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Elsevier

Books in Life sciences

  • Cardiometabolic Diseases

    Molecular Basis, Early Detection of Risks, and Management
    • 1st Edition
    • Gundu H. R. Rao + 1 more
    • English
    Cardiometabolic Diseases: Molecular Basis, Early Detection of Risks, and Management provides detailed information on all aspects of metabolic dysfunctions and associated risks for cardiometabolic diseases, including a thoughtful discussion of cellular and molecular mechanisms involved in the progression of metabolic risks, approaches for the early detection, and robust management of metabolic risks. Written by a team of expert contributors, this book is useful reading for researchers and clinicians interested on recent advances in etiology of cardiometabolic diseases, the latest noninvasive approaches for diagnosis, risk assessment tools, therapeutic strategies, and also aspects of prevention of cardiometabolic diseases.

  • Novel Drug Delivery Systems in the management of CNS Disorders

    • 1st Edition
    • Pooja A Chawla + 4 more
    • English
    Novel Drug Delivery Systems in the Management of CNS Disorders offers a comprehensive source of information on delivering drugs to the central nervous system to treat various diseases and conditions. The book covers a wide range of CNS disorders, including epilepsy, Parkinson's, Alzheimer's, Huntington's, multiple sclerosis, schizophrenia, cerebral palsy, autism, ALS, and others.The book begins by presenting the foundations of drug delivery to the brain and addressing the associated challenges. It then delves into clinical trials and explores the future potential of the presented technologies.This reference is designed for drug delivery researchers in academia and corporations, providing them with the essential knowledge about overcoming the Brain-Blood Barrier and achieving targeted drug delivery to the central nervous system.

  • The Charnolosome as a Novel Nanothereranostic Biomarker

    Overcoming Future Challenges in Medicine
    • 1st Edition
    • Sushil Sharma
    • English
    The Charnolosome as a Novel Nanothereranostic Biomarker: Overcoming Future Challenges in Medicine provides an overview of the charnolosome and its potential as a biomarker of cell injury. Based on the author’s original discovery of the charnoly body in the developing, undernourished rat cerebellar Purkinje neurons, this book delves into the potential for utilizing this mitochondria and lysosomal-derived intracellular organelle as a nanotheranostic biomarker to prevent and cure various diseases.The book discusses the cellular, molecular, genetic, and epigenetic mechanisms of charnolosomes and charnolosome-derived nano-vesicles. It also investigates the molecular mechanisms underlying auto-inflammatory, autoimmune, and infectious diseases resulting from their compromised mitochondrial bioenergetics, and the potential use of the charnolosome in preventing and curing such conditions.

  • Predictive Analytics using MATLAB(R) for Biomedical Applications

    • 1st Edition
    • L. Ashok Kumar
    • English
    Predictive Analytics using MATLAB(R) for Biomedical Applications is a comprehensive and practical guide for biomedical engineers, data scientists, and researchers on how to use predictive analytics techniques in MATLAB(R) for solving real-world biomedical problems. The book offers a technical overview of various predictive analytics methods and covers the utilization of MATLAB(R) for implementing these techniques. It includes several case studies that demonstrate how predictive analytics can be applied to real-world biomedical problems, such as predicting disease progression, analyzing medical imaging data, and optimizing treatment outcomes.With a plethora of examples and exercises, this book is the ultimate tool for reinforcing one’s knowledge and skills.

  • Bio Refinery of Wastewater Treatment

    Way to Generate Waste to Value
    • 1st Edition
    • Maulin P. Shah + 1 more
    • English
    Bio Refinery of Wastewater Treatment: Way to Generate Waste to Value focuses on the exploitation of various wastewater treatment technologies and microbial, chemical, and physical processes as tools for simultaneous value generation during treatment, degradation, detoxification, and stabilization of toxic and hazardous contaminants and restoring contaminated sites. The book provides recents advancements in integrative and cost-effective wastewater treatment strategies and stipulates all pros and cons of each strategy.Bio Refinery of Wastewater Treatment: Way to Generate Waste to Value is valuable to researchers and scientists, who are working in the field of effluent treatment plants/biodegradatio... of environmental contaminants for environmental protection and sustainable development.

  • Medical Image and Signal Analysis in Brain Research

    • 1st Edition
    • Volume 290
    • English
    Progress in Brain Research, Volume 290 highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this release include Image Analysis for Spinocerebellar Ataxia Type 3, Brain structural network modular and connectivity alterations in subtype of patients with migraine, Brain Functional Networks and Structures that Categorize Type 2 Bipolar Disorder and Major Depression, Reinforcement Learning Classification in fNIRS Signal of Olfactory Stimulated, The method of brain-computer interface using the forehead instead of the visual area to receive SSVEP signals and signal processing, and more.Additional chapters cover The relationship between flash-induced SSVEP in DELTA frequency band and sleep, Enhancing Facial Feature De-Identification in Multi-Frame Brain Images: A Generative Adversarial Network Approach, Comparative Analysis of MRI Markers in Heat and Mechanical Pain Sensitivity, and Analysis of the Difference Between Alzheimer’s Disease, Mild Cognitive Impairment and Normal People by Using Fractal Dimensions and Small-World Network.

