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Aging and the Kidney

Mechanisms, Consequences, and Management Strategies

  • 1st Edition - July 27, 2026
  • Latest edition
  • Editors: Stephen Fadem, Ahmed Arslan Yousuf Awan, Emaad Abdel-Rahman
  • Language: English

Aging and the Kidney: Possible Mechanisms, Consequences, and Management Strategies explores the connection between kidney health and overall well-being with increasing age and lo… Read more

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Description

Aging and the Kidney: Possible Mechanisms, Consequences, and Management Strategies explores the connection between kidney health and overall well-being with increasing age and longevity. The first part examines histological, structural, physiological, and functional changes that contribute to age-related declines in kidney function. The role of nutrition and proteomics is also discussed. The second part examines the functional decline in elderly patients and includes subparts on impaired quality of life, sleep quality, fall risk, frailty, depression, and sarcopenia. It also considers unique features of hypertension, diabetes, glomerulonephritis, and peripheral vascular disease.

The final part focuses on diagnostic, management, and prevention strategies. Common myths about chronic kidney disease in the elderly are addressed, with particular attention to how a solitary kidney in living donors ages over time. In addition, kidney function and its relationship to neurologic complications, cancers, and cardiovascular disease are explained, along with current treatment approaches, medications, and future directions in the care of elderly patients.

Key features

  • Covers histological, structural, physiological, and functional changes that lead to decline in kidney function with aging
  • Summarizes the most up-to-date research on the kidney’s impact on health and lifespan
  • Addresses common myths regarding kidney disease in the elderly
  • Provides guidance on diagnostic, management, and prevention strategies in kidney health and disease for the aging patient

Readership

Researchers and clinicians specifically in the fields of geriatrics, gerontology, nephrology or those dealing with elderly patients

Table of contents

Part 1: Mechanisms of aging in the kidney

1. Structural and functional changes in aging
Emaad M. Abdel-Rahman, Stephen Z. Fadem, and Brendan Bowman

2. Models of kidney aging
Emaad M. Abdel-Rahman, Stephen Z. Fadem, and Brendan Bowman

3. Molecular mechanisms of aging
Stephen Z. Fadem, Brendan Bowman, and Emaad M. Abdel-Rahman

4. A review of podocyte senescence and aging
Stuart J. Shankland, Shuta Ishibe, Jeffrey W. Pippin, and Oliver Wessely

5. Epigenetics and the kidney
Qingqing Wei and Zheng Dong

6. The influence of acute kidney injury on aging
Gonzalo Ramírez-Guerrero and Mitchell Rosner

7. Nutritional considerations and aging
Yoko Narasaki, Connie M. Rhee, and Kamyar Kalantar-Zadeh

8. Proteomics
Stephen Z. Fadem and Emaad M. Abdel-Rahman
Part 2: Unique characteristics of kidney diseases in the elderly

9. Impaired quality of life in elderly CKD patients
Zara Ijaz and Angelina Edwards

10. Sleep
Seki A. Balogun and Emaad M. Abdel-Rahman

11. Falls
Stephen Z. Fadem

12. Fatigue and frailty in kidney disease
Totini Sagorika Chatterjee and Lucile Parker Gregg

13. Hospitalizations
Neha Siddiqui and Samaya Anumudu

14. Depression
Jessica Lowe and Angelina Edwards

15. Sarcopenia
Sheryl Cababat Caberto, Lynn Schlanger, and Stephen Z. Fadem
Part 3: Aging in specific diseases

16. Hypertension
Faruk Hilmi Turgut and Emaad M. Abdel-Rahman

17. Diabetes in kidney disease progression
Sheryl Cababat Caberto, Lynn Schlanger, and Stephen Z. Fadem

18. Glomerulonephritis
Akwe Nyabera and Gerald Appel

19. Peripheral vascular disease
Eric Peden, Omodele Durojaye, and Brianna Whithorn
Part 4: Management and prevention

20. Diagnosis of CKD in an elderly individual, due to a decline in GFR with normal healthy aging
Bryce M. Churilla, Jae Hun Son, Khan Shabtab, Sheryl Cababat Caberto, and Stephen Z. Fadem

