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Elsevier

Books in Life sciences

  • An Introduction to Biochemistry

    • 2nd Edition
    • William Robert Fearon
    • English
    An Introduction to Biochemistry, Second Edition provides information pertinent to the fundamental aspects of biochemistry. This book presents several analytical methods, including the citrulline reaction for proteins and the diffusion test for acetone. Organized into two parts encompassing 25 chapters, this edition begins with an overview of the general composition of the organism and the chemical characteristics of the chief organic and inorganic compounds that enter into its structure. This text then examines the chemical composition of the tissues and physiological systems. Other chapters consider the occurrence and identification of several pathological constituents of urine, which presents features of biochemical interest. This book discusses as well the significance and analytical reactions of the bile acids and esters. The final chapter deals with the internal environment, which in the higher animal is represented by the blood and the cerebrospinal and other tissue fluids. This book is a valuable resource for biochemists.

  • Biochemistry of Lipids

    Biochemistry Series One
    • 1st Edition
    • T. W. Goodwin
    • English
    MTP International Review of Science: Biochemistry Series One, Volume 4: Biochemistry of Lipids focuses on the processes, methodologies, reactions, and approaches involved in the biochemistry of lipids. The selection first elaborates on the enzymes of sterol biosynthesis and lipids in glycan biosynthesis. Topics cover polyprenols and glycan biosynthesis in green plants; polyprenols and glycan biosynthesis in yeasts and fungi; undecaprenol and bacterial wall glycan biosynthesis; methods of investigating particle-bound enzymes of sterol biosynthesis; and relationship of the multi-enzymic synthesis of cholesterol to other microsomal processes. The text then elaborates on the biosynthesis of saturated fatty acids, dynamic role of lipids in the nervous system, and biosynthesis of unsaturated fatty acids. Discussions focus on anaerobic pathway of monoenoic fatty acid biosynthesis, exchange of brain lipids, lipids and transmission in the nervous system, fatty acid synthetase, and lipid distribution within the nervous system. The manuscript examines halogenated sulphatides and prostaglandins, including identification of prostaglandins in organs and body fluids, estimation of prostaglandins, and occurrence of halosulphatides in membranes. The selection is a valuable reference for researchers interested in the biochemistry of lipids.

  • The Peptides

    Methods of Peptide Synthesis
    • 1st Edition
    • Eberhard Schröder + 1 more
    • English
    The Peptides, Volume I: Methods of Peptide Synthesis focuses on detailed description of protecting groups, individual amino acids, and coupling reactions. The publication first offers information on amino-protecting and carboxyl-protecting groups, including carboxyl protection by salt formation, esterification, and amide formation and acyl-type, alkyl-type, and urethane protecting groups. The text then examines the formation of the peptide bond and amino acids. Discussions focus on amino acids with the alcoholic hydroxyl group, sulfur amino acids, basic and acidic amino acids, synthesis of peptides by activation of the amino group, and peptide synthesis by activation of the carboxyl group. The manuscript elaborates on the synthesis of cyclic peptides, depsipeptides, peptoids, and the plastein reaction. Topics include synthesis of plastein-active peptides, glycopeptides, phosphopeptides, and S-peptides. The publication is a dependable source of data for readers interested in the methods of peptide synthesis.

  • Immunological Methods

    Volume III
    • 1st Edition
    • Ivan Lefkovits + 1 more
    • English
    Immunological Methods, Volume III provides information pertinent to the fundamental aspects of immunological methods. This book presents recombinant DNA technology as applied to immunology. Organized into 25 chapters, this volume begins with an overview of the major histocompatibility complex. This text then examines the use of monoclonal antibodies in the identification of lymphocyte membrane antigens and explains the use of monoclonal antibodies in histocompatibility typing. Other chapters consider the methods in two-dimensional electrophoretic analysis of proteins and another to lymphokines that support B cells. This book discusses as well the production and expansion of cloned B and T cell lines and hybridomas. The final chapter deals with the sophisticated methodology used with particular animal species, namely, birds, sheep, and amphibians to probe specific immunological questions. This book is a valuable resource for immunologists and investigators with extensive experience in using immunological methods. Protein chemists and biologists will also find this book useful.

  • Malaria

    Immunology and Immunization
    • 1st Edition
    • Julius P. Kreier
    • English
    Malaria: Volume 3, Immunology and Immunization is a collection of papers dealing with malaria parasites, the methods for measuring the immunological response to plasmodia, and the vertebrates host's immune response to plasmodia. Some papers discuss immunization against sporozoites, against the exoerythrocytic stages of malaria parasites, against asexual blood-inhabiting stages of plasmodia, as well as gamete immunization in malaria. One paper describes various separation methods to isolate malaria parasites and their constituents. Another paper discusses in detail the theory and practice of methods used in measuring antibody responses which occur during plasmodial infections, including the antibody response against sporozoites, exoerythrocytic forms, and in the different blood stages. Another paper explains the vertebrate host's immune response to plasmodial infection as a homeostatic physiological response changing along with the progression of the disease. The changes in the dynamic cellular cascade are different as the disease progresses causing death, than when these lead to recovery. Another paper enumerates the parameters which determine malarial infectiousness from one individual to another such as the time of onset, duration, intensity of the blood infections, as well as the maturity, longevity, and rate of production of gametocytes. Pharmacologists, general medical practitioners, investigators, and laboratory technicians involved in malarial research will find the collection very useful.

  • Evolving Genes and Proteins

    A Symposium Held at the Institute of Microbiology of Rutgers • the State University with Support from the National Science Foundation
    • 1st Edition
    • Vernon Bryson + 1 more
    • English
    Evolving Genes and Proteins covers the proceedings of the "Evolving Genes and Proteins" symposium, held at the Institute of Microbiology of Rutgers, The State University on September 17 and 18, 1964, with support from the National Science Foundation. The book focuses on the structural and functional features of proteins and nucleic acids. The selection first offers information on lysine biosynthesis and evolution, lipid patterns in the evolution of organisms, and evolution of heme and chlorophyll. Discussions focus on the evolution of the genes of the porphyrin biosynthetic chain, polyunsaturated fatty acids in plants and animals, and diagnostic radiocarbon tracers. The text then examines evolutionary divergence and convergence in proteins; evolution of hemoglobin in primates; and constancy and variability of protein structure in respiratory and viral proteins. The publication takes a look at the comparative aspects of the structure and function of phosphoglucomutase, evolution of dehydrogenases, and enzymatic homology and analogy in phylogeny. The text also ponders on the evolution of an enzyme, role of mutations in evolution, enzyme catalysis and color of light in bioluminescent reactions, and evolution of the lactose utilization gene system in enteric bacteria. The selection is a valuable reference for microbiologists and readers interested in the study of genes and proteins.

