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Elsevier

Books in Life sciences

  • Novel Approaches to Cancer Chemotherapy

    • 1st Edition
    • Prasad S. Sunkara
    • English
    Novel Approaches to Cancer Chemotherapy compiles theories in tumor biology, emphasizing their potential use in developing therapeutic approaches to cancer therapy. This book emphasizes the unique property of a cancer cell and describes in detail how a novel therapeutic approach can be developed. This compilation consists of 11 chapters. Chapters 1, 2, 5, 6, and 7 deal with emerging areas of cancer therapy, such as the use of interferon, monoclonal antibodies, liposomes, lymphokines, and immunomodulators. The rest of the chapters cover some of the biochemical and enzyme targets in cancer cells, such as polyamines, prostaglandin, thromboxane, leukotrienes, 5a-reductase, aromatase, cell membrane glycoproteins, and sodium flux. The developments in relation to cancer therapy are mentioned in chapters dealing with biochemical approaches. This book is valuable to biologists, biochemists, immunologists, and molecular biologists intending to exploit the unique properties of cancer cells.

  • Recent Progress in Hormone Research

    Proceedings of the 1972 Laurentian Hormone Conference
    • 1st Edition
    • Roy O. Greep
    • English
    Recent Progress in Hormone Research, Volume 29 covers the proceedings of the 1972 Laurentian Hormone Conference held in Mont Tremblant, Province of Quebec, Canada, on August 27-September 1, 1972. The book discusses the studies on sex differentiation in mammals; male pseudohermaphroditis... in the laboratory Norway rat; and androgen metabolism and mechanism of action in male pseudohermaphroditis... The text also describes the mechanism of initiation of parturition in the ewe; the neurovascular regulation of the anterior hypophysis; and microtubules and beta cell secretion. The role of microtubules and microfilaments in thyroid secretion; the functional and morphological alterations produced in target cells by anti-inflammatory steroids; and protein kinases are also considered. The book further tackles the role of phospholipids in hormone activation of adenylate cyclise; the chemistry of growth hormone and the lactogenic hormones; and hormonal regulation of gene expression in mammary cells. The text then encompasses the endocrine and metabolic effects of experimental obesity in human; the studies on luteinizing hormone and its subunits; and chemical studies of luteinizing hormone from human and ovine pituitaries. The studies on the structure and function of interstitial cell-stimulating hormone are also looked into.

  • Additional Principles and Methods of Analysis

    Analytical Methods for Pesticides, Plant Growth Regulators, and Food Additives, Vol. 5
    • 1st Edition
    • Gunter Zweig
    • English
    Analytical Methods for Pesticides, Plant Growth Regulators, and Food Additives, Volume V: Additional Principles and Methods of Analysis covers the major advances in the analytical techniques used for the qualitative and quantitative determinations of minute amounts of pesticide and plant growth regulator residues in foods and crops. The book discusses developments in analytical methods (i.e. the polarographic technique, thin-layer chromatography) and their general applications; the analytical aspects of pesticide residue analyses in the environment; and specific analytical methods for formulation and residue analyses of insecticides, fungicides, herbicides and plant growth regulators. Agriculturists, agricultural engineers, toxicologists, and people involved in the study of pesticides and biochemicals will find the book invaluable.

  • Thin-Layer and Liquid Chromatography and Pesticides of International Importance

    Analytical Methods for Pesticides and Plant Growth Regulators, Vol. 7
    • 1st Edition
    • Joseph Sherma + 1 more
    • English
    Analytical Methods for Pesticides and Plant Growth Regulators, Volume VII: Thin-Layer and Liquid Chromatography Pesticides of International Importance covers information on the greatly expanded version of thin-layer chromatography and high-speed liquid chromatography. The book also discusses the formulation and residue analyses of individual compounds grouped according to uses, e.g., insecticides, herbicides, fungicides, and rodenticides. Toxicologists and people in agricultural chemicals and plant protection laboratories will find the book invaluable.

  • Water Activity: Influences on Food Quality

    A Treatise on the Influence of Bound and Free Water on the Quality and Stability of Foods and Other Natural Products
    • 1st Edition
    • Louis B. Rockland + 1 more
    • English
    Water Activity: Influences on Food Quality is a collection of papers presented at the 1978 International Symposium by the same title, held in Osaka, Japan. This book is a treatise on the influence of bound and free water on the quality and stability of foods and other natural products. This book is organized into seven sections encompassing 33 chapters. The first sections deal with the characterization of moisture sorption isotherms based on both theoretical and applied considerations, as well as the relationship of bound water to the physical and chemical properties of natural products, including foods. The succeeding sections consider the structure of water and the influence of solutes and solute mobility on water activity and the influence of water and water activity on the structural and functional characteristics of proteins, carbohydrates, and proteins. Other sections explore the influence of water activity and temperature on the rates of several important chemical reactions, such as lipid oxidation, vitamin decomposition, browning, and other reactions, which affect the chemical, physical, and nutritional properties of food. These sections also discuss the influence of water activity on food processing and storage practices from both theoretical and applied viewpoints, specifically the application of water activity principals to the processing and preservation of leafy vegetables, cheese, dried fish, and other products. The final section is devoted to the influences of water activity on the behavior of food-related microorganisms. This section emphasizes the role of solvents in controlling water activity and the related survival of certain microorganisms. This book will prove useful to food scientists and researchers.

