Principles, Statistics, and Applications

Preface

Part I. General Principles and Statistics


1. U.S. Government Regulation of Pesticides

I. Introduction

II. Laws Regulating Pesticides

III. Agency Review and Decision-Making

Bibliography


2. Statistical Evaluation of Results and Sampling Procedures

I. Introduction

II. Frequency Curves

III. Analysis of Variance and Evaluation of Mean Differences

IV. Regression

V. Sampling

VI. Kriging

VII. Computer Programming

VIII. Concluding Remarks

References

Appendix


3. Cleanup of Samples

I. Considerations in Selection of Cleanup Procedures

II. General Multiresidue Screening Methods

III. Procedures for Selected Chemical Classes

IV. Miscellaneous Cleanup Techniques

References


4. Validation of Official Methods

I. Introduction

II. Types of Regulatory Limits

III. Interlaboratory Collaborative Studies

IV. Activities of U. S. and International Organizations

References

Part II. Applications


5. Principles of Pesticide Formulation Analysis

I. Introduction

II. High-Performance Liquid Chromatography

III. Gas Chromatography

IV. Internal Standards

V. Chemical Assay of Microbiocides

References


6. Pesticide Residue Analysis of Foods

I. Introduction

II. Method Parameters

III. Method Selection

IV. Methods and Techniques

References


7. Pesticide Metabolism Studies in Animals: Principles and Methodology

I. Introduction

II. Radiolabeled Pesticide

III. Animals and Animal Management

IV. Dosing of Animals

V. Metabolism Cages and Stalls

VI. Separate Collection of Feces and Urine

VII. Collection of Volatile Products

VIII. Blood Collection

IX. Surgical Modification of Animals

X. Germ-Free Animals

XI. Whole-Body Autoradiography

XII. Sacrifice of Animals and Collection of Tissues

XIII. Concluding Remarks

References


8. Pesticide Metabolism in Plants

I. Introduction

II. Plant Metabolites

III. Methods for Studying Plant Metabolism

IV. Metabolism of Soil Residues in Rotational Crops

V. Analysis of Pesticide Residues

VI. Bound Residues

References


9. Pesticide Residues in Environmental Samples

I. Introduction

II. The Nature of Environmental Samples, Sampling, and Analysis

References

Index