  • Vegetative Physiology and Biochemistry

    The Eye
    • 1st Edition
    • Hugh Davson
    • English
    The Eye: Volume 1, Vegetative Physiology and Biochemistry is a compendium of papers that describes the physiology of the eye, particularly its gross anatomy and embryology including its intra-ocular fluids, the intra-ocular pressure, the vitreous body, lens, cornea, and sciera. Several papers review the eyeball, the protective apparatus of the eye, the structure of the tissue in relation to the intra-ocular fluids, and the flow of aqueous humor. Several methods can be used to measure the intra-ocular pressure such as the manometric method and the tonometer. Giles (1959) reports that tonometer measurements in the newborn are within the normal adult range. One paper notes that in man, liquefaction of the vitreous body (the clear jelly-like structure which fills the space between retina and lens,) which is caused by dissolution of the fibrous network, is never repaired. This suggests that new fibers are either not formed or are formed in insufficient amounts. Another paper examines the relationship between pressure in the eye vessels and eye tension. Investigators and researches in the fields of physiology, psychology, ophthalmology, and in all branches of ocular physiology will find the compendium very rewarding.

  • Mammalian Protein Metabolism

    Volume II
    • 1st Edition
    • H. N. Munro + 1 more
    • English
    Mammalian Protein Metabolism, Volume II focuses on the processes, methodologies, and reactions involved in mammalian protein metabolism, including toxicities, amino acid imbalance, and digestion and absorption. The selection first offers information on the nutritive value of dietary proteins, amino acid toxicities and imbalances, and protein requirements. Discussions focus on the protein requirements of adults, infants, and children, amino acid requirements, protein requirements in pregnancy, amino acid imbalance, mixed diets, and nutritive value and maintenance. The text then ponders on protein metabolism and requirements in pregnancy and lactation and protein metabolism and requirements in the newborn. The publication examines protein metabolism and requirements in the elderly; anomalies of amino acid metabolism; and physical injury and its effects on protein metabolism. Topics include general disturbance of protein metabolism following physical injury, nature of inflammatory reaction, acquired disturbances of amino acid metabolism, plasma proteins, nitrogen balance, digestion and absorption, and protein withdrawal. The text then elaborates on protein metabolism and tumor growth, experimental protein-calorie deficiency, and the clinical aspects of protein malnutrition. The selection is a dependable source of data for researchers interested in mammalian protein metabolism.

  • Oxygenases

    • 1st Edition
    • Osamu Hayaishi
    • English
    Oxygenases focuses on the processes, methodologies, technologies, and approaches involved in oxygenases, including its distribution in animals, plants, and microorganisms and its role in the metabolism of aromatic, cyclic, and aliphatic compounds. The selection first offers information on the history and scope of oxygenases, methodology of oxygen isotopes, and phenolytic oxygenases. Discussions focus on the separation and purification of compounds for isotopic analysis; general properties and mechanisms of action of oxygenases; physiological significance of oxygenases; dehydrogenases, oxidases, and oxygenases; and problems and restrictions in the use of oxygen-18. The text then examines aromatic hydroxylations, oxygenases in lipid and steroid metabolism, and bacterial oxidation of hydrocarbons. Topics include anaerobic oxidation of alkanes, involvement of molecular oxygen in hydrocarbon utilization, steroid hydroxylation mechanisms, oxygenases in the biosynthesis of steroid hormones, conversion of dopamine to norepinephrine, and general discussion of mechanism of aerobic hydroxylation reactions. The selection is a valuable reference for researchers interested in the process of oxygenases.

  • Hormonal Proteins and Peptides

    Volume II
    • 1st Edition
    • Choh Hao Li
    • English
    Hormonal Proteins and Peptides, Volume II reviews extensively the knowledge on the biology and chemistry of the protein and peptide hormones. This book presents the structures of the various protein and peptide hormones. Organized into three chapters, this volume begins with an overview of the various aspects of the structure and function of adrenocorticotropin hormone (ACTH) with reference to the ability to stimulate the adrenal gland of the rat, amphibian melanophores, and adipose tissues of the rat and rabbit. This text then reviews the isolation, purification, and elucidation of the amino acid sequence of corticotropins from various species. Other chapters consider the structures of porcine and human ACTH. This book discusses as well the working hypothesis for studies on the secondary-tertiary structure of peptide hormones. The final chapter deals with the abbreviations used for amino acids and protecting groups. This book is a valuable resource for peptide chemists, biologists, biochemists, and research workers.

  • Glutathione

    Proceedings of the Symposium Held at Ridgefield, Connecticut, November, 1953
    • 1st Edition
    • S. Colowick + 2 more
    • English
    Glutathione: A Symposium covers the proceedings of the symposium held in Ridgefield, Connecticut in November 1953. The book focuses on the chemistry, characteristics, reactions, and properties of glutathione (GSH). The selection first offers information on mercaptans and disulfides, reactivity of the sulfhydryl group in GSH and related peptides, and chemistry and properties of GSH. Discussions focus on isolation and occurrence of GSH, properties of GSH, general chemistry of acidity, oxidation, and disulfides, and application to the structure of GSH. The text then examines thiol-thiolester complex formation, methods of GSH assay, and paper chromatography of GSH and its hydrolysis products. The publication takes a look at histochemical experiments on sulfhydryls and disulfides, enzymatic oxidation and reduction of GSH, and biosynthesis of GSH. Topics include synthesis of GSH from the constituent amino acids, enzymatic oxidation of GSH, and methods for demonstrating protein-bound sulfhydryl and disulfide groups in tissues. The selection is a dependable reference for researchers interested in the chemistry, reactions, and properties of glutathione.

  • Normal and Malignant Cell Growth

    Recent Results in Cancer Research: Fortschritte der Krebsforschung, Progrès dans les Recherches sur le Cancer
    • 1st Edition
    • R. J. M. Fry + 2 more
    • English
    Normal and Malignant Cell Growth is a compendium of papers from the "Proceedings of the Third Cancer Training Grant" of the University of Chicago that deals with the processes associated with malignant neoplasia, as well as the cell proliferation kinetics of normal tissues. One paper presents the techniques used in the study on the proliferation kinetics of hemopoietic stem cells, suggesting that the hemopoietic stem cell population is not homogenous but consists of a "primitive pluripotential stem cell." A series of experiments at the Brookhaven National Laboratory investigates the relationship of cell survival, specifically that of stem cells, to the survival of the irradiated test animal. One result of the experiment shows a rapid migration of a number of stem cells from shielded marrow into unshielded marrow at the pressure of a rapid circulating pool. The numbers of stem cells are somewhat dependent on the dose given to the unshielded marrow, and are greater with the greater dose. Another paper also investigates the four methods that are used in the study of cellular kinetics in human tumors. This compendium can prove helpful for biochemists, micro-biologists, cellular researchers, and academicians involved in the study of cellular biology, physiology or oncology.

