This is a classic advanced neurochemistry and neurobiology textbook that has a renewed focus on clinical applications. The early chapters focus on fundamental membrane chemistry, cellular signaling, and development of the nervous system. Later chapters cover cell injury and inflammation, neurodegenerative diseases, sensory transduction, and neural processing/behavior. By understanding mechanisms at the molecular and systems level, scientists can develop new pharmacotherapies to treat diseases such as Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis as well as neuropsychiatric diseases (e.g., schizophrenia, depression, pain, addictions). This book provides a foundation of all key principles of neurochemistry and neurobiology--within the context of human diseases--for advanced students and graduate students in neuroscience, biomedical sciences, as well as clinical neuroscientists and neurologists.
Autism Autonomy: In Search of Our Human Dignity provides a new and unifying methodological framework and discusses machine learning and biometrics techniques to diagnose, characterize, and treat patterns of sensory motor control underlying autism symptoms. With the hope of improving basic research in these areas, this volume will allow readers to design better interventions and provide awareness of a number of new technologies used in the autism field. Wearable bio-sensing technologies, machine learning, and AI methods are all discussed regarding their applications to provide better self-awareness, interaction, diagnosis, and prognosis.This volume is useful for researchers and clinicians interested in learning about these new technologies and how to enhance machine learning use in ASD for the betterment of patients.
The emergence of gene and cellular therapeutics has changed the clinical landscape for a variety of disorders and is now ready to do so for neurological diseases. These therapeutic modalities currently complement and may in time supplant small molecule drugs. This volume comprehensively covers the scientific background, translational efforts, clinical developments and registered biologics that have entered into clinical practice. Coverage includes types of therapies available and in development, and best practice uses for a variety of neurological disorders including Parkinson’s, Huntington’s, ALS, stroke, spinal cord RP, demyelination, and epilepsy.
Handbook of Neural Engineering: A Modern Approach provides a comprehensive overview of the field from biology to recent technological advances through an interdisciplinary lens. The book is divided into three sections: 1) Biological Considerations for Neural Engineering, 2) Neural Engineering Strategies, and 3) Emerging Technologies for Neural Engineering. It provides the first comprehensive text that addresses this combination of subjects. Neurodegenerative diseases, including Alzheimer’s, Parkinson’s and Multiple Sclerosis, represent an enormous healthcare burden, and many of these diseases lack true cures, making it imperative to study the biological systems that become disordered to understand potential treatment options.This book covers the basic neurobiology and physiology, common neural engineering strategies, and emerging technologies in this field. It is designed to support an upper year/graduate elective course in neural engineering, and will provide a foundational overview of the field for interdisciplinary researchers, clinicians, engineers, and industry professionals. The handbook provides readers with a strong base in both biological and engineering principles along with the concepts necessary to implement solutions using Neural Engineering.
Inherited white matter disorders (WMDs) are a large and heterogeneous group where imaging abnormalities and pathology lie predominantly in the CNS white matter. Many acquired causes, such as multiple sclerosis, are readily diagnosed and familiar to the majority of neurologists. However, less common acquired causes, and genetic disorders (the leukodystrophies and genetic leukoencephalopathies) often present a diagnostic challenge. The evaluation of patients with White matter disorders (WMDs) has evolved enormously in recent decades, due to advances in genetics, radiology, and the development of treatments for specific disorders. There is a need for a book to bring together WMD research, spanning basic science, molecular genetics, and clinical and radiological phenotyping.This volume presents both common WMDs, and rare disorders according to their presentations or pathophysiology. Chapters lay out the clinical and radiological presentation of the disorder, followed by genetics and diagnostics, and finally discussion of pathophysiology and treatment. Chapter contain imaging, clinical pearls to diagnosis, and reference tables for genotype-phenotype correlation. For diagnostic work-up, easy to read algorithms are presented as well as clear guidance on indications for treatment, where applicable.
Biomarkers play an indispensable role in Alzheimer's Disease (AD) diagnosis, clinical research and clinical trials. Our understanding of AD biomarkers has been profoundly impacted by the study of Autosomal Dominant Alzheimer's Disease (ADAD). Though memory loss is the most common feature of ADAD, motor dysfunction, neuropsychiatric symptoms, and epileptiform abnormalities are present at a much higher rate in ADAD than sporadic, late-onset AD. There are over 250 known ADAD-causative variants in PSEN1, 2, and APP. This genetic heterogeneity is reflective in both biomarkers and cognitive heterogeneity across people with ADAD. Autosomal Dominant Alzheimer's Disease: A Pathophysiology Review discusses the history of ADAD and its cognitive, neuroimaging and biomarker trajectories. This book focuses how ADAD can provide a unique insight into genetically driven and sporadic forms of AD. Edited by Dr. Jasmeer Chhatwal and Dr. Eric McDade, and contributed by leading experts in the field, this book will be become the leading tool for researchers and clinicians in Alzheimer's Disease.
Translational Models of Parkinson’s Disease and Related Movement Disorders focuses on cutting-edge techniques for creating and validating current Parkinson’s Disease translational experimental models. Various characteristics of these models are examined, including the prion-like properties of -synuclein, mitochondrial functions connected to the PINK1-Parkin pathway/CHCHD2, the endolysosome pathway connected to LRRK2, VPS35, and ATP13A2 using cultured cells (including patient iPS cells). This book also highlights the future possibilities of introducing new models for Parkinson’s Disease and related movements disorders, underscoring current advancements, pre-clinical and clinical developments, and future scope related to numerous models.
Osteomyelitis and Discitis of the Spine: A Guide for the Management of Infectious Etiology of the Vertebral Column and Neurological Components examines these spinal conditions and provides readers with the most appropriate management plans, including surgical treatment together with its indications. This book guides spine neurosurgeons and others when choosing the optimal surgical approach for their patients, shedding light on current advances in surgical techniques used in the management of vertebral osteomyelitis and discitis, particularly minimally invasive spine approaches.With authors representing diverse specialties, chapters reflect current clinical and surgical practice and discuss pathophysiology and pain management and rehabilitation. The book begins with related anatomy and extends to post-management rehabilitation and pain control, including a chapter dedicated to paediatric patients and their differing causative organisms, etiology, diagnostic modalities, and pathophysiology. This reference will provide increased awareness of potential spinal infection, facilitating multidisciplinary management plans, improving patient safety and outcomes, and enabling early intervention alternatives that improve patient outcomes and long-term quality of life
Brain and Organ Communication: Effects of Crosstalk on Neurophysiology examines the intricate relationship between the brain and other organ systems within the body. With an emphasis on homeostasis of these systems, this book also explores how various systems are related and affected by the brain injury or organ damage from a neurophysiological standpoint.This book will be most useful to researchers in neuroscience and graduate students studying neurophysiology. Those with an interest in endocrinology, clinicians in various branches of neuroscience and physiology will also find this book of interest.