing on major retinal diseases and clinical assessments, including neuroimaging and electrophysiology, this volume highlights new restorative therapies such as gene therapy, stem cell therapy, retinal prosthetics, and novel tools to assess retinal function.

  • Advances in Tablet Manufacturing Technologies

    • 1st Edition
    • Honey Goel + 2 more
    • English
    Advances in Tablet Manufacturing Technologies consolidates cutting-edge information on the latest technologies in tablet design and manufacturing, addressing the pressing need for innovation in an increasingly complex global market. The book is structured to provide a thorough understanding of tablet technology, beginning with foundational concepts and progressing through specialized topics. Key sections explore the historical context of tablet development, the significance of pharmaceutical excipients, preformulation aspects, and the physics of tablet compression. Subsequent chapters explore advanced topics, including coated tablets, modified-release formulations, organ-specific tablets, and state-of-the-art innovations like 3D printed tablets.Each chapter is enriched with practical examples and case studies, ensuring that readers can apply theoretical knowledge to real-world scenarios. With contributions from a diverse group of national and international experts, this book is an invaluable asset for scientists in academia and industry alike. It elucidates preformulation parameters, outlines regulatory frameworks, and discusses recent advances in excipient technology and in-process testing equipment.

  • Transposable Elements in Health and Disease

    • 1st Edition
    • Volume 116
    • English
    Transposable Elements in Health and Disease, Volume 116 in the Advances in Genetics series, highlights new advances in the field, with this new volume presenting comprehensive chapters on a variety of timely topics. Specific chapters examine Transposable Elements in Human Cancer: Regulation, Activation, and Genomic Consequences, Retrotransposons as both “architects” and “saboteurs” in the nervous system, Shaping Mammalian Genomes: The Regulation and Co-option of Transposable Elements, Transposable element analysis in -omics data, and Transposable elements in Aging: from biomarkers to effectors.Together, these contributions provide valuable insights into the mechanisms and impacts of transposable element activity, advancing our understanding of their broad significance in genetics, development, health, and disease.

  • Pharma-Skript

    • 1st Edition
    • Michael Uhrig
    • German
    Pharmakologie kompakt. Klinisch gedacht. Nachhaltig gelernt.Pharmakologi... und Toxikologie sind komplex – müssen aber nicht kompliziert sein. Das Pharma-Skript bietet dir einen strukturierten Einstieg ins Fach und hilft dir, Arzneimittel wirklich zu verstehen: über 280 Wirkstoffe – von Aspirin bis Zolpidem – praxisnah erklärt und konsequent aufs Wesentliche fokussiert.Du lernst, Wirkmechanismen, Nebenwirkungen und Kontraindikationen systematisch herzuleiten – eine Fähigkeit, die sich in Prüfungen ebenso auszahlt wie im klinischen Alltag.Dabei unterstützen dich:einheitlich aufgebaute Kapitel für schnelle Orientierungüber 100 einprägsame Abbildungen zu zentralen Wirkmechanismenrund 275 kompakte Wirkstofftabellen mit allen prüfungsrelevanten Informationenklinisc... Fallbeispiele, die das pharmakologische Denken fördernein eigenes Kapitel zur Toxikologie mit typischen Toxidromen und TherapieansätzenDas Pharma-Skript ist ein zuverlässiger Begleiter für Studierende der Human- und Zahnmedizin, Physician Assistants, sowie für Auszubildende in medizinischen Berufen.Für alle, die Arzneimittel nicht nur lernen, sondern verstehen wollen.

  • Advances in Applied Microbiology

    • 1st Edition
    • Volume 133
    • English
    Advances in Applied Microbiology, Volume 133 presents a comprehensive exploration of the latest innovations in applied microbiology. The book delves into the diverse applications of microbiology across various industries, including agriculture, food production, biotechnology, environmental science, and healthcare. Through a collection of insightful chapters authored by experts in the field, readers are offered in-depth analyses of cutting-edge research, emerging trends, and practical applications of microbiological principles.From novel microbial technologies to the impact of microbiomes on human health and beyond, this book serves as a valuable resource for researchers, professionals, and students seeking to stay informed and inspired by the exciting advancements.

  • Non-Stationary and Nonlinear Data Processing for Automated Computer-Aided Medical Diagnosis

    • 1st Edition
    • Rajesh Kumar Tripathy + 3 more
    • English
    Non-Stationary and Nonlinear Data Processing for Automated Computer-Aided Medical Diagnosis demonstrates the applications of machine learning and deep learning combined with signal processing techniques for human-machine interface applications using EMG signals. The book includes the analysis and classification of various heart diseases based on bio-signals like electrocardiogram (ECG), photoplethysmography (PPG), and phonocardiogram (PCG) signals. Various machine learning approaches, including advanced algorithms like multivariate signal processing, time-frequency analysis, and nonlinear signal processing are covered for CAD of neural, muscular, and cardiovascular diseases. The methods for CAD of various brain disorders are also included.Presented techniques utilize advanced non-stationary and nonlinear signal processing, along with machine learning and deep learning-based classification processes. CAD methods for diagnosing various neurological diseases are based on bio-signals such as electroencephalogram (EEG) and magnetoencephalogram (MEG), as well as medical images like magnetic resonance imaging (MRI) and computerized tomography (CT). Finally, the book addresses various types of medical signals and images, integrating nonlinear and non-stationary signal processing, machine learning, and deep learning within the CAD framework for diagnosing various diseases.