  • Studies of the Development and Decay of the Human Frame

    • 1st Edition
    • Joseph Trueta
    • English
    Studies of the Development and Decay of the Human Frame provides information pertinent to the development of human skeleton. This book presents the study of the nature and reactions of the living tissues that constitute the skeleton. Organized into four parts encompassing 40 chapters, this book begins with an overview of the origin and characteristics of the chondroblast. This text then presents the investigations on the vascular characteristics of the blood supply in bone under variable experimental conditions. Other chapters consider the early descriptions of calcification, its role in osteogenesis, and the belief that calcification is a prerequisite to the laying down of bone. This book discusses as well the vascular anatomy of bone and the development of the nutrient arteries. The final chapter deals with the close origin and independence from the earliest stage of development of vessels and muscles on the one hand and bones and joint on the other. This book is a valuable resource for orthopedic surgeons.

  • Chemical Determinations

    • 1st Edition
    • Ralph I. Dorfman
    • English
    Chemical Determinations is a collection of papers that discusses chemical methods used in hormone investigation. One paper explains the physicochemical procedures used to separate estrogens from interfering material which leads to the possible determination of small amounts of hormones in biological fluids. One approach is through simpler methods for routine use, designed principally for the determination of estrogens in urine and in plasma. Another way is through more elaborate methods, designed to establish the presence and identity of various estrogens in small numbers of biological samples. Another paper explains the methods for the analysis of 17-ketosteroids of blood and urine, and a method for the assay of testosterone in plasma which correlates with the state of virilism of an individual. One paper describes the techniques utilized for extraction, preliminary purification, isolation, and quantitative estimation of progesterone. Another paper reviews the occurrence of pregnanetriolone (an inactive urinary metabolite), the significance of its estimation as an aid in differential diagnosis, the methods of estimation, as well as the metabolic pathways leading to the excretion of pregnanetriolone and related steroids. The collection is suitable for researchers, scientists, medical practitioners, or academicians involved in endocrinology, metabolism, and bio-research.

  • Introduction to Enzymology

    • 1st Edition
    • Alan H. Mehler
    • English
    Introduction to Enzymology focuses on the processes, methodologies, reactions, and approaches involved in enzyme chemistry. The book first offers information on the hydrolysis of peptides and proteins and fermentation and oxidation of major metabolic fuels. Discussions focus on oxidation of fatty acids, alternative pathways of carbohydrate metabolism, Krebs citric acid cycle, free energy and the concept of bond energy, pyruvate oxidation and acetyl coenzyme A formation, and glycolysis. The text then elaborates on the transfer of oxygen, hydrogen, and electrons and sugars and sugar derivatives. The publication takes a look at polynucleotides and their components, amino acids, and acids and acid derivatives. Topics include carbonic anhydrase, mechanism of action of pyridoxal phosphate enzymes, aromatic ring biosynthesis and metabolism of phenylalanine and tyrosine, metabolism of sulfur-containing amino acids, and oxidation of amino acids. The book is a valuable reference for chemists and researchers interested in enzymology.

  • Carbohydrate Metabolism

    And Its Disorders
    • 1st Edition
    • F. Dickens + 2 more
    • English
    Carbohydrate Metabolism and its Disorders focuses on the processes and methodologies involved in carbohydrate metabolism, including detection of diabetes, hypoglycemic syndromes, cardiovascular diseases, and atherosclerosis. The selection first takes a look at the detection of diabetes in man, hormonal disturbances in diabetes, and hypoglycemia. Topics include indications for testing for diabetes, reasons for early detection, testing for diabetes with tolbutamide, glucagon, corticosteroids, and hypoglycemic syndromes. The book also ponders on the physiological aspects of carbohydrate metabolism in the fetus and newborn and glycogen-storage diseases. The publication examines dietary intake of carbohydrate in relation to diabetes and atherosclerosis and glucose tolerance in ischemic cardiovascular disease. Discussions focus on epidemiological studies of diabetes and atherosclerosis, overt diabetes mellitus, and effects of selection, age, obesity, and other factors. The book also identifies disturbances of the digestion and absorption of carbohydrates; insulin antagonists and disturbances in carbohydrate metabolism; and glycosaminoglycans in joint disorders. The selection is a valuable reference for readers interested in carbohydrate metabolism.

  • Symposium on the Rehabilitation of the Cancer Disabled

    At the Royal College of Surgeons of England, Lincoln's Inn Fields, London
    • 1st Edition
    • Ronald W. Raven
    • English
    Symposium on the Rehabilitation of the Cancer Disabled provides information pertinent solutions provided for disabilities of various kinds, created by the cancerous diseases in different parts of the body. This book discusses special rehabilitation problems that are created by other amputations, including removal of external genitalia and the breast. Organized into 17 chapters, this book begins with an overview of the subject of rehabilitation of the cancer disabled. This text then presents the mortality and morbidity caused by the cancerous diseases. Other chapters consider various case histories that demonstrate some of the problems that are presented by patients suffering from cancerous diseases and who are rehabilitated. This book discusses as well the advantage of treatment by a linear accelerator or cobalt source. The final chapter deals with spiritual healing. This book is a valuable resource for physiotherapists, clinicians, radiotherapists, and researchers.

  • Environmental Regulation of Microbial Metabolism

    Proceedings of the Federation of European Microbiological Societies Symposium Held in Pushchino, USSR 1–7 June 1983
    • 1st Edition
    • I. S. Kulaev + 2 more
    • English
    Environmental Regulation of Microbial Metabolism contains the proceedings of the Federation of European Microbiological Societies Symposium held in Pushchino, USSR, on June 1-7, 1983. The symposium provided a forum for reviewing the environmental regulation of the metabolism of autotrophic and heterotrophic microorganisms; regulation of the biogenesis of cell walls and other structures in prokaryotic and eukaryotic microorganisms; and regulation of the secretion of macromolecules and transport of ions and solutes across microbial membranes. Comprised of 52 chapters, this book begins with an overview of some aspects of environmental regulation of microbial phosphorus metabolism, followed by a discussion on the role of covalent interconversion of enzymes in the regulation of microbial metabolism. Subsequent chapters explore the role and regulation of inorganic pyrophosphatase in bacteria; the central metabolism of pseudomonads degrading xenobiotics; the role of nickel enzymes in anaerobic metabolism; and the oxidation of aromatic compounds by microalgae. The book also considers carbon metabolism in phototrophic bacteria under different conditions of growth, along with the transport of solutes and metabolites in prokaryotes and eukaryotes. This monograph will be helpful to a wide range of specialists in the fields of biochemistry, physiology, molecular biology, and biotechnology.

