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Elsevier

Books in Life sciences

Elsevier's Life Sciences collection helps researchers get comprehensive coverage and up-to-date information on the study of living organisms, their processes, and interrelationships, spanning disciplines like biology, genetics, and biochemistry, and addressing emerging trends such as genomics, biotechnology, and sustainability, essential for advancing knowledge and driving innovation in the field.

  • A Structure-Function Toolbox for Membrane Transporter and Channels

    • 1st Edition
    • Volume 594
    • English
    A Structure-Function Toolbox for Membrane Transporter and Channels, Volume 594, a new release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. New chapters in the updated serial include Cryo-EM on membrane proteins embedded in nanodics, Solid-Supported membrane-based electrophysiology on membrane transporters and channels, Saposin-lipoprotein scaffolds for structure determination of membrane transporters and channels, Single-molecule FRET on transporters, Dynamics of channels and transporters investigated by NMR, Structure-function studies on channels and transporters, and a section on MemStar, a new GFP-based expression and purification system for transporters and channels.

  • Haematology Case Studies with Blood Cell Morphology and Pathophysiology

    • 1st Edition
    • Indu Singh + 3 more
    • English
    Hematology Case Studies with Blood Cell Morphology and Pathophysiology compiles specialized case studies with specific information on various hematological disorders with Full Blood Examination (FBE or CBC), blood film images and pathophysiology of each condition. In addition, it provides basic information on how to recognize and diagnose hematological conditions that are frequently observed in the laboratory. Technicians and scientists working in core laboratories such as biochemistry labs or blood banks will find this book to be extremely thorough. Moreover, it can be used as a reference book by technicians, scientists and hematologists in every level of expertise in diagnosing hematological disorders.

  • Myxomycetes

    Biology, Systematics, Biogeography and Ecology
    • 1st Edition
    • Carlos Rojas + 1 more
    • English
    Myxomycetes: Biology, Systematics, Biogeography, and Ecology is a comprehensive overview of the body of accumulated knowledge that now exists on myxomycetes. Its broad scope takes an integrated approach to the knowledge of this organismal group, considering a number of important aspects of their genetics and molecular phylogeny. It also treats myxomycetes as a distinct group from fungi, and includes molecular information that discusses the systematics and evolutionary pathways of the group. Additionally, biomedical and engineering applicability is discussed, thus expanding the audience and use of the book in a multidisciplinary context. The book provides an authoritative resource for students, researchers and educators interested in the fields of protistology, microbial ecology, molecular microbiology, biogeography, mycology, biodiversity, and evolutionary biology, and will also interest the amateur naturalist and biologist.

  • Separation of Cells and Subcellular Elements

    Proceedings of a Meeting Organised by EFRAC (European Working Party for the Separation and Detection of Biological Fractions), Sponsored by the Committee for Science and Technology of the Council of Europe, Brussels, 4-5 May 1979
    • 1st Edition
    • H. Peeters
    • English
    Separation of Cells and Subcellular Elements presents the chemical engineering approaches in bio-separation methods. This book evaluates the cellular aggregation in turbulent suspension, the phase partition of cells and subcellular particles, and the continuous free-flow electrophoresis. The first chapters deal with flow cytometric characterization of tumor associated changes in gynecologic malignancies; steady state rheolectrolysis; and electrophoretic approaches applicable to cell separation. The succeeding chapters consider the chromosome separation by velocity sedimentation at unit gravity and the separation of human lymphocytes based on volume and density. Other chapters describe the analysis of the gradient former for zonal rotors and the centrifugal elutriation of living cells. The last chapters are devoted to the human platelet isolation from whole blood on metrizamide gradients. The book can provide useful information to biochemists, cytologists, students, and researchers.

  • Evolution since Coding

    Cradles, Halos, Barrels, and Wings
    • 1st Edition
    • Zachary F. Burton
    • English
    Evolution since Coding: Cradles, Halos, Barrels, and Wings describes genesis of metabolism, transcription, translation, cell structure, eukaryotic complexity, LUCA (the last universal common (cellular) ancestor), the great divergence of archaea and bacteria, LECA (the last eukaryotic common ancestor), extinction, and cancer in very simple ways. The work (almost) "synthesizes life from scratch" (since coding) and describes the tools for readers to check the author’s work. As a result, readers understand living systems and their evolution in a conceptual way and are empowered to utilize powerful but accessible tools in computer-based biology. The work serves as foundational reading for a variety of researchers, academics, and students in life sciences, for example in evolution/evolutiona... biology, biochemistry, genetics/molecular genetics, molecular biology, cell biology, and microbiology, as well as disciplines beyond biological science. Its approachable style makes the book accessible for introductory students and educated laypersons. Evolution since Coding is suitable to supplement college courses that mix computers, evolution, and biology from freshman to senior level.

  • Advances in Microbial Physiology

    • 1st Edition
    • Volume 71
    • English
    Advances in Microbial Physiology, Volume 71, continues the long tradition of topical, important, cutting-edge reviews in microbiology. The book contains updates in the field, with comprehensive chapters covering The Microbiology of Ruthenium Complexes, The role of plant growth-promoting bacteria in metal phytoremediation, the Mechanism and Role of Globin Coupled Sensor Signaling, Cytochrome bd and gaseous ligands in bacterial physiology, and Haem-Based Sensors of O2: Lessons and Perspectives.

