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Elsevier

Books in Neuroscience

Elsevier's Neuroscience collection empowers educators, researchers, and students with actionable knowledge to drive collaborative research and advancements in the field. Content covers the nervous system's intricate workings, covering branches like Affective, Behavioral, and Cognitive neuroscience to investigate the neural basis of emotions, behavior, and cognitive functions. Spanning from Molecular and Cellular Neuroscience to Developmental Neuroscience, content provides insights into brain function in health and disease.

  • Colour Atlas of Ophthalmology

    • 2nd Edition
    • Arthur Lim Siew Ming + 1 more
    • English
    Colour Atlas of Ophthalmology, Second Edition provides information pertinent to the fundamental aspects of ophthalmology. This book provides the correct diagnosis and treatment of many ocular disorders. Organized into 11 chapters, this edition begins with an overview of the process of assessment of a patient with eye disease, which includes taking a good history, examining the eyes with adequate illumination, and testing the visual function. This text then describes exophthalmos, which is the most common condition of the orbit and indicates the possibility of thyroid disease or a space-occupying lesion. Other chapters consider the common causes of ocular injuries, including injury from flying particles, sharp instruments, chemicals, and ocular injury associated with head injury. The final chapter deals with the common, therapeutic, and diagnostic ocular drugs. This book is a valuable resource for ophthalmologists, physicians, nurses, students, and all those paramedical personnel who have to deal with common eye disease.

  • The Role of 5-HT Systems on Memory and Dysfunctional Memory

    Emergent Targets for Memory Formation and Memory Alterations
    • 1st Edition
    • Alfredo Meneses
    • English
    Drugs acting through 5-HT (5-hydroxytryptamine... or serotonin) systems modulate memory and its alterations, but the mechanisms by which they do so are poorly understood. Agonists and antagonists for 5-HT receptors, as well as serotonin uptake inhibitors, present promnesic (memory-promoting) and/or anti-amnesic effects under different conditions, and 5-HT receptors are also associated with neural changes. The Role of 5-HT Systems on Memory and Dysfunctional Memory: Emergent Targets for Memory Formation and Memory Alterations reviews and summarizes the most recent research related to 5-HT drugs and the mechanisms by which they effect alterations in memory. This latest evidence is reviewed in the context of memory deficits related to brain disorders, such as post-traumatic stress disorder, schizophrenia, post-stroke cognitive dysfunctions, Parkinson’s disease, and infection-induced memory impairments. Written by an expert in the field of memory, The Role of 5-HT Systems on Memory and Dysfunctional Memory provides an introduction to the latest research on 5-HT receptors and their contributions to the physiological and pharmacological basis of memory.

  • Aminoff's Neurology and General Medicine

    • 5th Edition
    • Michael J. Aminoff + 1 more
    • English
    Aminoff's Neurology and General Medicine is the standard and classic reference providing comprehensive coverage of the relationship between neurologic practice and general medicine. As neurologists are asked to consult on general medical conditions, this reference provides an authoritative tool linking general medical conditions to specific neurologic issues and disorders. This is also a valuable tool for the general practitioner seeking to understand the neurologic aspects of their medical practice. Completely revised with new chapters covering metastatic disease, bladder disease, psychogenic disorders, dementia, and pre-operative and post-operative care of patients with neurologic disorders, this new edition will again be the go-to reference for both neurologists and general practitioners.

  • Computational Neuroscience

    • 1st Edition
    • Volume 123
    • English
    Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references. This volume brings together different aspects of, and approaches to, molecular and multi-scale modeling, with applications to a diverse range of neurological diseases. Mathematical and computational modeling offers a powerful approach for examining the interaction between molecular pathways and ionic channels in producing neuron electrical activity. It is well accepted that non-linear interactions among diverse ionic channels can produce unexpected neuron behavior and hinder a deep understanding of how ion channel mutations bring about abnormal behavior and disease. Interactions with the diverse signaling pathways activated by G protein coupled receptors or calcium influx adds an additional level of complexity. Modeling is an approach to integrate myriad data sources into a cohesive and quantitative model in order to evaluate hypotheses about neuron function. In particular, a validated model developed using in vitro data allows simulations of the response to in vivo like spatio-temporal patterns of synaptic input. Incorporating molecular signaling pathways into an electrical model, allows a greater range of models to be developed, ones that can predict the response to pharmaceuticals, many of which target neuromodulator pathways.

  • Biomedical Imaging

    Applications and Advances
    • 1st Edition
    • Peter Morris
    • English
    Biomedical Imaging: Applications and Advances discusses the technologies and latest developments in the increasingly important field of imaging techniques for the diagnosis of disease, monitoring of medical implants, and strategies for personalized medicine. Chapters in part one explore the full range of imaging technologies from atomic force microscopy (AFM) to positron emission tomography (PET), as well as the next-generation techniques that could provide the basis for personalized medicine. Part two highlights application-specific biomedical imaging methods, including ophthalmic imaging of ocular circulation, imaging methods for detection of joint degeneration, neural brain activation imaging, and the use of brain imaging to assess post-therapy responses. Further chapters review intravascular, cardiovascular, and whole-body magnetic resonance imaging (MRI). Biomedical Imaging is a technical resource for those concerned with imaging and diagnosis, including materials scientists and engineers as well as clinicians and academics.

  • Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics

    • 1st Edition
    • Carl Faingold + 1 more
    • English
    Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics, edited by two leaders in the field, offers a current and complete review of what we know about neural networks. How the brain accomplishes many of its more complex tasks can only be understood via study of neuronal network control and network interactions. Large networks can undergo major functional changes, resulting in substantially different brain function and affecting everything from learning to the potential for epilepsy. With chapters authored by experts in each topic, this book advances the understanding of: How the brain carries out important tasks via networks How these networks interact in normal brain function Major mechanisms that control network function The interaction of the normal networks to produce more complex behaviors How brain disorders can result from abnormal interactions How therapy of disorders can be advanced through this network approach This book will benefit neuroscience researchers and graduate students with an interest in networks, as well as clinicians in neuroscience, pharmacology, and psychiatry dealing with neurobiological disorders.

