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Books in Life sciences

BooksJournals

  • Microbial Stress Biology

    • 1st Edition
    • Samiksha Joshi + 4 more
    • English
    Microbial Stress Biology offers a comprehensive understanding of the adaptation strategies of microbes at the biochemical and molecular level in response to stressful conditions and details the molecular mechanisms that enable microbial organisms to survive and persist under these adverse circumstances. The book discusses a wide array of topics related to microbial adaptation, covering fundamental biological responses to stress, microbial adaptations at cellular, genomic, and proteomic levels, as well as specific adaptations and regulations to various environmental stress factors such as pH fluctuations, chemicals, and extreme thermal conditions. The book also highlights the application of omics technology and predictive modeling in understanding microbial stress biology for various fields including biotechnology, medicine, bioremediation, and industrial processes. Microbial Stress Biology is an informative resource for those in microbiology, molecular biology, biotechnology, and other related fields to better understand how microbes are able to sense and respond to distinct stressors at both the molecular and cellular levels.

  • Magnetic Resonance Fingerprinting for Quantitative MRI

    • 1st Edition
    • Volume 14
    • Dan Ma + 2 more
    • English
    MR Fingerprinting is emerging as a clinically feasible and versatile tool for quantitative MR imaging. Magnetic Resonance Fingerprinting for Quantitative MRI focuses on all aspects of MR Fingerprinting techniques and applications. Presenting a detailed and clear description of the technology, implementation, clinical translation issues and applications, it emphasizes different perspectives of MR signals and their utilization, with the goal of inspiring readers to explore new MR Fingerprinting designs. The book starts each section with a discussion on rethinking the MR acquisition and the opportunities provided by, for example, different MR contrast mechanisms, signal modeling, post-processing and clinical applications.Magneti... Resonance Fingerprinting for Quantitative MRI is a complete reference for magnetic resonance imaging researchers and radiologists.

  • Unlocking the Secrets of Extracellular Vesicles and Exosomes

    A Journey into the Cutting-Edge Frontier of Cellular Communication
    • 1st Edition
    • Chandrashekhar Singh + 4 more
    • English
    Unlocking the secrets of extracellular vesicles and exosomes: A journey into the cutting-edge frontier of cellular communication provides a comprehensive overview of the latest advances and research on extracellular vesicles (EVs) and exosomes. The book begins with a historical introduction to the field and how this has evolved since EVs were first observed, before exploring their cellular mechanisms and approaches to study their isolation, characterization, and function. It then delves into exosomes in health and disease, considering their role across cancer, regenerative medicine, neurological disorders, and metabolic disorders, highlighting their potential as biomarkers for disease diagnosis. The book moves on to discuss cutting-edge technology for the engineering of EVs and exosomes, considering how the integration of AI, machine learning, and nanotechnology can be utilized to expand the therapeutic capabilities of EV and exosome-based applications. It then closes with chapters covering novel applications in nutraceutical and cosmetic production, and a look towards the future potential of EVs and exosomes. Unlocking the secrets of extracellular vesicles and exosomes offer a thorough exploration of EV and exosome research, covering various dimensions from basic science to clinical applications and future perspectives. It is an ideal guide for researchers working across a diverse range of disciplines, including cell biology, molecular biology, biotechnology, therapeutics, and biomedicine.

  • Reverse Aging

    Current Research and Future Directions
    • 1st Edition
    • Sandeep Kumar Singh + 1 more
    • English
    Reverse Aging: Current Research and Future Directions explores the integrated approach of aging and reverse aging to present a comprehensive understanding of the biological, genetic, and molecular mechanisms associated with aging. By targeting fundamental aging mechanisms, strategies are being developed to reverse and repair damage and potentially lead to greater healthspan benefits and optimal longevity. The book opens with the fundamentals of aging and how genetic, environmental, and lifestyle variables affect the biological, psychological, and social processes that lead to aging before delving into a comprehensive review of the hallmarks of aging. Next, an overview of the concept of reverse aging is presented, and subsequent chapters examine specific reverse aging models and approaches. The book explores use of cellular reprogramming techniques, provides an overview of the molecular processes that underlie NANOG-mediated reversal aging, and discusses the possible contribution of IGF-1/PKA signaling reduction to reverse aging via HSC-based therapies. The developing science of rejuvenating stems cells, histone modification, and stimulation of autophagic activity to facilitate the removal of cellular debris and reduce the impact of aging on various organ systems as well as novel concepts of mRNA enhanced cell therapy, immunological-driven signaling, mitochondrial modulations, cell-cycle regulation, and metabolic reprogramming for reserve aging are all examined. The wide range of nutritional therapies, phytochemical, prescription medications, and nutraceuticals impacting the aging process is reviewed, and the book closes with discussion of the revolutionary role AI has on anti-aging research and where the field is headed. In conclusion, the book emphasizes the importance of targeting fundamental aging mechanisms to extend health and achieve optimal longevity and provides insights into the potential implications for healthcare and aging research, highlighting the need for collaborative efforts and interdisciplinary perspectives to address the challenges of population aging and develop effective strategies for healthy aging practices.