  • Yoga and Prevention of Type 2 Diabetes

    An Integrated Approach to Wellness
    • 1st Edition
    • S.V. Madhu
    • English
    Yoga and Prevention of Type 2 Diabetes: An Integrated Approach to Wellness is a unique reference to approaching yoga, its principles, and how its various practices contribute to overall health and wellness and to understanding the scientific evidence and impact of yoga on glycemic control, insulin sensitivity, and stress reduction. The book lays the foundation to understanding the pathophysiology, epidemiology, and risk factors associated with type 2 diabetes while exploring the physiological and biochemical pathways by which yoga influences glucose metabolism and mitigates diabetes risk factors.Collectively... the book's chapters equip readers with a thorough understanding of Type 2 diabetes and the multifaceted role of yoga in its prevention and management. By combining theoretical knowledge with practical applications, this work will empower individuals and healthcare providers to take proactive steps toward better metabolic health through yoga.

  • Advances in Microbial Physiology

    • 1st Edition
    • Volume 88
    • English
    Advances in Microbial Physiology, Volume 88 explores the latest research and developments in microbial physiology, providing a comprehensive overview on how microorganisms function, adapt, and interact with their environments. This volume brings together leading experts to discuss fundamental processes such as metabolism, growth, gene regulation, signal transduction, stress responses, and cellular differentiation in bacteria, archaea, and fungi. Chapters cover Steroids as Antibacterials, From Feeding Cell to Fruiting Body: Multidrug Transport in the Life cycle of Dictyostelium discoideum, Evolution of xenobiotic catabolism, Glycyl-radical enzymes, How anaerobes cope with oxygen, and Extracellular Electron Transfer: From Early Life to Modern Biogeochemistry and Applications.

  • Advances in Parasitology

    • 1st Edition
    • Volume 131
    • English
    This book explores the intersection of molecular biology, genomics, and ecology to redefine our understanding of parasitic organisms and their management. Beginning with the application of -omics research in platyhelminth parasites of fish, demonstrating how genomic and proteomic data are essential for understanding host-parasite dynamics and developing novel vaccines and treatments to support sustainable aquaculture. The focus then shifts to the complex internal ecosystems of parasites, and examining how their associated microbiomes—comprisi... bacteria, fungi, and viruses—influence parasite fitness, virulence, and host interactions. Finally, the book highlights the genus Entamoeba, delving into how how next-generation and long-read sequencing technologies have revolutionized the identification of cryptic species and improved epidemiological surveillance for pathogens like E. histolytica. Together, these chapters provide a modern framework for parasitology through the lens of advanced genetic tools and ecological integration.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 133
    • English
    Advances in Clinical Chemistry, Volume 133 in this ongoing series, examines physiologic and pathophysiologic biochemistry and their impacts on Clinical Chemistry testing and design. Molecular mechanisms of disease processes are highlighted in the context of traditional, current, and emerging technologies, and advances in the development of improved diagnostic and predictive biomarkers are examined, especially those targeting early and emerging diseases. Specific chapters in this new release include Drug Induced Renal Injury (DIRI) Biomarkers, Unveiling tobacco markers in exhaled breath, Advances in small extracellular vesicle analysis, Piezoelectric Sensors in Point-of-Care Testing, Mitochondrial myopathy biomarkers, and Hormonal and Metabolic Biomarkers in Long COVID.

  • Multifunctional Nano pharmaceuticals for Biomedical Applications

    • 1st Edition
    • Sushil K. Kashaw + 3 more
    • English
    Multifunctional Nanopharmaceuticals for Biomedical Applications covers the latest advancements in multifunctional nanopharmaceuticals while also addressing the pressing need for innovative solutions for unmet medical challenges. Each chapter explores key topics such as the fundamentals of nanotechnology and drug delivery, PEGylated lipid carriers for cancer theranostics, and the latest in biomimetic nanomicells and nanorobots. With detailed discussions on design strategies, formulation techniques, and regulatory aspects, readers will gain a thorough understanding of the complexities and innovations in this dynamic field. The exploration of clinical applications and future trends also equips readers with the knowledge to navigate the evolving landscape of nanomedicine.This is an essential resource for researchers interested in the transformative potential of nanotechnology in drug delivery and disease treatment. It empowers readers to harness cutting-edge technologies for effective therapies, paving the way for a new era of personalized, precise, and potent medicine. With the rapid evolution of nanomedicine, this book serves as a crucial tool for researchers, students, healthcare professionals, and industry experts alike, bridging the gap between fundamental concepts and their real-world applications.

  • Biochar Applications

    Advances in Environmental Remediation and Resource Recovery
    • 1st Edition
    • Ahmad Hussaini Jagaba + 4 more
    • English
    Biochar Applications: Advances in Environmental Remediation and Resource Recovery provides a combined approach between environmental science and environmental engineering that involves the improvement of the natural environment, or the remediation, of polluted sites. In addition, it discusses bioprocess engineering, including the synthesis, modification, characterization, and management of biochar from biomass waste materials. The book includes coverage on sources, impacts, and applications of biochar that could potentially be used as catalysts to enhance environmental remediation and resource recovery processes. Examples of applied research that demonstrate the relationship between wastewater, soil, contaminated environments, remediation, resource recovery, sustainability, and circular bioeconomy are also included.The book bridges the gap between biochar applications in wastewater treatment, soil improvement, gas mitigation, and resource recovery.