  • Human Memory

    A Constructivist View
    • 1st Edition
    • Mary B. Howes + 1 more
    • English
    While memory research has recently focused on brain images and neurological underpinnings of transmitters, Human Memory: A Constructivist View assesses how our individual identity affects what we remember, why and how. This book brings memory back to the constructivist questions of how all the experiences of an individual, up to the point of new memory input, help to determine what that person pays attention to, how that information is interpreted, and how all that ultimately affects what goes into memory and how it is stored. This also affects what can be recalled later and what kind of memory distortions are likely to occur. The authors describe constructionist theories of memory, what they predict, how this is borne out in research findings, presenting everyday life examples for better understanding of the material and interest. Intended for memory researchers and graduate level courses, this book is an excellent summary of human memory research from the constructivist perspective.

  • Psychology of Learning and Motivation

    • 1st Edition
    • Volume 60
    • English
    Psychology of Learning and Motivation publishes empirical and theoretical contributions in cognitive and experimental psychology, ranging from classical and instrumental conditioning to complex learning and problem solving. Each chapter thoughtfully integrates the writings of leading contributors, who present and discuss significant bodies of research relevant to their discipline. Volume 60 includes chapters on such varied topics as the balance between mindfulness and mind-wandering; institutions; implications for the nature of memory traces; repetition, spacing, and abstraction; immediate repetition paradigms; stimulus-response compatibility effects; environmental knowledge; and the control of visual attention.

  • Literature, Neurology, and Neuroscience: Neurological and Psychiatric Disorders

    • 1st Edition
    • Volume 206
    • English
    This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume on the neurosciences, neurology, and literature vividly shows how science and the humanities can come together --- and have come together in the past. Its sections provide a new, broad look at these interactions, which have received surprisingly little attention in the past. Experts in the field cover literature as a window to neurological and scientific zeitgeists, theories of brain and mind in literature, famous authors and their suspected neurological disorders, and how neurological disorders and treatments have been described in literature. In addition, a myriad of other topics are covered, including some on famous authors whose important connections to the neurosciences have been overlooked (e.g., Roget, of Thesaurus fame), famous neuroscientists who should also be associated with literature, and some overlooked scientific and medical men who helped others produce great literary works (e,g., Bram Stoker's Dracula). There has not been a volume with this coverage in the past, and the connections it provides should prove fascinating to individuals in science, medicine, history, literature, and various other disciplines.

  • Advances in the Neurochemistry and Neuropharmacology of Tourette Syndrome

    • 1st Edition
    • Volume 112
    • English
    This volume of International Review of Neurobiology brings together cutting-edge research on advances in the neurochemistry and neuropharmacology of Tourette syndrome. It reviews current knowledge and understanding, provides a starting point for researchers and practitioners entering the field, and includes important topics regards tics, neurotransmitters, pharmacology and emerging treatments.

  • Neural Crest Cells

    Evolution, Development and Disease
    • 1st Edition
    • Paul Trainor
    • English
    Neural Crest Cells: Evolution, Development and Disease summarizes discoveries of historical significance and provides in-depth, current analyses of the evolution of neural crest cells, their contribution to embryo development, and their roles in disease. In addition, prospects for tissue engineering, repair and regeneration are covered, offering a timely synthesis of the current knowledge in neural crest cell research. A comprehensive resource on neural crest cells for researchers studying cell biology, developmental biology, stem cells and neurobiology, Neural Crest Cells: Evolution, Development and Disease provides foundational information needed for students , practicing physicians and dentists treating patients with craniofacial defects.

  • Metal Related Neurodegenerative Disease

    • 1st Edition
    • Volume 110
    • English
    This issue reviews the role of metals in neurodegenerative diseases; including Parkinson’s and Huntington’s disease; restless leg syndrome and NBIA disorders; and Wilson’s disease and manganese and calcium accumulation disorders. An update on advances in neuroimaging and pathology of metal related disease is also presented.

  • Diffusion MRI

    From Quantitative Measurement to In vivo Neuroanatomy
    • 2nd Edition
    • Heidi Johansen-Berg + 1 more
    • English
    Diffusion MRI remains the most comprehensive reference for understanding this rapidly evolving and powerful technology and is an essential handbook for designing, analyzing, and interpreting diffusion MR experiments. Diffusion imaging provides a unique window on human brain anatomy. This non-invasive technique continues to grow in popularity as a way to study brain pathways that could never before be investigated in vivo. This book covers the fundamental theory of diffusion imaging, discusses its most promising applications to basic and clinical neuroscience, and introduces cutting-edge methodological developments that will shape the field in coming years. Written by leading experts in the field, it places the exciting new results emerging from diffusion imaging in the context of classical anatomical techniques to show where diffusion studies might offer unique insights and where potential limitations lie.

  • Neuroanatomy of Language Regions of the Human Brain

    • 1st Edition
    • Michael Petrides
    • English
    Many studies of the neural bases of language processes are now conducted with functional and structural neuroimaging. Research is often compromised because of difficulties in identifying the core structures in the face of the complex morphology of these regions of the brain. Although there are many books on the cognitive aspects of language and also on neurolinguistics and aphasiology, Neuroanatomy of Language Regions of the Human Brain is the first anatomical atlas that focuses on the core regions of the cerebral cortex involved in language processing. This atlas is a richly illustrated guide for scientists interested in the gross morphology of the sulci and gyri of the core language regions, in the cytoarchitecture of the relevant cortical areas, and in the connectivity of these areas. Data from diffusion MRI and resting-state connectivity are integrated iwth critical experimental anatomical data about homologous areas in the macaque monkey to provide the latest information on the connectivity of the language-relevant cortical areas of the brain. Although the anatomical connectivity data from studies on the macaque monkey provide the most detailed information, they are often neglected because of difficulties in interpreting the terminology used and in making the monkey-to-human comparison. This atlas helps investigators interpret this important source of information. Neuroanatomy of Language Regions of the Human Brain will assist investigators of the neural bases of language in increasing the anatomical sophistication of their research adn in evaluating studies of language and the brain.

