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Elsevier

Books in Life sciences

  • Biochemical and Molecular Aspects of Selected Cancers

    Volume 2
    • 2nd Edition
    • Thomas G. Pretlow II
    • English
    This two-volume work not only includes much of the newer molecular biology research but also important earlier research in this area essential for the comprehensive understanding of the biochemistry of neoplastic diseases. As such it will provide an invaluable source of information for the young investigator. Human cancers, not experimental models of cancer, are emphasized.

  • Advances in Immunopharmacology

    Proceedings of the Second International Conference on Immunopharmacology, July 1982, Washington, USA
    • 1st Edition
    • J. W. Hadden + 1 more
    • English
    The second of two volumes covering the most recent developments in this new field. Like the previous volume, this book brings together the two fields of immunology and pharmacology, and offers a review format for advances in basic aspects, as well as an update in discussion format of therapy-related advances.

  • Atlas of Human Tumor Cell Lines

    • 1st Edition
    • Robert K.M. Hay + 2 more
    • English
    Human tumor cells in culture are valuable for studying cancer causes and properties. This convenient reference provides useful information for cancer researchers on commonly used, established tumor cell lines of the major human organ systems.Atlas of Human Tumor Cell Lines includes data about morphological, metabolic, genetic, and growth characteristics of human tumor cells, with morphological characteristics presented in more than 250 photomicrographs. It also contains information for establishing and maintaining human tumor cell lines in culture, and each chapter covers future perspectives.

  • Cisplatin

    Current Status and New Developments
    • 1st Edition
    • Archie W. Prestayko
    • English
    Cisplatin: Current Status and New Developments is a collection of papers presented at a symposium sponsored by the University of Alabama in Birmingham Comprehensive Cancer Center and the Bristol Laboratories in Syracuse, ?ew York, and held on September 27-28, 1979, in Atlanta, Georgia. The symposium provided a forum for assessing developments with regards to cisplatin as an anticancer drug, with emphasis on its clinical application in a wide variety of adult and pediatric malignancies as well as the mechanism by which the drug appears to cause tumor cell death. Comprised of 39 chapters, this book begins with a preclinical overview of cisplatin, focusing on its mechanism of action, pharmacology, antitumor activity, analogs, and toxicity. The discussion then turns to the effects of cisplatin on DNA and the possible relationships to cytotoxicity and mutagenicity in mammalian cells; lethal activity of platinum compounds in combination with pyrimidine derivatives; and ultrastructural effects of cisplatin. Subsequent chapters focus on the rationale of combination chemotherapy; toxic side effects of platinum analogs; radiopharmacokinetic... of cisplatin; and the use of cisplatin for the treatment of malignancies such as ovarian cancer and advanced adenocarcinoma of the prostate. This monograph will be useful to oncologists and pharmacologists.

  • The Effect of Modern Agriculture on Rural Development

    Comparative Rural Transformation Series
    • 1st Edition
    • Gyorgy Enyedi + 1 more
    • English
    The Effect of Modern Agriculture on Rural Development discusses the role of agriculture in rural development and analyzes the interaction between the social and technical aspects of rural development. The 22 chapters of the text are organized into five parts. Part I discusses social changes, modernization of agriculture, and process of rural transformation, and Part II deals with modernizing agriculture and the rural settlement pattern. Part III tackles agrotechniques and rural change, while Part IV covers the industrialization of agriculture and villages. Part V discusses agro-industrial integration and rural transformation. The book will be of great interest to individuals concerned with the effects of the modernization of agriculture on rural areas.

  • Anatomy and Human Movement

    Structure and Function
    • 1st Edition
    • Nigel Palastanga + 2 more
    • English
    Anatomy and Human Movement: Structure and Function describes the musculoskeletal structures of the human body and the biomechanics behind their movements. The book provides anatomical descriptions of bone and muscle groups with emphasis on the joints; enumeration of common traumatic or pathological problems affecting the musculoskeletal structures; and the use of palpation through intact skin to describe the structures, as well as how movements can be tested and analyzed with respect to joint movement, muscle work and function. Chapters on embryology; the skin and its appendages; terminologies used in the book; and an account of the structure and function of the nervous system are included as well. Students of anatomy will find the text a valuable reference material.

  • Infectious Diseases

    • 2nd Edition
    • A. Melvin Ramsay + 1 more
    • English
    Infectious Diseases, Second Edition furnishes the basic facts regarding the common infections encountered in the British Isles. The infectious diseases covered in this edition include varicella and herpes zoster, smallpox, tetanus, measles, mumps, influenza, and acute respiratory disease. The poliomyelitis, Stevens-Johnson syndrome, malaria, tuberculosis, cytomegalic inclusion disease, and rabies are also discussed. This book likewise deliberates the host-parasite relationship, control of infection in hospitals, sterilization and disinfection, pyrexia of undetermined origin (PUO), and public health law. This publication is valuable not only to clinicians but also to epidemiologists, microbiologists and community physicians whose work is connected with the many problems in the field of acute medicine.