  • Protein Serine/Threonine Kinases in Neurodegenerative Disorders

    • 1st Edition
    • Heba Mohamed Mansour + 1 more
    • English
    Protein Serine/Threonine Kinases in Neurodegenerative Disorders discusses protein kinase inhibitors and their potential role in modulating and treating neurodegenerative diseases. The book introduces protein kinases and inhibitors and includes detailed discussions on different types of kinases, including protein kinase C (PKC), AMP-activated protein kinase (AMPK), death-associated protein kinase 1 (DAPK1), cyclin-dependent kinases (CDKs), glycogen synthase kinases (GSKs), Rho-associated protein kinase (ROCK), microtubule affinity regulating kinases (MARKs), mammalian target of rapamycin (mTOR), leucine-rich repeat kinase 2 (LRRK2), PTEN-induced kinase 1 (PINK1), and dual-specificity tyrosine phosphorylation-regu... kinase (DYRK), and their roles in neurodegenerative disease, potential inhibitors, and therapeutic mechanisms.This book features 23 chapters written by renowned experts in the field of kinases. It explores novel targets modulated by protein kinases, including noncoding RNAs (ncRNAs) and mitogen-activated protein kinases (MAPKs) activated by tyrosine receptor kinases, and their roles in neurodegeneration. It also discusses the nexus between glycogen synthase kinases (GSKs) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) and their role of metabolic regulation in neurodegeneration. The modulatory effects of protein kinase B (PKB/AKT) pathways in various neurodegenerative disorders, particularly Parkinson’s disease, are also examined. This book sheds light on bioactive compounds from natural products that target kinases and explains the role of different kinases in various pathogenic pathways and mechanisms involved in neurodegeneration, including regulated cell death, autophagy, synaptic dysfunction, and neuroinflammation.

  • Cardiorespiratory Aspects of Duchenne Muscular Dystrophy

    New Perspectives and Controversies
    • 1st Edition
    • David J. Birnkrant
    • English
    Cardiorespiratory Aspects of Duchenne Muscular Dystrophy: New Perspectives and Controversies is designed to address key challenges in the field by providing a cardiorespiratory perspective on clinical care, drug development, and the regulatory approval of new drugs. The book discusses current achievements and limitations of care and addresses clinical challenges. It offers a detailed, critical examination of the drug development process and identifies potential flaws in current regulatory processes. Novel recommendations for improving study methodologies and regulatory decisions are discussed, with the goal of enabling more effective drugs to reach individuals with Duchenne Muscular Dystrophy (DMD).This book is designed to provide important and interesting information to a variety of stakeholders, including clinicians, researchers, and regulators, as well as patients and their caregivers. Clinicians will find a summary of standards of care and strategies to overcome the challenges they are likely to face in enacting those standards. Researchers will gain insights into the crucial importance of cardiorespiratory outcome measures and find recommendations designed to improve study methodologies. Regulators will benefit from an examination of potential flaws in the current drug approval process and from proposed recommendations aimed at ensuring that approved drugs are truly effective. The goal of this comprehensive approach is to enhance the outcomes and survival of individuals with DMD by focusing on key determinants of cardiorespiratory health.

  • Intelligent Osteogenesis

    How A.I., New Materials, and Manufacturing Technologies Are Reshaping Bone Regeneration
    • 1st Edition
    • Carlo Galli
    • English
    Intelligent Osteogenesis: How A.I., New Materials, and Manufacturing Technologies are Reshaping Bone Regeneration delves into the revolutionary intersection of technology and medicine. The book focuses on how cutting-edge advancements like artificial intelligence, nanotechnology, biotechnology, and material science significantly influence and transform bone regeneration therapies. It aims to shed light on the multifaceted nature of this field, bringing diverse elements together to reveal their collective impact. The book covers the use of A.I. to monitor advancements, the acceleration of research, and the technological influence on the application of bone regenerative techniques.Authored by experts, it serves as a definitive guide for both biomedical researchers and clinical practitioners in dentistry and orthopedics.

  • Human Microbiota for Skincare

    Sustainable, Innovative, and Personalized Skincare with Skin Microbiota
    • 1st Edition
    • Nar Singh Chauhan + 2 more
    • English
    Human Microbiota for Skincare: Sustainable, Innovative, and Personalized Skin Care with Skin Microbiota explores the latest trends, innovations, and emerging research in microbiota-based skincare, positioning readers at the forefront of skincare advancements. It presents a global overview of current and future research, providing a comprehensive understanding of the skin microbiome and its potential applications in skincare. The book offers detailed insights into the interplay between the skin microbiome and human health, with chapters covering essential topics such as Personalized Skincare, Macroecological Dynamics of Skin Microbiota, Host-Microbe Interplay During Skin Diseases and Aging, Microbiome-Based Skin Care Formulations, and Ethical Regulations of Skin Therapies.This book consolidates datasets and real-life case studies, offering practical advice on incorporating microbiota-based products into daily routines and exploring future trends in microbiota-based skincare. Whether you are a scientist, researcher, or clinician, this book is an essential resource. It provides authoritative advice from experts in microbiology, dermatology, and biochemistry, facilitating multidisciplinary research and enhancing your ability to treat patients.

  • AI-enabled Sustainable Healthcare

    Demystifying Secure Quantum Blockchain
    • 1st Edition
    • M. Nivaashini + 4 more
    • English
    AI-Enabled Sustainable Healthcare: Demystifying Secure Quantum Blockchain explores the convergence of quantum computing, blockchain technology, and artificial intelligence in the context of healthcare. In today's rapidly evolving technological landscape, traditional healthcare systems face challenges related to data security, interoperability, and the efficient utilization of patient information. The emergence of quantum computing, blockchain, and AI presents unprecedented opportunities to overcome these challenges and revolutionize healthcare delivery. This book provides a clear and accessible overview of these complex technologies and their potential applications in healthcare. By demystifying these concepts and illustrating their real-world implications, the book equips readers with the knowledge and insights needed to navigate the intersection of technology and healthcare effectively. Furthermore, as the demand for secure, transparent, and sustainable healthcare solutions continues to grow, there is an urgent need for informed discussions and innovative approaches in this field.

