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Books in Life sciences

Elsevier's Life Sciences collection helps researchers get comprehensive coverage and up-to-date information on the study of living organisms, their processes, and interrelationships, spanning disciplines like biology, genetics, and biochemistry, and addressing emerging trends such as genomics, biotechnology, and sustainability, essential for advancing knowledge and driving innovation in the field.

BooksJournals

    • Molecular Players in iPSC Technology

      • 1st Edition
      • August 29, 2021
      • Alexander Birbrair
      • English
      • Paperback
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      • eBook
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      The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology.Molecular Players in iPSC Technology, Volume 12 addresses the molecular players underlying induced pluripotent stem cell (iPSC) generation, maintenance, expansion, and differentiation. The discovery of iPSCs revolutionized biomedical research. iPSC technology involves multiple molecular mechanisms. This volume covers exosomal microRNAs, auxiliary pluripotency-associa... genes, inducible caspase-9 suicide gene, cell cycle proteins, ion channels, Notch signaling, kinase signaling, SOCS3/JAK2/STAT3 pathway, NANOG, Krüppel-like factors, H1FOO, and much more in iPSCs. The volume is written for researchers and scientists in stem cell therapy, cellular and molecular biology, and regenerative medicine and is contributed by world-renowned authors in the field.

    • Current Progress in iPSC-derived Cell Types

      • 1st Edition
      • June 2, 2021
      • Alexander Birbrair
      • English
      • Paperback
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      • eBook
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      The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Current Progress in iPSC-derived Cell Types, Volume 10 addresses how induced pluripotent stem cells can be differentiated into different cell types. Somatic cells can be reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells have been transforming biomedical research over the last 15 years. This volume will address the advances in research of how research of induced pluripotent stem cells can be reprogrammed to develop new treatment technologies in regenerative medicine. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field.

    • Human Growth and Development

      • 3rd Edition
      • November 18, 2021
      • Noel Cameron + 1 more
      • English
      • Paperback
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      • eBook
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      Human Growth and Development, Third Edition provides a comprehensive volume covering the biology of human growth and the genetic, endocrine, environmental, nutritional, and socio-economic factors that contribute towards its full expression. Human Growth and Development continues to be a valuable resource for researchers, professors and graduate students across the interdisciplinary area of human development. For the new edition, updates are made to all fourteen of the "core chapters" of the book which form the essential reading for a comprehensive understanding of human growth and development. Additionally, new special topics are covered including the interpretation of recently found sub-adult fossils that expand our understanding of the evolution of human growth and a discussion of the early pattern of growth and development as the developmental origins of risk for non-communicable diseases of adulthood. Human Growth and Development, Third Edition includes contributions from the well-known experts in the field and is the most reputable, comprehensive resource available.

    • Therapeutic Strategies to Overcome ALK Resistance in Cancer

      • 1st Edition
      • Volume 13
      • January 5, 2021
      • Luc Friboulet
      • English
      • Hardback
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      • eBook
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      Therapeutic Strategies to Overcome ALK Resistance in Cancer, Volume 13, presents current strategies to improve and prolong clinical benefit in ALK driven cancers. Most patients with ALK-driven cancer are sensitive to tyrosine kinase inhibitor (TKI) therapy, but resistance invariably develops. This book discusses topics such as structure and function of ALK, ALK rearranged lung cancer, resistance mechanisms to ALK TKI tumors, and novel therapeutic strategies to enhance crizotinib anti-tumor efficacy in ALCL. Additionally, it encompasses information on drug combinations to enhance ALK TKI anti-tumor efficacy in neuroblastoma and future perspectives in the field. This book is a valuable resource for cancer researchers, clinicians and several members of biomedical field who need to understand more about how to fight ALK resistance in cancer treatment.

    • Gigantism and Acromegaly

      • 1st Edition
      • June 1, 2021
      • Constantine A. Stratakis
      • English
      • Paperback
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      • eBook
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      Gigantism and Acromegaly brings together pituitary experts, taking readers from bench research, to genetic analysis, clinical analysis, and new therapeutic approaches. This book serves as a reference for growth hormone over-secretion and its diagnosis and treatment for endocrinologists, pediatricians, internists, and neurosurgeons, and for geneticists. Pharmaceutical companies may use it as a reference for drug development and research. Students, residents and fellows in medicine and endocrinology and genetics will also find it valuable as it provides a single up-to-date review of the molecular biology of gigantism and acromegaly as well as recommended approaches to evaluation and management. Acromegaly is a rare pituitary disorder that slowly changes its adult victim’s appearance over time: larger hands and feet, bigger jaw, forehead, nose, and lips. Generally, a benign pituitary tumor is the cause and symptoms of acromegaly can vary from patient to patient, making a diagnosis difficult and prolonging suffering for years. Early detection is key in the management of acromegaly as the pathologic effects of increased growth hormone (GH) production are progressive and can be life-threatening as the result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies.

