Handbook of Neural Engineering
A Modern Approach
- 1st Edition - September 11, 2024
- Imprint: Academic Press
- Editor: Stephanie Willerth
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 5 7 3 0 - 4
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 5 7 3 1 - 1
Handbook of Neural Engineering: A Modern Approach provides a comprehensive overview of the field from biology to recent technological advances through an interdisciplinary lens. Th… Read more
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Request a sales quoteHandbook of Neural Engineering: A Modern Approach provides a comprehensive overview of the field from biology to recent technological advances through an interdisciplinary lens. The book is divided into three sections: 1) Biological Considerations for Neural Engineering, 2) Neural Engineering Strategies, and 3) Emerging Technologies for Neural Engineering. It provides the first comprehensive text that addresses this combination of subjects. Neurodegenerative diseases, including Alzheimer’s, Parkinson’s and Multiple Sclerosis, represent an enormous healthcare burden, and many of these diseases lack true cures, making it imperative to study the biological systems that become disordered to understand potential treatment options.
This book covers the basic neurobiology and physiology, common neural engineering strategies, and emerging technologies in this field. It is designed to support an upper year/graduate elective course in neural engineering, and will provide a foundational overview of the field for interdisciplinary researchers, clinicians, engineers, and industry professionals. The handbook provides readers with a strong base in both biological and engineering principles along with the concepts necessary to implement solutions using Neural Engineering.
- Includes coverage of foundational concepts of the fast-moving field of Neural Engineering, from overview and structure of the nervous system, cellular biology of the nervous system, extracellular matrix of the nervous system, role of the immune system in the nervous system, disease states of the nervous system, and the effects of trauma and chronic pain on the nervous system
- Provides readers with understanding of Neural Engineering strategies, in key areas such as imagining, examining nervous system function, neural interfaces, Brain-Computer Interfaces, neural prostheses, neurorobotics, and neural tissue engineering
- Includes a complete section on emerging technologies for neural engineering applications, such as optogenetics, gene editing, brain organoids, and modeling with organ-on-a-chip systems
Researchers, clinicians, developers, and industry professionals in Neural Engineering, Neuroscience, Brain Computer Interfaces (BCI), Electrical engineering, and Artificial Intelligence. This Handbook is targeted at a broad audience consisting of Biomedical Engineers in both industry and academia who are working in Neural Engineering, Neuroscientists, doctors, and students
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Acknowledgments
- 1 Introduction to neural engineering
- Abstract
- 1 Introduction
- 2 Biomedical engineering and the evolution of neural engineering
- 3 Biological considerations for neural engineering
- 4 Neural engineering strategies
- 5 Emerging technologies for neural engineering
- 6 Conclusions
- References
- Section 1: Biological considerations for neural engineering
- 2 Overview of the structure and function of the nervous system
- Abstract
- 1 Introduction
- 2 Early development of the nervous system
- 3 Functional anatomy of the CNS
- 4 Cell types
- 5 Neuronal communication
- 6 Summary and conclusions
- References
- 3 Cellular biology of the central nervous system
- Abstract
- 1 Introduction
- 2 Neurons
- 3 Astrocytes
- 4 Microglia
- 5 Oligodendrocytes
- 6 Summary and conclusions
- References
- 4 Extracellular matrix of the nervous system
- Abstract
- 1 Introduction
- 2 Composition and assembly of ECM in the nervous system
- 3 ECM during brain development
- 4 Neural ECM in aging and disease
- 5 Engineering ECM for human brain tissue models
- 6 Summary
- References
- 5 The immune system and its role in the nervous system
- Abstract
- 1 Introduction
- 2 Overview of the immune system
- 3 Immunology within the nervous system
- 4 Interactions between the nervous system and the systemic immune system
- 5 Neuroimmunity in injury, disease, and aging
- 6 Methods in neuroimmunology
- 7 Neuroimmune engineering
- 8 Conclusion
- References
- 6 Modulating disease states of the central nervous system: Outcomes of neuromodulation on microglia
- Abstract
- 1 Introduction
- 2 CNS seen from the microglial angle
- 3 Memory disorders
- 4 Disorders of inhibition
- 5 Disorders of consciousness and coma
- 6 Challenges and limitations of the techniques
- 7 Conclusion
- References
- 7 The effect of traumatic injuries on the nervous system
- Abstract
- 1 Traumatic brain injury: Context and definitions
- 2 Primary injury and the onset of traumatic brain injury pathophysiology
- 3 The continuum of secondary injury
- 4 Acute phase
- 5 Subacute phase
- 6 Chronic phase
- 7 Repetitive TBI
- 8 Future directions in neurotrauma research