  • The Chemistry and Bacteriology of Public Health

    • 1st Edition
    • C. L. Dunn + 1 more
    • English
    The Chemistry and Bacteriology of Public Health deals with public health hygiene. This book reviews the alkalimetry, acidimetry, standard solutions, normal solutions, and the preparation of solutions in public health laboratories, including methods of estimating equivalent weights of substances. In collecting water samples for analysis, the investigator should avoid all sources of extraneous contamination. The Wanklyn's process analyzes organic matter in the water: different tests give quantitative estimates of water contamination or bacterial purity. The authors point that the process of analyzing sewage and sewage effluents are the same as in water analysis except that sewage is diluted with distilled water. The authors also explain how air and water are analyzed, soil analysis being a complex process. The authors discuss milk analysis (fresh, boiled, skimmed, powdered, condensed), butter, cheese, food grains. Microscopic examination of bacteria from samples taken are examined alive, in film preparations, or in sections. The book describes in detail the different types of bacteria, their occurrence, and how these are examined or cultured. This book is intended as a laboratory handbook for students taking up the examination in Public Health. The book can also prove beneficial for social worker, public health officials, and for undergraduate medical students.

  • Clinical Pharmacology

    Proceedings of the 7th International Congress of Pharmacology, Paris 1978
    • 1st Edition
    • P. Duchêne-Marullaz + 2 more
    • English
    Clinical Pharmacology provides a detailed discussion on toxicology. This discussion includes the chemotherapy of parasitic diseases. Some parts of the book focus on topics on immunopharmacology. Such topic as the genetic and environmental factors that contribute to individual’s varying response to drugs is explained. The book covers such topics as the methods and models for the isoniazid acetylation polymorphism. The issues that arise in the administration of drugs in the neonatal period are assessed. Another topic of interest is the effects of diseases on the absorption of drugs. The pharmacokinetic and pharmacodynamic characteristics of a drug are evaluated. The pharmacogenetic investigation amobarbital disposition is presented completely. The book then presents the use and consumption of drugs in different locations and some clinical considerations. The procedures and methods of analysis for such drug are also reviewed . The book can serve as a valuable tool for pharmacists, medical doctors, pediatricians, students, and researchers in the field of medicine.

  • Protein Contribution of Feedstuffs for Ruminants

    Application to Feed Formulation
    • 1st Edition
    • E.L. Miller + 2 more
    • English
    Protein Contribution of Feedstuffs for Ruminants: Application to Feed Formulation covers papers about the findings and knowledge on the ""Evaluation of the Protein Contribution of Feedstuffs for Ruminant"". The book presents papers about the recent advances in the knowledge of protein evaluation for ruminants; similarities and differences between rumen fermentation and postruminal utilization; and methods of assessing proteins for ruminants. The text also covers papers about protected proteins and amino acids for ruminants; validation and application of principles of protein evaluation for ruminants; practical feeding trials in Norway; and protein-energy interrelationships for growing and for lactating cattle. A report of co-ordinated trials carried out on commercial farms in the UK is also presented in the book. The text will be invaluable to feed compounders, research workers, advisors, farmers and agricultural students.

  • Recent Progress in Hormone Research - Volume 49

    Proceedings of the 1992 Laurentian Hormone Conference
    • 1st Edition
    • C. Wayne Bardin
    • English
    Among the topics covered in Volume 49 are neurotransmitter transporters circadian rhythms, transgenic model for studying isles development, protein phosphateses, the androgen receptor, molecular genetics of steroid 5oz-reductases and benign and malignant prostatic neoplasms.

  • Antarctic Fish Biology

    Evolution in a Unique Environment
    • 1st Edition
    • Joseph T. Eastman
    • English
    This important volume provides an original synthesis and novel overview of Antarctic fish biology, detailing the evolution of these fish in some of the most unusual and extreme environments in the world. Focusing on one group of fish, the notothenoioids, which contain the majority of the current organismal diversity, this book describes a fauna that has evolved in isolation and experienced incredible adaptive radiation by acquiring numerous physiological specializations. Darwin's finches and African cichlids may be joined by Antarctic fishes as exemplars of adaptive radiation.The books' coverage is detailed and comprehensive, and the author clearly recognizes the fact that these fish are a component of a most interesting and biologically unique ecosystem and environment. Topics in Antarctic Fish Biology include past and present environments, fossil records, taxonomic composition of fauna, systematic relationships, diversification, and physiological adaptations.

  • Comprehensive Insect Physiology, Volume 8

    Endocrinology II
    • 1st Edition
    • G. A. Kerkut
    • English
    Endocrinology II concerns the actions of hormones in insects, complementing Volume 7 which is concerned with the production and chemistry of insect hormones. While the preceding volume is directed mainly towards the insect endocrinologist, this volume has much of intrinsic interest to the general physiologist. It deals with the regulation of metabolism, reproduction, cuticle properties, and certain aspects of behaviour from a systems point of view and amply documents how hormones have provided basic insights into the functioning of such systems. Interference in endocrine regulation could provide future systems for insect control and this volume will provide the foundation on which the future formulation of these strategies is based. More information on diverse aspects of insect hormone action is brought together here than in any previous single work and this volume will therefore be a valuable reference source for many years to come.

  • The Biology of the Mollusca

    • 2nd Edition
    • R. D. Purchon
    • G. A. Kerkut
    • English
    Reviews the most important literature on the functional morphology and natural history of molluscs over a period of half a century, from 1925 to the present day, and draws extensively upon authoritative papers published mostly in the English language in a large number of international journals during this period. By these means it is hoped to provide an anthology of what is most interesting in the literature in a number of selected topics. Appendices give some practical assistance for the dissection of selected examples

  • In Vitro Biological Systems

    Methods in Toxicology, Vol. 1
    • 1st Edition
    • Charles A. Tyson + 1 more
    • English
    Methods in Toxicology, Volume 1: In Vitro Biological Systems, Part A provides basic techniques employed by widely recognized scientists to prepare and maintain the biological components of in vitro model systems. The book discusses the in vitro models of neural and neuromuscular systems; ocular system; respiratory system; cardiovascular system; and gastrointestinal system. The text also describes liver slices; liver hepatocytes; other liver cell systems; proximal tubule fragments; kidney cell culture; reproductive and developmental systems; immune system; and skin. Pharmacologists, toxicologists, cell biologists, physiologists, immunotoxicologists, and molecular toxicologists will find the book invaluable.