  • New Perspectives in Forensic Human Skeletal Identification

    • 1st Edition
    • Krista E. Latham + 2 more
    • English
    New Perspectives in Forensic Human Skeletal Identification provides a comprehensive and up-to-date perspective on human identification methods in forensic anthropology. Divided into four distinct sections, the chapters will reflect recent advances in human skeletal identification, including statistical and morphometric methods for assessing the biological profile (sex, age, ancestry, stature), biochemical methods of identification (DNA analysis, stable isotope analysis, bomb curve analysis), and use of comparative radiography. The final section of this book highlights advances in human identification techniques that are being applied to international populations and disaster victims. The contributing authors represent established experts in forensic anthropology and closely related fields. New Perspectives in Forensic Human Skeletal Identification will be an essential resource for researchers, practitioners, and advanced students interested in state-of-the-art methods for human identification.

  • Paleopathology of Children

    Identification of Pathological Conditions in the Human Skeletal Remains of Non-Adults
    • 1st Edition
    • Mary Lewis
    • English
    Palaeopathology of Children: Identification of Pathological Conditions in the Human Skeletal Remains of Non-Adults provides archaeological examples of pathological child remains with varying degrees of disease manifestation, and where possible, presents illustrations of individually affected bones to help with identification. The structure and inclusion of photographs and summary diagnostic tables make this suitable for use as a textbook. Each chapter includes a table of international archaeological cases collated by the author from published and unpublished literature. Child skeletal remains come in a variety of different sizes, with bones appearing and fusing at different times during growth. Identifying pathology in such unfamiliar bones can be a challenge, and we often rely on photographs of clinical radiographs or intact anatomical specimens to try and interpret the lesions we see in archaeological material. These are usually the most extreme examples of the disease, and do not account for the wide degree of variation we may see in skeletal remains.

  • Journeys in Science

    Inspiring the Next Generation
    • 1st Edition
    • Fanuel Muindi + 1 more
    • English
    Journeys in Science: Inspiring the Next Generation examines the STEM education pipeline and discusses important strategies on working through the various challenges that STEM trainees face. The book takes a look at career possibilities for scientists in the broadest sense, and is not solely limited to academia. Coverage includes individual and local concepts, as well as a discussion on how STEM education impacts trainee communities across the globe. The book also focuses on diversity in STEM and offers valuable insights based on the authors’ own experiences.

  • Health Professionals' Education in the Age of Clinical Information Systems, Mobile Computing and Social Networks

    • 1st Edition
    • Aviv Shachak + 2 more
    • English
    Health Professionals' Education in the Age of Clinical Information Systems, Mobile Computing and Social Networks addresses the challenges posed by information and communication technology to health professionals’ education, and the lessons learned from field experiences and research. This book is divided in three parts: "the changing landscape of information and communication technology in health care", in which it discusses how information and communication technology is transforming health care and the implications of these changes for health professions education; "experiences from the field", with real-life examples of health professionals’ education in and for the digital era; and "evaluation of students and programs", addressing the use of technology to assess learners as well as the complexity of evaluating programs to enhance competence in an information technology-rich health care world Written by leading researchers from different parts of the world, the book is a valuable source for educators and professionals who are active or wish to be part of the health informatics field.

  • Collective Oscillations in a Plasma

    International Series of Monographs in Natural Philosophy
    • 1st Edition
    • A. I. Akhiezer + 2 more
    • D. ter Haar
    • English
    International Series of Monographs in Natural Philosophy: Collective Oscillations in a Plasma, Volume 7 presents specific topics within the general field of radio waves propagation. This book contains five chapters that address the theory of linear oscillations in a plasma, the spectra of the eigen oscillations, and the mechanism of high-frequency heating. The opening chapters deal with the self-consistent fields; development of initial perturbation; dispersion permittivity tensor of a plasma in a magnetic field; effect of thermal motion of particles on low-frequency resonances; excitation of oscillations by modulated azimuthal currents; and cyclotron damping of low-frequency oscillations. The next chapters describe the nature of beam instability, the fluctuations in a free equilibrium plasma, and the current causing scattered waves. A study of the probability of scattering is presented. The concluding chapters are devoted to the scattering of electromagnetic waves in a plasma-beam system and the coefficient of reflection determination. The book can provide useful information to scientists, physicists, students, and researchers.

  • Cannabinoids and Their Receptors

    • 1st Edition
    • Volume 593
    • English
    Cannabinoids and Their Receptors, Volume 593, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This updated volume includes comprehensive chapters on a variety of topics, including Real time cAMP signaling in response to CB1 activation, CB1 signaling in mitochondria, Lipidomics of cannabinoid systems, Studying endocannabinoid transport, Metabolic profiling of CB1 neutral antagonists, Approaches to assess biased signaling at the CB1 receptor, and the Development of CB1 allosteric modulators.