  • The Rat Brain in Stereotaxic Coordinates

    • 7th Edition
    • George Paxinos + 1 more
    • English
    Since its first edition in 1982, the Paxinos and Watson rat brain atlas has become the most trusted source of accurate coordinates and anatomical information in laboratories throughout the world. It has been cited over 60,000 times, making it the most cited publication in neuroscience. The seventh edition incorporates new findings on developmental gene expression and presents the boundaries of neuromeres in sagittal sections.

  • Progress in Behavior Modification

    Volume 4
    • 1st Edition
    • Michel Hersen + 2 more
    • English
    Progress in Behavior Modification, Volume 4, is a multidisciplinary serial publication that encompasses the contributions of psychology, psychiatry, social work, speech therapy, education, and rehabilitation. This serial aims to meet the need for a review publication that undertakes to present yearly in-depth evaluations that include a scholarly examination of theoretical underpinnings, a careful survey of research findings, and a comparative analysis of existing techniques and methodologies. The discussions center on a wide spectrum of child and adult disorders. The present volume opens with a chapter on behavioral treatment for obesity. This is followed by separate chapters on applications of reinforcement techniques in the areas of pollution control and energy conservation, job performance and unemployment, community self-government, racial integration, and others; and behavior modification in community settings. Subsequent chapters deal with demand characteristics in behavior modification; the clinical utility of biofeedback procedures; and the technology of training parents in behavior therapy. The final chapter reviews the rationale and empirical support for the extinction approach of implosive (flooding) therapy.

  • Contemporary Neurology

    • 1st Edition
    • M.J.G. Harrison
    • English
    Contemporary Neurology compiles a large series of papers on the commonest neurological problems. This book discusses the management of epilepsy, involuntary movements, nerve and muscle diseases, and multiple sclerosis. The areas on infections, cerebrovascular disease, trauma, intracranial pressure, and vertebral column are also elaborated. This text likewise describes medical procedures on how to do a lumbar and cisternal puncture. Other topics include headache in children, hyperventilation, dizziness, funny turns—neurological, dysarthria, facial pain, and nystagmus. The weakness of the legs, loss of memory, coma, brain death, complications of alcoholism, and stupor and akinetic mutism are also covered. This publication is valuable to clinicians and examination candidates preparing for the DPM, MRCP (UK) and Neurology/Psychiatry “Boards”.

  • Antipsychotic Drugs and Their Side-Effects

    • 1st Edition
    • Thomas R.E. Barnes
    • English
    In line with other volumes in the Neuroscience Perspectives Series, this volume covers the background, pharmacology, molecular biology, and biochemistry of antipsychotic drugs, together with an overview assessment of the therapeutic considerations. Over the past 40 years, the effectiveness of conventional neuroleptic agents for psychotic illness has been offset by a wide range of adverse side-effects, including motor side-effects like parkinsonism. Studies show that lowering doses may still produce the antipsychotic effect while lessening the risk of side-effects. As all available antispychotic drugs are able to block dopamine, specifically D2 receptors, doses below the threshold level for producing acute motor disorder can still be therapeutically effective. With the identification and characterization of multiple dopamine receptors, the possibility of more selective drugs with better side-effect potential has arisen. Other novel antipsychotic agents include D1 receptor blockers, partial dopamine agonists and non-dopamine drugs such as 5-HT receptor blockers, sigma receptor antagonists and NMDA receptor agonists. This volume reviews both the basic science of the conventional and atypical neuroleptics and their present and potential therapeutic use.

  • Interleukin-1 in the Brain

    • 1st Edition
    • Nancy J. Rothwell
    • English
    Interest in interleukin-1 (IL-1) has increased dramatically over the last decade, but has been largely restricted to immunologists, cell biologists and those studying inflammation and cancer. However, it has recently been recognized that the brain directly controls or modulates many aspects of immune function, while molecules classically associated with the immune system, such as interleukin-1, are synthesised within the brain and act directly on the central nervous system to modify local and systemic functions. Thus, this topic is relatively new to neurobiologists, and this book is the first comprehensive description of current knowledge on interleukin-1 in the brain, including its location, synthesis and receptors, actions on behaviour, fever, metabolism, neuroendocrine function, electrical activity of the brain, nerve growth factor, and relationship to clinical indications. The book is organised into three sections. The first reviews the data available on the neural localisation of IL-1 and the nature of its central receptors. The main part of the book examines the different neural effects of IL-1 and the mechanisms which are involved in these actions, comparing IL-1 where possible to other inflammatory cytokines which also have neurotrophic effects. The final section evaluates the possible role of IL-1 in neural plasticity and neuronal degeneration.

  • Neurology for Nurses

    • 1st Edition
    • J Bickerton + 1 more
    • English
    Neurology for Nurses is an attempt to make neurology as clear as possible, using the nursing model. The first portion of this book provides a diagram of the planes of the body that considers the nervous system anatomically, which is referenced throughout the book. The different orientations and planes of the body include the anterior (ventral) surface, posterior (dorsal) surface, lateral, medial, sagittal (median) section, Coronal (frontal) section, and transverse. Other than detailed descriptions of the anatomy and functions of nerves and the nervous system, this book provides diagnostic evaluation of diseases and clinical conditions, such as multiple sclerosis, cerebrovascular accidents, brain tumors, head injury, epilepsy, Parkinson's disease, and meningitis. This book includes as well discussions on neurological examinations, investigations, and observations. The topic on nursing care for unconscious patients is also provided. This text is aimed primarily at nursing students in training, but will also benefits those taking a post-basic nursing course in neurology.

  • Clinical Methods of Neuro-Ophthalmologic Examination

    • 1st Edition
    • Alfred Kestenbaum
    • English
    Clinical Methods of Neuro-Ophthalmologic Examination presents the clinical methods of ophthalmologic examination that may be helpful in neurologic differential diagnosis. Neuro-ophthalmologic examination has developed in two directions: the more precise methods and the unrefined yet fairly exact methods, such as diagnostic measurement by means of a simple ruler. This book is based on lectures delivered by the author to neurologists and ophthalmologists. This book is composed of 13 chapters and begins with a presentation of anatomic details that are important for the understanding of the various signs and symptoms. The next chapters examine the development of simple perimetry into quantitative perimetry and angio-scotometry, as well as the pathology of the optic nerve. Considerable chapters are devoted to intensive discussions on group of diseases that affect in a parallel way the central nervous system and the eye, such as chiasmal and retrochiasmal lesions, nystagmus, symmetrical eye movement disturbance, palpebral fissure, hemicrania. The final chapter outlines a routine neuro-ophthalmologic... examination. This book is directed toward neurologists and ophthalmologists.