  • Mechanisms in Bioenergetics

    • 1st Edition
    • Efraim Racker
    • Anthony San Pietro
    • English
    Advanced Biochemistry: Mechanisms in Bioenergetics provides information pertinent to the fundamental aspects of the mechanisms in bioenergetics. This book covers a variety of topics, including the enzymatic mechanism of ATP formation and the regulatory mechanisms that control its metabolic utilization. Organized into three parts encompassing 18 lectures, this book begins with an overview of the process of converting nutrients into forms of useful energy, which is the essence of energy metabolism. This text then explores the properties that have a specific bearing on the problem of oxidative phosphorylation. Other lectures consider the phosphoroclastic reaction with pyruvate, which plays a curious and apparently specific role in nitrogen fixation. This book discusses as well the operation of control mechanisms of energy metabolism in intact cells. The final lecture analyzes the rate-limiting steps in carbohydrate metabolism of various cells and some of the metabolic factors that govern them. This book is a valuable resource for graduate students.

  • Primates

    A Compilation from the GenBank® and EMBL data libraries
    • 1st Edition
    • Edwin J. Atencio + 2 more
    • English
    Nucleotide Sequences 1986/1987, Volume I: Primates presents data that reflect the information found in GenBank Release 44.0 of August 1986. This book provides information pertinent to the unique international collaboration between two leading nucleotide sequence data libraries, one based in Europe and one in the United States. Organized into one section, this volume begins with an overview of the sequences, some basic identifying information, and some of the biological annotations. This text then discusses the EMBL Nucleotide Sequence Data Library, an international center of fundamental research with its main focus in the fields of cell biology, molecular structures, instrumentation, and differentiation. This book discusses as well the GenBank database. This book is a valuable resource for molecular biologists and other investigators collecting the large number of reported DNA and RNA sequences and making them available in computer-readable form.

  • Penicillins and Cephalosporins

    • 1st Edition
    • Robert B. Morin + 1 more
    • English
    Chemistry and Biology of ?-Lactam Antibiotics, Volume 1: Penicillins and Cephalosporins provides information pertinent to the study of antibiotics containing the ?-lactam moiety. This book discusses the occurrence of a group of ?-lactam antibiotics structurally related to cephalosporin C. Organized into five chapters, this volume begins with an overview of the mechanism of action of ?-lactam antibiotics that caused many microbiologists to develop screening tools for the detection of the ?-lactam moiety. This text then discusses the discovery of the nocardicins, the thienamycins, and olivanic acids. Other chapters provide a summary of the essential penicillin sulfoxide chemistry that gave rise to many compounds. This book discusses as well the ability of chemists to predict the level of biological activity of a compound from knowledge of its structure through theoretical and physicochemical studies. The final chapter deals with quantitative structure–activity relationships. This book is a valuable resource for microbiologists, chemists, and scientists.

  • Monoclonal Antibodies Against Bacteria

    Volume III
    • 1st Edition
    • Alberto J. L. Macario + 1 more
    • English
    Monoclonal Antibodies Against Bacteria, Volume III covers the basis for understanding developments of practical importance in the health sciences within the area of microbiology and infectious diseases, focusing on advances made possible by monoclonal antibodies. This 12-chapter volume specifically considers the basic principles of hybridoma technology. The introductory chapters deal with treponemal antigens of significance for understanding syphilis, yaws, pinta, salmonellosis, and other gastroenteropathies. The subsequent chapters highlight pediatric infections and the strategies for molecular analyses of bacterial antigens, focusing on cell walls, S layers, and sheaths. The remaining chapters examine the bacterial toxins involved in gaseous gangrene and other forms of cell damage, such as diphtheria, caries and periodontal diseases, and bacteria relevant to animal sciences. This book will prove useful to internists, pediatricians, surgeons, dentists, veterinarians, clinical pathologists, and laboratory technologists.

  • Biochemical and Molecular Aspects of Selected Cancers

    • 1st Edition
    • Thomas G. Pretlow + 1 more
    • English
    Biochemical and Molecular Aspects of Selected Cancers, Volume I provides an overview of important topics and prototypes in cancer research. The book consists of papers provided by outstanding investigators in diverse disciplines in different areas of cancer research. This volume focuses on topics relevant to cancers in humans. It covers such topics as tumor-suppressor genes and human neoplasia; protein kinase C in neoplastic cells; and extracellular matrix interactions with tumor-progressing cells: tumor versus cell type-specific mechanisms. Structural and functional characteristics of human melanoma; steroid hormones and hormone receptors in neoplastic diseases; and patterns and significance of genetic changes in neuroblastomas are expounded as well. Oncologists, biochemists, cytologists, and other researchers in allied fields will find the book invaluable.

  • Proteins and Nucleic Acids

    The Biochemistry of Plants
    • 1st Edition
    • Abraham Marcus
    • English
    The Biochemistry of Plants: A Comprehensive Treatise, Volume 6: Proteins and Nucleic Acids provides information pertinent to the nucleic acids and the regulation of the expression of this information. This book presents the processes by which the nucleic acids are finally expressed as proteins. Organized into 14 chapters, this volume begins with an overview of the overall structure of eukaryotic genomes, with emphasis on higher-plant DNA. This text then examines the enzymes involved in the cleavage and degradation of DNA. Other chapters provide a critical assessment of eukaryotic nucleic acid polymerases. This book discusses as well some examples from plant mitochondrial systems. The final chapter deals with two special areas of plant biology where the expression of the nucleic acids is seen in striking relief, the formation of plant tumors, and the growth and expression of plant viruses. This book is a valuable resource for plant biochemists, molecular biologists, senior graduate students, and research workers.