  • Principles, Statistics, and Applications

    Analytical Methods for Pesticides and Plant Growth Regulators, Vol. 15
    • 1st Edition
    • Gunter Zweig + 1 more
    • English
    Analytical Methods for Pesticides and Plant Growth Regulators, Volume XV: Principles, Statistics, and Applications covers general principles of pesticide analysis and application of the techniques. The book discusses methods dealing with the analysis of pesticide formulations and residues in biological systems, food, and the environment; government regulations for the safe use of pesticides; and the rationale for the need for pesticide analyses. The text also describes the statistics of sampling and analyses, including the application of computers; clean-up techniques; and the international acceptance and interlaboratory comparisons of pesticide residue data. A discussion, review, and description of analytical methods to meet the unique requirements imposed by analyses of active ingredients in formulations (finished products), pesticide residues in foods and the environment, and pesticide metabolites in plants and animal tissues (metabolism studies) are also considered. People involved in pesticide analysis will find the book invaluable.

  • Recent Progress in Hormone Research

    Proceedings of the 1983 Laurentian Hormone Conference
    • 1st Edition
    • Roy O. Greep
    • English
    Recent Progress in Hormone Research, Volume 40 presents the proceedings of the 1983 Laurentian Hormone Conference held in Mont Tremblant, Canada. The book presents papers on promoter elements of genes coding for proteins and modulation of transcription by estrogens and progesterone; the structure, expression, and evolution of the genes for the human glycoprotein hormones; and the regulation and organization of thyroid stimulating hormone genes. The text also includes papers on the mouse mammary tumor virus model in studies of glucocorticoid regulation; the role of the circadian system in reproductive phenomena; and endocytosis and membrane traffic in cultured cells. Other papers on neuroendocrinology, mechanism of hormone action, reproductive biology, subcellular processing of hormones and their receptors, hereditary resistance to 1,25-dihydroxyvitami... D are also encompassed. Physiologists, endocrinologists, biochemists, and scientists involved in hormone research will prove the book invaluable.

  • The Pathophysiology and Pharmacotherapy of Myocardial Infarction

    • 1st Edition
    • Nabil El-Sherif + 1 more
    • English
    The Pathophysiology and Pharmacotherapy of Myocardial Infarction deals with the advances in the pathophysiology and pharmacotherapy of acute myocardial infarction and related complications. This book covers two major consequences—cardiac muscle dysfunction and cardiac electrical dysfunction. This text begins by reviewing the controversy surrounding the pathogenetic mechanisms of atheroma formation and its potential reversibility, including the status of coronary risk factors and benefits of primary prevention. The pathophysiologic mechanisms of pump failure and the current approach to its management are then deliberated, followed by a discussion on the rational use of vasodilators in post-infarction heart failure and pharmacotherapy of cardiogenic shock. The rationale for the interest in the role of coronary vasospasm and thrombolytic therapy for acute myocardial infarction is also covered. This publication concludes by reviewing the approaches for the management of post-infarction ventricular tachyarrhythmias and concept of secondary prevention of sudden cardiac death. This compilation is valuable to medical students, primary care physicians, and cardiovascular specialists.

  • Cellular and Molecular Renewal in the Mammalian Body

    • 1st Edition
    • Ivan L. Cameron + 1 more
    • English
    Cellular and Molecular Renewal in the Mammalian Body concerns the dynamic nature of body constituents at the molecular, organelle, and cellular level of structural organization. Each chapter of this book deals with cellular and molecular renewal, proliferation, and loss, focusing on the body's major macromolecular classes, such as DNA, RNA, proteins, lipids, and carbohydrates. Other topics discussed include the subcellular renewal, DNA stability, regulation of cell proliferation, and changes in mitotic rates. The intracellular sites of RNA synthesis, proteins of the nucleus, and epithelial-mesenchym... interactions are also elaborated. This text likewise covers the brown adipose tissue, histochemistry of polysaccharides, and calcification. This publication is beneficial to students and investigators intending to acquire knowledge of the dynamic nature of body constituents and its influence to the analysis and experimentation of normal, disease, and repair processes within the body.

  • Radiation Research

    Biomedical, Chemical, and Physical Perspectives
    • 1st Edition
    • Oddvar F. Nygaard + 2 more
    • English
    Radiation Research: Biomedical, Chemical and Physical Perspectives documents the proceedings of the Fifth International Congress of Radiation Research held in Seattle, Washington, 14-20 July 1974. While the focus of the Congress was on fundamental research, there were several well-attended sessions on the practical aspects of radiation research as it relates to radiotherapy, central station power generation by both nuclear fission and fusion, and the environment. This volume contains 126 papers organized into 31 parts. Beginning with a keynote address and a lecture on the time scale in radiobiology, the subsequent contributions cover a wide range of topics presented over several sessions. Topics discussed during these sessions include energy needs, nuclear power, and the environment; prospects for fusion power; technological applications of radiation; human radiobiology; hazards of radiation exposure relative to other environmental agents; the basic physics of the interactions of radiation with matter; particle penetration phenomena; and radiation effects in frozen media.

  • Parasitic Protozoa

    Volume 9
    • 2nd Edition
    • Julius P. Kreier
    • English
    Updated and much expanded, the Second Edition of Parasitic Protozoa is designed to be useful to physicians, veterinarians, and research scientists concerned with diseases caused by protozoa in man, and in domestic and wild animals including fish, mollusks and insects, as well as the more commonly considered vertebrate animals. Each section contains information on disease pathogens, treatment, diagnosis, and epidemiology of the diseases caused by the various protozoans. The book is not limited to these medically-oriented subjects, but treats taxonomy, morphology, and metabolism of the organisms in such a way as to be of interest to scientists and graduate students working in the field of protozoology. The entire edition, published in ten volumes, is arranged so that subjects of common interest occupy individual volumes.