  • Nitric Oxide

    Biology and Pathobiology
    • 3rd Edition
    • Louis J. Ignarro + 1 more
    • English
    Nitric Oxide: Biology and Pathobiology, Third Edition, provides information on nitric oxide, a signaling molecule of key importance for the cardiovascular system that regulates blood pressure and blood flow to different organs. With recent links to the role of nitric oxide in the expression of healthy benefits of controlled diet and aerobic exercise, and the reactions of nitric oxide that can impact cell signaling, this book provides a comprehensive resource during a time when increased research attention is being paid across the fields of pharmacology, biochemistry, cell and molecular biology, chemistry, immunology, neurobiology, immunology, nutrition sciences, drug development and the clinical management of both acute and chronic diseases.

  • The Role of Chromosomes in Cancer Biology

    Recent Results in Cancer Research
    • 1st Edition
    • Peo C. Kollerr
    • V. G. Allfrey + 2 more
    • English
    The Role of Chromosomes in Cancer Biology provides a description of the molecular organization and function of chromosomes and the consequences of chromosomal aberrations in human development. The book presents accounts on the structure and function of the chromosome; the cellular features of primary tumors and ascetic fluid; the cytological actions of radiation and drugs and their relevance to therapy. Developmental disorders caused by chromosomal anomalies; chromosome aneuploidy in human malignancies; and viral oncogenesis are discussed as well. The book will prove to be very insightful to those involved in cancer research, oncologists, cytologists, and molecular biologists.

  • New Health Systems

    Integrated Care and Health Inequalities Reduction
    • 1st Edition
    • Mohamed Lamine Bendaou + 1 more
    • English
    New health systems exist today thanks to the changing nature of diseases as a result of the integration of new technologies and new approaches in care giving and the management of healthcare systems.This book studies the health inequalities in these new health systems, structured according to the integrated health services approach. The authors investigate a wide range of debates and issues, including the consequences of a collaborative economy on healthcare and the possible “uberization” of a wide range of its services.The first part of the book offers an overview of the problem of inequalities in the field of health. The second part discusses the possibility of a sustainable and equitable architecture for health systems..

  • Saliva Protection and Transmissible Diseases

    • 1st Edition
    • Crispian Scully + 2 more
    • English
    Saliva Protection and Transmissible Diseases provides a review of saliva protection, raising debate on micro-organisms potentially transmissible in saliva, and also considering the evidence on diseases that may be transmitted by kissing. Saliva is a complex body fluid essential to health, especially mastication, swallowing and speech, and hyposalivation can lead to dysfunction and even infection. More serious pathogens, such as herpes viruses and papillomaviruses can be conveyed by kissing, as can potentially lethal micro-organisms present in some saliva, such as meningococci, fungal organisms and Ebola viruses.

  • Viroids and Satellites

    • 1st Edition
    • Ahmed Hadidi + 3 more
    • English
    Viroids and Satellites describes plant diseases and their causal agents while also addressing the economic impact of these diseases. The book discusses various strategies for state-of-the-art methods for the detection and control of pathogens in their infected hosts and provides pivotal information from the discovery of viroids through the analysis of their molecular and biological properties, to viroid pathogenesis, host interactions, and RNA silencing pathways. Students, researchers and regulators will find this to be a comprehensive resource on the topics presented.

  • Advances in Applied Microbiology

    • 1st Edition
    • Volume 100
    • English
    Advances in Applied Microbiology, Volume 100 continues to be one of the most widely read and authoritative review sources in microbiology, containing comprehensive reviews of the most current research in applied microbiology. This latest release includes specific chapters on a variety of topics, most notably, Current interventions for controlling pathogenic Escherichia coli, Microbial ecology and process technology of sourdough fermentation, Diversity, Application, and Synthetic Biology of Industrially Important Aspergillus Fungi, and Advances in the Microbial Ecology of Biohydrometallurgy. Users will find invaluable references and information on a variety of areas, including protozoan grazing of freshwater biofilms, metals in yeast fermentation processes, the interpretation of host-pathogen dialogue through microarrays and the role of polyamines in bacterial growth and biofilm formation. Eclectic volumes are supplemented by thematic volumes on various topics, including Archaea and sick building syndrome.

  • Ebola's Curse

    2013-2016 Outbreak in West Africa
    • 1st Edition
    • Michael B.A. Oldstone + 1 more
    • English
    Ebola‘s Curse: 2013-2016 Outbreak in West Africa is about hemorrhagic fever viruses, especially Ebola, its initial origin in central Africa 1976, its unprecedented appearance in West Africa in 2013. The book records in sequence and detective style how the initial outbreak of Ebola from the index case in rural Guinea traveled to Sierra Leone, the work and fate of those working in the Kenema Government Hospital (KGH) isolation ward in Sierra Leone. The book provides vignettes of the three main players involved with Ebola at KGH, Sheik Khan, Pardis Sabeti, and Robert Garry. Khan was the head of the unit, declared a national hero by his Sierra Leone government. He died fighting Ebola and was/is recognized in the USA by American societies by awards created for his historic work and death. Pardis Sabeti, a geneticist from Harvard and Broad MIT Institute, who was honored as a "Scientist of the Year" by Time Magazine and the Smithsonian Institute. Robert Garry, head of the operation to fight hemorrhagic fevers and Ebola, shuttled between Tulane University, KGH, and The White House to make aware through the press and others the dilemma and tragedy that was unfolding, and the need to obtain additional medical and health care support and supplies. Sabeti and Garry currently work with Oldstone on Ebola at KGH and thus personal communication and knowledge was/is available to the author for the book.