  • Two Sides of Nanovaccines and Nanomedicines in Cancer Treatments

    • 1st Edition
    • Tuan Anh Nguyen + 2 more
    • English
    Two Sides of Nanovaccines and Nanomedicines in Cancer Treatments provides a balanced exploration of the dual roles of nanotechnologies in oncology. Structured in four parts, the book begins with foundational knowledge of nanovaccines and nanomedicines, detailing their applications in cancer care and highlighting their precision in targeting cancer cells while reducing systemic toxicity. Importantly, the book addresses potential drawbacks, discussing side effects and safety concerns associated with these innovations. The final section emphasizes ethical, regulatory, and safety challenges, underscoring the need for careful oversight as nanotechnologies advance. For the academic audience, this book serves as a vital resource, offering insights that equip researchers and healthcare professionals to make informed decisions regarding clinical applications. Its focus on both the benefits and risks, alongside forward-looking perspectives, ensures that readers are well-prepared for future developments in the field of nanomedicine and cancer therapy.

  • 2D and 3D Cellular Screening Models and AI Guided Analysis

    • 1st Edition
    • Volume 204
    • English
    2D and 3D Cellular Screening Models and AI Guided Analysis provides a comprehensive overview of the latest advancements in cellular screening models, with a particular focus on both 2D and 3D systems. It explores the development, application, and comparative benefits of 2D monolayer cultures and 3D organoids, spheroids, and tissue-engineered constructs for biomedical research and drug discovery.

  • Host-Microbe Co-metabolism System in Health and Disease

    • 1st Edition
    • Xiao Zheng + 1 more
    • English
    Host-Microbe Co-metabolism System in Health and Disease is an easy-to-follow reference of research progress in host-microbiome co-metabolism system (HMMS) and how this frontier could imply a better understanding of health, disease, and the discovery of novel drugs. The book summarizes recent studies that are progressing to complete a panorama of the host-microbiome co-metabolism system (HMMS) in health and disease. It discusses how sophisticated bioanalytical tools, tractable model organisms, and artificial intelligence could be integrated to answer key biological questions related to HMMS in the broader context of human health and drug discovery.

  • Immunological Aspects of Preterm Birth

    Phenotypes of Preterm Birth, Immune Mechanisms, and Pathway Forward
    • 1st Edition
    • Volume 4
    • Irina Burd MD
    • English
    Immunological Aspects of Preterm Birth: Phenotypes of Preterm Birth, Immune Mechanisms, and Pathway Forward bridges reproductive immunology of preterm birth to subtypes, phenotypes, and bedside prevention and treatment. The book reviews the role of the different immune mechanisms during pregnancy that lead to preterm birth, along with the fetal programming effects that are connected to maternal immune activation. In addition, it discusses immune cells and their products and cytokines and chemokines as central for the success of the pregnancy.While our knowledge on the role of immune cells and the inflammatory process in preterm birth has grown exponentially in the last 10 years, connecting basic science to clinical science and the development of new therapeutics has not progressed as rapidly. This book assists researchers in understanding the basic immunologic mechanisms and inflammatory processes associated with preterm birth and fills an urgent need for the development of therapeutics in this space.

  • Moving Toward Nonanimal Approaches in Medical Research and Testing

    • 1st Edition
    • Gail A. Van Norman + 1 more
    • English
    Moving Toward Nonanimal Approaches in Medical Research and Testing pioneers a single-source guide for researchers regarding nonanimal research tools and methodologies and their many advantages and applications in place of animals. This book is presented in three parts: historical, ethical, legislative, and scientific contexts on the need to shift away from animal-based research and testing; the latest advances in nonanimal tools and methods for biomedical research and testing of human therapeutics and other compounds, including microphysiological systems, bioprinting, biobanks, and artificial intelligence; and achieving a practical shift toward these powerful approaches, including advocacy for legal, regulatory, and policy change, securing funding for nonanimal studies, and how to overcome bias against nonanimal methods. This book, primarily directed to researchers in biomedicine, human medical therapeutics, and toxicology, will also appeal to researchers in industry, providing overview and insights about the latest applications of nonanimal research tools and methods for product development and testing. Clinicians who wish to understand the reliability of testing therapeutics with nonanimal versus animal methods, as well as advocacy groups seeking an up-to-date understanding of ethical, economic, political, and scientific considerations in moving toward nonanimal approaches, will also find significant value in this text. Finally, legislators and those involved in regulatory review and oversight will benefit from this single comprehensive source for developing a basic understanding of nonanimal research and human safety.

  • Cerebellum Development and Disease

    • 1st Edition
    • Volume 167
    • English
    Cerebellum Development and Disease offers a comprehensive overview of the intricate processes underlying the formation, maturation, and function of the cerebellum, as well as the wide spectrum of disorders that can affect this essential brain region. The book brings together leading experts in neurodevelopment, neurobiology, genetics, and clinical neurosciences to explore the molecular and cellular mechanisms guiding cerebellar development, from embryogenesis to adulthood.

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