    • Peripartum Cardiomyopathy

      • 1st Edition
      • January 8, 2021
      • Karen Sliwa
      • English
      • Paperback
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      • eBook
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      Peripartum Cardiomyopathy: From Pathophysiology to Management covers the pathophysiology and the heterogenous mode of presentation of PPCM to assist in risk stratification and provide a guide for the acute and long-term management of women affected by this serious condition. Each chapter provides structured figures and practical algorithms as well as prints of electrocardiograms, echocardiographic, MRI images and several case studies throughout. This title is a must have reference for those doing basic research in this area as well as all healthcare providers caring for peripartum women, including obstetricians, general physicians, cardiologists, intensivists, as well as nurses caring for heart failure patients.

    • Tumor Microenvironment Regulation of Tumor Expansion

      • 1st Edition
      • April 4, 2021
      • Domenico Ribatti
      • English
      • Paperback
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      • eBook
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      Tumor Microenvironment Regulation of Tumor Expansion is a practical guide to understand and perform research on tumor microenvironments, and to support related clinical decisions. Tumor progression is linked to an imbalance between positive and negative regulators, and mainly depends on the release of specific growth factors by inflammatory or neoplastic cells. Inflammatory infiltrate contributes to tumor progression and the metastatic process, and there are many reports of associations between tumor inflammatory infiltrate, progression, and prognosis. Understanding different contexts of organs is a key factor in improving treatment outcome, especially in new therapeutic treatments targeting components of the tumor microenvironment. This book is a valuable resource for cancer researchers, clinicians, graduate students, and scientists in many biomedical fields who are interested in the complex relationship between the tumor microenvironment and its context in specific organs.

    • Mitochondrial Metabolism

      • 1st Edition
      • July 28, 2021
      • Jalal Pourahmad + 1 more
      • English
      • Paperback
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      • eBook
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      Mitochondrial Metabolism: An Approach for Disease Management covers mitotherapy from three combined perspectives, Pharmacology, Toxicology and Biochemistry. After an introduction from world-renowned experts, the book's chapters cover the balancing role in reduction/oxidation mitochondria play, mitochondria as targets for therapeutics through its metabolism, mitochondrial contributions to the cell death process, mitochondrial response to environmental toxicants, the mitochondrial role in aging, the impact of calorie restrictive diets, new advances in the identification of altered mitochondria associated signaling pathways in carcinogenesis, and much more. This book provides bioscientists new horizons to realize the importance of mitochondria in present-day research on therapies dealing with mitochondria associated chronic diseases, including diabetes, cancer and neurodegenerative disorders.

    • Rational Machines and Artificial Intelligence

      • 1st Edition
      • March 31, 2021
      • Tshilidzi Marwala
      • English
      • Paperback
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      • eBook
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      Intelligent machines are populating our social, economic and political spaces. These intelligent machines are powered by Artificial Intelligence technologies such as deep learning. They are used in decision making. One element of decision making is the issue of rationality. Regulations such as the General Data Protection Regulation (GDPR) require that decisions that are made by these intelligent machines are explainable. Rational Machines and Artificial Intelligence proposes that explainable decisions are good but the explanation must be rational to prevent these decisions from being challenged. Noted author Tshilidzi Marwala studies the concept of machine rationality and compares this to the rationality bounds prescribed by Nobel Laureate Herbert Simon and rationality bounds derived from the work of Nobel Laureates Richard Thaler and Daniel Kahneman. Rational Machines and Artificial Intelligence describes why machine rationality is flexibly bounded due to advances in technology. This effectively means that optimally designed machines are more rational than human beings. Readers will also learn whether machine rationality can be quantified and identify how this can be achieved. Furthermore, the author discusses whether machine rationality is subjective. Finally, the author examines whether a population of intelligent machines collectively make more rational decisions than individual machines. Examples in biomedical engineering, social sciences and the financial sectors are used to illustrate these concepts.

    • Vascular Surgery

      • 1st Edition
      • October 14, 2021
      • Piergiorgio Settembrini + 1 more
      • English
      • Paperback
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      • eBook
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      Vascular Surgery: A Clinical Guide to Decision-making is a concise but comprehensive resource for operating vascular surgeons and clinicians. It serves as an essential reference manual, particularly to young vascular surgeons, for consulting the basic scientific knowledge of pathogenesis of various illnesses, as well as how to approach them in a clinical setting. Adopting a translational approach, this book dissects the background of vascular pathology and links it to application in surgical techniques, as well as providing practical tips and tricks for surgical maneuvers. With insights and suggestions from various experienced and skilled vascular surgeons, this book covers a range of topics including the origin of diseases, clinical presentation, and therapeutic options, from medical therapy to surgical or endovascular approach. Each chapter also reviews international cutting-edge research in the vascular field and its clinical application, illuminating future developments in the field. With the contributions of first-class vascular surgeons, this book also covers uncommon and advanced case studies while exploring the pros and cons of each intervention option, helping practitioners make informed decisions when facing difficult cases. This unique reference also helps young surgeons to make quick decisions in challenging cases, such as how to choose between open and endo treatment.

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