  • Textbook of Neuropathology

    • 2nd Edition
    • Arthur Weil
    • English
    Textbook of Neuropathology, Second Edition covers some of the significant advances in understanding the theoretical and experimental aspects of neuropathology. Neuropathology is the study of the nervous tissue in disease and the determination of deviations of its structures from the normal. This edition is composed of 13 chapters, and begins with the description of the chemical changes occurring in the cell through autolysis and fixation. The subsequent chapters are devoted to studies on better understanding of the vitamin deficiencies, the discovery of the sulfonamides and their contribution to the therapy of meningitis, and the different forms of shock treatment applied to selected cases of neurosis and psychosis. The remaining chapters explore the contribution of neuropathological investigation in various medical conditions, including anemic softening, arteriosclerosis, inflammation, infections, intoxications, injuries, degenerative diseases, tumors, and congenital malformations. This book will be of use to neuropathologists and workers and researchers in the allied fields.

  • Clinical Anesthesia in Neurosurgery

    • 1st Edition
    • Elizabeth A. M. Frost
    • English
    Clinical Anesthesia in Neurosurgery, Second Edition, integrates the evolution of the field of neuroanesthesia with the major areas of neurosurgical activity to give the reader the required perspective and requisite information to help in laying the foundation for future advances as well as describing the current state of the art. The book contains 25 chapters organized into five parts. Part I presents studies on cerebral physiology and evaluation. Topics covered include cerebral circulation and metabolism, intraoperative neurophysiologic monitoring, and central nervous system effects of anesthetic agents. Part II covers neurosurgical and related procedures, such as posterior cranial fossa surgery, surgery of the spine, and peripheral nerve surgery. Part III examines central nervous system trauma including spinal cord trauma and cardiovascular effects of severe head injury. Part IV takes up postoperative and intensive care, including postanesthetic care, neurosurgical intensive care, and parenteral nutrition while Part V deals with the medical criteria and legal aspects of brain death.

  • Principles, Practices, and Positions in Neuropsychiatric Research

    Proceedings of a Conference Held in June 1970 at the Walter Reed Army Institute of Research, Washington, D.C., in Tribute to Dr. David Mckenzie Rioch upon His Retirement as Director of the Neuropsychiatry Division of That Institute
    • 1st Edition
    • Joseph V. Brady + 1 more
    • English
    Principles, Practices and Positions in Neuropsychiatric Research contains the proceedings of a conference held in June 1970 at the Walter Reed Army Institute of Research, Washington, D.C., in tribute to Dr. David McKenzie Rioch upon his retirement as Director of the Neuropsychiatry Division of that institute. This book is composed of the original contributions presented at the conference, as well as several invited papers that could not be programmed at the meeting because of certain limitations. Topics covered in some papers focus on anatomy of the thalamus; glia-neuronal interaction; receptor characteristics and conduction velocities in bladder afferents; responses of photoreceptors; and specificity of responses of cells in the visual cortex. This text also discusses the channeling of responses elicited by hypothalamic stimulation; neurochemistry of reward and punishment; behavioral analysis of aphasia; and biology of sleep. The military psychiatry and changing systems of mental health care, as well as psychological issues in training for research in psychiatry are also addressed. The contributions in this book will serve to reflect the remarkable range of bio-social research interest and competence.

  • Developmental Neuropsychobiology

    • 1st Edition
    • William T Greenough + 1 more
    • English
    Developmental Neuropsychobiology is a compendium of papers that deals with developmental neuroscience and developmental psychology, as well as the broad range of approaches toward brain-behavior development. One paper reviews the embryonic mechanisms including the pattern formation that develops in a single fertilized egg, particularly focusing on limb innervation as a special case of pattern formation. Another paper discusses the regulation of nerve fiber elongation during embryogenesis. One author analyzes the pathways and changing connections in the nervous system of the insect: he shows that manipulating neural organization by grafting results in the ability of the transplanted sensory cells to find the proper central connections. Another paper reviews the sex differences in developmental plasticity of behavior and the brain. These differences point to the vulnerability of males during development to incidences of autism, dyslexia, or cerebral palsy compared to females. One paper also examines alternative perceptions of parent- offspring relationships. This collection can prove helpful for researchers, students, and academicians involved in the disciplines of biological or psychological sciences.

  • Clinical Neuroendocrinology

    • 1st Edition
    • G. M. Besser + 1 more
    • English
    Clinical Neuroendocrinology, Volume II discusses neuroendocrine science and its application to the analysis of human physiology and behavior. This book stresses the importance of the interrelationships between central and peripheral signals, neurotransmitters and neuromodulators, and target glands and peripheral tissues to ensure coordination of somatic and behavioral development and function. The ""centralist"" concepts of the importance of brain hormones are revised in this text, emphasizing that neurohumoral factors isolated from brain tissues, and initially considered to be primarily involved in the central nervous system regulation of the endocrine system, also exist outside the brain and spinal cord. This volume is valuable to neuroendocrinologist... but is also a good source for those involved in basic and clinical research and patient management.

  • Neurocutaneous Diseases

    A Practical Approach
    • 1st Edition
    • Manuel Rodriguez Gomez
    • English
    Neurocutaneous Diseases is a systematic presentation limited to diseases that affect both of the nervous system and skin of humans. Neurologists and dermatologist will find knowledge of these diseases of real clinical value. Many of the diseases described in these pages do not affect the skin and nervous system simultaneously. Many of these diseases, mostly not well understood, may stimulate new lines of scientific inquiry, for understanding of a pathologic change in easily accessible dermal cells that promises to clarify a more recondite brain disease. This book is organized into five main parts. The chapters describe different types of diseases including those with autosomal dominant inheritance, those with autosomal recessive inheritance, those with x-linked inheritance, those with unknown or multiple inheritance and congenital and vascular anomalies. These diseases include neurofibromatosis, Cockayne's Syndrome, adrenoleukodystrophy... albinism and neurocutaneous melanosis. This book will be of interest to dermatologists and neurologists.