  • Water in Foods

    Fundamental Aspects and Their Significance in Relation to Processing of Foods
    • 1st Edition
    • Fito + 2 more
    • English
    Water in Foods: Fundamental Aspects and their Significance in Relation to Processing of Foods contains the proceedings of the Fifth International Symposium on the Properties of Water in Foods (ISOPOW-V), held in Peniscola, Valencia, Spain, on November 8-14,1992. Organized into 31 chapters, each chapter representing the papers presented in the meeting, this book begins with a review of the theoretical aspects of hydration. Some chapters follow discussing the basic physical chemistry and links between hydration and solute interactions; computer modeling studies of the interaction of water with carbohydrates; and theories of liquid-glass transition. This book also describes the NMR imaging in the study of diffusion of water in foods, mechanical properties of frozen model solutions, and the role of water in biomembrane structures. Other chapters relate water to the methods of food preservation.

  • Research in Protozoology

    In Four Volumes
    • 1st Edition
    • Tze-Tuan Chen
    • English
    Research in Protozoology is the third book in a four-volume series on protozoological research. Like the previous two, this volume covers the cytology, parasitology, fibrillar systems, and genetics of protozoans. This volume explores the immunological aspects of infections caused by protozoans, identifies the organisms that live in and on protozoans, and describes the pathogenic and metabolic pathway of protozon infections. It also discusses the protozoan fibrillar system and the macronucleus of ciliates. This book will be of interest to persons dealing with studies on the genetics aspects, cytology and parasitology of protozoans.

  • Joll's Diseases of the Thyroid Gland

    • 2nd Edition
    • Francis F. Rundle
    • English
    Joll's Diseases of the Thyroid Gland, Second Edition provides information pertinent to the fundamental aspects of thyroid diseases. This book discusses the physiology structure, and development of the thyroid gland. Organized into 29 chapters, this edition begins with an overview of the function of the thyroid gland to trap and concentrate iodine, harness it in organic combination, and then to secrete it into the blood. This text then discusses the evolutionary scheme showing the development of thyroid gland as a special organ for the control of iodine metabolism. Other chapters consider the various types of thyroid diseases, including simple goiter, acute inflammations, Grave's disease, and granulomatous diseases of the thyroid. This book discusses as well the etiological or clinico-pathological basis of the classification of simple goiter. The final chapter deals with the post-operative complications of thyroidectomy and their treatment. This book is a valuable resource for physicians, surgeons, and clinical researchers.

  • Evaluating Alcohol and Drug Abuse Treatment Effectiveness

    Recent Advances
    • 1st Edition
    • Linda Carter Sobell + 2 more
    • English
    Evaluating Alcohol and Drug Abuse Treatment Effectiveness: Recent Advances is a collection of papers that covers the advancement in rehabilitation of individuals with a history of substance abuse. The title aims to find ways in identifying the treatment that best fits a specific patient. The text first provides a historical account of alcohol and drug treatment outcome research. Next, the selection considers the use of multiple measures of life health to assess alcohol treatment. Chapter 3 deals with the behavioral assessment and treatment evaluation of narcotic addiction, while Chapter 4 talks about the evaluation of behavioral and traditional treatment of alcoholics. The fifth chapter tackles the contingency contracting with drug abusers, and the sixth chapter covers the development of a prototype for the evaluation of alcohol treatment. The text also details the problems in alcohol treatment along with the improvement of confidence in treatment of substance abuse. The book will be of great use to behavioral scientists, social workers, and mental health specialists.

  • Secondary Plant Products

    A Comprehensive Treatise
    • 1st Edition
    • Volume 7
    • Walter Stumpf + 1 more
    • English
    The Biochemistry of Plants: A Comprehensive Treatise, Volume 7: Secondary Plant Products focuses on the biochemistry of secondary compounds, including tissue culture and differentiation, complexes, and plant systematics. The selection first elaborates on the physiological roles of secondary natural products, tissue culture and the study of secondary natural products, and turnover and degradation of secondary natural products. Discussions focus on degradative reactions of nitrogenous and phenolic compounds, concept of turnover of secondary products, and plant-vertebrate interactions. The text then elaborates on secondary plant products and cell and tissue differentiation; compartmentation in natural product biosynthesis by multienzyme complexes; and secondary metabolites and plant systematics. The manuscript examines the stereochemical aspects of natural products biosynthesis, nonprotein amino acids, and amines. Topics include tryptamines, phenethylamines, and histamine, nonprotein amino acids as analogues and antimetabolites, chemistry and biogenesis, and nonprotein amino acids as indexes for chemotaxonomy. The book also tackles glycosylation and glycosidases; transmethylation and demethylation reactions in the metabolism of secondary plant products; and oxygenases and the metabolism of plant products. The selection is a vital reference for researchers interested in the biochemistry of secondary compounds.

