Current Progress in iPSC-derived Cell Types
- 1st Edition - June 2, 2021
- Imprint: Academic Press
- Editor: Alexander Birbrair
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 3 8 8 4 - 4
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 3 8 8 5 - 1
The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Current Progress… Read more
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Request a sales quoteThe series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Current Progress in iPSC-derived Cell Types, Volume 10 addresses how induced pluripotent stem cells can be differentiated into different cell types.
Somatic cells can be reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells have been transforming biomedical research over the last 15 years. This volume will address the advances in research of how research of induced pluripotent stem cells can be reprogrammed to develop new treatment technologies in regenerative medicine.
The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field.
- Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine and therapeutics
- Covers iPSCs derived cardiomyocytes, skeletal muscles, brown adipocytes, airway epithelial cells, and much more
- Contributed by world-renown experts in the field
Researchers and scientists in stem cell therapy, cell biology, regenerative medicine, and organ transplantation. Graduate and undergraduate students in the above fields
- Cover image
- Title page
- Table of Contents
- Advances in Stem Cell Biology
- Copyright
- Dedication
- Contributors
- About the editor
- Preface
- Chapter 1. Human-induced pluripotent stem cell–derived macrophages for studying infection biology and immunology
- Generation of human-induced pluripotent stem cells
- Diversity of stem cell differentiation and infection models
- iPSCs and infection biology
- Future trends and directions
- Chapter 2. In vitro T lymphopoiesis: iPSCs for T cell generation, foundations, innovations, and future directions
- iPSC discovery, method of generation, and current uses
- Hematopoietic progenitor cells from pluripotent stem cells
- Introduction to T cells: brokers of adaptive immunity
- T-cell development in humans
- Naïve T-cell activation, effector differentiation, and memory phenotypes
- Engineered autologous T cells as therapy for hematopoietic malignancies
- In vitro model systems for generation of T cells
- In vitro generation of T cells: beyond UCB
- Future trends: T-cell generation and expansion from iPSCs to enhance therapeutic efficacy and availability of CAR-T cell therapy
- Conclusion
- Chapter 3. Chondrocytes derived from pluripotent stem cells: applications in cartilage repair
- Introduction
- Cartilage structure, disease, and repair
- Generation of chondrocytes from pluripotent stem cells
- Use of iPSC-derived chondrocytes in cartilage disease modeling and therapeutic discovery
- iPSC-derived chondrocytes—a potential source for cartilage repair and regeneration
- Current challenges and future perspectives
- Chapter 4. Induced pluripotent stem cell-derived odontoblasts for disease modeling, drug development, and craniofacial applications
- Induced pluripotent stem cells: characteristics and reprogramming
- iPSCs from craniofacial sources
- Conclusion
- Chapter 5. Insights into current models for developing brown adipocytes from induced pluripotent stem cells
- Introduction
- Developmental origins of adipocytes
- Transcriptional regulation and molecular profiling of major adipocyte populations
- Models for generating adipocytes from hiPSCs
- Insights and future perspectives
- Chapter 6. Differentiation of human-induced pluripotent stem cells to the neural crest lineage
- Perturbation of the neural crest leads to congenital malformations and cancer
- The embryonic neural crest lineage
- Use of hiPSCs for modeling of neural crest disease
- Acquisition of patient-specific or genotype-specific hiPSCs for disease modeling
- Current approaches to differentiating distinct neural crest subtypes from hiPSCs
- The need for more refined neural crest differentiation protocols
- Functional analysis of hiPSC-derived neural crest cells
- Chapter 7. Differentiation of human induced pluripotent stem cells to hepatocyte-like cells for toxicological applications: recent advances using small molecule approaches
- Introduction