  • Computers and Computations in the Neurosciences

    • 1st Edition
    • P. Michael Conn
    • English
    Methods in Neurosciences, Volume 10: Computers and Computations in the Neurosciences discusses the use of computers in the neurosciences. The book deals with data collection, analysis, and modeling, with emphasis on the use of computers. Section I involves data collection using a personal microcomputer system. One paper presents a tutorial on using a PC-based motor control composed of an electronic circuit to adjust the motion of a light microscope stage through a software program. Other papers discuss computer methods in nuclei cartography and a computer-assisted quantitative receptor autoradiography in studying receptor density distribution. Section II deals with data analysis and some computer programs for kinetic modeling of gene expression in neurons. The book also discusses a computerized analysis of opioid receptor heterogeneity by ligand binding in test animals using computerized programs instead of employing manual or graphical methods. Computerized curve-fitting allows the researcher to utilize a more precise mathematical model to describe the binding of one ligand to one class of sites. Section III evaluates data modeling and simulations and describes the practicality of using computers to design model ion channels. Another paper discusses a graphical interaction program called MEMPOT to simulate an electrophysiological investigation of the properties of the membrane potential in stimulated cells. The book also presents a quantitative data gathered from computer simulation of the factors that affect neuronal density per measured sections. The book is suitable for microbiologists, biochemists, neuroscientists, and researchers in the field of medical research, as well as for advanced computer programmers in medical research work.

  • Nervous System Theory

    An Introductory Study
    • 1st Edition
    • K. N. Leibovic
    • English
    Nervous System Theory: An Introductory Study focuses on the nervous system theory, stressing the means for understanding the nature of the biological system rather than the elaboration of mathematical theories. This book begins with a discussion on single-cell responses, followed by a discussion of sensory information processing that leads into models of perceptual processes and their possible neural bases. This text concludes with some general principles and theoretical investigations relating to units that make up a nervous system, through a sensory pathway and central structures. The peripheral stimuli that explain the operations of the brain are also described. This publication is a good reference for neurologists, medical practitioners, and researchers conducting work on the nervous system theory.

  • Peripheral Neuropathies

    Proceedings of the International Symposium on Peripheral Neuropathies Held in Milan, Italy, on June 26–28, 1978
    • 1st Edition
    • N. Canal + 1 more
    • English
    Peripheral Neuropathies compiles lectures presented at the Symposium on Peripheral Neuropathies held in Milan, Italy on June 26-28, 1978. This book covers the basic problems in peripheral nerve pathology; axonal transport; neuropathies in chronic renal failure; peripheral neuropathies in diabetes; compression neuropathies; and metabolic, genetic, and inflammatory neuropathies. This text also discusses topics such as filamentous inclusions in Schwann cell nuclei; autonomie dysfunction and myokymia in gold neuropathy; study of the effect of gangliosides on experimental carbon disulfide neuropathy; and peripheral nerve changes in Refsum's disease before and after treatment. This compilation is a useful source of information for students and researchers conducting investigative work on peripheral neuropathy.

  • Steroid Hormone Regulation of the Brain

    Proceedings of an International Symposium Held at the Wenner-Gren Center, Stockholm, 27-28 October 1980
    • 1st Edition
    • Kjell Fuxe + 2 more
    • English
    Steroid Hormone Regulation of the Brain focuses on the advancement of knowledge of the properties of brain steroid receptors and steroid target nerve cells, including the actions of gonadal steroids, adrenocortical steroids, and androgenic steroids on the brain. The selection features the work of authors who have inspiringly conducted extensive studies on the action of steroid hormones. The book starts with discussions that point out that steroid hormones not only function through intracellular steroid receptors, but possibly through steroid membrane actions as well. Studies to support this claim are presented. As to the action of steroid hormones on presynaptic transmitter mechanisms, the book suggests that adrenocortical and gonadal steroids can create alterations in noradrenaline, adrenaline, and dopamine levels and turnover within the hypothalamus and preoptic area. The effects of catecholestrogens on the brain are also elaborated. A contribution to this paper stresses that estrogens have antidopaminergic action in the extrapyramidal system. This idea is identified through a series of behavioral experiments and measurements of the levels of striatal acetylcholine. This selection is recommended to scientists interested in studying the effect of hormones on the brain.

  • Methods in Neurosciences

    Electrophysiology and Microinjection
    • 1st Edition
    • P. Michael Conn
    • English
    Methods in Neurosciences, Volume 4: Electrophysiology and Microinjection is a collection of papers that deals with the electrically excitability feature of many cell types. This volume describes the characteristic features of some nervous tissue to conduct signals along cellular paths or ""wires."" The text presents such paths as a way stimuli are transferred in the nervous system. Section I reviews the recording methodologies such as those used in measuring noninactivating calcium current in smooth muscles cells or the two-suction electrode voltage-clamp recording. Section II deals in detail with voltage clamping and voltammetry; the text also explains the practical steps in using the current pump-assisted voltage clamp. One paper examines the X-ray microprobe analysis of voltage clamped single heart ventricular myocytes, while another paper explains in vivo voltammetry. Section III addresses electrophysiology and purification of specific receptors; one paper presents the results of an electrophysiological study of hormone secretion by single adenohypophyseal cells. Section IV describes special electrodes and equipment, while Section V deals with special preparations needed in culture preparation or in the study of pharmacology of excitatory amino acids on neurons found in the central nervous system. Chapter VI addresses data analysis and reduction such as digital filtering of bioelectric potentials in personal computers. This book will prove valuable for microbiologists, cellular scientists, microchemists, and academicians working in the fields of neuroscience.