  • Plant Biotechnology

    Comprehensive Biotechnology Second Supplement
    • 1st Edition
    • M.W. Fowler + 2 more
    • English
    Today it is generally accepted that one of the key areas of biotechnology for the next century will be in plant-based biotechnology. Biotechnology has created new opportunities for plant scientists, with important applications to agriculture and forestry. This reference text is divided into five sections for ease of presentation. The first section focuses on the structure, composition and functionality of plant cells and genes with particular emphasis on the cellular and molecular biology of plants and cultured cells. Section two is concerned with the direct exploitation of cell cultures for the production of useful substances. The third section deals with regeneration and propagation systems. The fourth section considers the increasingly central area of genetic manipulation of plant cell systems. The last section is on specific applications in plant biotechnology. This reference work is a survey of these various facets of plant biotechnology. The individual chapters and the follow-up literature cited allow an easy access to the various subject areas and will, hopefully, stimulate interest in these rapidly moving and exciting fields of research.

  • Antibody Techniques

    • 1st Edition
    • Vedpal S. Malik + 1 more
    • English
    The applicability of immunotechniques to a wide variety of research problems in many areas of biology and chemistry has expanded dramatically over the last two decades ever since the introduction of monoclonal antibodies and sophisticated immunosorbent techniques. Exquisitely specific antibody molecules provide means of separation, quantitative and qualitative analysis, and localization useful to anyone doing biological or biochemical research.This practical guide to immunotechniques is especially designed to be easily understood by people with little practical experience using antibodies. It clearly presents detailed, easy-to-follow, step-by-step methods for the widely used techniques that exploit the unique properties of antibodies and will help researchers use antibodies to their maximum advantage.

  • Proceedings of the Fourth International Congress on Hormonal Steroids

    Mexico City, September 1974
    • 1st Edition
    • V. H. T. James + 1 more
    • English
    Proceedings of the Fourth International Congress on Hormonal Steroids contains plenary speeches and symposia from the Fourth International Congress on Hormonal Steroids held in Mexico City in September 1974

  • Epidemiology in Country Practice

    • 1st Edition
    • William Norman Pickles
    • English
    Epidemiology in Country Practice presents the development of the catarrhal jaundice and myalgia. It discusses the epidemiological and clinical observations of country doctors. It addresses the conditions of life of a country doctor. Some of the topics covered in the book are the appeal to improved medical research; methods of communicating medical research; techniques in acquisition of clinical data; types of diseases of the people living in the country; description of influenza, measles, scarlet fever, whooping-cough, and mumps; and diagnosis and behavior of chicken-pox and shingles. The description of sonne dysentery is fully covered. An in-depth account of the diagnosis, symptoms, and treatment of undulant fever are provided. The characteristic mononucleosis of glandular fever is completely presented. A chapter is devoted to the classification and description of different skin conditions. Another section is focus on the diagnosis of malignant disease. The book can provide useful information to doctors, students, and researchers.

  • Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells

    • 1st Edition
    • T.E. Gram
    • English
    Research has shown that the lung is capable of metabolically activating xenobiotics into intermediates that can covalently bind to pulmonary tissue. Further, it has been shown that the lung consists of many distinct cell types with the ability to take up and sequester metabolically unchanged drugs and chemicals that are ultimately toxic in effect. This volume reflects the extent of these developments and provides a state-of-the art reference in a rapidly evolving field incorporating both drug metabolism and pulmonary toxicology research.

  • Cellular and Molecular Mechanisms of Inflammation

    Signal Transduction in Inflammatory Cells, Part A
    • 1st Edition
    • Charles G. Cochrane + 1 more
    • English
    Cellular and Molecular Mechanisms of Inflammation: Signal Transduction in Inflammatory Cells, Part A is a collection of papers that discusses the mechanisms of the transduction of signals linking stimulated receptors and cellular function. This book describes the pathways of signal transduction involved in stimulating functions of inflammatory cells connected with host defense and development of inflammatory injury. One paper notes the potential of using fluorescence methodology in analyzing ligand-receptor interactions in living systems during the natural abundance of cell surface receptors. Another paper discusses the structure and function of GTP-binding proteins in neutrophil signal transduction, particularly the role of oligomeric G proteins in signal transduction. One concern in signal transduction research is the physiological significance of the presence of multiple forms of proteins that can have identical functions. One paper reviews phosphatidylcholine breakdown and hormone action in the rat liver, focusing on G proteins and on inositol phospholipid breakdown. This book also discusses calcium translocation in signal transduction, as well as, a novel signal transduction pathway involving phosphatidylinositol 3-kinase. This book can prove beneficial for biochemists, micro-biologists, cellular researchers, and academicians involved in the study of cellular biology, physiology or oncology.

  • Drug Design

    Medicinal Chemistry: A Series of Monographs, Vol. 6
    • 1st Edition
    • E. J. Ariëns
    • English
    Drug Design, Volume VI covers practical approaches to the development of bioactive compounds, with focus on antiradiation agents, organ-imaging radiopharmaceuticals... X-ray contrast media, proteinase inhibitors, and pesticide formulations. The book discusses the chemical routes available for the synthesis of diphenhydramine derivatives, the biological activities, the relationships between structure and activity, and the phase of manipulation in the design of diphenhydramine derivatives. The text also describes the design of antiradiation agents, organ-imaging radiopharmaceuticals... and X-ray contrast media, as well as the rational approach to proteinase inhibitors. The chemical and physical methods of formulation of agricultural pesticides are also encompassed. Chemists, biochemists, pharmacologists, and people involved in drug design and manufacture will find the book invaluable.

