Gene and Cell Therapies

Interest in gene and cell therapies has increased dramatically following powerful demonstrations of their capability to treat rare genetic disorders, advanced cancers, and regenerate or repair tissues. Although these new, advanced medicines are continually being improved upon, their complex manufacture remains a key obstacle to increasing patient access. Gene and Cell Therapies: Principles of Pharmaceutical Development provides insight to the key principles of emerging scientific and technical strategies to overcome these obstacles. How the design of viral vectors, oncolytic viruses, ribonucleic acid cancer vaccines, autologous and allogeneic cell therapies, impacts their pharmaceutical development is outlined. The advances in molecular and cell biology that have led to efficacious and safe gene and cell therapies are related to the process and analytical developments that ensure their quality. The scope and style, along with included case studies, learning points and lecture slides, will allow the non-specialist to develop a foundational understanding, while the contemporary concepts discussed will urge further advancement of these exciting medicines.