  • Public Participation and Ethics Communication in Brain Research, Innovation, and Health

    • 1st Edition
    • Volume 9
    • English
    Public Engagement and Ethical Communication in Brain Research, Innovation, and Health, Volume Nine in the Developments in Neuroethics and Bioethics series, provides a comprehensive overview of various understandings of neuroscience and (neuro)ethics communication across research, policy, and society. Specific chapters in this new release include Neurohype Across Borders: How Media Narratives Shape Public Perception of Neurotechnology in English- and Spanish-Speaking Countries, Physicians’ Resistance Towards Pandemic Public Health Policies in Romania: Navigating Misinformation, Ethical Challenges, and Responsibility in Science Communication, Foresight Scenarios as Communicative Instruments in Anticipatory Neuroethics, and much more.Additional chapters include Draw closer to me: Participatory visual storytelling to include socio-cultural perspectives in neuroethics and policymaking, Against the Narrative of the Insufficiency of Human Rights on the Neurorights Discourse, Reflective accounts from collaborative neuro-oncology research: perspectives from patient partners and researchers, Responsible conceptualization in research and innovation, Anticipating Polarization: Public Discourse and the Unpreparedness of Neuroethics Communication, Shared Responsibility for Communicating Neuroscience Research: A Case Study for Spinal Cord Injury, and much more.Featured topics include creative and participatory approaches to (neuro)ethics communication, the impact of narratives on public perception and science policy, the importance of responsible communication in neuroscience, and the dynamics between patient partners and researchers. The volume also addresses cross-cultural perspectives and focuses on comparative case studies of current emerging neuroscience research and neurotechnologies across countries.

  • Intelligent Cyber-Physical Systems for Sustainable Healthcare

    • 1st Edition
    • Vandana Bajaj + 5 more
    • English
    Intelligent Cyber-Physical Systems for Sustainable Healthcare addresses the integration of emerging technologies like Virtual Reality, Smart Robotics, and Human-Computer Interaction, which are crucial for maximizing digital health's potential. The book includes case studies that highlight challenges faced by medical practitioners and industry professionals, providing valuable insights for designing sustainable iCPS solutions. Aimed at biomedical engineers, researchers, and industry professionals, it offers guidance for developing practical applications in sustainable healthcare. Additionally, shared, cross-disciplinary experiences assist engineers with less clinical expertise in enhancing healthcare applications in the intelligent digital health sector.Overall, case studies illustrate past challenges in the healthcare industry and present effective solutions to overcome them, making the book a comprehensive resource for advancing sustainable healthcare practices.

  • Advances in Biomedical Engineering - Part A

    • 1st Edition
    • Volume 402
    • English
    Advances in Biomedical Engineering, Part A, Volume 402 provides a comprehensive overview of the latest developments, innovations, and research in the rapidly evolving field of biomedical engineering. This book covers a broad spectrum of topics, including medical imaging, biomaterials, tissue engineering, biomechanics, bioinstrumentation, and healthcare technologies. Specific chapters include Advances in biomedical engineering, Recent advances in nanomedicine as drug delivery systems, Advances in Nano biomaterials for Biomedical Engineering, Neurodiagnostic: Advances in diagnostic tools, Advances in Ferroptosis Research and Application, Bioink-based 3D Bioprinting: Paving the Path for Regenerative Medicine, and MRI Acute/Sub-Acute Ischemic Stroke Segmentation with Deep Learning: A Comprehensive Review.

  • Emerging Diagnostic Glucose Sensing Approaches

    Diabetes
    • 1st Edition
    • Abhishek Kandwal + 2 more
    • English
    Emerging Diagnostic Glucose Sensing Approaches: Diabetes surveys past and recent work on non-invasive blood glucose monitoring. The book highlights two complementary paths: electromagnetic-wave... sensing, using physical models and advanced sensors to measure glucose non-invasively; and physiological techniques (ECG/EEG) integrated with artificial intelligence and deep learning to infer glucose levels. It discusses how physical models, biomedical methodologies, and engineering prototyping enable accurate analysis and device development. With a focus on breakthroughs in electromagnetic sensors and non-invasive research, this volume serves as a foundational reference for biomedical researchers and engineers pursuing next-generation glucose monitoring.

  • Targeting DNA Repair Mechanisms, Tumor Genetics, and Signaling Pathways

    Synergistic Approaches in Gastrointestinal Cancer Treatment
    • 1st Edition
    • Ganji Purnachandra Nagaraju + 1 more
    • English
    Targeting DNA Repair Mechanisms, Tumor Genetics, and Signaling Pathways: Synergistic Approaches in Gastrointestinal Cancer Treatment provides a comprehensive exploration of the complex mechanisms underlying gastrointestinal (GI) cancers, including colorectal, gastric, liver, and pancreatic malignancies. The book addresses the urgent need for innovative therapeutic strategies by synthesizing current research on DNA repair, tumor genetics, and cellular signaling pathways critical to cancer progression and treatment. It examines the roles of DNA repair mechanisms and the influence of genetic factors on personalized medicine while also discussing the potential of combining targeted therapies to enhance treatment efficacy.Featuring real-world case studies and insights from leading experts, the book bridges the gap between basic research and clinical application. For an academic audience, this resource promotes a holistic understanding of GI cancer biology, addresses treatment resistance, and fosters collaboration among researchers and clinicians, ultimately improving patient outcomes in this rapidly evolving field.

  • Fruit Seeds and Peels for Sustainable Biomaterials

    • 1st Edition
    • Sneh Punia Bangar + 1 more
    • English
    Fruit Seeds and Peels for Sustainable Biomaterials explores the utilization of fruit and vegetable waste in the production of bioplastics as environmentally friendly alternatives to conventional petroleum-based plastics. The book presents innovative approaches to reducing the carbon footprint of the packaging industry while advancing principles of recyclability, sustainability, and the circular economy.The chapters provide an in-depth examination of various waste valorization techniques and compile global research efforts focused on the transformation of various fruit processing by-products. These industrial wastes are rich in polysaccharides, such as cellulose, hemicellulose, and lignin, which can be further treated to synthesize nanocellulose crystals or fibers using different physicochemical and nonconventional methods.The book highlights the application of these biomaterials in packaging, offering food professionals and other stakeholders sustainable alternatives to traditional plastic polymers. It delivers comprehensive insights into the potential of fruit seeds as a renewable source of biomaterials, and presents valuable scientific information on the technologies involved in using bio-based materials for food preservation. These insights aim to reduce the use of non-biodegradable plastic packaging materials.