  • Piezo Channels

    • 1st Edition
    • Volume 79
    • English
    Piezo Channels, Volume 79, the latest volume in the Current Topics in Membranes series provides the necessary membrane research to assist readers in discovering the current state of a particular field and future directions. New chapters in the updated volume include A Tour de Force: The Discovery, Properties, and Function of Piezo Channels, Piezo1 Channels in Vascular Development and the Sensing of Shear Stress, the Origin of the Force: The Force-From-Lipids Principle Applied to Piezo Channels, Genetic Diseases of PIEZO1 and PIEZO2 Dysfunction, and The Structural Basis for Sensing by the Piezo1 Protein. Users of this series will find an up-to-date presentation of the current knowledge in the field of Piezo Channels.

  • MiRNAs in Differentiation and Development

    • 1st Edition
    • Volume 333
    • English
    MiRNAs in Differentiation and Development, Volume 333, the latest in the International Review of Cell and Molecular Biology series, reviews and details current advances in cell and molecular biology. Topics in this updated volume include chapters on the Regulation of the DNA damage response by miRNAs, miRNAs and the p53 network, the Impact of miRNAs in the cellular response to hypoxia, miRNAs in oncogenesis and tumor suppression, and the Role of miRNAs in metastatic dissemination. The IRCMB series has a worldwide readership, maintaining a high standard by publishing articles on timely topics that are authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of nine years. This great resource ranks high amongst scientific journals dealing with cell biology.

  • Cytokine Effector Functions in Tissues

    • 1st Edition
    • Maria Foti + 1 more
    • English
    Cytokine Effector Functions in Tissues discusses the cytokines networks in the context of the specific-tissue environment. It is an up-to-date collection of articles that addresses the specific issue of how the cytokines are able to condition tissue specific homeostasis. The book helps the reader understand how cytokines network inside the tissues and highlights whether tissue-protection or exacerbation will be finally controlled. It describes the cytokines detected and regulated in different tissues, such as the brain, lungs, spleen, liver, pancreas and intestine, also addressing the issue of timing in specific cell types.

  • Advances in Optical and Electron Microscopy

    • 1st Edition
    • Volume 11
    • T Mulvey + 1 more
    • English
    Advances in Optical and Electron Microscopy, Volume 11 compiles papers on the important developments in optical and electron microscopy. This book discusses the instrumentation and operation for high-resolution electron microscopy; diffraction pattern and camera length; and electron microscopy of surface structure. The history of surface imaging by conventional transmission electron microscopy; ion probe microscopy; and secondary ion mass spectrometry with high lateral resolution are also elaborated. This text likewise covers the acoustic microscopy; quantitative methods; biological applications and near-surface imaging of solids; and interior imaging. This publication is a beneficial to students and individuals researching on optical and electron microscopy.

  • Gene Editing in Plants

    • 1st Edition
    • Volume 149
    • English
    Gene Editing in Plants, Volume 149 aims to provide the reader with an up-to-date survey of cutting-edge research with gene editing tools and an overview of the implications of this research on the nutritional quality of fruits, vegetables and grains. New chapters in the updated volume include topics relating to Genome Engineering and Agriculture: Opportunities and Challenges, the Use of CRISPR/Cas9 for Crop Improvement in Maize and Soybean, the Use of Zinc-Finger Nucleases for Crop Improvement, Gene Editing in Polyploid Crops: Wheat, Camelina, Canola, Potato, Cotton, Peanut, Sugar Cane, and Citrus, and Gene Editing With TALEN and CRISPR/Cas in Rice. This ongoing serial contain contributions from leading scientists and researchers in the field of gene editing in plants who describe the results of their own research in this rapidly expanding area of science.

  • Handbook of Epigenetics

    The New Molecular and Medical Genetics
    • 2nd Edition
    • Trygve O. Tollefsbol
    • English
    Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition, provides a comprehensive analysis of epigenetics, from basic biology, to clinical application. Epigenetics is considered by many to be the new genetics in that many biological phenomena are controlled, not through gene mutations, but rather through reversible and heritable epigenetic processes. These epigenetic processes range from DNA methylation to prions. The biological processes impacted by epigenetics are vast and encompass effects in lower organisms and humans that include tissue and organ regeneration, X-chromosome inactivation, stem cell differentiation, genomic imprinting, and aging. The first edition of this important work received excellent reviews; the second edition continues its comprehensive coverage adding more current research and new topics based on customer and reader reviews, including new discoveries, approved therapeutics, and clinical trials. From molecular mechanisms and epigenetic technology, to discoveries in human disease and clinical epigenetics, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics, to therapeutic interventions for epigenetic-based disorders.