  • Methods in Neuropsychology

    • 1st Edition
    • M. A. Jeeves + 1 more
    • English
    Efforts to relate neuroscience and anatomy with ethology and psychology have involved an ever widening group of scientists from diverse backgrounds and it has become increasingly evident that interaction is harder to arrange. This book is offered as a first attempt to address some of these interdisciplinary problems. First, it aims to provide a critical evaluation of some of the principal methods used by neuropsychologists in research and assessment. Second, it provides short evaluations of the methods which they use to shed further light on brain dysfunction. In this way it is hoped that it offers a further insight into this multidisciplinary field.

  • Energy Metabolism

    Proceedings of the Eighth Symposium on Energy Metabolism Held at Churchill College, Cambridge, September, 1979
    • 1st Edition
    • Laurence E. Mount
    • English
    Studies in the Agricultural and Food Sciences: Energy Metabolism is a compilation of works on the energy metabolism in animals, especially animals of agricultural importance. The book is written by authoritative workers in the field and is divided into six parts; each chapter is based on a selected paper presented at the Eighth Symposium on Energy Metabolism held at Cambridge in September 1979. The text discusses feed evaluation; use of energy for maintenance and growth; and simulation models for energy exchange and growth. The book also covers the comparative aspects of energy metabolism; use of energy in production and lactation; and metabolic responses in the growing animal. The monograph is recommended for those who plan to study about energy metabolism of farm animals and its relationship with certain biological processes. The book will also appeal to those who develop feeds and methods that can help improve energy metabolism of farm animals.

  • Business of Biotechnology

    From the Bench to the Street
    • 1st Edition
    • R. Ono
    • English
    The Business of Biotechnology: From the Bench to the Street thoroughly examines the existing and future business challenges for biotechnology, providing a unique insight into the intricate web of critical factors with which biotechnology entrepreneurs must come to terms if they wish to be successful. The book begins with discussions of the evolution of biotechnology; entrepreneurship in the biotechnology industry; university-industry technology transfer process; and the life cycle of a biotechnology company. It considers the prospects for biotechnology, from the perspective of a venture capitalist and human resource practitioner. There are separate chapters that deal with the cloning and expression of recombinant gene products; developing strategies to reduce the cost-to-produce (CTP) therapeutic proteins; intellectual property protection; and the regulation of commercial biotechnology. The final chapters cover the marketing of biotechnology companies and products; the performance of biotechnology stocks; mergers and acquisitions in the biotechnology industry, and prospects for the Japanese and European biotechnology industry.

  • Biotechnology of Filamentous Fungi

    Technology and Products
    • 1st Edition
    • David B. Finkelstein
    • English
    Biotechnology of Filamentous Fungi: Technology and Products provides a comprehensive discussion of the molecular biology, genetics, and biochemistry of filamentous fungi. It also deals with general principles of biochemical engineering such as process design and scaleup. The book's main emphasis, however, is on the commercial significance of filamentous fungi. The book highlights the unique aspects of filamentous fungi along with those aspects common to most microorganisms studied in industries that use biotechnology. Filamentous fungi can generate a wide range of industrial products including primary metabolites such as organic acids, secondary metabolites such as β-lactam antibiotics, nonantibiotic drugs, and enzymes for use in food production. Whole organisms such as mushrooms can be used as well as organisms used as insecticides and herbicides. Filamentous fungi also qualify as potential hosts for the secretion of certain heterogeneous proteins such as mammalian proteins. However, not all things related to fungi are beneficial. Mycotoxins products by fungi can be lethal to humans; there is also a need to develop antifungal agents to destroy fungi that can kill animals and plants. These topics are important aspects of the biotechnology of filamentous fungi and are dealt with in this text.

  • Assessing Ecological Risks of Biotechnology

    • 1st Edition
    • Lev R. Ginzburg
    • English
    Assessing Ecological Risks of Biotechnology presents a comprehensive analysis of ecological risk assessment for biotechnology as viewed predominantly by scientists doing research in this area, but also by regulators, philosophers, and research managers. The emphasis is on the ecological risks associated with the release of genetically engineered organisms into the environment. The book contains 17 chapters that are organized into four parts. Part I discusses the ecological experience gained from previous biological introductions. Part II explores the ecology and the genetics of microbial communities. Emphasis is given to the transport of microorganisms since one of the major ecological concerns about biotechnology is the danger of the spread of genetically engineered organisms to ecosystems other than the one to which they are released. Part III reviews mathematical models that can be used for ecological risk assessment at four different levels. Part IV concerns the regulation of biotechnology, current research trends, and social values.

  • Animal Cell Bioreactors

    • 1st Edition
    • Chester S. Ho
    • English
    Animal Cell Bioreactors provides an introduction to the underlying principles and strategies in the in vitro cell culture biotechnology. It addresses engineering aspects such as mass transfer, instrumentation, and control ensuring successful design and operation of animal cell bioreactors. The goal is to provide a comprehensive analysis and review in the advancement of the bioreactor systems for large-scale animal cell cultures. The book is organized into four parts. Part I traces the historical development of animal cell biotechnology. It presents examples of work in progress that seeks to make animal cell biotechnology processes as productive on a cost per unit of product basis as that achieved by other microbial systems. Part II includes chapters dealing with the implications of cell biology in animal cell biotechnology; protein-bound oligosaccharides and their structures; the development of serum-free media and its use in the production of biologically active substances; and the metabolism of mammalian cells. Part III focuses on animal cell cultivation, covering topics such as the fixed bed immobilized culture; three-dimensional microcarriers; and hydrodynamic phenomena in microcarrier cultures. Part IV discusses the design, operation, and control of animal cell bioreactors.