  • Vector-Borne Diseases

    • 1st Edition
    • Volume 58
    • English
    Vector Borne Diseases, Volume 58 in the Methods in Microbiology series, highlights new advances in the field, with this new volume presenting interesting written by an international board of authors. Chapters in this new release cover Methods for Isolation and Characterization of Arthropod Hemocytes, Tick-to-Host Transmission of B. burgdorferi: In Vitro and In Vivo Methodologies, Decoding the Zika Virus outbreak and Infection Dynamics, Visual and molecular methods for studying pathogen persistence in flea vectors, Lipidomic Analysis of Virus-infected Cells, and Implementation of the Neutropenic Thigh Infection Murine Model with Francsiella tularensis for Development of New Antibacterials.

  • Computational Approaches to Natural Products Discovery

    • 1st Edition
    • Volume 730
    • English
    Computational Approaches to Natural Products Discovery, Volume 720 provides descriptions of the latest techniques in computational methods for the study of natural products. Techniques covered are related to genome mining, natural product biosynthesis, natural product evolution, and natural product structure. Chapters in this new release cover Prediction of natural product bioactivity from BGC sequence to guide genome mining efforts, Genome mining for resistance genes to identify bioactive natural products with ARTS, Predicting lasso peptide structure with LassoPred, Predicting lanthipeptide structure with Rosetta, Using lsaBGC to investigate BGC Evolution, and an Analysis of BGC evolution with CORASON.

  • Novel and Innovative Drug Delivery Systems to Overcome Chemoresistance in Human Malignancies

    • 1st Edition
    • Shuvomoy Banerjee + 1 more
    • English
    Novel and Innovative Drug Delivery Systems to Overcome Chemoresistance in Human Malignancies addresses the critical challenge of cancer chemoresistance, synthesizing insights from cancer biology, molecular biology, biotechnology, and nanotechnology. The book explores the complex mechanisms underlying drug resistance, including alterations in key signaling pathways and the tumor microenvironment's role in cancer cell survival. It highlights advancements in drug delivery technologies, such as nanomedicine and biomimetic strategies, which enhance drug targeting and minimize off-target effects. The integration of techniques like CRISPR-Cas9 and artificial intelligence in developing next-generation therapies is also emphasized.For an academic audience, this book serves as an essential resource to foster interdisciplinary collaboration in cancer research. It equips researchers, clinicians, and industry professionals with the knowledge needed to navigate the evolving landscape of cancer therapeutics, addressing critical challenges in drug delivery and chemoresistance to improve patient outcomes.

  • Working Memory

    • 1st Edition
    • Christos Constantinidis
    • English
    Working Memory provides a comprehensive examination of the neural basis of working memory, defined as the cognitive ability to maintain information over short periods. This volume addresses the need for an accessible, yet thorough resource that bridges cognitive psychology and neuroscience, focusing on how neuronal activity in the cerebral cortex underpins memory processes. It is primarily designed for undergraduate and early graduate students in neuroscience, psychology, and related fields such as cognitive science and biomedical engineering. Topics covered include brain anatomy, organization, neurophysiology, and neuroimaging techniques, all contextualized within the study of working memory.

  • Advances in Virus Research

    • 1st Edition
    • Volume 124
    • English
    Advances in Virus Research, Volume 124 in this ongoing seriesseries, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Emerging and Reemerging Viral Threats to Pregnancy and Nomenclature for vertically transmitted plant.

  • Artificial Intelligence for Multi-omics Analysis Part B

    • 1st Edition
    • Volume 222
    • English
    Artificial Intelligence for Multi-omics Analysis Part B, Volume 222 in the Progress in Molecular Biology and Translational Science series, highlights recent advances, with this new volume presenting chapters on a variety of topics, including Artificial Intelligence in multi-omics analysis of small molecule drug discovery, AI in multi-omics analysis in antimicrobial resistance, Artificial Intelligence and multi-Omics Approach in Vaccine Development, Artificial Intelligence in multi-omics Analysis of heart diseases, Artificial Intelligence in multi-omics Analysis of Kidney Diseases, Artificial Intelligence in multi-omics Analysis of Gastrointestinal Diseases, AI in multi-omics analysis in Stem cell research, and AI in multi-omics analysis in cancer, and more.Additional sections cover AI in multi-omics analysis in obstructive lung diseases, AI in multi-omics analysis in neurodiseases, AI in multi-omics analysis in autoimmune diseases, AI in multi-omics analysis of liver diseases, AI in multi-omics analysis of COVID-19 patient data, and AI in multi-omics analysis of Type 2 diabetes.

  • Advances in Immunology

    • 1st Edition
    • Volume 168
    • English
    Advances in Immunology, Volume 168, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Sample topics in this new release include Alarmins in mucosal tissues and how they regulate health and disease, and more.