  • Dietary Fiber for the Prevention of Cardiovascular Disease

    Fiber’s Interaction between Gut Microflora, Sugar Metabolism, Weight Control and Cardiovascular Health
    • 1st Edition
    • Rodney A. Samaan
    • English
    Dietary Fiber for the Prevention of Cardiovascular Disease: Fiber’s Interaction between Gut Micoflora, Sugar Metabolism, Weight Control and Cardiovascular Health compiles the most up-to-date research discoveries to provide a timely and scientific rationale for the significant impact of a fiber rich diet for the prevention of heart disease. By focusing on the science behind how fiber, both soluble and insoluble can lead to lower rates of heart disease, this important reference will educate researchers, cardiologists, medical providers and students on how to improve patients’ hearts via a fiber rich diet. Coverage includes the known mechanisms of how fiber works to reduce insulin resistance, control weight, reduce cholesterol by binding with bile, maintain stable glucose levels and influence gut microflora.

  • Western Blotting Guru

    • 1st Edition
    • Ayaz Najafov + 1 more
    • English
    Western Blotting Guru provides researchers in molecular biology with a handy reference for approaching and solving challenging problems associated with immunoblotting setup and optimization. As a laboratory guide, it emphasizes the technical aspects of efficiently employing immunoblotting as a tool in molecular biology laboratories. The book covers the basic science underlying immunoblotting and detailed description of the method parameters, followed by good benchtop practices, tips and tricks for obtaining high-quality data and a detailed troubleshooting guide addressing a variety of problem types.

  • Structural and Mechanistic Enzymology

    • 1st Edition
    • Volume 109
    • English
    Structural and Mechanistic Enzymology, Volume 109, the latest release in the Advances in Protein Chemistry and Structural Biology series, is an essential resource for protein chemists. Chapters in this new volume include Collagenolytic Matrix Metalloproteinase Structure–Function Relationships: Insights from Molecular Dynamics Studies, Computational Glycobiology: Mechanistic Studies of Carbohydrate-Active Enzymes and Implication for Inhibitor Design, Computational Biochemistry─Enzyme Mechanisms Explored, and A Paradigm for C─H Bond Cleavage: Structural and Functional Aspects of Transition State Stabilization by Mandelate Racemase. This series presents new information on protocols and analysis of proteins, with each volume guest edited by leading experts in a broad range of protein-related topics. This volume presents state-of-the-art contributions, providing insights into the relationship between enzyme structure, catalysis, and function.

  • Encyclopedia of Sustainable Technologies

    • 1st Edition
    • English
    Encyclopedia of Sustainable Technologies, Eight Volume Set provides an authoritative assessment of the sustainable technologies that are currently available or in development. Sustainable technology includes the scientific understanding, development and application of a wide range of technologies and processes and their environmental implications. Systems and lifecycle analyses of energy systems, environmental management, agriculture, manufacturing and digital technologies provide a comprehensive method for understanding the full sustainability of processes. In addition, the development of clean processes through green chemistry and engineering techniques are also described. The book is the first multi-volume reference work to employ both Life Cycle Analysis (LCA) and Triple Bottom Line (TBL) approaches to assessing the wide range of technologies available and their impact upon the world. Both approaches are long established and widely recognized, playing a key role in the organizing principles of this valuable work.

  • Treating Life-Threatening Bleedings

    Development of Recombinant Coagulation Factor VIIa
    • 1st Edition
    • Ulla Hedner
    • English
    Treating Life-Threatening Bleedings: Development of Recombinant Coagulation Factor VIIa provides a comprehensive understanding of the first new drug within the area of hemostasis, describing a new mechanism of action that has resulted in a modified concept of the whole hemostasis mechanism. As the treatment of life-threatening bleedings is a serious challenge for clinicians, this powerful and historic case study presents a detailed roadmap on how a new medicine can be developed, stressing the interaction between science and clinical work. The book stresses the importance of patient care in the learning process and provides new ideas on how to approach diseases and their treatment. Users will find a real world example that will act as a timely resource for those learning about, or engaged in, performing and supervising research across the biomedical sciences.

  • Board Review in Preventive Medicine and Public Health

    • 1st Edition
    • Gregory M. Schwaid
    • English
    Board Review in Preventive Medicine and Public Health prepares physicians for their initial and recertification board exams in the related specialties of preventive, occupational and aerospace medicine. Formatted in a question and answer based style that imitates material on specialty exams, each question is linked to a detailed answer. The book contains over 640 question and answer sets covering areas such as general public health, health management, health law, community health, infectious disease, clinical preventive medicine, occupational medicine, aerospace medicine, environmental medicine, correctional (prison) medicine, emergency preparedness, epidemiology and biostatistics. The book is an essential board preparation for physicians with a background in the fields of preventive medicine, occupational medicine, and aerospace medicine. It is also useful for medical students, public health students and those wishing to gain an understanding of the key points in these fields.

  • Viral Proteases and Their Inhibitors

    • 1st Edition
    • Satya Prakash Gupta
    • English
    Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents.