- References
- 8 Chronic pain as a neurological disease and neural engineering strategies for its management
- Abstract
- Acknowledgment
- 1 Pain is a protective mechanism necessary for survival
- 2 The nociceptive pain circuit
- 3 Chronic pain is a disease in its own right
- 4 Neuromodulation as an engineering approach in managing chronic pain
- 5 Conclusions
- References
- Section 2: Neural engineering strategies
- 9 An overview of noninvasive imaging strategies in neural engineering
- Abstract
- 1 Introduction
- 2 Utility of imaging modalities to neural engineering
- 3 Optical imaging
- 4 Ultrasound (US)
- 5 Magnetic resonance imaging (MRI)
- 6 X-rays and computed tomography (CT)
- 7 Positron emission tomography (PET) and single photon emission computed tomography (SPECT)
- 8 Electroencephalogram/magnetoencephalography (EEG/MEG)
- 9 Conclusions
- References
- 10 Brain-computer interface
- Abstract
- 1 Defining brain-computer interface
- 2 History of BCI
- 3 Innovations in modern-day BCIS
- 4 Brief introduction to the nervous system
- 5 BCI types
- 6 BCI components
- 7 BCI applications
- 8 Challenges and future direction
- References
- 11 Neuroprosthetics
- Abstract
- 1 Auditory prosthesis
- 2 Deep brain stimulation
- 3 Spinal cord neuroprosthetics
- 4 Neuromuscular prosthetics
- 5 Neuroprosthetics for internal organs
- 6 Outlook: The next generation of neuroprosthetics
- References
- 12 Neural tissue engineering
- Abstract
- 1 Functional bio/nanomaterials
- 2 In vitro 3D tissue culture platforms for nervous system (spheroids and organoids)
- 3 Microfluidic systems
- 4 Scaffolding (implantable neural interfaces)
- 5 Electrical stimulations
- 6 Summary
- References
- Section 3: Emerging technologies for neural engineering
- 13 Optogenetics for neural tissue engineering applications
- Abstract
- 1 Biophysics of microbial rhodopsin
- 2 Diversity of optogenetic channels, pumps, and receptors
- 3 Use of light-sensitive proteins to manipulate intracellular signaling and metabolism
- 4 Visualization of cell activity
- 5 Optogenetics in biological systems
- 6 Optogenetics in medical applications
- 7 Future aims in optogenetic engineering
- References
- 14 Neuroengineering: History, modeling, and deliverables
- Abstract
- 1 History of genomic editing
- 2 Neuronal cell models
- 3 In vivo models and applications of delivery
- References
- 15 Recent developments in 3D bioprinting for neural tissue engineering
- Abstract
- Graphical abstract
- 1 Overview of modeling neural tissue: From 2D and 3D culture systems to 3D bioprinting
- 2 How 3D bioprinting works
- 3 Design of biomaterial-based bioinks to mimic the neural microenvironment
- 4 3D bioprinted models for studying neurodegenerative diseases
- 5 Conclusion
- References
- 16 Maximizing the utility of brain organoid models and overcoming their perceived limitations
- Abstract
- 1 Introduction
- 2 Current methods for generating brain organoids
- 3 Uses of brain organoids
- 4 Ethical considerations and limitations to data interpretation
- 5 Perspective and summary
- References
- 17 Modeling the synapse and neuromuscular junction using organ-on-a-chip technology
- Abstract
- Acknowledgments
- 1 Introduction
- 2 Synapse- and NMJ-on-a-chip: Design and fabrication
- 3 Applications of synapse and NMJ chips
- 4 Challenges and future directions
- References
- Index
- Edition: 1
- Published: September 11, 2024
- Imprint: Academic Press
- No. of pages: 678
- Language: English
- Paperback ISBN: 9780323957304
- eBook ISBN: 9780323957311
SW
Stephanie Willerth
Dr. Stephanie Willerth, Ph.D., F.C.S.S.E., F.B.S.E., is a Full Professor in Biomedical Engineering at the University of Victoria, where she has dual appointments in the Department of Mechanical Engineering and the Division of Medical Sciences. She runs an internationally recognized research group focused on tissue engineering and regenerative medicine. She also holds an appointment with the School of Biomedical Engineering at the University of British Columbia. She was elected to the Royal Society of Canada’s College of New Scholars in 2021 and received the 2021 Engineers and Geoscientists of British Columbia’s Teaching Award for Excellence. She founded the award winning start-up company Axolotl Biosciences, which sells high-quality bioinks for bioprinting human tissue models. Dr. Willerth is an active member of the steering committee of the B.C. Regenerative Medicine Initiative and the Stem Cell Network. She also serves as a staff scientist at Creative Destruction Lab. Dr. Willerth served as the Director of the Centre for Biomedical Research and the Biomedical Engineering undergraduate program at the University of Victoria from 2018-2021 and as the President of Canadian Biomaterials Society from 2018-2019. Dr. Willerth is the author of Engineering Neural Tissue from Stem Cells, published by Elsevier Academic Press in 2016.
Affiliations and expertise
Full Professor of Biomedical Engineering, University of Victoria, Canada Affiliate Professor – School of Biomedical Engineering, University of British Columbia C.E.O. of Axolotl BiosciencesRead Handbook of Neural Engineering on ScienceDirect