  • Advanced Methodologies to Study and Enhance Cellular Cytotoxicity Against Cancer

    • 1st Edition
    • Volume 207
    • English
    Advanced Methodologies to Study and Enhance Cellular Cytotoxicity Against Cancer, Volume 207 covers the latest techniques and strategies used to investigate and boost cytotoxic activity in cells targeting cancer. Chapters include An ex vivo assay to assess CAR T cell cytotoxicity in viable tumor tissues using a two-step staining protocol, New protocol to measure mitochondria polarization/functio... at the immunological synapse, Analysis of CAR-T cell–mediated cytotoxicity in solid tumor models, Investigation of the in vitro lytic capacity of CAR-T by microscopyal, Antigen-specific T cell cytotoxicity toward target tumor cells, In vitro expansion of stem-like memory T cells via D-mannose supplementation, and much more.Additional chapters explore High-throughput time-lapse imaging of B16 target cell killing by ovalbumin-specific CD8+ T cells, Evaluation of an intracellular magneto-mechanical approach for regulating dendritic cell activation, Analyzing the effect of NK cells on in-vivo models of tumor dissemination by digital pathology and flow cytometry, Super-resolution imaging of the NK cell synapse on supported lipid bilayers using MINFLUX nanoscopy, ASSESSMENT OF NK CELL CYTOTOXICITY INDUCED BY IL-15 BASED IMMUNOTHERAPY AGAINST CANCER CELLS, Combined phenotyping and functional analysis of isolated human natural killer cells using spectral flow cytometry, and much more.

  • Immunomodulators Part B

    • 1st Edition
    • Volume 152
    • English
    Immunomodulators Part B brings together a curated set of research-focused chapters that explore how the immune system is influenced by microbes, immune checkpoint molecules, genetic regulation, and emerging therapeutic strategies. It covers the role of the microbiome and microbial products in shaping immune responses relevant to gastrointestinal cancers, examines VISTA as a “double-edged” checkpoint in cancer and autoimmunity, and uses bioinformatics to uncover immune-modulatory patterns in HPV-associated head and neck squamous cell carcinoma and bladder cancer.

  • Advances in Agronomy

    • 1st Edition
    • Volume 197
    • English
    Advances in Agronomy, Volume 197, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field, each written by an international board of authors. Chapters in this new release include Distribution, characteristics and management of Andisols for agricultural production and carbon sequestration, Reducing Emissions from Fertilizers: Opportunities and Challenges, The Unintended Consequences of N: Addressing Pollution from Nitrogenous Fertilizers with Potential Remedies, and Reconciling soil health benefits with carbon sequestration value of organic carbonaceous amendments.

  • Biofabrication and Synthetic Biology in Medicinal Plants

    Advances in Biotechnology and Breeding
    • 1st Edition
    • Eti Sharma + 2 more
    • English
    Biofabrication and Synthetic Biology in Medicinal Plants: Advances in Biotechnology and Breeding presents recent technological advances for enhancing medicinal plants as sources of plant-based biopharmaceuticals. It covers biofabrication, synthetic biology, modern biotechnological tools, and innovative breeding strategies tailored for medicinal plant improvement. While these technologies are well established in crop plants, their application in medicinal plants remains underexplored. Medicinal plants are rich sources of therapeutic compounds traditionally used across cultures to treat a wide range of diseases and health conditions. These plants produce diverse bioactive molecules, including terpenoids, flavonoids, alkaloids, and phenolics, many of which exhibit significant pharmacological potential. For centuries, medicinal and aromatic plants have played a vital role in human healthcare and continue to be valued globally. Recent advances in synthetic biology, metabolic engineering, and biotechnology promise to enhance the production, quality, and efficacy of these bioactive compounds, addressing unmet medical needs and contributing to sustainable healthcare. This book compiles insights from leading experts, offering a comprehensive reference for researchers, early-career scientists, students, and professionals working in medicinal plant biotechnology and breeding.

  • Nutrition and Neurotoxicology Part A

    • 1st Edition
    • Volume 15
    • English
    Nutrition and Neurotoxicity, Part A highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including the Effect of toluene on memory: A focus on humans, experimental models and treatment approaches, Neurotoxicological Mechanisms of Ethanol, Neurobehavioral Aspects and Methodology of Solvents, Organic solvents and neurodegenerative diseases: exploring a possible link, Neurotoxicity of propylene ethers.

  • Microbial and Biochar Technology for Waste Valorization

    • 1st Edition
    • Maulin P. Shah + 2 more
    • English
    Microbial and Biochar Technology for Waste Valorization delves into the innovative integration of microbial and biochar technologies, presenting a compelling case for their combined utilization in waste reuse to aid environmental sustainability. The book opens with a discussion of current and emerging environmental issues and the need for implementing integrated microbe-biochar processes. Initial chapters explore the fundamentals of biochar, its sources, synthesis routes, characterization methods, its impact on soil, environment, and water microbiomes, and approaches to biochar production.The book then delves deeper into its role in environmental remediation, its suitability as a microbe carrier, and the combination of biochar and microbes for various applications, including microbial fuel cells, biofertilizer, biopesticide, and water treatment processes. Final sections highlight the use of machine learning and AI for predicting biochar characteristics, biochar's potential in promoting a circular economy and carbon neutrality, and future directions for biochar-microbe applications.

  • Biomarkers for Cancer Screening, Diagnosis and Targeted Therapeutic Approaches

    • 1st Edition
    • Volume 170
    • English
    Biomarkers for Cancer Screening, Diagnosis and Targeted Therapeutic Approaches, Volume 170 provides an integrated overview of the current state and future directions of biomarker research in oncology. The book bridges fundamental molecular insights with clinical applications, emphasizing how biomarkers are transforming cancer detection, diagnosis, prognosis, and personalized treatment strategies. Chapters cover an Introduction to cancer biomarkers and current research, Role of Biomarkers for cancer detection, diagnosis, and treatment, Classification of Cancer Biomarkers based on treatment strategies, Predictive, Prognosis and Diagnostic Cancer Biomarker in cancer therapeutic approaches, Biomarkers for targeted therapy and treatment decision-making, and much more.Additional sections delve in to Emerging trends in cancer biomarker and their clinical effect on personalized treatment, Recent advances in detection techniques regarding predictive, prognostic and diagnostic biomarkers in solid cancers and its future challenges, Recent advances in detection techniques regarding predictive, prognostic and diagnostic biomarkers in body fluids and its future challenges, Emerging biomarkers for non-invasive cancer diagnosis and treatment, and more. The brings together recent advancements in molecular diagnostics, predictive and prognostic markers, and targeted therapeutic development across a wide range of cancer types.