  • Autoradiography and Immunocytochemistry

    Practical Methods in Electron Microscopy
    • 1st Edition
    • M.A. Williams
    • Audrey. M. Glauert
    • English
    Autoradiography and Immunocytochemistry sets out in detail the preparation of autoradiographs and methods of preparing and use of immunological staining reagents. This book begins with an introduction to the demand for autoradiography and immunocytochemistry and their most advantageous use, followed by a discussion on the immunocytochemistry at the electron microscopical (EM) level in relation to the preparation of labeled antibodies. Other topics include the general remarks on “staining” with antibodies; applying Fer-Ab conjugates to ultrathin sections; and controls in immunoferritin staining. The multistep antibody staining methods with unmodified proteins; control observations in staining experiments using lectins; and pattern analysis in EM immunocytochemistry are also covered. This text concludes with a description of the preparation of electron microscope autoradiographs, including the radioisotopes in EM autoradiography, preparation of radioactively-labele... tissues and cells, and methods of applying nuclear emulsions. This publication serves as a detailed laboratory guide for researchers and workers to successfully conduct electron microscope techniques.

  • Engineering Processes for Bioseparations

    • 1st Edition
    • LAURENCE R. WEATHERLEY
    • English
    The use of biotechnology in chemical synthesis offers up numerous advantages to the engineer in the process industries, but it also presents a number of fundamental challenges and difficulties which impinge directly on separation process requirements. The use of biochemical separations has grown significantly during the past decade, and is especially used in process industries such as healthcare and food processing. However it is becoming increasingly more important in areas such as recycling and waste-water treatment and as industry shifts towards cleaner processes biochemical separations will continue to grow. The two main objectives of this book are to focus on the application of existing separation process techniques to the recovery and purification of biologically derived products and to examine the state of knowledge of new techniques which have future potential. Within these objectives the complexities and breadth of problems associated with biological separations are discussed, specific engineering techniques are featured and their adaptation to biochemical separations are highlighted.

  • Updated General Techniques and Additional Pesticides

    Analytical Methods for Pesticides and Plant Growth Regulators, Vol. 11
    • 1st Edition
    • Gunter Zweig + 1 more
    • English
    Analytical Methods for Pesticides and Plant Growth Regulators, Volume XI: Updated General Techniques and Additional Pesticides covers the techniques in the automated pesticide analytical laboratory. The book discusses the application of quantitative thin layer chromatography to pesticide analysis; as well as analytical methods for formulations and residues of developed pesticides following the order of insecticides and acaricides, fungicides, and herbicides and plant growth regulators. The text also describes the analysis of N-nitroso compounds; the analysis of ethylenebisdithiocar... fungicides and degradation products; and the analytical methods for the toxicologically important degradation product ethylene thiourea. Toxicologists and people involved in the study of pesticides will find the book invaluable.

  • Biological Functions of Microtubules and Related Structures

    • 1st Edition
    • Hikoichi Sakai + 2 more
    • English
    Biological Functions of Microtubules and Related Structures is a compendium of papers presented at the 13th Oji International Seminar on The Biological Functions of Microtubules and Related Structures, held at Komaba Eminence in Tokyo in November, 1981. The papers discuss the molecular function of tubulin in various biological processes or events. The book is divided into six sections focusing on the various aspects of the functions and structures of microtubules -- the biochemistry and molecular biology of tubulin, including regulation of microtubule assembly; microtubule-dynein systems and other proteins in cell motility; microtubules and related proteins in mitosis; the interactions of cytoskeletal components; the cytoskeleton; and microtubules in membrane functions and transport. Biochemists, biologists, and molecular biologists will find the book interesting.

  • Water Relations in Membrane Transport in Plants and Animals

    • 1st Edition
    • Arthur M. Jungreis + 2 more
    • English
    Water Relations in Membrane Transport in Plants and Animals contains the presentations in a symposium dealing with Water Relations in Membranes in Plants and Animals, during the 27th Annual Fall Meeting of the American Physiological Society held at The University of Pennsylvania, 17-19 August 1976. The purpose of the symposium was to explore the common modes of water regulation in plants and animals. In these proceedings, the mechanisms employed to restrict water flow across plant and metazoan animal cells are described. Putative differences in mechanisms of water regulation retained by plant versus animal cells become inconsequential in the light of the numerous similarities: dependence upon bioelectric potentials maintained across cell membranes, energy dependence of uphill water movement, and solute coupling during water transport. The presentations can be organized into four. The first takes up specific mechanisms of water transport in plants. The second and third parts deal with specific mechanisms in invertebrates and vertebrates, respectively. The fourth part covers generalized mechanisms common to plants and animals.

  • Human Cytogenetics

    Clinical Cytogenetics
    • 1st Edition
    • John L. Hamerton
    • English
    Human Cytogenetics: Clinical Cytogenetics, Volume II presents the general theoretical principles and clinical aspects of cytogenetics, a branch of genetics that deals specifically with the study of the chromosomes. The volume focuses on the clinical cytogenetics of human. It discusses the sex chromosomes and their abnormalities and the abnormalities of sexual development and differentiation; mechanism of sex determination in mammals; major autosomal abnormalities found in human populations; and chromosome abnormalities in relation to human pregnancy wastage and chromosome changes in neoplasia. The book will be a great reference book for geneticists, cytogeneticists, pathologists, clinicians, and medical students.