  • The Physiology of Synapses

    • 1st Edition
    • John Carew Eccles
    • English
    The Physiology of Synapses covers the considerable advances in understanding the complex physiology of synapses. This book is divided into 16 chapters that emphasize the mechanism of synaptic transmission. The first chapters describe the structural and physiological features of chemically transmitting synapses. The subsequent chapters deal with the excitatory postsynaptic responses to presynaptic impulse and the release of transmitter by presynaptic impulses. These topics are followed by discussions of the impulse generation by the excitatory postsynaptic potential; the postsynaptic electrical events produced by chemically transmitting inhibitory synapses; the ionic mechanism generating the inhibitory postsynaptic potential. The last chapters consider the mechanism of inhibitory transmitter substances, pathways responsible for postsynaptic inhibitory action, and the trophic and plastic properties of synapses. This book will prove useful to physiologists, neurologists, and researchers.

  • Variation in Chemical Composition of the Nervous System

    As Determined by Developmental and Genetic Factors
    • 1st Edition
    • G. B. Ansell
    • English
    Variation in Chemical Composition of the Nervous System: As Determined by Developmental and Genetic Factors documents the proceedings of the International Neurochemical Conference held in Oxford, 1965. The three years since the last neurochemical meeting have witnessed rapid progress in the whole field of biology, including the development of new concepts based on fresh experimental data and new technical tools. A great deal of concentrated effort have led to advances in the molecular aspects of biological processes ,which have perhaps had most to offer to the formation of new concepts of primary cellular events, especially the genetic mechanism, regulatory cell processes, and protein production. This volume contains 100 chapters that provide an overview of the state of knowledge on the genetic and developmental aspects of the central nervous system. Topics covered include the activity of a plasma logenase in the brain of the developing rat; genetic selection of rats differing in brain biochemistry; the effects of thyroid hormones on steroid deposition in developing chick brain; and developmental changes in the gamma globulins of bovine cerebrospinal fluid.

  • Case Presentations in Neurology

    • 1st Edition
    • G. S. Venables + 2 more
    • English
    Case Presentations in Neurology presents a selection of case histories demonstrating how patients with often quite simple problems may present and to bring out aspects of their diagnosis and management. All the patients presented to the Department of Neurology including those with more obscure diagnoses. The book consists of 12 exercises, each of six cases broadly corresponding to the style of the MRCP (UK) written case history papers. Each case is set out with the history and physical findings given first. There follows either a series of questions or true/false statements on one side of the page which the reader should attempt before continuing on to the answer section on the other side. There then follows a short discussion about each case and a single reference. This book is intended for those doctors studying for higher professional qualifications such as the MRCP, although it may be of interest and use to medical students approaching their final examinations.

  • Minireviews of the Neurosciences from Life Sciences

    • 1st Edition
    • Bernard B. Brodie + 1 more
    • English
    Minireviews of the Neurosciences from Life Sciences is a collection of minireviews of research in the neurosciences and originally published by the Journal of Life Sciences. These minireviews cover a wide range of topics such as the function and organization of the chromaffin vesicle; taste receptor proteins; the role of cyclic nucleotides in visual excitation; and regulation of tryptophan and tyrosine hydroxylase. Comprised of 34 chapters, this volume begins with a discussion on Na,K-ATPase, followed by an analysis of the function and organization of the chromaffin vesicles of the adrenal medulla. Subsequent chapters focus on the nerve growth factor and the acetylcholine receptor; sympathetic regulation of thyroid hormone secretion; the role of cyclic AMP in the action of antidiuretic hormone on the kidney; and neurochemical correlates of synaptically active amino acids. The role of calcium in the central effects of biogenic amines is also examined, along with the brain mechanisms underlying motor control, molecular coding of memory, and opiate receptors. This book should be of value to teachers, researchers, and students.

  • The Neuropsychology of Consciousness

    • 1st Edition
    • A. D. Milner + 1 more
    • English
    The Neuropsychology of Consciousness is based on a symposium entitled “Consciousness and Cognition: Neuropsychological Perspectives” held at the University of St Andrews, September 1990. The intention was to assemble a group of the major researchers at the forefront of this field. The starting point for the symposium and for the book was the widespread realization that in several areas of human cognition (e.g. visual perception, memory, language comprehension, and attention), the severe and profound impairments due to brain damage that have been described over the past 150 years are often not absolute. In particular, the use of indirect methods of testing may reveal unsuspected preservation of capacities that are undetected by more traditional direct methods. The book opens with a discussion of the epidemic of dissociations and how well the phenomena within either neuropsychology or within normal human experimental psychology map onto each other. This is followed by separate chapters on topics such as blindsight, covert visual processing in patients, face recognition and awareness following brain injury, and the relationship between the study of attention and the understanding of consciousness.

  • Neuromuscular Function and Disorders

    • 1st Edition
    • Alan J. McComas
    • English
    Neuromuscular Function and Disorders focuses on the various processes underlying disordered neuromuscular function. Topics covered include the nature of membrane defects in myotonia and familial periodic paralysis; the disorder of neuromuscular transmission responsible for myasthenia gravis and the various pseudo-myasthenic syndromes; and the disorders of Schwann cell function which cause demyelination. This book is comprised of 28 chapters divided into two sections and begins with a discussion on the normal anatomy and physiology of peripheral nerve and muscle. Included in the first section are descriptions of the ionic mechanisms responsible for the resting and action potentials of nerve and muscle; the sequential stages in neuromuscular transmission; excitation-contracti... coupling; the sliding filament mechanism of myofibrillar shortening; and the morphological and functional properties of motor units. The neurophysiology of exercise and muscle fatigue is also considered, along with the nature of the trophic influences exerted by the motoneuron and muscle fiber upon each other. The second half of the book deals entirely with various diseases of peripheral nerve and muscle, together with diagnostic procedures and therapeutic management. A consistent theme in this section is the recognition of neural abnormalities in diseases hitherto considered as primary disorders of the muscle fiber. This monograph should be of value to neurologists, medical students, research workers, and students and research scientists in physiology, zoology, pharmacology, kinesiology, and physical education.