  • Women and Health

    • 3rd Edition
    • Rebecca Troisi + 3 more
    • English
    Women and Health, 3rd Edition, addresses health issues affecting women of all ages from adolescence through maturity. Extending far beyond other books on women’s health, which tend to focus on reproductive health alone, this book covers key issues ranging from osteoporosis to breast cancer, domestic violence, sexually transmitted diseases, occupational hazards, eating disorders, heart disease and other chronic illnesses, substance abuse, and societal and behavioral influences on health.In this third edition of Women and Health, the chapters incorporate issues that affect women across the life course with a special emphasis on the health of mid-life and older women. Changes in the field of women’s health since the first and second editions, for example, in genetics and the impact of sex and gender on health, are represented with the latest scientific findings and controversies.This book provides a comprehensive compendium of the epidemiology of health conditions affecting women internationally and over the life course for the lay reader, clinician, and health research scientist.

  • Artificial Intelligence Interventions in Agriculture, Food and Health Sectors

    • 1st Edition
    • Narashans Alok Sagar + 4 more
    • English
    Artificial Intelligence Interventions in Agriculture, Food and Health Sectors provides an integrated connection among agriculture, food, nutrition, and health sectors, compiling the history and evolution of AI, the scope of AI in the agricultural and food sectors, AI applications in the food processing and supply chain, and the role of AI in the food safety and healthcare industry. Edited by a multidisciplinary team, this book is a unique resource covering the innovative concepts of AI in the agriculture and food sectors, while providing useful insights to students, scientists, progressive farmers, food processing, and healthcare industries about the scope of AI applications.Users will find this to be a single platform for progressive farmers, food processing researchers, and healthcare professionals who are interested in learning about the potential of AI across a broad range of sectors. The book emphasizes the significance of stakeholder collaboration across disciplines to properly utilize the strengths of AI and handle its limitations.

  • Exploring Nanocarriers in Breast Cancer Management

    • 1st Edition
    • Amarjitsing Rajput + 3 more
    • English
    Exploring Nanocarriers in Breast Cancer Management comprehensively delves into the realm of nanocarrier systems, which have shown immense potential in the management of breast cancer. The scope of this book encompasses a thorough exploration of various nanocarrier systems, including, amongst others, liposomes, niosomes, and microneedles. It highlights recent advancements in these systems and their promising results in breast cancer treatment. Additionally, the book addresses the crucial aspects of toxicity and regulatory considerations associated with nanocarriers. It aims to provide a foundational understanding of nanocarriers, their unique features, and their significant role in breast cancer management.As breast cancer remains one of the most prevalent forms of cancer today, with no definitive cure currently available, this book is an essential resource for researchers, healthcare professionals, and anyone interested in cutting-edge developments in breast cancer treatment.

  • Pesticides and Neurotoxicant Exposures

    Impacts of Neurodevelopment and Long-Term Brain Health
    • 1st Edition
    • Neha Gogia + 1 more
    • English
    Pesticides and Neurotoxicant Exposures: Impacts of Neurodevelopment and Long-Term Brain Health explores neuroscience research, revealing how chronic pesticide exposure contributes to neurodegenerative diseases and cognitive decline. This new volume synthesizes findings on the mechanisms of pesticide-induced neurotoxicity and its impact on brain health. Targeted at researchers, clinicians, and policymakers, the book explores gaps in knowledge and the urgent need for improved regulation to protect vulnerable populations. By bridging scientific insights with public health, the book aims to advance understanding and prevention of pesticide-related neurological disorders.

  • Cytokine-Based immunotherapy Part B

    • 1st Edition
    • Volume 401
    • English
    Cytokine-Based immunotherapy: Part B, Volume 401 delves into the intricate world of cytokines, the vital signaling proteins that orchestrate the immune response and their pivotal role in modulating various immune functions. From fundamental mechanisms to their therapeutic applications, this book offers a thorough examination of the latest trends and developments in leveraging cytokines for immunotherapy. Chapters cover Cytokine-based immunotherapy in pancreatic cancer, IL-33 and its pleiotropic role in cancer, Immunocytokines based on IL-12 for cancer therapy: enhancing efficacy and reducing toxicity, Cytokine network in immunosuppression and tumor development in glioblastoma, The Double-Edged Role of Interferon Gamma in Cancer Immunity, and much more.An additional section covers Engineering Interleukin-10 for Therapeutic Applications, IL-23 Blockade: A Strategy for Relieving Inflammatory Diseases. Targeting TNF-alpha examines the immunotherapeutic approach for alleviating neuropathic pain. The key role of immunomodulatory cytokines for the development of novel nk cell-based cancer therapies focuses on the importance of cytokines in developing new cancer treatments. Finally, complexities in the clinical development of TGFβ inhibitors covers the challenges in creating inhibitors for TGFβ.

  • Sports Medicine and the Pelvic Floor

    Science to Practice
    • 1st Edition
    • Gráinne M. Donnelly
    • English
    Sports Medicine and the Pelvic Floor: Science to Practice shines a spotlight on a critical but often overlooked aspect of female athlete health: the pelvic floor. Bringing together the expertise of international clinicians and researchers, this book highlights persistent gaps in knowledge and practice, offering valuable direction for future research. It educates professionals on how to effectively screen, treat, and rehabilitate athletes, emphasizing that pelvic floor dysfunction can profoundly impact engagement, athletic performance, and overall well-being. By addressing this traditionally taboo subject, the authors provide evidence-based insights that call for the pelvic floor to be considered as essential in sports medicine.Sections discuss practical strategies for screening and supporting athletes, managing or alleviating symptoms, and ensuring a safe return to sport, all while prioritizing long-term pelvic health. This is an indispensable resource for anyone working with female athletes, blending science and clinical experience to advance care in this vital area.