  • Interlimb Coordination

    Neural, Dynamical, and Cognitive Constraints
    • 1st Edition
    • Stephan P. Swinnen + 3 more
    • English
    This comprehensive edited treatise discusses the neurological, physiological, and cognitive aspects of interlimb coordination. It is unique in promoting a multidisciplinary perspective through introductory chapter contributions from experts in the neurosciences, experimental and developmental psychology, and kinesiology. Beginning with chapters defining the neural basis of interlimb coordination in animals, the book progresses toward an understanding of human locomotor control and coordination and the underlying brain structures and nerves that make such control possible. Section two focuses on the dynamics of interlimb coordination and the physics of movement. The final section presents information on how practice and experience affect coordination, including general skill acquisition, learning to walk, and the process involved in rhythmic tapping.

  • NMR In Physiology and Biomedicine

    • 1st Edition
    • Robert J. Gillies
    • English
    This book provides a comprehensive review of modern nuclear magnetic resonance approaches to biomedical problems in vivo using state-of-the-art techniques. It devotes equal attention to the methods and applications of NMR and addresses the potential of each of the techniques discussed. The volume includes late-breaking areas such as functional imaging, flow imaging, bioreactor spectroscopy, and chemical shift imaging. All chapters are written in a "current concepts" style that renders information accessible to readers at all levels. Contributors are known experts in the field, lending the book an international perspective.

  • Atlas of the Prenatal Mouse Brain

    • 1st Edition
    • Uta B. Schambra + 1 more
    • English
    The Atlas of the Prenatal Mouse Brain is the latest addition to Academic Press' list of atlases for neuroscientists and neuroscience students. It fills an urgent need for a comprehensive atlas of the developing mouse brain for use in studies of both normal and abnormal development. High-quality photomicrographs of brain sections are depicted in sagittal, coronal, and horizontal planes for four gestational age groups. Each photomicrograph is accompanied by a fully labeled, precision-drawn diagram for easy identification of brain structures. Researchers and students using normal, transgenic, or mutant mouse preparations in developmental neurobiology, neurotoxicology, and biotechnology will welcome this meticulously assembled and accessible guide.

  • Marine Mammals and the Exxon Valdez

    • 1st Edition
    • Thomas R. Loughlin
    • English
    The oil spill disaster that occurred when the Exxon Valdez ran aground has become part of the iconography of ecological disaster. This book synthesizes previously confidential data only recently released by the U.S. government. The data concerns the effects of this nightmarish spill on marine mammals, such as sea otters, harbor seals, killer whales, and humpback whales. Because many of the book's contributors were on site within 24 hours of this 11 million gallon catastrophe, the book is a unique longitudinal study of the demise of an ecosystem due to a single acute environmental perturbation.These certain-to-be-influe... results reported here should assist marine biologists, pathologists, toxicologists, environmentalists, engineers, and coastal planners in assessing the nature of this now legendary disaster.

  • Structure-Function Properties of Food Proteins

    • 1st Edition
    • Lance G. Phillips
    • Steve L Taylor
    • English
    The functional properties of food proteins affect behavior in food systems and influence the quality attributes, structure, texture, mouth-feel, and flavor of the final product. These attributes are precisely those with which food engineers and technologists are concerned when developing new products. This innovative book provides an overview of the physical properties of proteins and how dynamic changes in conformation, structural changes, and protein-protein interactions are involved in the performance of particular functional properties such as gelation, emulsification, and foaming properties. Models used include B-Lactoglobulin, soy, and meat proteins.

  • Experimental Analysis of Behavior

    • 1st Edition
    • Volume 6
    • I.H. Iversen + 1 more
    • English
    This volume is dedicated to the late B.F. Skinner as a tribute to his pioneering work on the Experimental Analysis of Behavior. This science that he initiated studies the behavior of individual organisms under laboratory conditions.The volume describes a broad collection of representative and effective research techniques in the Experimental Analysis of Behavior; techniques derived solely from infrahuman subjects, which have been selected both for their utility in behavior analysis and for their potential value in expanding the use of behavior analysis in the neurosciences. By bringing together under one cover the expertise of individual authors regarding techniques based on their particular laboratory experiences, the book provides an informative and practical source of methods and techniques for those practising or interested in Experimental Analysis of Behaviour.

  • Stability and Stabilization of Enzymes

    Proceedings of an International Symposium Held in Maastricht, The Netherlands, 22-25 November 1992
    • 1st Edition
    • Volume 47
    • W.J.J. van den Tweel + 2 more
    • English
    These proceedings contain most of the oral presentations and posters of the international symposium on Stability and Stabilization of Enzymes held in Maastricht in November 1992. They provide a comprehensive overview of the state-of-the-art in this field.The possible applications of enzymes are enormous. Years of development have seen many enzymes brought onto the market, but they are still expensive to use. Therefore, their efficient application is a prerequisite for common usage. One of the main factors for this efficiency is the stability of the enzymes. The topics thus ranged from the extensive fundamental thermodynamic knowledge gathered in academic research to the practical applied knowledge built up in industry during the time that enzymes have been produced commercially.The subject Stability and Stabilization of Enzymes was discussed from various points of view, as was reflected in the themes of the symposium sessions. In the session on Fundamentals of Enzyme Stabilisation the thermodynamic background of the phenomenon was highlighted. In yet another session, the recently developed analytical tools to measure enzyme stability and stabilisation were discussed. Further sessions comprised the physical, chemical and biological ways to obtain enzyme stabilisation and finally, the industrial practice of enzyme stabilisation was treated by representatives of the world's most important enzyme producers. The book will be of interest to researchers in universities and industry in the fields of biochemistry, enzymology and biotechnology.