  • Water for the Thousand Millions

    Written by the Water Panel of the Intermediate Technology Development Group Founded by Dr. E. F. Schumacher
    • 1st Edition
    • Arnold Pacey
    • English
    Water for the Thousand Millions focuses on the distribution of safe water through effective water supply technology. This book discusses developments in the intermediate technology of water supplies such as rainwater catchment tanks, water conservation techniques, small solar distillation plants, and wind-pump projects. The topics discussed include water supply objectives and criteria of appropriateness; technically appropriate water supplies; socially appropriate water supplies at village level; and economically appropriate water supplies. This book is a good source for students and researchers conducting work on environmental science, specifically on water supply technology.

  • Drug Testing

    • 1st Edition
    • John Fay
    • English
    Drug Testing focuses on the contributions of drug testing in the identification of the state of drug abuse and the implementation of policies and regulations making drug use unacceptable either socially or in the workplace. The book first gives an overview of drug-testing policy, facilitating drug testing and treatment, challenges to drug-testing programs, and state, local, and federal legislation on drug testing. The text then defines the problem of drug abuse, including dimensions of abuse, defining the problem and the needs of employers, employing a drug abuse survey, and treatment modalities. The manuscript ponders on the development of a drug-testing policy, education of employees, and training of supervisors. Discussions focus on the nature of learning, principles of supervision, training process, program implementation, basic assumptions, final policy content, and problematic issues. The implementation of a drug-testing program, collection of specimens for drug testing, and understanding the drug testing program are also underscored. The publication is a valuable reference for readers interested in drug testing policies, treatment, and effects of drug abuse in the workplace.

  • Plant Virology

    • 2nd Edition
    • R. E. F. Matthews
    • English
    Plant Virology, Second Edition, was written to cover the substantial developments in many areas of plant virology since the first edition was published. Advances have been made in all branches of the subject, but these have been most far reaching with respect to the structure of viruses and of their components, and in the understanding of how viral genomes are organized and how viruses replicate in cells. Significant developments have also occurred in the understanding of how viruses are transmitted by invertebrates and in the application of control measures for specific diseases. The taxonomy of viruses has advanced significantly, and there are now 25 internationally approved families and groups of plant viruses. All these developments have required that most sections be entirely rewritten. This book is intended primarily for graduate students in plant pathology, plant virology, general virology, and microbiology, and for teachers and research workers in these fields. It should also prove useful to some people in related disciplines—molecula... biologists, biochemists, plant physiologists, and entomologists.

  • Membrane Fluidity in Biology

    Cellular Aspects
    • 1st Edition
    • Roland C. Aloia + 1 more
    • English
    Membrane Fluidity in Biology, Volume 4: Cellular Aspects provides a unique interpretation of membrane and cellular activity, as well as cellular aspects of membrane fluidity. This book discusses the influence of membrane fluidity on enzyme activity, function of the sarcoplasmic reticulum in skeletal muscle, role of cholesterol in membrane function, phospholipid methylation, glycosyltransferases... and membrane fusion. The realm of normal cellular function and mechanisms involved in the modulation of cellular function by membrane lipids are also elaborated in this publication. This volume is intended for cell and molecular biologists and clinical-medical scientists, but is also beneficial to individuals researching on the effects of membrane lipids and fluidity in cellular function.

  • Spectroscopic Methods of Analysis

    Analytical Methods for Pesticides and Plant Growth Regulators, Vol. 9
    • 1st Edition
    • Gunter Zweig + 1 more
    • English
    Analytical Methods for Pesticides and Plant Growth Regulators, Volume IX: Spectroscopic Methods of Analysis covers the progress in spectroscopic methods for pesticide analysis. The book discusses the use of high-pressure liquid chromatography coupled to mass spectrometry for the analysis of heat-labile compounds; and the applications of nuclear magnetic resonance spectroscopy and related techniques, and visible and ultraviolet spectrophotometry. The text also describes the applications of spectrophotofluorome... infrared spectrometry, and a collection of infrared spectra of important pesticides. Toxicologists, chemists, and people working in pesticide laboratories will find the book invaluable.

  • Animal Memory

    • 1st Edition
    • Werner K. Honig + 1 more
    • English
    Animal Memory is based on the proceedings of a symposium held at Dalhousie University in the summer of 1969. Each of the seven chapters provide broad coverage of the topic with which it is concerned, and the experimental work reported is representative of the most significant developments in the field. The book includes two studies on associative memory—the memory of one event which is essential to its association (over a delay) with subsequent events. One study shows that shows that animals can remember events from one learning trial to the next and that their behavior will be determined largely by the sequences of trials with differing outcomes; the other presents research on the association of flavors with toxicosis in a conditioning paradigm. Separate chapters deal with retentive memory—the retention and forgetting of learned behavior over time; and the physiological basis of memory in terms of consolidation theory. These studies demonstrate that animals do forget and examine theories of forgetting. The final chapter provides a critical discussion based on all of the foregoing material in which the topics covered in the book are related to current work on human retention and forgetting.