  • Carbohydrates: Structure and Function

    The Biochemistry of Plants
    • 1st Edition
    • Jack Preiss
    • English
    The Biochemistry of Plants: A Comprehensive Treatise, Volume 3: Carbohydrates: Structure and Function is a compilation of contributions dealing with studies in the area of plant carbohydrates. The articles in this volume are grouped into three sections. The first section deals with topics concerning the monosaccharides and their derivatives found in plants. The integration and control of vital pathways concerned with hexose phosphate metabolism, glycolysis, gluconeogenesis; the metabolism of monosaccharide derivatives; and the formation of sugar nucleotides and their various transformations to the many novel sugar derivatives normally found in plant cell walls and complex carbohydrates are discussed in this section. The second part deals with the occurrence, biosynthesis, and transport of disaccharides and oligosaccharides. The final section of the volume is concerned with the occurrence, structure, and biosynthesis of simple and complex polysaccharides and glycoconjugates associated with cell walls and membranes. Biochemists and botanists will find the book a great reference material.

  • The Antigens

    Volume V
    • 1st Edition
    • Michael Sela
    • English
    The Antigens, Volume V is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology as well as their immunologic role and expression. Four complex problems of direct relevance to human health are explored, namely, tumor antigens, antigens of helminths, cytotoxic lymphocytes, and complement. Comprised of four chapters, this volume begins with a review of classic studies of tumor-specific transplantation antigens, followed by a discussion on the detection and purification of tumor antigens; the immune response to tumor antigens; and the role of tumor antigens in the escape of tumors from immunological control. The reader is then introduced to some aspects of the different functions of antigens of helminths, along with the immune response in helminthiasis. The book also examines the generation, properties, and mode of action of antibody-independent cytolytic T lymphocytes before concluding with an analysis of the complement system and its reaction pathways as well as its role as an autoantigen. This monograph will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.

  • Alcohol and Aldehyde Metabolizing Systems

    Intermediary Metabolism and Neurochemistry
    • 1st Edition
    • Ronald G. Thurman + 2 more
    • English
    Alcohol and Aldehyde Metabolizing Systems, Volume III: Intermediary Metabolism and Neurochemistry contains some of the papers presented at the Second International Symposium on Alcohol and Aldehyde Metabolizing Systems, held at the University of Pennsylvania in October 1976. Experts in the field from a wide variety of backgrounds tackled the problems of alcohol and aldehyde metabolism, discussed research findings, and examined controversial issues such as the effects of alcohol and aldehydes on intermediary metabolism. Comprised of 64 chapters, this volume begins with an analysis of the non-equilibrium behavior of biochemical systems, followed by a discussion on the configurational specificity of glycolytic enzymes. The reader is methodically introduced to redox compartmentation and the measurement of intracellular compartmentation of metabolites in rat liver; effect of chronic alcohol and oxygen tension on the development of hepatic necrosis in rats; and actions of ethanol metabolism on fatty acid synthesis in the liver. Subsequent chapters focus on regional metabolic rate in the central nervous system as related to function; effects of tetrahydroisoquinoli... derivatives of catecholamines and aldehydes on tyrosine hydroxylase; and lowering of blood acetaldehyde levels as a therapeutic approach to alcoholism. This book will be of value to practitioners and researchers from a variety of disciplines, including neurochemistry, biochemistry, physiology, cell biology, and pharmacology.

  • Monoclonal Antibodies Against Bacteria

    Volume II
    • 1st Edition
    • Alberto J. L. Macario + 1 more
    • English
    Monoclonal Antibodies Against Bacteria, Volume II provides the basis for understanding new developments of practical importance in the health sciences within the area of microbiology and infectious diseases, focusing on advances made possible by monoclonal antibodies. This 12-chapter volume starts with the analysis of streptococcal antigens implicated in the causation of rheumatic fever and heart disease to find ways of inducing protective immunity. The next chapters deal with the detection of staphylococcal enterotoxins in foods and treatment of staphylococcal food poisoning, the classification of meningococcal isolates associated with meningitis and related disorders, and the immunology of brucellosis with emphasis on the problem of distinguishing antibrucella antibodies elicited by vaccination of cattle from antibodies elicited by infection. These topics are followed by discussions of the diagnostic and epidemiologic studies of legionellosis; the identification of antigens in gram-negative bacteria; and the development of means to study and control infections by Pseudomonas in cystic fibrosis and other pathologic conditions. Other chapters explore the analysis of toxigenicity and neutralization of botulinum toxin, the pathogenetic role of Escherichia coli's pili, and study of its antigens to understand regulatory networks of the immune system involving antiidiotypic antibodies. The remaining chapters consider the elucidation of antigenic mosaics of archaebacteria and identification of their molecular signatures in their ecological niches and other life forms. These chapters also look into the combination of bacterial genetics with hybridoma technology for elucidating structure-function relationships in membrane molecules, as well as the strategies, methods, quality control, and other practical aspects connected with industrial production of monoclonal antibodies against bacteria. This book will prove useful to internists, pediatricians, surgeons, dentists, veterinarians, clinical pathologists, and laboratory technologists.

  • The Antigens

    Volume I
    • 1st Edition
    • Michael Sela
    • English
    The Antigens, Volume I is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology, structure and function, their initiation of the immune response, and the nature of the products of this response. The nature of the reaction of antigens with antibodies and with sensitized cells is also explored. Comprised of seven chapters, this volume begins with a discussion on the antigenic functions of nucleic acids as well as their immunogenicity, hapten functions, and serologic reactions. The reader is then introduced to the immunochemistry and antigenic determinants of enzymes, along with the structure and phylogeny of immunoglobulins and immunoglobulin allotypes. The evolution of proteins and their structure and function is also considered, paying particular attention to evolution by the random fixation of selectively neutral alleles, the rates of protein evolution, gene duplication, and divergence or convergence. The final chapter is devoted to the chemistry and biology of immunoglobulin E as well as the regulation of formation of their antibodies. This book will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.

  • Photosynthesis

    The Biochemistry of Plants
    • 1st Edition
    • M. D. Hatch + 1 more
    • English
    The Biochemistry of Plants: A Comprehensive Treatise, Volume 8: Photosynthesis provides information pertinent to the biochemistry of photosynthesis. This book focuses on the photosynthesis of higher plants but some consideration is given to algal and bacterial photosynthesis. Organized into 11 chapters, this volume begins with an overview of the excitation of a light-harvesting pigment by an absorbed light quantum. This text then discusses the evidence to support the hypothesis that chlorophyll–protein complexes are represented at the supramolecular level by some of the intramembranous particles seen on chloroplast freeze-fracture faces. Other chapters consider the absorption of light energy by accessory pigments and transferred to chlorophyll in the blue-green, red, and brown algae. This book discusses as well that certain cyanobacteria respond to the color of the incident light by altering their biliprotein composition. The final chapter deals with dark reaction of photosynthesis. This book is a valuable resource for plant biochemists, neurobiochemists, molecular biologists, senior graduate students, and research workers.