  • Freshwater Ecosystems

    Modelling and Simulation
    • 1st Edition
    • A.H. Gnauck + 1 more
    • English
    Ecosystem analysis and ecological modelling is a rapidly developing interdisciplinary branch of science used in theoretical developments in ecology and having practical applications in environmental protection. In this book, the authors introduce new holistic, particularly cybernetic, concepts into ecosystem theory and modelling, and provide a concise treatment of mathematical modelling of freshwater ecosystems which covers methods, subsystem models, applications and theoretical developments.Part I begins with a brief introduction to the principles of systems theory and their applications to ecosystems, and provides a summary of various methods of systems analysis. In Part II emphasis is laid on the pelagic processes in standing water, characterised by relatively uninvolved structures from which models can be readily developed. Part III describes applications of the technique of modelling to solutions of theoretical and practical problems, with different modelling methods and objectives being used in the various chapters. More recent developments in the methods and theory of ecosystem modelling are covered in Part IV which also includes a discussion of future trends. The book is addressed to practising ecologists and engineers in the fields of ecology, limnology, environmental protection, and water quality managements, as well as to graduate/post-gradua... university students in science and engineering. Students and researchers involved in environmental applications of mathematics and cybernetics will also find the book of interest.

  • Methods in Behavioral Pharmacology

    • 1st Edition
    • Volume 10
    • F. van Haaren
    • English
    Methods in Behavioral Pharmacology is unique in offering a complete description and critical evaluation of most, if not all, methods available to study the effects of drugs on behavior. It stands apart in that it is not limited to the analysis of a particular class of pharmacological agents in a limited number of paradigms. Methods in Behavioral Pharmacology covers all paradigms without reference to specific pharmacological compounds.The book provides a comprehensive overview of the methodology used to study the behavioral effects of legal and illegal drugs. It also provides an in-depth presentation of dependent variables, their quantification and a critical evaluation of their advantages and disadvantages. An excellent work, contributed to by well-known experts in the different fields of behavioral pharmacology.

  • International Review of Connective Tissue Research

    Volume 5
    • 1st Edition
    • David A. Hall + 1 more
    • English
    International Review of Connective Tissue Research, Volume 5 presents a detailed review of the end products of collagen metabolism, which is important in understanding certain diseases involving the connective tissues. This book discusses the progress in collagen research. Organized into four chapters, this volume begins with an overview of the metabolism of proline and hydroxyproline that are derived from studies using microorganisms. This text then examines the increasing interest in the more complex tissues and elucidates the marked differences one may expect to find in such tissues. Other chapters consider the process of calcification and the various conflicting theories. This book discusses as well the influence of the impurities, such as fluoride and carbonate, on the nature and formation of biological apatite. The final chapter deals with the contrast between the dynamic state of connective tissue cells and the inert aspect of the intercellular substances. This book is a valuable resource for biochemists, physicians, and surgeons.

  • Advances in Drug Research

    • 1st Edition
    • Volume 19
    • Bernard Testa
    • English
    Each volume in this distinguished series presents authoritative reviews on topics of broad interest in drug research and on novel and established therapeutic classes. Acknowledged experts contribute in areas such as drug design, clinical and molecular pharmacology, drug metabolism, and mechanisms of action. Reviewers have consistently praised Advances in Drug Research for its comprehensive and lucid summaries of up-to-date knowledge.

  • Advances in Drug Research

    • 1st Edition
    • Volume 17
    • Bernard Testa
    • English
    This volume comprises five authoritative reviews on timely topics in drug research. The first two chapters deal with chemotherapeutic agents (selective antiviral agents and cepham antibiotics) and subsequent chapters deal with the cardiovascular system and topics in neuropharmacology.

  • The Biology and Control of Weeds in Sugarcane

    • 1st Edition
    • Volume 4
    • S.Y. Peng
    • English
    Offering much new information on the subject, this volume discusses the problems of weed control in sugarcane against the background of world-wide cultivation, with emphasis on Taiwan's intensive pattern of crop farming. After a brief botanical description of sugarcane and its cultivation in relation to weed control, the weeds themselves are studied. Chemical control of weeds, problems of crop tolerance and responses of weed species to chemicals are examined. Techniques for evaluating new herbicides, research and practices of chemical weed control in the leading industries of the world, and the application of techniques and equipment are all described in detail.The author has served the Taiwan sugar industry for more than 30 years and many of his techniques and approaches have been adopted by industries in other countries. To his own extensive experience, he has added a large amount of information published in recent years to compile this treatise which is both a contribution to the field of weed science, and a valuable practical manual for agronomists in general.

  • Drainage Geochemistry

    • 1st Edition
    • Volume 6
    • M. Hale + 1 more
    • English
    The considerable exploration success achieved by geochemistry over the last several decades - and still continuing - has provided both the basis and rationale for the Handbook of Exploration Geochemistry series, including Volume 6, Drainage Geochemistry in Mineral Exploration. With contributions from 25 experts of truly global professional experience in drainage geochemistry, this book is a thorough appraisal of the state of the art in the use of surface and sub-surface waters, stream and lake sediments, heavy minerals for mineral exploration in tropical rain forests, temperate glaciated terrains, mountain chains, arid deserts and regions of agricultural and industrial pollution. Additional attention is given to gold and uranium exploration, and to the growing role of drainage geochemistry as a multi-purpose environmental mapping technique with applications in human health studies, ore deposit modelling and pollution monitoring. It comprises 16 chapters, more than 250 figures and a bibliography of some 1600 references.This book is the most extensive and detailed single work on the principles and applications of drainage geochemistry in mineral exploration blending both theoretical considerations and practical implementations.