  • Neuroendocrine Perspectives

    Volume 3
    • 1st Edition
    • Eugenio E. Müller + 1 more
    • English
    Neuroendocrine Perspectives, Volume 3 provides information on amine and peptide biochemistry. This book discusses the availability of specific biochemical and histochemical techniques that have greatly advanced knowledge of central nervous system neurotransmitter and neuropeptide systems. Organized into nine chapters, this volume begins with an overview of the structure of corticotropin releasing hormone. This text then examines the possible role of the cerebrospinal fluid in the regulation of pituitary function. Other chapters consider the importance of cerebrospinal fluid as a route for the hypothalamic regulation of pituitary function. This book discusses as well the available information concerning the neuroendocrine mechanisms involved in the onset of female puberty in primate and subprimate species. The final chapter deals with pineal indole metabolism and its controlling mechanisms as well as information on the interactions of the pineal hormones with neuroendocrine-repro... axis. This book is a valuable resource for pharmacologists, research workers, and students.

  • Neuropeptide Technology

    Synthesis, Assay, Purification, and Processing
    • 1st Edition
    • P. Michael Conn
    • English
    Methods in Neurosciences, Volume 6: Neuropeptide Technology: Synthesis, Assay, Purification, and Processing describes procedures and tools of assay useful for the identification, purification, and quantification of neuropeptides and their receptors. This volume is divided into four sections— chemical synthesis and biosynthesis; measurement of neuropeptides; purification and characterization; and neuropeptide degrading and processing enzymes. In these sections, this book specifically discusses the synthesis of peptide substrates for protein kinase C; synthesis of glycosyl neuropeptides; and ultrastructural localization of peptides. The measurement of neurokinin B by radioimmunoassay; purification and characterization of neuroendocrine peptides from rat brain; and preparation of glia maturation factor ß are also elaborated. This text likewise covers the assays for arginine/lysine carboxypeptidases and enzymes that metabolize atrial natriuretic peptide. This publication is beneficial to neuroscientists and students researching on the synthesis, assay, purification, and processing of neuropeptides.

  • Aspects of Neural Ontogeny

    • 1st Edition
    • A. F. W. Hughes
    • English
    Aspects of Neural Ontogeny focuses on the interaction between the nervous system and peripheral organs during development, including history and development of neurons and the functions of nerves and muscles. The book first offers information on the development of neurons, including formation and growth of nerve fibers; growth cone and the extension of nerve fibers; history of the neuron theory; and path of nerve fibers. The manuscript then elaborates on the innervation of the tetrapod limb and the center and periphery. Discussions focus on the relationships between the ventral horn and muscles of the limb; experimental studies on limb plexus and limb nerves; and relationships between spinal nerves and limb muscles. The publication takes a look at the ontogeny of behavior, as well as pattern of motility, spontaneous movements, tetrapod limb, and experimental studies. The book is a dependable reference for readers interested in neural ontogeny.

  • The Molecular Biology of Neurological Disease

    Butterworths International Medical Reviews
    • 1st Edition
    • Roger N. Rosenberg + 1 more
    • English
    The Molecular Biology of Neurological Disease reviews advances that have been made in understanding the molecular mechanisms of neurological disorders as well as immediate and future applications of molecular biological techniques to clinical practice. This book explores the molecular genetics of neurological disease such as muscular dystrophy, Joseph disease, and Huntington's disease, along with the mitochondrial genes implicated in such conditions. This text is comprised of 18 chapters and begins by introducing the reader to the basic principles and methods of molecular genetic techniques used in the diagnosis of neurological disease. Attention then turns to several aspects of genetic expression in the brain, including the extent to which the genome is expressed in the brain. The next chapter focuses on the visualization of polyadenylated messenger RNAs in individual cells in mammalian brain using in situ hybridization techniques, combined with immunohistochemical localization of specific proteins and neuropeptides implicated in diseases such as Alzheimer dementia. This book also discusses the molecular biology of chemical synaptic neurotransmission; proteins involved in the regulation of nervous system development; and gene expression in skeletal muscle. This text then concludes with a summary of the ""neurological gene map"" as it stands in the latter part of 1987. This book is intended for physicians who grapple with the problems of neurological disorders on a daily basis, including neurologists, neurologists in training, and those in related fields such as neurosurgery, internal medicine, psychiatry, and rehabilitation medicine.

  • Providing Pharmacological Access to the Brain

    Alternate Approaches
    • 1st Edition
    • Volume 21
    • P. Michael Conn + 1 more
    • English
    This volume focuses on contemporary approaches for delivering experimental and therapeutic agents into the brain. The contributions provide methodological details that are typically not available in the literature. Subtleties and shortcuts critical to each procedure are included to facilitate their use by both the experienced researcher and novice.

  • Cell Culture

    • 1st Edition
    • P. Michael Conn
    • English
    Methods in Neurosciences, Volume 3: Quantitative and Qualitative Microscopy is a collection of papers that deals with microscopic techniques in statistical measures. This volume describes microscopy using sophisticated stains and dyes to advance observation of tests and experiments. Section I describes autoradiography including micro chemical methods, high-resolution autoradiography, and single- or double-label quantitative autoradiography for use in imaging of brain activity patterns or determining cerebral physiology. Section II discusses the quantification of structures through statistical and computational methods including dynamic video imaging technology. Section III explains the use of tracers, toxins, or dyes in tracing neuronal connections. One paper addresses the use of small injections of axonally transported fluorescent tracers. Section IV explains staining technology such as using the silver impregnation method for frozen sections of human nervous tissue that are gathered from tissues preserved in formalin. Section V addresses freezing techniques and those using freeze-fracture methods in neurobiology. The text also discusses cryoprotection and other freezing methods to control ice crystals found in fixed or unfixed brain tissues. Section VI presents the combined and high-resolution methods in polarization microscopy and microscopic investigations. Cellular biologists, micro-chemists, and scientific researchers in the field of micro- and cellular biology will appreciate this book.