  • Progress in Immunology VI

    Sixth International Congress of Immunology
    • 1st Edition
    • B Cinader + 1 more
    • English
    Progress in Immunology VI: Sixth International Congress of Immunology contains the proceedings of the Sixth International Congress of Immunology held in 1986. The papers review advances that have been made in the field of immunology and cover topics ranging from ontogeny and differentiation of B and T lymphocytes to diversification of immunoglobulins and T cell receptors. Antigen presentation and processing, the complement system, and regulation of the immune response are also discussed. Comprised of 105 chapters, this book first explores the developmental biology of the immune system by focusing on the origins of selective theories of antibody formation and the clonal selection hypothesis. Clonal selection and the problem of immunologic tolerance are also considered. Subsequent chapters deal with the structure and function of recognition structures; B cell subsets and B cell activation; T cell subsets and T cell activation; lymphokines and growth factors; and autoimmune disorders. The remaining sections are devoted to oncogenesis and tumor immunity; the response of the host to the environment; and host-graft relationship. This monograph will be of interest to immunologists and biologists.

  • The Antigens

    Volume IV
    • 1st Edition
    • Michael Sela
    • English
    The Antigens, Volume IV is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology as well as their immunologic role and expression. Topics covered range from the immune reactions of lipids and lipid model membranes to the immunology of antibiotics and protective antigens of bacteria. Antigens of pathogenic fungi are also explored, along with adjuvants and antigenic competition. Comprised of seven chapters, this volume begins with a review of lipids as antigens, followed by a discussion on the immunological aspects of antibiotics. The next two chapters are concerned with more complex antigens, namely, bacteria and fungi, as well as the relationship between immunity and infection. The last three chapters deal with three important areas of immunology: antigenic competition, adjuvants, and lectins. In particular, the chemistry of lectins and their application to immunology are examined. This monograph will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.

  • Plants and Organelles

    A Compilation from the GenBank® and EMBL data libraries
    • 1st Edition
    • Edwin J. Atencio + 2 more
    • English
    Nucleotide Sequences 1986/1987, Volume IV: Plants and Organelles presents data that reflect the information found in GenBank Release 44.0 of August 1986. This book provides information pertinent to the unique international collaboration between two leading nucleotide sequence data libraries, one based in Europe and one in the United States. Organized into two sections, this volume begins with an overview of the sequences, some basic identifying information, and some of the biological annotations. This text then discusses the EMBL Nucleotide Sequence Data Library, an international center of fundamental research with its main focus in the fields of cell biology, molecular structures, instrumentation, and differentiation. This book discusses as well the GenBank database established in 1982 by the National Institute of General Medical Sciences of the U.S National Institutes of Health. This book is a valuable resource for molecular biologists and other investigators collecting the large number of reported DNA and RNA sequences and making them available in computer-readable form.

  • The Antigens

    Volume VII
    • 1st Edition
    • Michael Sela
    • English
    The Antigens, Volume VII is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology as well as their immunologic role and expression. Different aspects of the genetic control of the immune response are explored, along with the link between infection and autoimmunity. Comprised of four chapters, this volume begins with a discussion on the determinant-specific genetic regulation of the immune response and the genes that control it. The next chapter deals with the molecular genetics and polymorphism of of class II (Ia) antigens, as well as the correlation between immunogenetic and molecular genetic maps. The antigen-specific T cell clones and the specific factors derived from them are then examined. The last chapter considers the relationship between infection and autoimmunity; the role of infection in the expression of class II antigens; and processes responsible for the induction of autoimmune diseases. A specific therapy for these diseases is described. This monograph will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.

  • Recent Progress in Hormone Research

    Proceedings of the 1991 Laurentian Hormone Conference
    • 1st Edition
    • C. Wayne Bardin
    • English
    Recent Progress in Hormone Research, Volume 48 provides information pertinent to endocrine research dealing with all aspects of biological organization. This book covers a variety of topics, including differentiation of the embryo, development and growth at puberty, maintenance of adult well-being, and aging. Organized into 29 chapters, this volume begins with an overview of the role of oncogenes in fetal development. This text then compares the molecular descriptions of the genes for growth hormone and prolactin receptors to receptors for s variety of other hormones, peptide, and growth factors. Other chapters consider the three-dimensional structure of the growth hormone receptor. This book discusses as well the conventional and nonconventional uses of human growth hormone, with emphasis on the wide availability of protein that is possible only through molecular biology. The final chapter deals with the effect of hormones on primate behavior. This book is a valuable resource for geneticists and biologists.

  • Biochemistry of Metabolism

    The Biochemistry of Plants
    • 1st Edition
    • David D. Davies
    • English
    The Biochemistry of Plants: A Comprehensive Treatise, Volume 11: Biochemistry of Metabolism provides information pertinent to the chemical and biochemical aspects of metabolism. This book discusses the control mechanisms of metabolism. Organized into nine chapters, this volume begins with an overview of the history of biochemistry and discusses the developments in the kinetics of regulatory enzymes. This text then examines a theory that explains how subunit interactions modulate the rate of conversion of a substrate into a product. Other chapters consider some relation between cell-wall elongation and cell-wall charge density and explore the subcellular localization of the enzymes of glycolysis. This book discusses as well the regulation of glycolysis and the pentose phosphate pathway. The final chapter deals with the pathways of C1 metabolism that are of prime importance, as the synthesis of several cellular constituents depends directly or indirectly on folate metabolism. This book is a valuable resource for plant biochemists, neurobiochemists, molecular biologists, senior graduate students, and research workers.

  • The Antigens

    Volume III
    • 1st Edition
    • Michael Sela
    • English
    The Antigens, Volume III is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology as well as their immunologic role and expression. Topics covered range from microbial polysaccharides and lymphocytic receptors for antigens to antigenic determinants and antibody-combining sites. Allergens and the genetics of allergy are also explored. Comprised of seven chapters, this volume begins with a review of microbial polysaccharides as antigens, followed by a discussion on antigenic determinants and their specific reaction with antibody-combining sites. The reader is then introduced to the reaction of antigens with their specific receptors on lymphocytes. The next four chapters are concerned with several categories of more complex antigens which, in most cases, have yet to be characterized adequately at a molecular level: allergens, histocompatibility antigens, antigens of Mycoplasmatales and chlamydiae, and animal viruses. The book concludes with an analysis of virus infections and the immune responses they elicit. This monograph will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.