  • International Review of Connective Tissue Research

    Volume 2
    • 1st Edition
    • M. A. Epstein
    • English
    International Review of Connective Tissue Research, Volume 2 is a collection of papers that deals with the morphological background, physiological, and pathological aspects of studies done on connective tissues. One paper discusses the precipitation of collagen fibers from solution — that fibrils form in vitro and in vivo by similar mechanisms. Another paper examines the importance of elastic tissues in the reactions of connective tissue including diseases of the vascular and pulmonary systems. As simple as elastic tissues appear to be, these can be models in studies of the basic structure and function of other more complicated tissues. One author discusses the physiology of the connective tissues of the reproductive tract; he concludes that defects in the connective tissue functions can cause failure in ovulation or the formation of cystic ovaries. Other authors discuss the diseases of collagen and related tissues (rheumatic fever, rheumatoid arthritis, systemic lupus erythematous, osteoarthritis, osteoporosis), as well as the aging process. One author analyzes the role of collagen fibers in aging: whether factors exist that causes cross-linking or ester cross-links or the dissolution of the collagen macromolecule associated with the aging of collagen. This book can prove helpful for molecular or cellular biologists, pathologists, physiologists, gerontologists, and researchers in gene therapy, pharmacology or micro-chemistry.

  • Essays in Toxicology

    Volume 7
    • 1st Edition
    • Wayland J. Hayes
    • English
    Essays in Toxicology, Volume 7 presents essays on toxicology and related topics. The book presents essays on the effects of toxicants on reproductive performance; an overall view of carcinogenesis from an epidemiological viewpoint and the potentialities and limitations of the epidemiological method in cancer control; and the activity of cytochrome P450 and mixed-function oxidase in target and nontarget organisms. The text also includes essays on the toxicity of hexachlorophene and the use of hexachlorophene as an antibacterial agent; the methodology, dose measurement, and respiratory function assessment in respiratory toxicology; as well as behavioral toxicology, with focus on early warning and worker safety and health. Pharmacologists, biochemists, pathologists, neurophysiologists, epidemiologists, and toxicologists will find the book invaluable.

  • Essays in Toxicology

    Volume 6
    • 1st Edition
    • Wayland J. Hayes
    • English
    Essays in Toxicology, Volume 6 approaches toxicology by very different routes; two essays with materials (plastics and tobacco alkaloids), one deals with the effects of abnormal pressure, one considers the biochemistry of the lung, and one discusses poison control centers and other mechanisms for limiting the injury done by toxic materials. The book presents essays on the topological problems and untoward effects from plastic devices used in medical applications; the metabolism of tobacco alkaloids; and poisons control center. The text also includes essays on the toxicology of hypobaric and hyperbaric environments; as well as the exploitable biochemical approaches for the evaluation of toxic lung damage. Biochemists, physical chemists, neurophysiologists, epidemiologists, and social scientists will find the book invaluable.

  • Neurobiology of Steroids

    • 1st Edition
    • Volume 22
    • E. Ronald de Kloet + 1 more
    • English
    Steroid hormones are unique compounds in that they are active at the interface of peripheral endocrine events and neural mechanisms. Thus their effects present an important peripheral signaling system to alter brain function. This volume presents state-of-the-art and classical techniques for the study of steroid hormones and their receptors and their effects and actions.

  • International Review of Connective Tissue Research

    Volume 3
    • 1st Edition
    • M. A. Epstein
    • English
    International Review of Connective Tissue Research, Volume 3 is a collection of papers that deals with the histochemisty of connective tissues. One paper reviews the histochemistry of connective tissues, including fibrous components such as collagen, reticulum, cellulose fibers, elastic fibers. Connective tissues known as osteoblasts and odontoblasts produce bone/cartilage and teeth. One author examines the biochemistry and pathology of the connective tissue of the periodontium that is related to periodontal disease. He also examines the role of oral bacteria in the pathogenesis of periodontitis; he concludes that bacterial enzymes can increase permeability for other bacterial types to directly elicit inflammation. One author analyzes the physical chemistry of gelatin and gelatin transition. He concludes that the rate of fold formation and the stability of the fold-units on single-chain gelatins and on multichain gelatins depend on the relative effectiveness of ions. Single-chain gelatins have the highest rate of network junction point formation; multichain gelatins, with enhanced cyclic junction point formation, have less network-forming properties. Cellular biologists, pathologists, physiologists, gerontologists, and researchers in gene therapy, pharmacology, micro- or molecular chemistry will find this book highly informative.

  • International Review of Connective Tissue Research

    Volume 8
    • 1st Edition
    • David A. Hall + 1 more
    • English
    International Review of Connective Tissue Research, Volume 8, provides an overview of the state of knowledge in connective tissue research. The details of the structure of collagen and its biosynthesis are now well established, and attention has focused on the finer details of the biochemical mechanisms involved. The knowledge achieved so far is also being applied to studies of various physiological, developmental, and pathological mechanisms involving the connective tissues. These trends are reflected in the subject covered by this volume. The enzymes involved in the posttranslation modifications of collagen are being intensively investigated. The book deals with three of these: lysyl oxidase, the enzyme involved in the first stage of cross-link formation; and the two glycosyl transferases involved in the glycosylation of hydroxylysome residues. New collagen types are reviewed together with recent work on collagen messenger RNA. Both of these topics are important to the understanding of the control of collagen biosynthesis. The involvement of connective tissues in physiological and pathological processes is discussed in three areas. These are interaction of collagen with platelets in hemostasis; the biosynthesis of connective tissue components by smooth muscle cells; and biochemical research on the intervertebral disc, the disease of which is behind the majority of back pain problems.

  • Current Topics in Comparative Pathobiology

    Volume 2
    • 1st Edition
    • Thomas C. Cheng
    • English
    Current Topics in Comparative Pathobiology, Volume 2 covers several areas of pathobiology. The book discusses the biology of trematodes of the genus Paragonimus that occur in the Americas; the milky disease of beetles; and the biochemical exploration in insect pathology. The text describes the application of invertebrate tissue culture to the in vitro study of animal parasites; and the use of hydra-hydramoeba as a model system for the study of epizootic processes. The aspects of the biology of nudibranchs are reviewed, with emphasis on nudibranchs as members of associations, including functional morphology, physiology, utilization of host pigments and nematocysts, life history, behavior, defensive mechanisms, and ecology. Chemists, bacteriologists, parasitologists, invertebrate pathologists, immunologists, and protozoologists will find the book invaluable.