  • Step-by-step Approach to the Radiological Evaluation of Arthritis

    • 1st Edition
    • Muthusamy Chandramohan + 1 more
    • English
    Step-by-step Approach in the Radiological Evaluation of Arthritis is a concise, practical reference source for the evaluation and interpretation of arthritis images. The book begins by briefly reviewing relevant anatomy, clinical and biochemical considerations. Subsequent chapters analyze specific arthritis indications in radiographic images using a simple, systematic approach. The book presents guidelines for when and when not to consider other advanced imaging techniques. Final chapters are devoted to troubleshooting strategies and key not-to-miss indications in rheumatic imaging. X-rays play a crucial role in the diagnosis and management of arthritis. This book’s clear and simple explanations of the subtleties and distinctions in arthritis imaging aims to improve investigative accuracy and aid healthcare professionals in monitoring disease progression and driving treatment decisions. Clinicians and radiologists in rheumatology as well as orthopedics will find certain value in integrating this must-have handbook into their daily practice.

  • Viruses

    Molecular Biology, Host Interactions, and Applications to Biotechnology
    • 2nd Edition
    • Paula Tennant + 2 more
    • English
    Viruses: Molecular Biology, Host Interactions, and Applications to Biotechnology, Second Edition provides an update on recent developments and perspectives, including coverage on the history of viruses, their structure, the organization of their genomes, and strategies in replication and expression. It emphasizes their diversity and versatility, how they cause disease, and how their human, animal, and plant hosts react. Sections also explore the beneficial aspects of viruses and how they can be utilized as tools and targets for biotechnological applications. This edition will appeal to a wide audience, including academics, researchers, and students studying the molecular biology and applications of viruses.Advances in technologies and enhanced surveillance have facilitated the monitoring of virus evolution, transmission dynamics, and pathogenesis. Coupled with the experiences of the COVID-19 pandemic, we have a better understanding of the interconnectedness of human, animal, and environmental health and the impact viruses have on society and the economy. This new release updates on many critical aspects of viruses and recent research.

  • Building Resilient Water and Food Systems under Climate Change

    • 1st Edition
    • Thendiyath Roshni + 3 more
    • English
    Building Resilient Water and Food Systems Under Climate Change aims to help readers understand and implement strategies to build resilient communities that can ensure sustainable access to both food systems and water resources. The book examines the impact of climate change on food and water security and explores how communities can adapt to these challenges. It provides an in-depth analysis of climate change science, focusing on its effects on agriculture, water resources, and ecosystems. Additionally, the book showcases case studies of communities that have successfully employed resilience strategies by integrating traditional and local knowledge systems with modern techniques.Readers will find practical solutions for managing risks and building sustainable, climate-resilient systems. By combining theoretical insights with real-world examples, this comprehensive guide is designed for policymakers, researchers, and community leaders to effectively safeguard essential resources at both macro and micro levels in the face of climate change.

  • Behavioral Biometrics and Artificial Intelligence for Neurodegenerative Diseases Assessment

    • 1st Edition
    • Vincenzo Dentamaro + 2 more
    • English
    Behavioral Biometrics and Artificial Intelligence for Neurodegenerative Diseases Assessment explores cutting-edge, non-invasive techniques for the early detection of neurodegenerative diseases. The book focuses on behavioral biometrics, which analyzes patterns in a person’s actions rather than directly measurable traits. By utilizing artificial intelligence methods—like machine learning and deep neural networks—it enables the observation of subtle changes in gait, handwriting, and speech. These advanced approaches offer promise for earlier and more accurate diagnosis, potentially improving outcomes for millions affected by conditions such as Alzheimer’s and Parkinson’s diseases through timely intervention and personalized care.In addition to its core coverage, the book delves into the practical applications of wearable sensors and the use of everyday devices like smartphones and tablets in assessments. It provides comprehensive chapters on how these technologies can aid clinicians and researchers in monitoring disease progression outside traditional clinical settings.

  • Silicon as a Sustainable Solution for Mitigating Abiotic and Biotic Stress in Plants

    • 1st Edition
    • Volume 118
    • English
    Silicon as a Sustainable Solution for Mitigating Abiotic and Biotic Stress in Plants, Volume 118 in the Advances in Botanical Research series, presents interesting chapters on a variety of topics, including Silicon in Soil and Plant, Silicon Transporters in Agronomic Crops, The Role of Silicon in Sustainable Disease Management of Monocot Plants, Silicon in the Management of Diseases in Dicot Crops, Silicon and Biocontrol Agents for Plant Growth and Control of Diseases in Rice, Silicon for the Control of Insect Herbivores in Agronomic Crops, Silicon-Driven Phenotypic Induction Enhances Physiological Tolerance to Water Deficit and Waterlogging in Agronomic Crops, and much more.Additional sections cover Silicon Nutrition for Sugarcane Production, Silicon Nutrition of Agronomic Crops, Physiological Aspects of Silicon in Plants under Stress, and Alleviation of Heavy Metal Stress in Plants by Silicon.

  • Neurological Assessment Made Easy

    A Step-by-Step Guide for Physiotherapists
    • 1st Edition
    • Vishal Verma
    • English
    Neurological Assessment Made Easy: A Step-by-Step Guide for Physiotherapists delves into the intricacies of neurological assessment, covering a wide range of topics such as sensory and motor function, reflexes, coordination, balance, and cognition. This text provides physiotherapists and clinicians with a comprehensive framework to systematically assess and evaluate the neurological status of their patients. This book provides practical strategies and tips to navigate challenges effectively, ensuring accurate and meaningful assessment results and emphasizes the importance of effective neurological assessment in guiding the development of personalized treatment plans.

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