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Tumor Microenvironment Regulation of Tumor Expansion

  • 1st Edition - April 4, 2021
  • Latest edition
  • Author: Domenico Ribatti
  • Language: English

Tumor Microenvironment Regulation of Tumor Expansion is a practical guide to understand and perform research on tumor microenvironments, and to support related clinical decisions… Read more

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Description

Tumor Microenvironment Regulation of Tumor Expansion is a practical guide to understand and perform research on tumor microenvironments, and to support related clinical decisions.

Tumor progression is linked to an imbalance between positive and negative regulators, and mainly depends on the release of specific growth factors by inflammatory or neoplastic cells. Inflammatory infiltrate contributes to tumor progression and the metastatic process, and there are many reports of associations between tumor inflammatory infiltrate, progression, and prognosis. Understanding different contexts of organs is a key factor in improving treatment outcome, especially in new therapeutic treatments targeting components of the tumor microenvironment.

This book is a valuable resource for cancer researchers, clinicians, graduate students, and scientists in many biomedical fields who are interested in the complex relationship between the tumor microenvironment and its context in specific organs.

Key features

  • Provides a holistic approach to understanding the crucial role of the tumor microenvironment in tumor progression
  • Encompasses the basic knowledge necessary to understand and undertake further studies related to tumor microenvironments
  • Discusses new therapeutic approaches developed to control tumor progression by targeting different components of the tumor microenvironment

Readership

Cancer researchers, medical scientists, clinicians, graduate students

Table of contents

1. Tumor microenvironment1.1. Metastatic cascade1.2. Epithelial-mesenchymal transition1.3. The extracellular matrix2. Tumor blood vessels and tumor endothelial cells3. Tumor angiogenesis4. Inflammatory cells in tumor microenvironment4.1. Neutrophils4.2. Eosinophils and dendritic cells4.3. Lymphocytes and platelets4.4. Mast cells4.5. Macrophages4.6. Tie-2 expressing monocytes (TEMs)4.7. Fibroblasts4.8. Osteoblasts and osteoclasts4.9. Cancer stem cells (CSCs)4.10. Circulating endothelial cells and endothelial precursor cells4.11. Multipotents adult progenitor cells (MAPCs) and myeloid-derived suppressor cells (MDSCs)5. Therapeutic strategies

Product details

  • Edition: 1
  • Latest edition
  • Published: April 9, 2021
  • Language: English

About the author

DR

Domenico Ribatti

Domenico Ribatti was awarded his M.D. degree in October 1981, with full marks. In 1983, D.R. joined the Medical School as Assistant at the Institute of Human Anatomy, University of Bari. In 1984, he took the specialization in Allergology. In 1989, he spent one year in Geneva, working at the Department of Morphology (Prof. R. Montesano). In 2008, he received the honoris causa degree in Medicine and Pharmacy form the University of Timisoara (Romania). D.R. is author of 866 publications as reported in PUBmed and contributed to 50 chapters to books. Overall, his papers have been cited 51153 times. He has published many books with both Elsevier and Springe
Affiliations and expertise
Full Professor of Human Anatomy, University of Bari Medical School, Bari, Italy

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