  • The Microbiome in Health and Disease

    • 1st Edition
    • Volume 149
    • English

  • DNA Repair Enzymes: Structure, Biophysics, and Mechanism

    • 1st Edition
    • Volume 592
    • English
    DNA Repair Enzymes, Part B, Volume 592 is the latest volume in the Methods in Enzymology series and the first part of a thematic that focuses on DNA Repair Enzymes. Topics in this updated volume include MacroBac: New Technologies for Robust and Efficient Large-Scale Production of Recombinant Multiprotein Complexes, Production and Assay of Recombinant Multisubunit Chromatin Remodeling Complexes, Analysis of Functional Dynamics of Modular Multidomain Proteins by SAXS and NMR, the Use of Single-Cysteine Variants for Trapping Transient States in DNA Mismatch Repair, and Structural Studies of RNases H2 as an Example of Crystal Structure Determination of Protein-Nucleic Acid Complexes.

  • Key Advances in Clinical Informatics

    Transforming Health Care through Health Information Technology
    • 1st Edition
    • Aziz Sheikh + 3 more
    • English
    Key Advances in Clinical Informatics: Transforming Health Care through Health Information Technology provides a state-of-the-art overview of the most current subjects in clinical informatics. Leading international authorities write short, accessible, well-referenced chapters which bring readers up-to-date with key developments and likely future advances in the relevant subject areas. This book encompasses topics such as inpatient and outpatient clinical information systems, clinical decision support systems, health information technology, genomics, mobile health, telehealth and cloud-based computing. Additionally, it discusses privacy, confidentiality and security required for health data. Edited by internationally recognized authorities in the field of clinical informatics, the book is a valuable resource for medical/nursing students, clinical informaticists, clinicians in training, practicing clinicians and allied health professionals with an interest in health informatics.

  • Matrix Metalloproteinases and Tissue Remodeling in Health and Disease: Target Tissues and Therapy

    • 1st Edition
    • Volume 148
    • English
    Matrix Metalloproteinases and Tissue Remodeling in Health and Disease: Target Tissues and Therapy, Volume, Volume 148, the latest volume in the Progress in Molecular Biology and Translational Science series covers a variety of timely topics, with chapters focusing on The Role of Matrix Metalloproteinases in Development, Repair, and Destruction of the Lungs, Matrix Metalloproteinases in Kidney Disease: Role in Pathogenesis and Potential as a Therapeutic Target, Regulation of Matrix Metalloproteinase in the Pathogenesis of Diabetic Retinopathy, Matrix Metalloproteinases in Normal Pregnancy and Preeclampsia, and Matrix Metalloproteinases, Neural Extracellular Matrix, and Central Nervous System Pathology. This volume is the second part of a thematic on matrix metalloproteinases and tissue remodeling in health and disease. It focuses on the role of MMPs in other systems, target tissues, and pathological disorders and the potential benefits of MMP inhibitors in various disorders.

  • Erythropoietin

    • 1st Edition
    • Volume 105
    • English
    Erythropoietin, Volume 105, the latest release in the Vitamins and Hormones series first published in 1943, and the longest-running serial published by Academic Press, provides up-to-date information on crystal structures and basic structural studies on neurotrophins and their receptors, neurotrophin functions and the biological actions of neurotrophins related to clinical conditions and disease. Topics covered in this new volume include Erythropoietin Receptor Structural Domains, Analysis of the Asymmetry of Activated EPO Receptor Enables Designing Small Molecule Agonists, Endogenous Erythropoietin, Erythropoietin Receptor Signaling and Lipid Rafts, and Erythropoietin and Hypothalamic-Pituita... Axis. Each thoroughly reviewed volume focuses on a single molecule or disease that is related to vitamins or hormones, with the topic broadly interpreted to include related substances, such as transmitters, cytokines, growth factors and others. This volume documents the activities of this vital molecule, also describing the structure and function of erythropoietin and its receptor.

  • Ethical Challenges in Oncology

    Patient Care, Research, Education, and Economics
    • 1st Edition
    • Colleen Gallagher + 1 more
    • English
    Ethical Challenges in Oncology: Patient Care, Research, Education, and Economics covers a wide variety of topics and viewpoints about ethical issues that arise in oncology throughout the full cancer care continuum. This book provides a holistic view on oncology ethics, incorporating the knowledge and expertise of authors from various departments and oncology specialties within the University of Texas MD Anderson Cancer Center. The first section focuses on the ethical issues associated with treating cancer patients. Next, the ethical challenges associated with oncology research, including funding, regulation, subject selection and the big picture are explored. The third section covers ethical issues associated with education in oncology as it reflects both past and future trends in developing proficient health care providers, patients and even executives. Final sections concentrate on the ethical dilemmas associated with the economic repercussions of oncology, offering thoughts on how to alleviate the ethical consequences that can arise from the global effects of cancer and cancer treatment. Each chapter includes discussion topics, answers pertinent questions and provides an ethical framework for problem- solving in each scenario. The topics uncover the ethical apprehensions and problems associated with oncology research and practice in order to determine best practices as well as provide guidance for all parties involved.