  • Mechanisms of Drug Resistance in Neoplastic Cells

    Bristol-Myers Cancer Symposia, Vol. 9
    • 1st Edition
    • Paul V. Woolley + 1 more
    • English
    Bristol-Myers Cancer Symposia, Volume 9: Mechanisms of Drug Resistance in Neoplastic Cells provides information on both basic scientific and clinical studies on the causes and implications of tumor cell resistance to common antineoplastic agents. The book describes the colon cancer as a model for resistance to antineoplastic drugs; mathematical modeling of drug resistance; and the mechanism of induced gene amplification in mammalian cells. The text also discusses the cellular concomitants of multidrug resistance; resistance to alkylating agents; and the phosphoprotein and protein kinase C changes in human multidrug-resistant cancer cells. Novel drugs that affect glutathione metabolism; the regulation of genes encoding drug-metabolizing enzymes in normal and preneoplastic tissues; and the relevance of glutathione S-transferases to anticancer drug resistance are also considered. The book further tackles the cellular resistance to cyclophosphamide; the preclinical and clinical experiences with drug combinations designed to inhibit DNA repair in resistant human tumor cells; and the modification of the cytotoxicity of DNA-directed chemotherapeutic agents by polyamine depletion. The text also demonstrates multidrug resistance and the circumvention of resistance. Oncologists, molecular biologists, biochemists, geneticists, and pharmacologists will find the book invaluable.

  • Birds

    Brain and Behavior
    • 1st Edition
    • Irving J. Goodman + 1 more
    • English
    Birds: Brain and Behavior is a collection of papers that discusses brain-behaviors problems concentrating on the bird's complex and well-integrated central nervous system. This collection reviews the theoretical and methodological problems concerning comparative studies of bird behavior in a brain-behavior relationship. The book explains the structural organization of the avian brain including the spinal cord and the general ascending/descending patterns of sensory projections. One paper analyzes the hearing and vocalization in songbirds that are composed of the auditory mechanisms, as well as the vocalization and audition systems. A study by Falls (1963) notes that songbirds use more than one type of auditory cue for species recognition. Another paper present brain stimulation parameters that affect bird vocalization. Other papers examine the neural basis of avian discrimination and reversal learning, memory disruptions by brain perturbation, and the behavioral and physiological correlations between the sleep and awake states. This book will prove useful for avian biologists, zoologists, and readers who have a general interest in birds.

  • Synthetic Pyrethroids and Other Pesticides

    Analytical Methods for Pesticides and Plant Growth Regulators, Vol. 13
    • 1st Edition
    • Gunter Zweig + 1 more
    • English
    Analytical Methods for Pesticides and Plant Growth Regulators, Volume XIII: Synthetic Pyrethroids and Other Pesticides covers the important role of the synthetic pyrethroids as pesticides. The book discusses discussion the analytical methods used for synthetic pyrethroids. The text describes analytical methods for carbaryl, diflubenzuron, asulam, betasan, diuron, eptam, fluometuron, propanil, and Sutan. A detailed description of methods of analysis for technical-grade products, formulations, and residues of pesticides is also provided. Toxicologists and people involved in the analysis of pesticide formulations will find the book invaluable.

  • Research Surgery and Care of the Research Animal

    Patient Care, Vascular Access, and Telemetry
    • 1st Edition
    • William I. Gay + 1 more
    • English
    Methods of Animal Experimentation, Volume VII: Research Surgery and Care of the Research Animal, Part A is a collection of papers that deals with methods used in animal experiments involving patient care, vascular access, and telemetry. This book concerns technologies in experimental surgery — complicated procedures requiring longer observation time of the test animal, and an increase in the spectrum of animals that can be used. One paper describes the anesthesia, analgesia, and kinds of restraints that are suited for the test animal. A wide array of choices of inhalational agents, injectable, local anesthesia (lidocaine), analgesics (opioids and aspirin), and restraint (nonanesthesia and neuromuscular-blocki... agents) is available for the researcher to choose from. Several authors also describe the use of telemetry devices that are implantable in test animals to achieve minimal interference from the investigator. These devices include sensors such as flow transducers and probes to use in pulse or continuous wave-applications; electromagnetic flowmeters for blood monitoring; and integrated circuits for various applications. One paper discusses postoperative care including a patient care checklist, treatment of common postoperative complications, as well as venous catheters for fluid administration. This text will be appreciated by veterinarians, technicians dealing with laboratory animals, and researchers designing animal and medical experiments.

  • A Guide to Alcohol and Drug Dependence

    • 2nd Edition
    • J. S. Madden
    • English
    A Guide to Alcohol and Drug Dependence, Second Edition provides information on the recognition of alcohol misuse, on alcohol dependence among the elderly, and on outpatient withdrawal from opioids. This book emphasizes the detection and early treatment of alcohol misuse, the detoxification of drug users followed by drug-free counseling, and preventive measures. Organized into nine chapters, this edition begins with an overview of the various types of dependence-producing drugs, including morphine, cocaine, cannabis, alcohol-barbiturate, amphetamine, hallucinogen, and inhalants and volatile solvents. This text then explains the depressant actions of alcohol on the central nervous system that affects first the higher cerebral functions responsible for concern about personal behavior and for self-restraint. Other chapters consider the physical disabilities that heavy drinkers are prone to develop. The final chapter deals with the preventive measures directed against the problems presented by drugs and alcohol. This book is a valuable resource for social workers, nurses, occupational therapists, and clinical psychologists.

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