  • Stem Cells in Neurotoxicology

    • 1st Edition
    • Volume 12
    • English
    Stem Cells in Neurotoxicology, Volume Twelve in the Advances in Neurotoxicology series, presents interesting chapters written by an international board of authors. Chapters in this new release include Brain organoids as a translational model of human developmental neurotoxicity, Self-organizing human neuronal cultures in the modeling of environmental impacts on learning and intelligence, Utilization of human stem cell/neural progenitor tests to examine neurotoxic impacts on differentiation, Characterization of neuronal and other cellular sub-types in human stem cell cortical neuron differentiations, Utility of human stem cell models to study persistent neurotoxicity, and Utility of human stem cell models to study chronic neurotoxicity.

  • Neuroscience Research in Short-Duration Human Spaceflight

    • 1st Edition
    • Bader Shirah
    • English
    Neuroscience Research in Short-duration Human Spaceflight encapsulates a groundbreaking neuroscience portfolio conducted during the Axiom Mission 2 in May 2023, offering an examination of the effects of short-duration orbital spaceflight on aspects of the human brain. Addressing limitations in existing literature, the research includes astronauts of diverse ages, genders, and ethnic backgrounds, broadening the understanding of the impact of spaceflight on human physiology. A significant aspect of the suite of studies is the validation of two novel devices providing unprecedented information about the pupillary light reflex and neuroimaging in microgravity: automated pupillometry and functional near-infrared spectroscopy. The portfolio extends to explore spaceflight-associat... neuro-ocular syndrome, offering valuable contributions to the evolving field of space medicine. Furthermore, the research delves into the utilization of electroencephalograp... to monitor brain activity, acknowledging its potential in assessing cognitive health, stress levels, and mental workload in real time. Despite promising prospects, challenges in electroencephalograp... system adaptability within the International Space Station environment are highlighted, emphasizing the need for specialized design considerations. In addition, analysis is extended into the molecular biomarkers through minimally invasive blood monitoring. This book represents a pivotal advancement in space neuroscience, laying the foundation for safer space travel and fostering the development of monitoring tools crucial to observing adverse changes and potentially developing countermeasures that can aid in the establishment of a permanent human presence beyond Earth.

  • The Physics of Protein Structure and Dynamics

    When and Why Proteins Fold or Don’t Fold
    • 1st Edition
    • Reinhard Schweitzer-Stenner
    • English
    The Physics of Protein Structure and Dynamics looks at various aspects of protein structure and dynamics from a physico-chemical point of view. It goes into some depth regarding the description of non-covalent forces that determine the relative stability of folded and unfolded proteins. Anharmonic protein dynamics involving motions between different minima of a rugged Gibbs energy landscape is described in great detail. The book combines various aspects of the protein folding/unfolding processes with an overview of intrinsically disordered proteins, which have attracted considerable interest of the protein community over the last 25 years but are thus far underrepresented in classroom-oriented textbooks. The book looks at protein folding and intrinsically disordered proteins as heavily interrelated topics that need to be viewed together. Furthermore, it presents some basic physico-chemical aspects of protein/peptide self-assembly into nanoscale fibrils. Intrinsically disordered peptides and proteins play a major role particularly in aggregation and self-assembly processes that lead to various diseases (Alzheimer, Parkinson, Huntington, Mad-Cow). Therefore, the relevance of protein disorder for protein self-assembly deserves a closer look. Protein self-assembly cannot be separated from protein folding since it is frequently the product of misfolding. With regard to modern theories, the folding processes are linked to insights on protein dynamics and the discovered relationship between proteins and spin glasses.

  • Inherited White Matter Disorders and Their Mimics

    • 1st Edition
    • Volume 204
    • English
    Inherited White Matter Disorders and Their Mimics, Volume 204 discusses where imaging abnormalities and pathology lie predominantly in the CNS white matter. Many acquired causes, such as multiple sclerosis, are readily diagnosed and familiar to the majority of neurologists. However, less common acquired causes and genetic disorders (the leukodystrophies and genetic leukoencephalopathie... often present a diagnostic challenge. The evaluation of patients with White matter disorders (WMDs) has evolved enormously in recent decades, due to advances in genetics, radiology, and the development of treatments for specific disorders. This book brings together WMD research, spanning basic science, molecular genetics, and clinical and radiological phenotyping.This volume presents both common WMDs and rare disorders according to their presentations or pathophysiology. Chapters lay out the clinical and radiological presentation of the disorder, followed by genetics and diagnostics, and finally discussion of pathophysiology and treatment. Chapter contain imaging, clinical pearls to diagnosis, and reference tables for genotype-phenotype correlation. For diagnostic work-up, easy to read algorithms are presented as well as clear guidance on indications for treatment, where applicable.

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