21. Myths about chronic kidney disease in the elderly
Ahmed Awan and Sarwar Khan

22. The living donor and aging
Catherine Cecelia Vatsis and Sean Hebert

23. CNS limitations in elderly kidney patients
Stephen Z. Fadem and Totini Sagorika Chatterjee

24. Cancer and the kidney in an elderly individual
Raad Chowdhury and Si Yuan Khor

25. Cardiovascular disease in aging kidney
Ahmad Armoghan Yousuf Awan, Muhammad Rizwan, Rameesha Awan, and Carl Peter Walther

26. Benefits of renin angiotensin aldosterone system blockage
Faruk Hilmi Turgut and Emaad M. Abdel-Rahman

27. Active medical care without dialysis
Ojaswi Singh Tomar, Rebecca J. Schmidt, and Alvin Howard Moss

28. Drugs to avoid with geriatric kidney disease
Stephen Z. Fadem

29. Innovations in chronic kidney disease and aging
Stephen Z. Fadem

Product details

  • Edition: 1
  • Latest edition
  • Published: July 27, 2026
  • Language: English

About the editors

SF

Stephen Fadem

Stephen Z Fadem has been in clinical practice since 1978 and is currently a Clinical Professor of Medicine at Baylor College of Medicine. During his career, he has been involved in both teaching and clinical research. Dr. Fadem’s special interests revolve around how the morbidities associated with advancing kidney disease lead to sarcopenia and frailty. He is currently in the process of planning a large fall prevention research project for dialysis patients. He has participated in 44 clinical trials and currently has 93 publications and book chapters, as well as 38 patient education articles. Dr. Fadem is the recipient of several national awards. He has been recognized as a Top Doctor by Castle-Connolly for several years, has won the Medal of Excellence from AAKP, and the Presidents Lifetime Achievement Award.

Affiliations and expertise
Clinical Professor of Medicine, Baylor College of Medicine, USA

AA

Ahmed Arslan Yousuf Awan

Dr. Ahmed Arslan Yousuf Awan is a practicing nephrologist and Assistant Professor, Department of Medicine, Nephrology and Abdominal Transplantation at the Baylor College of Medicine. Dr. Awan is founder and director of Hepatorenal services and site director for Nephrology fellowships at Baylor St. Luke’s Medical Center (BSLMC) and is the elected faculty senator for BSLMC. He is winner of Faculty of the Year award, Leadership award, Excellence in Patient Care award and has received the Houstonia top doctors award for 3 consecutive years. He is the principal investigator for an ongoing study regarding racial disparities in living kidney donation and a member of the KDIGO focused group that recently published updated guidelines regarding management of hepatitis C and CKD. He is on the faculty at Baylor College of Medicine as well as a lead in innovative national and international courses like Nephrology Business Leaders University (NBLU) and the GlomCon Fellowship.

Affiliations and expertise
Assistant Professor, Department of Medicine, Nephrology and Abdominal Transplantation, Baylor College of Medicine, USA

EA

Emaad Abdel-Rahman

Emaad M Abdel-Rahman, MD, PhD, has been a nephrologist for over three decades specializing in caring for elderly patients with kidney disease, dialysis patients, and patients with acute and chronic kidney diseases. He is director of the UVA Kidney Center Clinic and main hemodialysis unit and leads one of the few home hemodialysis units in the country. Abdel-Rahman has been actively involved in clinical research throughout his career, including both investigator-initiated and industry-related trials. Dr Abdel-Rahman is a recipient of the UVA School of Medicine Dean’s Award for Clinical Excellence and the Department of Medicine Mentoring Excellence award. He has served on the Advisory Geriatric Nephrology Committee and as a member of the steering committee of the Kidney Health Initiative at the American Society of Nephrology. He now serves as interim director of the Nephrology Clinical Research Center within the UVA Division of Nephrology.

Affiliations and expertise
Director or the UVA Kidney Center Clinic and interim Director of the Nephrology Clinical Research Center, UVA Division of Nephrology, USA

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