  • Photoreceptor Cells

    Methods in Neurosciences, Vol. 15
    • 1st Edition
    • Paul A. Hargrave
    • English
    Photoreceptor Cells, Volume 15 covers the advances in the study of photoreceptor cells. The book discusses biochemical, cell and structural biological, and molecular biological techniques needed for the study of photoreceptor cells. The text also describes the methods for observing the structure of photoreceptor cells and for studying their metabolism. The procedures for photoreceptor cell isolation are also considered. The book further tackles the preparation of proteins involved in rod cell metabolism, with particular emphasis on proteins of the visual transduction cascade. The text also encompasses the application of molecular biological techniques for the examination of molecular components of the visual system and their structure, distribution, and function. Neuroscientists, ophthalmologists, biochemists, and people involved in the study of photoreceptor cells will find the book invaluable.

  • Molybdenum

    An Outline of its Chemistry and Uses
    • 1st Edition
    • Volume 19
    • E.R. Braithwaite + 1 more
    • English
    Molybdenum is an element with an extremely rich and interesting chemistry having very versatile applications in various fields of human activity. It is used extensively in metallurgical applications. Because of their anti-wear properties, molybdenum compounds find wide applications as lubricants - particularly in extreme or hostile environmental situations. Many molybdates and heteropolymolybdates are white and therefore used as pigments. In addition, they are non-toxic and act as efficient corrosion inhibitors and smoke suppressants. Hydroprocessing of petroleum is one of the largest industries employing heterogeneous catalysts. Molybdenum catalysts have shown great promise in the liquefaction of coal and this may develop into one of its most important catalytic uses. The use of molybdenum compounds in homogeneous catalysis is also significant.Three important classes of molybdenum compounds in the solid state are reviewed, viz., oxides, sulphides and halides. The role of molybdenum in inorganic catalysis and enzymes receives prominent mention because of their impact on the progress of science and technology. Further biochemical and enzymic factors are discussed in separate chapters and their reaction to agriculture and animal husbandry.A new classification of covalent compounds which abandons the traditional oxidation state concept allows a powerful approach to the organisation of the complex and rich chemistry of molybdenum. Dramatic colour diagrams of abundances of molybdenum compounds provide broad insights into the important features and trends in the chemistry of molybdenum including reactivity and mechanism.The book is intended for use mainly as a research monograph by the many workers who may encounter molybdenum chemistry or who are looking for its application and potential uses in different technological fields. However, it will also serve as an advanced text for university lecturers and postgraduate students interested in inorganic, physical and industrial chemistry, chemical technology or biochemistry and biotechnology.

  • International Review of Connective Tissue Research

    Volume 6
    • 1st Edition
    • David A. Hall + 1 more
    • English
    International Review of Connective Tissue Research, Volume 6 presents the relationship between structure and function in connective tissue. This book deals with articular cartilage, a connective tissue that depends for its function on the integrity of its surface. Organized into six chapters, this volume begins with an overview of the structure, biology, chemistry, and biochemistry of collagen. This text then summarizes the data on the construction and application of collagen products to medicine and surgery. Other chapters consider the characteristic of the amino acid composition of basement membranes and the structural features of the synovial joint. This book discusses as well the functional properties of collagenous tissues with emphasis on their behavior when internal or external mechanical stresses are applied. The final chapter deals with the structure of fresh connective tissue based on conventional histological procedures such as dehydration, fixation, embedding, and staining. This book is a valuable resource for biochemists, rheologists, and physicists.

  • Trends in Receptor Research

    Proceedings of the 8th Camerino-Noordwijkerhout Symposium, Camerino, Italy, 8-12 September 1991
    • 1st Edition
    • Volume 18
    • P. Angeli
    • English
    The 8th Camerino-Noordwijker... Symposium has continued along its traditional path of interdisciplinary cooperation. Chemists, biochemists, pharmacologists, biophysicists and physiologists are all involved in the task of improving our knowledge of the mechanisms of drug-receptor interaction and of the heterogeneous nature of biological molecules. In this volume, leading researchers have contributed state of the art information on receptor chemistry. Newest developments are covered with particular reference to receptors of the nervous system; SAR studies; receptor isolation; receptor cloning; receptor topography; biomedical consequences of occupancy; receptor regulation and receptor theory. This will be of great interest to pharmacologists, biochemists and medicinal chemists, as well as a valuable source of reference for medical students and postgraduate students in related fields.

  • Ion Channels of Excitable Cells

    • 1st Edition
    • Volume 19
    • P. Michael Conn + 1 more
    • English
    Because of the highly significant and widely recognized roles of ion channels in physiology, pathophysiology, pharmacology, and toxicology, the term ion channel has now become a household word in the biomedical sciences. This volume covers preparations and techniques for the study of various ion channels. Both voltage-gated and ligand-gated ion channels of neurons, axons, and cardiac and smooth muscles are covered. It includes not only patch clamp techniques but molecular biology and imaging techniques as well.

  • Advances in Cellular Neurobiology

    Volume 3
    • 1st Edition
    • Sergey Fedoroff + 1 more
    • English
    Advances in Cellular Neurobiology, Volume 3 discusses the anatomy and functional relation of the brain and spinal cord. This book is divided into three main sections—cell differentiation and interaction, aging and pathology, and methodologies. The topics discussed include Schwann cells, an in vitro perspective; molecular and cell biological aspects of learning toward a theory of memory; and aging of autonomic synapses. The axonal elongation in peripheral and central nervous system transplants; isolation and characterization of the cells of the cerebral microvessels; and PCI2 pheochromocytoma cultures in neurobiological research are also deliberated in this text. This publication is intended for neurologists, but is also beneficial to students researching on the central nervous system.