- Hepatocytes and in vitro hepatotoxicity models
- Hepatocyte differentiation in vivo—organogenesis and development of the liver
- Generating hepatocytes from pluripotent stem cells
- Hepatocyte-like cells derived from human induced pluripotent stem cells for toxicological applications
- Perspectives
- Chapter 8. Progress in generating iPSC-derived dopaminergic neurons as accurate models of neurodegenerative disease
- Introduction
- Midbrain dopaminergic neuronal development
- The generation of DA neurons from human pluripotent stem cells
- Generation of correct, functional midbrain DA neurons from hPSCs
- Need for a standardized protocol
- Steps toward optimizing the protocol
- Applications
- Modifications or methods to improve the current protocols
- Coculturing with astrocytes
- Expert opinion on future trends
- Chapter 9. Cellular bioenergetics in human iPSC–derived glutamatergic neurons in health and disease
- Introduction
- Generation of cortical glutamatergic neurons from induced pluripotent stem cells
- Brain bioenergetics: the basics
- Cell bioenergetics: methodological approaches
- Alteration of metabolism in brain disorders: hiPSC as model
- Concluding remarks and perspectives
- Chapter 10. Astrocytes in neurodegenerative disorders: from disease modeling to therapeutic interventions
- Introduction
- Astrocytes in neurodegenerative diseases
- Astrocyte-targeting drugs: an alternative strategy to identify neuroprotective medicines
- In vivo astrocyte-to-neuron conversion to regenerate lost neuronal populations
- Conclusions
- Chapter 11. Notochord-like cells derived from induced pluripotent stem cells and their therapeutic potential in treating sympathetic disc degeneration
- The intervertebral discs and the pathology of chronic low back pain
- The origin of IVDs
- Molecular signals deriving notochord and subsequent NP development
- Loss of notochordal-like cells and the coincidence with disc degeneration
- Cell transplantation to treat IVD degeneration
- Generation of NCs from PSCs
- Biological restoration of NP by NC transplantation
- Therapeutic effects of the NC secretions
- Antiinflammatory activities of NCs
- Safety concerns of NC transplantation
- Future perspectives
- Chapter 12. iPSC-derived gonadal cell models
- Regulation of gonadal formation and sex development
- Available models for gonadal research
- hiPSC-derived somatic gonadal cell models
- hiPSC-derived germ cell models
- Future of iPSC-derived gonadal cell models
- Index
- Edition: 1
- Published: June 2, 2021
- No. of pages (Paperback): 336
- No. of pages (eBook): 336
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780128238844
- eBook ISBN: 9780128238851
AB
Alexander Birbrair
Dr. Alexander Birbrair received his bachelor’s biomedical degree from Santa Cruz State University in Brazil. He completed his PhD in Neuroscience, in the field of stem cell biology, at the Wake Forest School of Medicine under the mentorship of Osvaldo Delbono. Then, he joined as a postdoc in stem cell biology at Paul Frenette’s laboratory at Albert Einstein School of Medicine in New York. In 2016, he was appointed faculty at Federal University of Minas Gerais in Brazil, where he started his own lab. His laboratory is interested in understanding how the cellular components of different tissues function and control disease progression. His group explores the roles of specific cell populations in the tissue microenvironment by using state-of-the-art techniques. His research is funded by the Serrapilheira Institute, CNPq, CAPES, and FAPEMIG. In 2018, Alexander was elected affiliate member of the Brazilian Academy of Sciences (ABC), and, in 2019, he was elected member of the Global Young Academy (GYA), and in 2021, he was elected affiliate member of The World Academy of Sciences (TWAS). He is the Founding Editor and Editor-in-Chief of Current Tissue Microenvironment Reports, and Associate Editor of Molecular Biotechnology. Alexander also serves in the editorial board of several other international journals: Stem Cell Reviews and Reports, Stem Cell Research, Stem Cells and Development, and Histology and Histopathology.
Affiliations and expertise
Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Department of Radiology, Columbia University Medical Center, Medical Center, USARead Current Progress in iPSC-derived Cell Types on ScienceDirect