  • Quantitative and Qualitative Microscopy

    • 1st Edition
    • P. Michael Conn
    • English
    Methods in Neurosciences, Volume 3: Quantitative and Qualitative Microscopy is a collection of papers that deals with microscopic techniques in statistical measures. This volume describes microscopy using sophisticated stains and dyes to advance observation of tests and experiments. Section I describes autoradiography including micro chemical methods, high-resolution autoradiography, and single- or double-label quantitative autoradiography for use in imaging of brain activity patterns or determining cerebral physiology. Section II discusses the quantification of structures through statistical and computational methods including dynamic video imaging technology. Section III explains the use of tracers, toxins, or dyes in tracing neuronal connections. One paper addresses the use of small injections of axonally transported fluorescent tracers. Section IV explains staining technology such as using the silver impregnation method for frozen sections of human nervous tissue that are gathered from tissues preserved in formalin. Section V addresses freezing techniques and those using freeze-fracture methods in neurobiology. The text also discusses cryoprotection and other freezing methods to control ice crystals found in fixed or unfixed brain tissues. Section VI presents the combined and high-resolution methods in polarization microscopy and microscopic investigations. Cellular biologists, micro-chemists, and scientific researchers in the field of micro- and cellular biology will appreciate this book.

  • Progress in Behavior Modification

    Volume 2
    • 1st Edition
    • Michel Hersen + 2 more
    • English
    Progress in Behavior Modification, Volume 2 reviews issues and developments in the field of behavior modification, with emphasis on a wide spectrum of child and adult disorders. Topics covered range from behavioral assessment and treatment of alcoholism to sexual arousal in male sexual deviates, along with aversion therapy and research methods in behavior modification. Comprised of eight chapters, this volume begins with a discussion on the status and future trends in behavior assessment of alcoholism and behavior modification with alcoholics. The next chapter deals with therapy models, focusing on the domain of social learning, removal of fears, and assertive and social skill training. The discussion then turns to the measurement and generation of sexual arousal in male sexual deviates; applications of behavior modification in nursing practice; aversion therapy and its clinical effects; deceleration of aberrant behavior among retarded individuals; and research methods in behavior modification. The final chapter examines clinical issues regarding behavioral self-control. This book should be of value to theoreticians, researchers, or practitioners in the fields of psychiatry, psychology, and behavior therapy as well as social work, speech therapy, education, and rehabilitation.

  • Presynaptic Receptors and Neuronal Transporters

    Official Satellite Symposium to the IUPHAR 1990 Congress Held in Rouen, France, on 26–29 June 1990
    • 1st Edition
    • S.Z. Langer + 2 more
    • English
    Advances in the Biosciences, Volume 82: Presynaptic Receptors and Neuronal Transporters documents the proceedings of the Official Satellite Symposium to the IUPHAR 1990 Congress held in Rouen, France on June 26-29, 1990. The first part of this book deals with the extensive and still increasing list of presynaptic release-modulating auto and heteroreceptors, emphasizing the various subtypes of presynaptic receptors that are characterized by functional studies, both in vitro and in vivo, using a number of experimental approaches. The next chapters are devoted to the molecular pharmacology of presynaptic receptors, of which can interfere with G proteins and modify the activity of adenylate cyclase, guanylate cyclase, or protein kinase C. The purification and molecular biology of transporter systems, including cloning and sequencing of the neuronal sodium-ion coupled GABA transporter are also discussed. This compilation concludes with insights on the function of presynaptic receptors and neuronal transporters both in the periphery and in the CNS, as well as their ubiquitous locations and physiological roles. This publication is a good reference for students and individuals researching on the presynaptic autoreceptors and neurotransmitters.

  • Neuroendocrinology

    Volume II
    • 1st Edition
    • Luciano Martini + 1 more
    • English
    Neuroendocrinology, Volume II, is the second in a two-volume treatise designed to provide a survey of all aspects of the rapidly expanding science of neuroendocrinology. Only in recent years have the relations between the nervous system and the endocrine system come under intensive scrutiny, but their interactions have already been shown to be multiple and diverse. This diversity is reflected in the range of subjects covered. There are chapters on neural control of endocrine function; the effects of hormones on the brain; brain-endocrine interrelations during various phases of development; and the comparative aspects of neuroendocrine integration. The relation of brain chemistry to endocrine function, the effect of drugs on neuroendocrine mechanisms, and the new discipline of clinical neuroendocrinology have also been considered. Not only neurophysiologists and endocrinologists, but pharmacologists, zoologists, biochemists, psychologists, and those in clinical medicine will find the treatise of interest. Parts of neuroendocrinology have been discussed in other works, but this is the first treatise in which an attempt has been made to cover all ramifications of neuroendocrinology. This book can be used both as a text for advanced students and as a reference source.

  • Diagnostic Reference Index of Clinical Neurology

    • 2nd Edition
    • Pasquale F. Finelli
    • English
    Diagnostic Reference Index of Clinical Neurology aims to give the busy clinician a fast, easy-to-use guide to the core neurological literature published from 1980 to 1986. This book is divided into two sections, key words and references. The keywords section consists of neuroscience terms and each main entry is followed by reference citation numbers and corresponding references. This index, unlike the usual computerized systems for literature retrieval, is structured around clinical problems and uses the approach and terminology of a practicing neurologist. The contents were sources from the full text of articles that were published in critical core of fourteen major international English-language journals in medicine and neurology. This book will be of interest to neurology students and to practicing clinical neurologists.

  • Progress in Behavior Modification

    Volume 5
    • 1st Edition
    • Michel Hersen + 2 more
    • English
    Progress in Behavior Modification, Volume 5, is a multidisciplinary serial publication that encompasses the contributions of psychology, psychiatry, social work, speech therapy, education, and rehabilitation. This serial aims to meet the need for a review publication that undertakes to present yearly in-depth evaluations that include a scholarly examination of theoretical underpinnings, a careful survey of research findings, and a comparative analysis of existing techniques and methodologies. The discussions center on a wide spectrum of child and adult disorders. The book opens with a chapter on the assessment and treatment of minimal dating behavior in college students. This is followed by separate chapters on methods of behavioral control of excessive drinking; behavioral analysis and treatment of child noncompliance to parental requests; and behavioral group therapy. Subsequent chapters deal with the conceptual underpinnings of research in children's self-management and treatment strategies; the assessment and therapeutic functions of self-monitoring; and behavioral treatment in homosexuality.

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