  • Analytical Microbiology

    Volume II
    • 1st Edition
    • Frederick Kavanagh
    • English
    Analytical Microbiology, Volume II is a six-chapter work that covers the significant changes and improvements made in the theory and practice of analytical microbiology. The first chapter is devoted to the theoretical aspects of assaying of specific compounds. These topics are followed by discussions of the theoretical and practical aspects of diffusions assays, as well as the theoretical developments of photometric methods of assay, including their improvement resulting from automation. A chapter explores the assay methods for various antibiotic groups. Another chapter discusses the advances in assay technology and analytically important interrelations among the folic acid complex. The last chapter describes a simple diffusion method designed for the assay of certain amino acids in a wide variety of samples. This book will prove useful to analytical microbiologists.

  • Mollusca

    Metabolic Biochemistry and Molecular Biomechanics
    • 1st Edition
    • Peter W. Hochachka
    • English
    The Mollusca, Volume 1: Metabolic Biochemistry and Molecular Biomechanics provides information pertinent to the advances in the traditional areas of biochemistry and in other developed areas that have become a part of molluskan biochemistry. This book discusses the developments in the various aspects of molecular biomechanics and environmental biochemistry. Organized into 11 chapters, this volume begins with an overview of the phylum Mollusca. This text then provides information about the general features of the main classes and their evolution, the anatomical organization of mollusks, and a classification of the primary taxonomic groups of mollusks. Other chapters consider the functional mechanical properties of two protein rubbers found in molluskan connective tissues. This book discusses as well the mechanical properties of molluskan mucins. The final chapter deals with the significance of quinone tanning in mollusks. This book is a valuable resource for researchers of the Mollusca and other phyla, as well as to teachers and qualified graduate students. Biochemists and physiologists will also find this book useful.

  • Viruses

    A Compilation from the GenBank® and EMBL data libraries
    • 1st Edition
    • Edwin J. Atencio + 2 more
    • English
    Nucleotide Sequences 1986/1987, Volume VI: Viruses presents data that reflect the information found in GenBank Release 44.0 of August 1986. This book provides information pertinent to the unique international collaboration between two leading nucleotide sequence data libraries, one based in Europe and one in the United States. Organized into one section, this volume begins with an overview of the sequences, some basic identifying information, and some of the biological annotations. This text then discusses the EMBL Nucleotide Sequence Data Library, an international center of fundamental research with its main focus in the fields of cell biology, molecular structures, instrumentation, and differentiation. This book discusses as well the GenBank database established in 1982 by the National Institute of General Medical Sciences (NIGMS) of the U.S National Institutes of Health (NIH). This book is a valuable resource for molecular biologists and other investigators collecting the large number of reported DNA and RNA sequences and making them available in computer-readable form.

  • Protection of Functional Groups in Peptide Synthesis

    The Peptides Analysis, Synthesis, Biology, Vol. 3
    • 1st Edition
    • Erhard Gross + 1 more
    • English
    The Peptides: Analysis, Synthesis, Biology, Volume 3: Protection of Functional Groups in Peptide Synthesis focuses on protection of functional groups in peptide synthesis. This book consists of seven chapters. Chapter 1 reviews the large variety of amine protecting groups. The protection of carboxyl groups is described in Chapter 2, while the chemistry of sulfhydryl group protection in peptide synthesis is discussed in Chapter 3. Chapter 4 covers the protection of the hydroxyl groups of serine, threonine, tyrosine, and other hydroxyl-containing amino acids. Differential protection and selective deprotection in peptide synthesis is deliberated in Chapter 5. In chapter 6, the opportunities and constraints of the tactics of minimal protection of side-chain functions during peptide synthesis are reviewed. The last chapter is devoted to the interesting aspects of dual function groups. This volume is recommended for specialists and researchers concerned with peptide and protein research.

  • Disorders of Auditory Function

    Volume III
    • 1st Edition
    • Ian G. Taylor + 1 more
    • English
    Disorders of Auditory Function, Volume III presents the proceedings of the Third Conference of the British Society of Audiology, held at the University of Manchester on July 18–20, 1979. This book provides information pertinent to five major areas of interest to the principles and practice of audiology, namely, pediatric audiology, communication, vestibular function, noise-induced hearing loss, and aural rehabilitation. Organized into four sections encompassing 29 chapters, this volume begins with an overview of the conditions that occur in the first years of life that may result in hearing impairment. This text then examines the methods for the early identification of hearing loss. Other chapters consider the implementation of an effective mass hearing screening program for neonates. This book discusses as well the rules and strategies that hearing-impaired children are using to interpret word order. The final chapter reviews the development in British audiology. This book is a valuable resource for otologists, audiologists, and physicians.

  • Disorders of Mineral Metabolism

    Trace Minerals
    • 1st Edition
    • Felix Bronner + 1 more
    • English
    Disorders of Mineral Metabolism, Volume I: Trace Minerals covers the pathophysiology of clinically relevant minerals and elements. This volume focuses on minerals whose average daily intake is under 50 mg. This text is composed of 12 chapters that tackle the clinical relevance and essentiality of various trace minerals in the human body, with particular emphasis on the disorders due to their abnormal metabolism. The trace mineral and elements considered in this volume include iron, coppers, zinc, lead, nickel, manganese, chromium, molybdenum, cadmium, aluminum, tin, lithium, and fluoride. Each chapter discusses the properties, body requirements, analysis, nutritional interactions, and toxicity of the mineral. This book will prove useful to biochemists, pathophysiologists, and workers in the medical field.

  • The Cell: Supplementary Volume

    Biochemistry, Physiology, Morphology
    • 1st Edition
    • Jean Brachet + 1 more
    • English
    The Cell: Biochemistry, Physiology, Morphology, Volume VI: Supplementary Volume focuses on the advancements of processes, technologies, and approaches employed in studies on the structure and functions of cells. The selection first offers information on the cytoplasm of Protozoa, fungi, and the aspects of the form and function of plant cells. Topics include special structures, basic genetics, physiology, life cycles and sexuality, special fungal genetics, basal bodies or kinetosomes, mitochondria, and symbiotes in Protozoa. The text then elaborates on sensory and connective tissue cells.Discussions focus on some catabolic processes of connective tissues, formation and cytology of connective tissues, nature of the extracellular constituents, and pseudosensory, neurosensory, and true sensory cells. The selection is a vital reference for researchers interested in the biochemistry, physiology, and morphology of cells.

