Tumor Microenvironment Regulation of Tumor Expansion
- 1st Edition - April 4, 2021
- Imprint: Academic Press
- Author: Domenico Ribatti
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 2 8 0 3 - 6
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 2 8 0 4 - 3
Tumor Microenvironment Regulation of Tumor Expansion is a practical guide to understand and perform research on tumor microenvironments, and to support related clinical decisions… Read more
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Request a sales quoteTumor Microenvironment Regulation of Tumor Expansion is a practical guide to understand and perform research on tumor microenvironments, and to support related clinical decisions.
Tumor progression is linked to an imbalance between positive and negative regulators, and mainly depends on the release of specific growth factors by inflammatory or neoplastic cells. Inflammatory infiltrate contributes to tumor progression and the metastatic process, and there are many reports of associations between tumor inflammatory infiltrate, progression, and prognosis. Understanding different contexts of organs is a key factor in improving treatment outcome, especially in new therapeutic treatments targeting components of the tumor microenvironment.
This book is a valuable resource for cancer researchers, clinicians, graduate students, and scientists in many biomedical fields who are interested in the complex relationship between the tumor microenvironment and its context in specific organs.
- Provides a holistic approach to understanding the crucial role of the tumor microenvironment in tumor progression
- Encompasses the basic knowledge necessary to understand and undertake further studies related to tumor microenvironments
- Discusses new therapeutic approaches developed to control tumor progression by targeting different components of the tumor microenvironment
Cancer researchers, medical scientists, clinicians, graduate students
- Cover image
- Title page
- Table of Contents
- Copyright
- Preface
- Chapter 1. Tumor microenvironment
- 1.1. Introduction
- 1.2. Tumor microenvironment
- 1.3. Tumor hypoxia and interstitial fluid pressure
- Chapter 2. Bone marrow niches
- 2.1. Introduction
- 2.2. Vascular niche
- 2.3. Endosteal niche
- 2.4. Bone marrow niche and vessel formation
- Chapter 3. Metastatic cascade
- 3.1. Introduction
- 3.2. Mechanisms of metastasis
- 3.3. Lymphatic vessels
- 3.4. Premetastatic niche
- Chapter 4. Epithelial mesenchymal transition
- 4.1. Epithelial–mesenchymal transition and mesenchymal to epithelial transition
- Chapter 5. The extracellular matrix
- 5.1. The components of the extracellular matrix
- 5.2. Proteolytic enzymes
- 5.3. Angiogenesis stimulators and inhibitors in the extracellular matrix
- 5.4. Desmoplasia and cancer
- Chapter 6. Tumor blood vessels and tumor endothelial cells
- 6.1. Tumor blood vessels
- 6.2. Tumor endothelial cells
- 6.3. Note
- Chapter 7. Tumor basement membrane
- 7.1. The structure of the basement membrane
- 7.2. Tumor basement membrane
- Chapter 8. Tumor pericytes
- 8.1. Morphological and functional characteristics of pericytes
- 8.2. Tumor pericytes
- Chapter 9. Inflammatory cells in tumor microenvironment
- 9.1. The link between chronic inflammation and tumorigenesis
- 9.2. Neutrophils
- 9.3. Eosinophils
- 9.4. Dendritic cells
- 9.5. Lymphocytes
- 9.6. Natural killer cells
- 9.7. Platelets
- 9.8. Mast cells
- 9.9. Monocytes and macrophages
- Chapter 10. Other cells of the tumor microenvironment
- 10.1. Tie-2 expressing monocyte
- 10.2. Fibroblasts
- 10.3. Osteoblasts, osteoclasts, and adipocytes
- 10.4. Cancer stem cells
- 10.5. Circulating endothelial cells and endothelial precursor cells
- Chapter 11. Therapeutic strategies
- 11.1. Anti-inflammatory compounds
- 11.2. Therapeutic vaccines and immune checkpoints
- 11.3. Targeting the tumor vasculature
- Index
- Edition: 1
- Published: April 4, 2021
- No. of pages (Paperback): 172
- No. of pages (eBook): 172
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780128228036
- eBook ISBN: 9780128228043
DR
Domenico Ribatti
Domenico Ribatti was awarded his M.D. degree in October 1981, with full marks. In 1983, D.R. joined the Medical School as Assistant at the Institute of Human Anatomy, University of Bari. In 1984, he took the specialization in Allergology. In 1989, he spent one year in Geneva, working at the Department of Morphology (Prof. R. Montesano). In 2008, he received the honoris causa degree in Medicine and Pharmacy form the University of Timisoara (Romania). D.R. is author of 866 publications as reported in PUBmed and contributed to 50 chapters to books. Overall, his papers have been cited 51153 times.
He has published many books with both Elsevier and Springe
Affiliations and expertise
Full Professor of Human Anatomy, University of Bari Medical School, Bari, ItalyRead Tumor Microenvironment Regulation of Tumor Expansion on ScienceDirect