  • Biomedical Engineering in Gastrointestinal Surgery

    • 1st Edition
    • Armin Schneider + 1 more
    • English
    Biomedical Engineering in Gastrointestinal Surgery is a combination of engineering and surgical experience on the role of engineering in gastrointestinal surgery. There is currently no other book that combines engineering and clinical issues in this field, while engineering is becoming more and more important in surgery. This book is written to a high technical level, but also contains clear explanations of clinical conditions and clinical needs for engineers and students. Chapters covering anatomy and physiology are comprehensive and easy to understand for non-surgeons, while technologies are put into the context of surgical disease and anatomy for engineers. The authors are the two most senior members of the Institute for Minimally Invasive Interdisciplinary Therapeutic Interventions (MITI), which is pioneering this kind of collaboration between engineers and clinicians in minimally invasive surgery. MITI is an interdisciplinary platform for collaborative work of surgeons, gastroenterologists, biomedical engineers and industrial companies with mechanical and electronic workshops, dry laboratories and comprehensive facilities for animal studies as well as a fully integrated clinical "OR of the future".

  • DNA Repair Enzymes: Cell, Molecular, and Chemical Biology

    • 1st Edition
    • Volume 591
    • English
    DNA Repair Enzymes, Part A, Volume 591 is the latest volume in the Methods in Enzymology series and the first part of a thematic that focuses on DNA repair enzymes. Topics in this new release include chapters on the Optimization of Native and Formaldehyde iPOND Techniques for Use in Suspension Cells, the Proteomic Analyses of the Eukaryotic Replication Machinery, DNA Fiber Analysis: Mind the Gap!, Comet-FISH for Ultrasensitive Strand-Specific Detection of DNA Damage in Single Cells, Examining DNA Double-Strand Break Repair in a Cell Cycle-Dependent Manner, Base Excision Repair Variants in Cancer, and Fluorescence-Based Reporters for Detection of Mutagenesis in E. coli.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 81
    • English
    Advances in Clinical Chemistry, Volume 81, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. New to this latest release are chapters that cover Microparticles in Chronic Heart Failure, Peptide Antibodies in Clinical Laboratory Diagnostics, Measurement and Clinical Utility of βCTX in Serum and Plasma, Human Papillomavirus and its Testing Assays, Cervical Cancer Screening, and Vaccination, and Physical Exercise and DNA Injury: Good or Evil? The serial presents the latest technologies related to the field of clinical chemistry, and is the benchmark for novel analytical approaches in the clinical laboratory.

  • Molecular Approach to Cancer Management

    • 1st Edition
    • Gajanan V. Sherbet
    • English
    Molecular Approach to Cancer Management discusses molecular mechanisms of cancer initiation, growth and secondary spread, emphasizing how this information can be used to devise new modes of treatment of cancer, especially in combatting secondary spread. The book addresses the basic concepts relating to cancer biology, the genetic determinants, and the signal transduction cascades associated with tumor growth, EMT, stem cell maintenance and propagation, and invasion and metastasis. The salient features of the signaling systems that are amenable to targeted manipulation are emphasized to facilitate research and development in the design of novel therapies and for the planning of new trials. This book is the only unique volume with coverage of topics that target therapy. As such, it is a valuable source for cancer researchers, molecular oncologists and members of the biomedical field who are interested in knowing more about molecular approaches to cancer therapy.

  • Microbiology and Molecular Diagnosis in Pathology

    A Comprehensive Review for Board Preparation, Certification and Clinical Practice
    • 1st Edition
    • Audrey Wanger + 5 more
    • English
    Microbiology and Molecular Diagnosis in Pathology: A Comprehensive Review for Board Preparation, Certification and Clinical Practice reviews all aspects of microbiology and molecular diagnostics essential to successfully passing the American Board of Pathology exam. This review book will also serve as a first resource for residents who want to become familiar with the diagnostic aspects of microbiology and molecular methods, as well as a refresher course for practicing pathologists. Opening chapters discuss issues of laboratory management, including quality control, biosafety, regulations, and proper handling and reporting of laboratory specimens. Review chapters give a quick overview of specific clinical infections as well as different types of bacteria, viruses, fungal infections, and infections caused by parasites. Following these, coverage focuses on diagnostic tools and specific tests: media for clinical microbiology, specific stains and tests for microbial identifications, susceptibility testing and use of antimicrobial agents, tests for detecting antibodies, antigens, and microbial infections. Two final chapters offer overviews on molecular diagnostics principles and methods as well as the application of molecular diagnostics in clinical practice.

  • Agriculture to Zoology

    Information Literacy in the Life Sciences
    • 1st Edition
    • Jodee L Kuden + 2 more
    • English
    Agriculture to Zoology: Information Literacy in the Life Sciences sets the stage for purposefully integrating information literacy activities within the subject-specific content of the life sciences. The book is written for librarians and other professionals who teach information literacy skills, especially those in the science disciplines, and most especially the life sciences. It is also intended to be helpful to secondary school teachers, college faculty who teach life science-related subjects, library school students, and others interested in information literacy and science education. Anyone wanting to learn more about the Earth’s life sciences, from citizen to scientist, will benefit as well. The book’s seven chapters fill a gap with varying perspectives of literacy instruction in the life sciences and include resources identified by academic librarians as important for use in subject-specific research in higher education. Contributors are longtime specialists in the fields of the life sciences, science and information literacy, scientific and electronic communication, assessment, and more, including Arctic and Antarctic information.