  • Progress in Behavior Modification

    Volume 3
    • 1st Edition
    • Michel Hersen + 2 more
    • English
    Progress in Behavior Modification, Volume 3, is a multidisciplinary serial publication that encompasses the contributions of psychology, psychiatry, social work, speech therapy, education, and rehabilitation. This serial aims to meet the need for a review publication that undertakes to present yearly in-depth evaluations that include a scholarly examination of theoretical underpinnings, a careful survey of research findings, and a comparative analysis of existing techniques and methodologies. The discussions center on a wide spectrum of child and adult disorders. The present volume opens with a chapter on behavior modification and hypnosis. This is followed by separate chapters on applications of behavior modification procedures in classroom settings; smoking behavior modification; and psychotherapy outcome research. Subsequent chapters deal with the behavioral approach to teaching learning disabled children; evaluation of animal analogues of behavioral treatment; therapy for sexual dysfunction; and research in the area of transfer of training of operant treatment effects with children.

  • Advances in Drug Research

    • 1st Edition
    • Volume 20
    • Bernard Testa
    • English
    Advances in Drug Research, Volume 20 focuses on the general themes of drug research and description of specific drug classes. This book is divided into four chapters. Chapter 1 discusses the extrapolation of toxicological and pharmacological data from animals to humans. The second chapter deals with the tissue binding of drugs, considering the relative ponderal importance of tissue versus blood macromolecules. The therapeutic use of plants and consumption of medicinal plants are elaborated in Chapter 3. The last chapter covers the field of histaminergic agonists and antagonists, describing breakthroughs such as H2-receptor antagonists, non-sedating H1-receptor antagonists, and H3-receptors. This publication is valuable to drug researchers and students interested in advances in drugs.

  • Progress in Biomass Conversion

    Volume 3
    • 1st Edition
    • Kyosti V. Sarkanen + 2 more
    • English
    Progress in Biomass Conversion, Volume 3, attempts to reflect and consider the current status of knowledge and development in the biomass energy and chemicals field. It covers topics such as combustion, gasification, alcohol fuels, liquefaction, whole tree chipping, baling, and fuel consumption. It deals not only with wood but also with agricultural wastes such as rice hulls, cotton gin trash, and other crop residuals. This book begins with a review of biomass energy development. This is followed by discussions of the integration of biomass into the total fuels community; the growth in understanding of biomass combustion; the use of European technology. Subsequent chapters present a review of supply issues; a technical evaluation of cogeneration; and a thoughtful, future-oriented, position paper in biomass fuels for energy security.

  • Progress in Behavior Modification

    Volume 6
    • 1st Edition
    • Michel Hersen + 2 more
    • English
    Progress in Behavior Modification, Volume 6, is a multidisciplinary serial publication that encompasses the contributions of psychology, psychiatry, social work, speech therapy, education, and rehabilitation. This serial aims to meet the need for a review publication that undertakes to present yearly in-depth evaluations that include a scholarly examination of theoretical underpinnings, a careful survey of research findings, and a comparative analysis of existing techniques and methodologies. The discussions center on a wide spectrum of child and adult disorders. The book opens with a chapter on the various behavioral procedures for treating insomnia. This is followed by separate chapters on behavioral analysis and formulation of the problem of stuttering; the assessment and treatment of enuresis and encopresis in children; and the development of behavior modification in Latin America. Subsequent chapters deal with the analysis of behavior modification from the point of view of its social identity; the conceptual and clinical literature resulting from the broader emphasis in behavior modification; and the relationship between therapist and client.

  • Progress in Chemical Toxicology

    Volume 1
    • 1st Edition
    • Abraham Stolman
    • English
    Progress in Chemical Toxicology, Volume 1 covers the developments in toxicology, including the usefulness of the developed techniques and methods with necessary modifications for toxicological studies. The book describes the isolation and separation techniques for the identification of poisons; the application of gas chromatograph to toxicology; and the pharmacological and toxicological effects aliphatic alcohols. The text also discusses the isolation, purification, identication, and the toxicology of acidic and neutral poisons, ataraxics and nonbarbiturate sedatives. The determination of antiarthritics, antihistamines, and thymoleptics; the physicochemical properties for the identification of narcotics and related bases; and the toxicity of air pollutants are also considered. The book further tackles the analytical methods for air pollutants; the occurrence, symptoms, and treatment of mushroom poisoning; and the toxic components of poisonous seeds and fruits poisonous seeds and fruits. Toxicologists, chemists, and scientists in forensic science laboratories will find the text invaluable.

  • Progress in Biomass Conversion

    Volume I
    • 1st Edition
    • Kyosti V. Sarkanen + 1 more
    • English
    Progress in Biomass Conversion, Volume 1 reviews advances in the conversion of biomass sources such as wood and wood residues, agricultural materials, and municipal refuse to fuel, with emphasis on the potential of wood to reduce our dependence on fossil fuels. Topics covered range from wood fuel use in the forest products industry to the economic values of wood residues as fuel. Methanol from wood and pyrolysis of wood residues with a vertical bed reactor are also considered. Comprised of seven chapters, this volume begins with a discussion on living resources and renewing processes, focusing on carbon resources and cycles, biomass system assessment, and the renewability of biomass as well as the feedstock approach of producing chemicals from renewable resources. The use of wood fuel in the forest products industry is then examined, along with the economic importance of wood residues as fuel. Subsequent chapters deal with the pyrolysis of wood residues in a vertical bed reactor; the derivation of methanol from wood; practices for recovering energy from municipal waste in Europe and the United States; and silvicultural energy farms as a potential source of wood fuel in the long term. This book should appeal to energy policymakers as well as public utilities, manufacturing plants, and public institutions interested in biomass fuel utilization.