  • Bacteria and Bacteriophage

    A Compilation from the GenBank® and EMBL data libraries
    • 1st Edition
    • Edwin J. Atencio + 2 more
    • English
    Nucleotide Sequences 1986/1987, Volume V: Bacteria and Bacteriophage presents data that reflect the information found in GenBank Release 44.0 of August 1986. This book provides information pertinent to the unique international collaboration between two leading nucleotide sequence data libraries, one based in Europe and one in the United States. Organized into two sections, this volume begins with an overview of the sequences, some basic identifying information, and some of the biological annotations. This text then discusses the EMBL Nucleotide Sequence Data Library, an international center of fundamental research with its main focus in the fields of cell biology, molecular structures, instrumentation, and differentiation. This book discusses as well the GenBank database established in 1982 by the National Institute of General Medical Sciences (NIGMS) of the U.S National Institutes of Health (NIH). This book is a valuable resource for molecular biologists and other investigators collecting the large number of reported DNA and RNA sequences and making them available in computer-readable form.

  • The Receptors

    Volume IV
    • 1st Edition
    • P. Michael Conn
    • English
    The Receptors, Volume IV deals with receptors for intracellular hormones, estrogen, and sex steroids as well as for dopamine, cholecystokinin, and corticotropin. The role of surface recognition receptors in disease is also discussed, along with receptors for plant auxin action and auxin transport. Comprised of 11 chapters, this volume begins with a detailed account of the ?-adrenergic receptor-coupled adenylate cyclase and the reconstitution of the functional interactions of its various purified components. The discussion then turns to the mechanism of action of steroid and thyroid hormones and how abnormalities in their receptors lead to disease; nuclear location of estrogen receptors; and the biochemistry of the fungal sex steroid receptors as well as the use of Achlya as a model system for the study of the mechanism of action of steroid hormones in general. Subsequent chapters focus on dopamine receptors; cholecystokinin receptor; corticotropin receptors; and the search for receptors that mediate sweetness. The book concludes with an analysis of endocrine receptors on lymphocytes and the integration of endocrine and immune systems, with emphasis on large granular lymphocytes. This monograph will be a valuable resource for students and practitioners in fields ranging from cell biology and biochemistry to physiology, endocrinology, and pharmacology.

  • Hepatic Plasma Proteins

    Mechanisms of Function and Regulation
    • 1st Edition
    • Barbara H. Bowman
    • English
    Hepatic Plasma Proteins: Mechanisms of Function and Regulation covers the mechanisms of function, inherited variation, and regulation of genes encoding the plasma proteins synthesized in the liver. The book discusses the physiological and clinical implications of human plasma protein abnormalities; the acute-phase reactants; and the variety of human plasma proteinase inhibitors. The text also describes the plasma protein vehicles (transferrin, ceruloplasmin, transthyretin, haptoglobin, hemopexin, and the vitamin D binding protein), as well as cytokines and transcription factors involved in the regulatory process. The protein and gene anatomies are discussed in terms of evolutionary relationships and genetic variations, especially those with mutations causing clinical manifestations. The book also encompasses the mechanisms responsible for tissue specific and developmental expression of plasma protein genes. Geneticists, biochemists, molecular biologists, physicians, and other students of biology will find the book invaluable.

  • Bacterial Immunoglobulin–Binding Proteins

    Applications in Immunotechnology
    • 1st Edition
    • Michael D. P. Boyle
    • English
    Bacterial Immunoglobulin-Bindi... Proteins: Applications in Immunotechnology, Volume 2 covers the state of knowledge of bacterial immunoglobulin-bindi... proteins. The book focuses on practical approaches to isolation, characterization, and use of bacterial immunoglobulin-bindi... proteins. The majority of these studies involve the type I Fc-binding protein (staphylococcal protein A) and the type III Fc-binding protein (streptococcal protein G). Physiological chemists, pediatricians, and microbiologists will find the book invaluable.

  • Metabolic Conjugation and Metabolic Hydrolysis

    Volume I
    • 1st Edition
    • William H. Fishman
    • English
    Metabolic Conjugation and Metabolic Hydrolysis, Volume I is a comprehensive account of the main conjugation mechanisms and hydrolytic reactions. Topics covered range from the metabolic conjugates of steroids and N-hydroxy compounds to the effects of conjugated steroids on enzymes. The glucuronic acid pathway is also discussed, along with sulfoconjugation and sulfohydrolysis. Comprised of eight chapters, this volume first looks at the history of conjugation mechanisms before proceeding to developments in metabolic conjugations. The isolation, recognition, enzymic formation and hydrolysis, and the possible significance of steroid N-acetylglucosaminid... and glucosides are considered. The book also examines the mechanisms involved in the enzymic formation of N-hydroxy compounds; the pathways by which N-hydroxy compounds may be further metabolized in vivo; and the chemical properties of conjugates of N-hydroxy compounds, particularly as these properties are related to the generation of reactive cations or free radicals in vivo. The possible role of conjugates of N-hydroxy compounds in the mechanism of carcinogenesis by aromatic amines and their N-acyl derivatives is also analyzed. Finally, glycoprotein and mucopolysaccharide hydrolysis and the role of hydrolases in cellular death are described. This monograph will be a useful resource for biologists, biochemists, physiologists, and pharmacologists.

  • Meiosis and Mitosis

    Biochemistry, Physiology, Morphology
    • 1st Edition
    • Jean Brachet + 1 more
    • English
    The Cell: Biochemistry, Physiology, Morphology, Volume III: Meiosis and Mitosis covers chapters on meiosis and mitosis. The book discusses meiosis with regard to the meiotic behavior of chromosomes; the anomalous meiotic behavior in organisms with localized centromeres and in forms with nonlocalized centromeres; and the nature of the synaptic force. The text also describes the mechanism of crossing over; the relationship of chiasmata to crossing over and metaphase pairing; and the reductional versus equational disjunction. The process of mitosis and the physiology of cell division are also considered. The book further tackles the significance of cell division and chromosomes; the essential mitotic plan and its variants; the preparations for mitosis; and the transition period. The text also demonstrates the time course of mitosis; the mobilization of the mitotic apparatus; metakinesis; the metaphase; the mitotic apparatus; anaphase; telophase; cytokinesis; and the physiology of the dividing cell. Physiological reproduction; mitotic rhythms and experimental synchronization; and the blockage and stimulation of division are also encompassed. Biologists, microbiologists, zoologists, and botanists will find the book invaluable.

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