  • Nitric Oxide (Donor/Induced) in Chemosensitization

    • 1st Edition
    • Volume 1
    • Benjamin Bonavida
    • English
    Nitric Oxide as a Chemosensitizing Agent, Volume One is the first book to describe several reviews by authoritative scientists and clinicians on novel findings in the reversal of drug resistant cancers by the combination treatment of Nitric Oxide and sub toxic concentrations of chemotherapeutic drugs that have been reported in both in vitro, in vivo and preclinical models. The book describes the various underlying chemical, molecular and genetic mechanisms by which NO and NO reactive species mediate the anti-cancer activity, thus reducing the threshold of drug resistance and enabling chemo therapeutic drugs to induce their cytotoxic activity and reversal of resistance. This book exposes scientists and clinicians to this highly beneficial topic for research investigations and pharmaceutical companies to new avenues for R&D. It is a valuable resource for cancer researchers, oncologists and members of several areas of the biomedical field who are interested in understanding how to use Nitric Oxide as a sensitizing agent for chemotherapy.

  • Biomechanics of Living Organs

    Hyperelastic Constitutive Laws for Finite Element Modeling
    • 1st Edition
    • Yohan Payan + 1 more
    • English
    Biomechanics of Living Organs: Hyperelastic Constitutive Laws for Finite Element Modeling is the first book to cover finite element biomechanical modeling of each organ in the human body. This collection of chapters from the leaders in the field focuses on the constitutive laws for each organ. Each author introduces the state-of-the-art concerning constitutive laws and then illustrates the implementation of such laws with Finite Element Modeling of these organs. The focus of each chapter is on instruction, careful derivation and presentation of formulae, and methods. When modeling tissues, this book will help users determine modeling parameters and the variability for particular populations. Chapters highlight important experimental techniques needed to inform, motivate, and validate the choice of strain energy function or the constitutive model. Remodeling, growth, and damage are all covered, as is the relationship of constitutive relationships of organs to tissue and molecular scale properties (as net organ behavior depends fundamentally on its sub components). This book is intended for professionals, academics, and students in tissue and continuum biomechanics.

  • RNA Modification

    • 1st Edition
    • Volume 41
    • English
    RNA Modification, Volume 41 examines the powerful ability to regulate the function of RNA molecules or modify the message transmitted by RNA molecules. Chapters in this newly released volume include The Importance of Being Modified: Modifications Shape RNA Function through Chemistry, Structure and Dynamics, The evolution of multi-substrate specificity by RNA modification enzymes, TrmD: a methyl transferase for tRNA methylation with m1G37, Structures and activities of the Elongator complex and its co-factors, RNA pseudouridylation: Mechanism and Function, The activity of 5’3' exonucleases on hypo modified tRNA substrates and other structured RNAs, and the Synthesis, heterogeneity and function of post-transcriptional nucleotide modifications in eukaryotic ribosomal RNAs. This field has recently seen a very rapid progress in the understanding of the mechanism and enzymes involved in RNA modification. This volume presents some of the most recent advances in the identification and function of enzymes involved in modifying RNA molecules.

  • Kidney Transplantation, Bioengineering, and Regeneration

    Kidney Transplantation in the Regenerative Medicine Era
    • 1st Edition
    • Giuseppe Orlando + 2 more
    • English
    Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era investigates how the field of regenerative medicine is changing the traditional premises of solid organ transplantation, specifically within the field of kidney transplantation. In Section 1, chapters illustrate the state of the art in kidney transplantation as well as the research behind the bioengineering and regeneration of kidney organoids for therapeutic renal replacement. In Section II, chapters catalog the technologies that are being developed and the methods that are being implemented to bioengineer or regenerate kidneys in order to restore function, while critically highlighting those technological advances which hold the most promise. The book thus encompasses clinical renal transplantation, tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, as they are all applied to the kidney.

  • Alpha-1-antitrypsin Deficiency

    Biology, Diagnosis, Clinical Significance, and Emerging Therapies
    • 1st Edition
    • Noor Kalsheker + 1 more
    • English
    Alpha-1-antitrypsin Deficiency: Biology, Diagnosis, Clinical Significance, and Emerging Therapies is the authoritative reference on AATD, providing standards for diagnosis, monitoring, treatment and appropriate avenues of research. The book covers the disease from basic biology and epidemiology, to clinical impact, and includes the understanding of the natural history of the disease and the significant advances that have been made in the last 20 years, including the three-dimensional structure of the molecule, its broad biological activity and improved therapeutic options, including replacement therapy and gene therapy. The editors have recruited international experts in the field to contribute evidence-based chapters and insights on future developments in the understanding of this disease.

  • Physiology of the Cladocera

    • 2nd Edition
    • Nikolai N. Smirnov
    • English
    Approx.402 pages

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