  • Advances in Cellular Neurobiology

    Volume 2
    • 1st Edition
    • Sergey Fedoroff + 1 more
    • English
    Advances in Cellular Neurobiology, Volume 2 discusses the central nervous system, focusing on the structure and function of the brain and spinal cord at cellular level and higher brain functions such as learning, memory, and intelligence. This book is divided into three main sections— cell differentiation and interaction, aging and pathology, and methodologies. The topics discussed include APUD cells and paraneurons: embryonic origin; trophic and specifying factors directed to neuronal cells; and cellular aspects of human brain tumors (gliomas). The astrocyte in liver disease; radioenzymatic methods for analysis of neurotransmitters; and application of immunofluorescence in studies of cytoskeletal antigens are also deliberated in this text. This publication is intended for neurologists, but is also beneficial to students researching on the topographical anatomy and functional relation of the brain and spinal cord.

  • Progress in Hodgkin's Disease

    • 1st Edition
    • G. W. Richter + 1 more
    • English
    International Review of Experimental Pathology, Volume 33: Progress in Hodgkin's Disease summarizes the progress made in the diagnosis and understanding of the pathogenesis of Hodgkin's disease. The first half of this volume deals with diagnostic aspects, whereas the second half focuses on recent developments in the understanding of the pathogenesis of Hodgkin's disease. The book opens with a chapter on the differential diagnosis between Hodgkin's disease and non-Hodgkin's lymphomas, and provides guidelines on how to deal with the grey areas between these two groups of diseases. Separate chapters follow on the criteria for a prognostically relevant histological grading of the most common subtype of Hodgkin's disease; data on the nodular lymphocyte predominance subtype of Hodgkin's disease; and the various reagents used to define the immunophenotype of Reed-Sternberg cells. Subsequent chapters deal with potential mediators of lymphocyte agglutination to Reed-Sternberg cells; immunological alterations in Hodgkin's disease; molecular genetic studies into the pathogenesis of Hodgkin's disease; and results of studies on Hodgkin cell lines. This book provides data that go beyond those covered in textbooks in pathology and hematology and should be of interest to all pathologists and clinicians dealing with the diagnosis and management of Hodgkin's disease, as well as to lymphoma researchers.

  • Essays in Toxicology

    • 1st Edition
    • Wayland J. Hayes
    • English
    Essays in Toxicology, Volume 3 covers the significant advances in several areas of toxicology, including inhalation toxicology and the tests for toxicity measurement. This volume contains four chapters, and begins with discussion of the mechanisms of pulmonary toxicology, such as the deposition of respirable materials and the cellular role in pulmonary clearance. The subsequent chapter examines the impact of physical environmental factors on drug response, including the effect of ionizing radiation and atmospheric pressure and temperature. These topics are followed by surveys of several toxicological measures for determination of the effects of long-term toxicant exposure. The concluding chapter explores the molecular and biochemical studies of toxicants, specifically their interactions resulting in binding to proteins or nucleic acids. This book will be of value to toxicologists, researchers, teachers, and students who wants to obtain a clearer view of the various aspects of toxicology.

  • Progress in Behavior Modification

    Volume 2
    • 1st Edition
    • Michel Hersen + 2 more
    • English
    Progress in Behavior Modification, Volume 2 reviews issues and developments in the field of behavior modification, with emphasis on a wide spectrum of child and adult disorders. Topics covered range from behavioral assessment and treatment of alcoholism to sexual arousal in male sexual deviates, along with aversion therapy and research methods in behavior modification. Comprised of eight chapters, this volume begins with a discussion on the status and future trends in behavior assessment of alcoholism and behavior modification with alcoholics. The next chapter deals with therapy models, focusing on the domain of social learning, removal of fears, and assertive and social skill training. The discussion then turns to the measurement and generation of sexual arousal in male sexual deviates; applications of behavior modification in nursing practice; aversion therapy and its clinical effects; deceleration of aberrant behavior among retarded individuals; and research methods in behavior modification. The final chapter examines clinical issues regarding behavioral self-control. This book should be of value to theoreticians, researchers, or practitioners in the fields of psychiatry, psychology, and behavior therapy as well as social work, speech therapy, education, and rehabilitation.

  • Progress in Behavior Modification

    Volume 5
    • 1st Edition
    • Michel Hersen + 2 more
    • English
    Progress in Behavior Modification, Volume 5, is a multidisciplinary serial publication that encompasses the contributions of psychology, psychiatry, social work, speech therapy, education, and rehabilitation. This serial aims to meet the need for a review publication that undertakes to present yearly in-depth evaluations that include a scholarly examination of theoretical underpinnings, a careful survey of research findings, and a comparative analysis of existing techniques and methodologies. The discussions center on a wide spectrum of child and adult disorders. The book opens with a chapter on the assessment and treatment of minimal dating behavior in college students. This is followed by separate chapters on methods of behavioral control of excessive drinking; behavioral analysis and treatment of child noncompliance to parental requests; and behavioral group therapy. Subsequent chapters deal with the conceptual underpinnings of research in children's self-management and treatment strategies; the assessment and therapeutic functions of self-monitoring; and behavioral treatment in homosexuality.

  • Pulsatility in Neuroendocrine Systems

    • 1st Edition
    • Volume 20
    • P. Michael Conn + 1 more
    • English
    Pulsatility is now recognized as a nearly ubiquitous functional feature of neuroendocrine systems. This volume presents a comprehensive guide to the established and emerging technologies being used to study the perplexing phenomenon of pulsatility. Molecular, cellular, physiological, and mathematical approaches are described in detail.

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